JP5734947B2 - 異常型ミトコンドリアｄｎａ、関連融合転写物および翻訳産物、並びにそのハイブリダイゼーションプローブ - Google Patents

異常型ミトコンドリアｄｎａ、関連融合転写物および翻訳産物、並びにそのハイブリダイゼーションプローブ Download PDF

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JP5734947B2
JP5734947B2 JP2012501093A JP2012501093A JP5734947B2 JP 5734947 B2 JP5734947 B2 JP 5734947B2 JP 2012501093 A JP2012501093 A JP 2012501093A JP 2012501093 A JP2012501093 A JP 2012501093A JP 5734947 B2 JP5734947 B2 JP 5734947B2
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cancer
transcript
mitochondrial
fusion
transcripts
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JP2012501093A
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Japanese (ja)
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JP2012521745A5 (enExample
JP2012521745A (ja
Inventor
パー，ライアン
ダクボ，ガブリエル
ハーボトル，アンドリュー
レガリー，ブライアン
クリード，ジェニファー
ロビンソン，ケリー
クライン，ダニエル
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Genesis Genomics Inc
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Genesis Genomics Inc
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Priority claimed from PCT/CA2009/000351 external-priority patent/WO2009117811A1/en
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Publication of JP2012521745A5 publication Critical patent/JP2012521745A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2012501093A 2009-03-27 2010-03-29 異常型ミトコンドリアｄｎａ、関連融合転写物および翻訳産物、並びにそのハイブリダイゼーションプローブ Expired - Fee Related JP5734947B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CAPCT/CA2009/000351 2009-03-27
PCT/CA2009/000351 WO2009117811A1 (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
PCT/CA2010/000423 WO2010115261A1 (en) 2009-03-27 2010-03-29 Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor

Publications (3)

Publication Number Publication Date
JP2012521745A JP2012521745A (ja) 2012-09-20
JP2012521745A5 JP2012521745A5 (enExample) 2013-05-16
JP5734947B2 true JP5734947B2 (ja) 2015-06-17

Family

ID=42937093

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012501093A Expired - Fee Related JP5734947B2 (ja) 2009-03-27 2010-03-29 異常型ミトコンドリアｄｎａ、関連融合転写物および翻訳産物、並びにそのハイブリダイゼーションプローブ

Country Status (6)

Country Link
EP (2) EP2411522B1 (enExample)
JP (1) JP5734947B2 (enExample)
KR (1) KR101720555B1 (enExample)
AU (1) AU2010234238B2 (enExample)
RU (1) RU2011137486A (enExample)
WO (1) WO2010115261A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10970604B2 (en) 2018-09-27 2021-04-06 Industrial Technology Research Institute Fusion-based classifier, classification method, and classification system

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101693387B1 (ko) 2008-03-28 2017-01-05 엠디엔에이 라이프 사이언시즈 인코퍼레이티드 비정상적인 미토콘드리아 ｄｎａ, 그것에 연관된 융합 트랜스크립트 및 혼성화 프로브
CN113025633B (zh) * 2019-12-09 2024-08-27 武汉纽福斯生物科技有限公司 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6218117B1 (en) * 1998-06-15 2001-04-17 Mitokor Compositions and methods for identifying agents that quantitatively alter detectable extramitochondrial DNA:mitochondrial DNA ratios
US20030162174A1 (en) * 2001-06-11 2003-08-28 Sutherland John W. Detecting nucleic acid deletion sequences
WO2002101086A2 (en) * 2001-06-11 2002-12-19 1304854 Ontario Ltd. Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
DE602006017534D1 (de) * 2005-04-18 2010-11-25 Mitomics Inc Mitochondriale mutationen und umlagerungen als diagnostisches werkzeug zum nachweis von sonneneinstrahlung, prostatakrebs und anderen krebserkrankungen
EP2634267B1 (en) * 2007-09-26 2015-02-18 Mitomics Inc. 3.4 kb mitochondrial DNA deletion for use in the detection of cancer
KR101693387B1 (ko) * 2008-03-28 2017-01-05 엠디엔에이 라이프 사이언시즈 인코퍼레이티드 비정상적인 미토콘드리아 ｄｎａ, 그것에 연관된 융합 트랜스크립트 및 혼성화 프로브

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10970604B2 (en) 2018-09-27 2021-04-06 Industrial Technology Research Institute Fusion-based classifier, classification method, and classification system

Also Published As

Publication number Publication date
KR101720555B1 (ko) 2017-03-29
RU2011137486A (ru) 2013-05-10
EP3272871A1 (en) 2018-01-24
AU2010234238B2 (en) 2016-07-28
EP2411522B1 (en) 2017-09-06
KR20140014360A (ko) 2014-02-06
EP2411522A4 (en) 2013-01-02
AU2010234238A1 (en) 2011-09-29
EP3272871B1 (en) 2020-01-15
JP2012521745A (ja) 2012-09-20
WO2010115261A1 (en) 2010-10-14
EP2411522A1 (en) 2012-02-01

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