JP5721099B2 - Disposable test plate and analyzer - Google Patents

Description

  The present invention relates to a disposable test plate and an analyzer.

2. Description of the Related Art Conventionally, in hospitals and the like, various components contained in urine are analyzed, and urine is collected from the patient and analyzed in order to determine the health condition of the patient from the analysis result.
There are three types of analysis of urine analysis: qualitative analysis, quantitative analysis and sedimentation analysis.
Qualitative analysis is an analysis to determine whether or not a specific component is present in urine. Test paper with a plurality of reagent pads attached to a strip-shaped support is used as urine in a test tube. After soaking, the color reaction of each reagent pad is analyzed using a dedicated qualitative analyzer configured to measure the color reaction of each reagent pad by an optical technique such as a reflection photometry.
The quantitative analysis is an analysis for measuring the amount of characteristic components in urine, and the analysis is performed by a dedicated quantitative analysis device.
The sedimentation analysis is an analysis for measuring sediments in urine, and the analysis is performed with a dedicated sedimentation analyzer and a microscope.
As described above, since a dedicated device is used for each analysis, a test tube containing urine is required for each type of analysis, but urine is usually collected in a paper cup called a Harun cup. It is necessary to dispense urine from the Harun Cup into several tubes before.
The inventor of this application invented an automatic urine dispensing device capable of fully automatically performing urine dispensing processing from a Harun cup to a test tube and applying a patient identification label to each test tube. An application has been filed (Patent Document 1).
However, since urine tests are frequently performed, the consumption of test tubes and labels is considerably increased. For this reason, it is desirable to reduce the consumption of test tubes and labels. However, when all analyzes are performed with a dedicated analyzer as in the prior art, the consumption of test tubes and labels cannot be reduced.
The applicant pays attention to the above-mentioned problems, and can perform qualitative analysis without dispensing urine into the test tube. At the same time, the applicant can transfer from the Harun Cup to the test tube for quantitative analysis or sedimentation analysis, if necessary. Proposed a qualitative analysis device equipped with an automatic dispensing mechanism that can dispense urine and automatically attach a patient identification label to a test tube (Patent Document 2).

JP-A-10-142235 JP 2006-275697 A

FIG. 19 is a schematic top view of a qualitative analyzer equipped with an automatic dispensing mechanism proposed by the applicant in Patent Document 2.
As shown in the drawing, the qualitative analyzer equipped with this automatic dispensing mechanism is
A Harun cup supply and accommodation mechanism 103 comprising a pre-treatment Harun cup housing portion 100, a post-treatment Harun cup housing portion 101, and a transfer means 102 for transferring the Harun cup from the pre-treatment Harun cup housing portion 100 to the post-treatment Harun cup housing portion 101;
Test tube supply / accommodation provided with a pre-treatment test tube housing portion 104, a post-treatment test tube housing portion 105, and a transfer means 106 for transferring the test tube from the pre-treatment test tube housing portion 104 to the post-dispensing test tube housing portion 105 A mechanism 107;
And a qualitative analysis mechanism 108 disposed between the Harun cup supply / accommodation mechanism 103 and the test tube supply / accommodation mechanism 107.
The qualitative analysis mechanism 108 accommodates a plurality of test papers 109 each provided with a plurality of reagent pads on an elongated support, takes out the stored test papers 109 one by one, and sequentially sends them to the spotting position T5 and the measurement position T6. It is configured. FIG. 19B shows a test paper 109 used in the qualitative analysis mechanism 108.
However, as described above, in order to sequentially take out and send the independent test papers 109 one by one, a complicated transfer structure is required. Further, in the case of the individual test papers 109 one by one, since the test paper 109 is small, the test paper 109 may drop or shift during the transfer, and the test paper 109 is often wasted. This is a major problem because the test paper 109 is relatively expensive.
Also, as described above, when the test paper 109 is taken out one by one and sent to the spotting position T5 and the measurement position T6, the test paper 109 needs to be sent in series, so that the color reaction on the test paper 109 is caused over time. Cannot be observed.
Furthermore, there is a problem that the test papers that are independent one by one may cause the specimens to hang down from the test papers and stain the device when the specimens are spotted.
It is an object of the present invention to provide an analyzer test plate that can solve the above-described conventional problems and an analyzer that uses the test plate.

In order to achieve the above-described object, the test plate according to the present invention is a disposable test plate used in an analyzer that optically measures a color reaction of a test reagent part by spotting a sample on the test reagent part. a is, the test plate, on a disposable disc body, the inspection unit for one sample having a plurality of reagent portion comprises a plurality radially arranged opening mutually spacing the disc on the body In addition, an individual identifier obtained by electronically coding identification information that can identify individual disposable test plates is provided .
In addition, each of the inspection units can have recesses radially disposed on the disposable disk, and in this case, a plurality of reagent units can be provided at the bottom of the recesses.
Further, each of the inspection sections may have a test paper provided with a plurality of inspection reagent sections on the strip.
Moreover, the said recessed part may be comprised so that the said test paper can be attached so that attachment or detachment is possible.
Furthermore, prior SL disc on the body, can be provided with color sample as an internal standard for optical measurement. In this case, color information of the color sample may be included in the individual identifier.
The plate body may be configured to be stackable. Preferably, the plate body has an outer peripheral wall extending downward on an outer periphery thereof, and when a plurality of disposable test plates are stacked, the inner surface of the outer peripheral wall of the upper test plate is the outer peripheral wall of the lower test plate. It may be configured to contact the outer surface to form a sealed space between the upper test plate and the lower test plate. In addition, when a plurality of disposable test plates are stacked, each inspection part of the lower test plate is closed by the back surface of the plate body of the upper test plate so that each inspection part is sealed. The plate body may be formed.
An analyzer according to the present invention is an analyzer using the disposable test plate according to any one of claims 1 to 8 , wherein a sample is spotted on a test reagent unit provided in the test unit. A spotting mechanism, a test reagent portion spotted with a specimen, and a rotating means for rotating the disposable test plate. The spotting position by the spotting mechanism and the measurement position by the optical measuring means are the same as those of the disposable test plate. The rotating means is configured to arrange and rotate the disposable test plate so as to be positioned on the rotation trajectory of each inspection unit, and reads the individual identifier provided on the disc body of the test plate positioned on the rotating means. Each analysis result is stored in association with the individual identifier .
In addition, the analyzer may include a test plate storage unit that stores a plurality of disposable test plates, and may include transfer means that sequentially takes out the test plates from the test plate storage unit and transfers them to the spotting measurement position.
Furthermore, the rotation means may be configured to rotate the test plate at an arbitrary time interval, and the optical measurement means may measure the color reaction of the test reagent part after spotting with time.
In addition, the rotating means can be configured to rotate the test plate before use, and the optical measuring means can confirm whether or not each inspection portion of the test plate is usable.

In the test plate according to the present invention, a plurality of test sections for one specimen are provided radially with a space between each other, so that the test sections are arranged on the same circumference. Thereby, even if it does not move a test plate back and forth, right and left, it becomes possible to move each test | inspection part to the spotting position of a test substance and the measurement position of a color reaction only by rotating a test plate. Therefore, a plurality of specimens can be inspected with a single test plate without requiring a complicated structure in the analyzer. In addition, each test unit can be moved to the spot position of the specimen and the measurement position of the color reaction by rotating the test plate, so that the same test unit can be repeatedly sent to the measurement position. Thus, it becomes possible to measure the color reaction of the inspection reagent part in each inspection part over time.
In addition, each inspection unit has recesses radially arranged on the disposable disk with a space between each other, and a plurality of reagent units are provided at the bottom of the recesses so that the test units are mutually recessed. It is possible to prevent cross contamination between inspection parts. Further, the sample spotted on the test reagent section of the test section does not hang from the test plate and contaminate the apparatus.
Further, by providing an individual identifier obtained by electronically identifying identification information that can identify individual disposable test plates on the disc body, the analyzer can inspect the test plate identification information and the used inspection unit or defective inspection. It is possible to associate and store information related to parts, for example, even when a test plate using only a part of the inspection part is temporarily stored and used later. It becomes possible to recognize the inspection unit.
Furthermore, since each test part is composed of test paper provided with a plurality of test reagent parts on the strip, a test plate can be manufactured simply by placing a commercially available test paper on a disposable disk. The test plate can be easily manufactured and the price can be reduced.
In addition, by configuring the test paper so that it can be detachably attached to the recess provided on the disc body, a test plate can be manufactured simply by attaching a commercially available test paper to the recess. The plate is easy to manufacture and the price is low. In addition, when there is a defect such as a discoloration of the inspection reagent part in some inspection parts during use, only the test paper of the inspection part with the defect can be replaced, so there is no waste. The
Also, on each said disk body is provided with a color sample as an internal standard for optical measurement, and the by including color information of the color sample to the individual identifier, the color analysis device for each test plate The sample and color information can be read, and the analyzer can be calibrated based on the read information.
Furthermore, since the test plates can be stacked, a plurality of test plates can be stacked and stored, so that the test plate management place can be made compact.
In addition, when the test plates are stacked, it is configured to form a sealed space between the upper test plate and the lower test plate, preventing each test plate from deteriorating during storage. can do.
Furthermore, when a plurality of disposable test plates are stacked, each inspection portion of the test plate located on the lower side is blocked by the back surface of the plate body of the test plate located on the upper side, and each inspection portion is sealed. By forming the plate body as described above, for example, after using a part of the inspection unit, the test plate is stored in a state where an unused inspection unit remains, and the test is performed after a predetermined time or number of days has elapsed. When the plate is used again, the unused inspection section is not deteriorated by the humidity of the inspection section that has been used (that is, the sample has been spotted) during storage.
The analyzer according to the present invention is provided with a rotating means for rotating the disposable test plate, and a disposable test plate in which a plurality of test parts for one specimen are radially provided with a space between each other is spotted by a spotting mechanism. By configuring the rotation means so that the position and the measurement position by the optical measurement means are positioned on the rotation trajectory of each inspection part of the disposable test plate, the rotation means is configured to rotate the test plate forward, backward, left and right. Even if it does not move, it is possible to move each inspection section to the spotting position of the specimen and the measurement position of the color reaction only by rotating the test plate. Therefore, a plurality of specimens can be inspected with a single test plate without providing a complicated moving mechanism for moving the test plate.
Further, since the rotating means is configured to rotate the test plate at an arbitrary time interval, the same inspection section can be repeatedly sent to the measurement position, and the inspection reagent section of each inspection section It becomes possible to measure the color reaction over time.
Furthermore, the analyzer is configured to read the individual identifier provided on the disk main body of the test plate located on the rotating means and store each analysis result in association with the individual identifier. Identification information and information on used inspection units or defective inspection units can be stored in association with each other.For example, a test plate using only a part of the inspection units is temporarily stored. Even when used later, it becomes possible to automatically recognize the inspection unit that can be used.
In addition, by rotating the test plate before use and checking the deterioration of the inspection part with the optical measurement means, it is possible to prevent the sample from being spotted on the inspection part in an unusable state. It can be performed reliably and the sample is not wasted.

It is a top view of a test plate. (A) is an AA end view in FIG. 1, and (b) is a BB end view in FIG. (A) is CC sectional drawing in FIG. 1, (b) has each shown the DD end elevation in FIG. It is the schematic which shows the relationship between a test plate and an analyzer. It is a figure which shows the test plate of another shape. Schematic top view showing the layout of each mechanism of the analyzer according to the present invention It is a schematic top view which shows the analyzer of the state which removed the test tube supply accommodation mechanism 20 for dispensing. Schematic perspective view of Harun cup supply and accommodation mechanism 10 Schematic perspective view of dispensing test tube supply and storage mechanism 20 It is a schematic perspective view of an automatic dispensing unit. (A)-(c) is a figure explaining operation | movement of a dispensing mechanism. (A)-(c) is a figure explaining operation | movement of a spotting mechanism. 3 is a schematic perspective view of an analysis mechanism 80. FIG. In this figure, the optical measuring means is omitted. 3 is a schematic perspective view of a dry box 82. FIG. 4 is a schematic perspective view of a test plate cutting unit 83. FIG. 3 is a schematic perspective view of a shutter unit 84. FIG. 3 is a schematic perspective view of a turntable unit 85. FIG. 3 is a schematic perspective view of a shooter unit 86. FIG. The schematic top view of the conventional qualitative analyzer is shown.

  Hereinafter, embodiments of a test plate according to the present invention and an analyzer using the test plate will be described with reference to an embodiment shown in the accompanying drawings.

(Explanation of test plate)
1 is a top view of one embodiment of a test plate according to the present invention, FIG. 2 (a) is an AA end view in FIG. 1, and FIG. 2 (b) is a BB end view in FIG. is there. 3A is a cross-sectional view taken along the line CC in FIG. 1, and FIG. 3B is an end view taken along the line DD in FIG.
As shown in these drawings, the test plate A has a disk-shaped disc main body A2 in which an outer peripheral wall A1 extending downward is formed around the test plate A. A flange A3 extending radially outward is formed at the lower end of the outer peripheral wall A1.
At the center of the test plate A, there is formed a locking portion A4 that is locked to a turntable 85a (rotating means according to the present invention) described later, and a donut-shaped groove A5 is formed so as to surround the locking portion A4. A donut-shaped protrusion A6 is formed around the donut-shaped groove A5. Further, on the side wall of the groove A5, there are formed protrusions A7 projecting radially inward at four positions at intervals of 90 degrees (see FIG. 1 and FIG. 2), and 60 degrees on the outer peripheral wall A1. Protrusions A8 projecting radially outward are formed at six locations at intervals of (see FIGS. 1 and 2A). When the test plates A are stacked, the bottom surface of the groove A5 and the bottom surface of the flange A3 are locked to the protrusions A7 and A8 so that the test plate A does not completely overlap.
On the upper surface of the disk main body A2 of the test plate A, a plurality of inspection portions A9 made of elongated concave portions extending in the radial direction are formed at intervals from each other (22 in this embodiment). A plurality of protrusions A10 are formed on the side walls of the recesses forming the inspection portions 9 so as to accommodate and hold the test paper therein.
Each test section A9 is provided with a test paper A12 having a plurality of test reagent sections A11 carrying a reagent that reacts with the substance to be detected in the sample and develops a color on the strip, and each test section A1. Functions as an inspection unit for one specimen. Although the test paper A12 is omitted in FIGS. 2 and 3, the test paper A12 is basically mounted and used in all the inspection sections A9.
Further, a label A13 on which an individual identifier converted into an electronic code is printed in the form of a barcode or the like is attached to the disk main body A2 of the test plate A. Further, a color sample serving as an internal standard for optical measurement can be printed on the label A13. In the individual identifier, in addition to the identification information that can identify the individual disposable test plate A, in the case where a color sample is printed, color information relating to the color sample (color sample serving as an internal standard for optical measurement). Can be included. Specifically, the color information of the color sample may be, for example, an RGB value and a light / dark value.
In this embodiment, the label A13 on which the individual identifier and the color sample are printed is affixed to the disc main body A2. However, the individual identifier and the color sample may be directly printed on the disc main body A2, or the individual identifier. May be configured with a tag or the like.

According to the test plate A configured as described above, since one test plate A is provided with a plurality of test sections A9 for one sample, a plurality of samples can be analyzed with one test plate A. Can do.
Further, since each inspection portion A8 is formed by an elongated recess and the test paper A12 is held in the recess, the accommodated test paper A12 is partitioned by a peripheral wall that forms the recess of each inspection portion A8. Is done. As a result, the specimen spotted on the reagent part A11 of each test paper A12 leaks to other test paper A11 and causes cross contamination, or leaks outside the test plate A and contaminates the analyzer. Can be prevented.

As shown in FIG. 4, the test plate A configured as described above is used on an appropriate rotating means B of the analyzer.
In addition to the rotation means B, the analyzer draws a specimen from a specimen cup (not shown) and places the specimen on the reagent part A11, and presents the reagent part A11 on which the specimen is spotted. Optical measurement means D for optically measuring the color reaction.
The spotting mechanism C and the optical measurement means D are arranged on the rotation path of the inspection part A8 of the test plate A rotated by the rotation means B.
In FIG. 4, a symbol T5 indicates a position of the test plate A that can be spotted and measured, a symbol T6 indicates a position at which one sample is spotted by the spotting mechanism C, and a symbol T7 indicates optical. The position where measurement by the measuring means D is performed is shown.
Here, an example of the operation of the analyzer will be briefly described. When the test plate A is set at the spotting measurement position T5, the rotating means B rotates the test plate A before spotting is performed. The optical measuring means D reads the information of the individual identifier of the test plate A, stores the identification information of the test plate A, optically measures the color of each reagent part A11 of each inspection part A9, and cannot be used due to deterioration. The presence or absence of a proper inspection unit A9 is confirmed. When the unusable inspection part A9 is found, the means B, C, and D are operated so as to perform spotting measurement by skipping the unusable inspection part A9, or the unusable inspection part A9. Is displayed to the user on a monitor (not shown) and the user is prompted to replace the test paper A12 of the inspection unit A9. Further, when the test plate A is provided with a color sample serving as an internal standard for optical measurement, the optical measuring means D obtains color information of the color sample included in the color sample of the test plate A and the individual identifier. Read and calibrate based on the read information.
After completion of the preliminary check of the test plate A, the spotting mechanism C and the rotating means B are moved in conjunction with each other to spot one sample on the reagent part A11 of the examination part A8 at the spotting position T6. .
The rotation means B rotates the reagent plate A when the spotting on the reagent part A11 in one inspection part A8 is completed. And when inspection part A8 passes measurement position T7 by optical measurement means D, optical measurement means D optically measures the color reaction of each reagent part A11 of inspection part A8 using CCD etc., for example.
The rotating means B rotates the reagent plate A once, and then stops the inspection unit A8 next to the inspection unit A8 previously spotted at the spotting position T6.
Thereafter, the spotting mechanism C and the rotating means B are moved in conjunction with each other to start spotting the next sample. When the spotting of the sample is completed, the rotating means B rotates the test plate A again. During this rotation, both the inspection unit A8 that has been spotted before and the inspection unit A8 that has been spotted next pass through the measurement position T7. The optical measuring means D optically measures the color reaction of each reagent part A11 of both inspection parts A8 passing through the measurement position T7. Thereby, the optical measuring means D measures the color reaction of the reagent part A11 of the same inspection part A8 a plurality of times over time with a predetermined time interval.
As described above, the rotating means B may be configured to rotate the test plate A every time the spotting of each inspection unit A8 is completed, but when the next spotting process is not performed immediately. May be configured to rotate the test plate A periodically at predetermined time intervals.
Further, the rotating means B may be configured so that the test plate A can be rotated at an arbitrary timing by an operation by the user as required. Furthermore, the rotation speed of the test plate A by the rotation means B, the rotation time interval and / or the number of rotations, and the measurement timing by the optical measurement means D according to the rotation of the test plate A by the rotation means B are not shown. It can be configured to be arbitrarily set via an interface.
The measurement result of each inspection unit A8 by the optical measurement unit D is stored in an appropriate storage unit together with the identification information of the test plate A read from the individual identifier and the position of the inspection unit A8 in the test plate A.
Since the test plate A is provided with a plurality of inspection portions A8, not all inspection portions A8 are used in one inspection. When all the inspection parts A8 are not used, the test plate A is removed from the rotating means B and stored, and is used again after a predetermined time has elapsed or another day. Even in such a case, as described above, the measurement result of each inspection unit A8 by the optical measurement unit D is recorded in the storage unit together with the identification information of the test plate A read from the individual identifier and the position of the inspection unit A8 in the test plate A. Therefore, the position of the unused inspection unit A8 can be automatically recognized based on the identification information of the test plate A at the preliminary check stage of the test plate A.

In the above-described embodiment, the disk main body A2 of the test plate A is circular. However, the shape of the disk main body A2 is not limited to this embodiment, and a plurality of inspection portions A8 are provided radially with a predetermined interval. Any shape may be used as long as it is, for example, as shown in FIG. 5, it may be rectangular or polygonal.
Furthermore, in the above-described implementation, the inspection unit A8 in the test plate A has a recess, and is configured to attach the test paper A12 provided with the reagent unit A11 in the recess. The configuration is not limited to this example. For example, the reagent part A11 may be formed directly on the bottom surface of the recess, and the test paper A12 is directly pasted on the upper surface of the flat disk body A2. Also good.
Furthermore, when the test plate A is stacked with a plurality of disposable test plates, the inner surface of the outer peripheral wall A1 of the upper test plate A comes into contact with the outer surface of the outer peripheral wall A1 of the lower test plate A, and A sealed space may be formed between the test plate A and the lower test plate A.
In addition, when a plurality of disposable test plates are stacked, each inspection part of the lower test plate is closed by the back surface of the plate body of the upper test plate so that each inspection part is sealed. The plate body may be formed.

Next, an embodiment of an analyzer equipped with an automatic dispensing mechanism using the above-described test plate A will be described.
FIG. 6 is a schematic top view showing the layout of each mechanism of an analyzer equipped with an automatic dispensing mechanism (hereinafter simply referred to as an analyzer). As shown in FIG. A dispensing test tube supply / accommodating mechanism 20, a dispensing mechanism 30, a spotting mechanism 40, a reading mechanism 50, a label printing / sticking mechanism 60, and an analysis mechanism 80 are provided.
The Harun cup supply / accommodation mechanism 10, the dispensing test tube supply / accommodation mechanism 20, the dispensing mechanism 30, the spotting mechanism 40, the reading mechanism 50, and the label printing / sticking mechanism 60 are configured as one automatic dispensing unit, and are analyzed. It can be separated from the mechanism 80. The automatic dispensing unit can operate as an automatic dispensing machine independently while being separated from the analysis mechanism 80.
Further, the analysis mechanism 80 can operate as an independent analyzer by adding the spotting mechanism 40.
In the automatic dispensing unit, the Harun cup supply / accommodation mechanism 10 and the dispensing test tube supply / accommodation mechanism 20 are arranged one above the other. Specifically, the dispensing test tube supply / accommodating mechanism 20 is disposed above the Harun cup supply / accommodating mechanism 10.
Hereinafter, the configuration of each mechanism constituting the analyzer will be described in detail.

(Description of Harun cup supply and accommodation mechanism 10)
7 is a schematic top view showing the analyzer with the dispensing test tube supply / accommodating mechanism 20 removed, FIG. 8 is a schematic perspective view of the Harun cup supply / accommodating mechanism 10, and FIG. 9 is a dispensing test tube supply / accommodating mechanism. 20 is a schematic perspective view, and FIG. 10 is a schematic schematic perspective view of an automatic dispensing unit.
The Harun cup supply / accommodating mechanism 10 includes:
A pre-processing Harun cup 1 from which a patient's urine was collected is stored in a rack 11;
A post-treatment cup housing portion 13 that is arranged side by side with the pre-treatment cup housing portion 12 and collects and stores the Harun cup 1 after being subjected to processing such as dispensing and spotting in units of racks;
A rack transfer means 14 is provided along the pre-processing cup housing portion 12 and the post-processing cup housing portion 13 and transports the Hahn cup 1 from the pre-processing cup housing portion 12 to the post-processing cup housing portion 13 in units of racks. .
The pre-processing cup storage unit 12 is configured to store the above-described Harun cup racks 11 in a plurality of rows, and is configured to supply the stored racks 11 to the rack transfer means 14 one after another.
The rack transfer means 14 extends along the pre-processing cup storage part 12 and the post-processing cup storage part 13 and is read from the Hahn cup by the reading position T1 for reading patient identification information from the Hahn cup by the reading means, and by the dispensing spotting mechanism 40. A transfer passage 15 that passes through a suction position T2 for sucking urine, and a rack 11 supplied from the pre-processing cup storage portion 12 to the passage 15 is processed in units of Harun cups stored therein. The rack 11 is configured to move toward the housing portion 13 and finally, the rack 11 can be pushed out from the passage 15 to the post-processing cup housing portion 13.
The post-processing cup housing part 13 is configured to accommodate the above-described Harun cup racks 11 in a plurality of rows.
In the figure, reference numeral 17 denotes an emergency cup supply unit. This emergency cup supply unit supplies the Harun cup rack not accommodated in the pre-treatment cup accommodating portion 12 to the transfer passage 15 in an emergency. Used.

(Description of the test tube supply / accommodation mechanism 20)
The test tube supply and storage mechanism 20
A pre-dispensing test tube storage unit 22 for storing a test tube rack 21 storing a plurality of empty test tubes 2 before the dispensing process;
A post-dispensing test tube housing portion 23 which is arranged side by side with the pre-dispensing test tube housing portion 22 and collects and stores the test tubes 2 after the dispensing in units of racks;
It is arranged along the pre-dispensing test tube housing part 22 and the post-dispensing test tube housing part 23, and the test tubes 2 are transferred from the pre-dispensing test tube housing part 22 to the post-dispensing test tube housing part 23 in rack units. Rack transfer means 24.
The pre-dispensing test tube storage unit 22 is configured to store the racks 21 in a plurality of rows, and is configured to push the stored racks 21 onto the transfer passage 25 of the rack transfer means 24.
The rack transfer means 24
It extends from the pre-dispensing test tube storage unit 22 to the post-dispensing test tube storage unit 23, and is applied by the label application / reading position T3 where the patient identification label is applied by the label printing / applying mechanism 60 and the dispensing spotting mechanism 40. A transfer passage 25 that passes through a dispensing position T4 for pouring is provided, and the rack 21 supplied onto the passage 25 from the pre-dispensing test tube storage portion 22 is divided in units of test tubes accommodated therein. It is configured to move toward the test tube housing part 23 after the injection, and finally to push the rack 21 from the passage 25 to the test tube housing part 23 after the dispensing.
The transfer passage 25 is arranged in parallel with the transfer passage 15 of the Harun cup housing and supplying mechanism 10.
The post-dispensing test tube housing part 23 is configured to accommodate a plurality of rows of test tubes after dispensing in rack units.
In the figure, reference numeral 27 denotes an emergency test tube supply unit, and this emergency test tube supply unit transfers a test tube rack rack that is not accommodated in the pre-dispensing test tube accommodation portion 12 in the event of an emergency. 25 is used to supply.

(Description of layout)
The dispensing test tube supply / accommodation mechanism 20 configured as described above has a pair of leg portions 26 on both sides thereof, and the leg portions 26 are mounted on the Harun cup supply / accommodation mechanism 10. The test tube supply / accommodating mechanism 20 for injection is arranged in a state of being superimposed above the Harun cup supply / accommodating mechanism 10.
Further, the depth dimension of the dispensing test tube supply / accommodating mechanism 20 is made smaller than the depth dimension of the Harun cup supply / accommodating mechanism 10, and the Harun cup supply / accommodating mechanism 10 and the dispensing test tube supply / accommodating mechanism 20 are laid out in a platform shape. It is possible to use. By laying out the Harun cup supply / accommodation mechanism 10 and the dispensing test tube supply / accommodation mechanism 20 in the shape of a platform, the user can perform the additional operation and the removal operation of the Harun cup and / or the test tube from the same position. become.
Preferably, the Harun cup supply / accommodating mechanism 10 is slidably provided back and forth on a base (not indicated), and the maintenance can be performed by pulling the Harn cup supply mechanism 10 forward as necessary. Can be configured as follows.

(Description of dispensing mechanism 30 and spotting mechanism 40)
The dispensing mechanism 30 and the spotting mechanism 40 are disposed along the Harun cup supply / accommodating mechanism 10 and the dispensing test tube supply / accommodating mechanism 20.
The dispensing mechanism 30 includes a shaft 31 that can be moved up and down, a nozzle member 32 having one end fixed to the shaft 31 and rotatable about the shaft 31, and a cleaning pot 33 for the nozzle member 32.
When dispensing is required, the nozzle member 32 sucks urine from the Harn cup 1 at the suction position T2 (see FIG. 11A), and then is lifted from the Harn cup 1 by the shaft 31 and then further upwards. The urine that has been raised to the test tube supply / accommodating mechanism 20 and dispensed into the test tube 2 at the dispensing position T4 (see FIG. 11B) is then washed in the washing pot 33 (FIG. 11). (See (c)).
The spotting mechanism 40 includes a shaft 41 that can be moved up and down, a nozzle member 42 having one end fixed to the shaft 41 and rotatable about the shaft 41, and a cleaning pot 43 for the nozzle member 42.
When spotting is required, the nozzle member 42 sucks urine from the Harn cup 1 at the suction position T2 (see FIG. 12A), and then is lifted from the Harn cup 1 by the shaft 41 to measure spotting by the analysis mechanism 80. Urine is spotted on the test plate A at the position T5 (see FIG. 11B). At this time, spotting by the nozzle member 42 is performed on all the reagent parts A11 of the inspection part A9 at the spotting start position T6 in cooperation with 85a described later. After the spotting is completed, the nozzle member 42 is cleaned in the cleaning pot 43 (see FIG. 11C).
In addition, in FIG. 7, the code | symbol 45 has shown the stirring means for stirring the urine in a Harun cup. The stirring means 45 includes a stirring rod (not shown), a drive mechanism that drives the stirring rod, and a cleaning means that cleans the stirring rod. The stirring means 45 is inserted into the Harun cup to be dispensed, and stirs urine before suction.

(Description of reading mechanism 50)
Next, the reading mechanism 50 will be described.
The reading mechanism 50 includes a Harun cup reading mechanism 51 and a test tube reading mechanism 52.
The Harun cup reading mechanism 51 is provided at a position corresponding to the reading position T <b> 1 in the Harun cup supply and accommodation mechanism 10. A label on which identification information for identifying a patient corresponding to the urine collected in the Harun cup 1 is previously printed is attached to the Harun cup 1. The reading mechanism 51 rotates the Harun cup 1. However, the barcode attached to the Harun cup 1 is read.
The test tube reading mechanism 52 is provided at a position corresponding to the labeling and reading position T3 in the dispensing test tube supply / accommodating mechanism 20. The test tube reading mechanism 52 is configured to read a barcode of a label attached to the test tube 2 while rotating the test tube 2, and a label printing / sticking means described later while the test tube 2 is rotating. A label printed with patient information in the form of a barcode (and characters) is attached to the test tube 2 by 60, and at the same time, the information on the label attached to the test tube 2 is read.

(Description of label printing / sticking mechanism 60)
A label printing / pasting mechanism 60 is provided between the pre-dispensing test tube housing portion 22 and the post-dispensing test tube housing portion 23 in the test tube supply / housing mechanism 20.
The label printing / pasting mechanism 60 prints the patient identification information on the label in the form of a barcode (and characters) based on the patient identification information read from the barcode of the Harun Cup 1 by the Harun Cup reading mechanism 51. After that, the label affixed and the printed label is affixed to the surface of the test tube 2 at the reading position T3.

(Description of analysis mechanism 80)
The analysis mechanism 80 is configured as a unit different from the automatic dispensing unit, and is used by being arranged in the automatic dispensing unit.
As shown in FIGS. 6, 7, and 13, the analysis mechanism 80 includes a dry box 82, a test plate cutting unit 83, a shutter unit 84, a turntable unit 85, a shooter unit 86, and optical measurement means on a frame unit 81. 87 is arranged.
The dry box 82 is a box provided with a dehumidifier 82a therein, and is configured so that a plurality of test plates A can be stacked and accommodated therein.
FIG. 14 is a schematic perspective view of the dry box 82. As shown in the drawing, the dry box 82 has a door 82b for replenishing the test plate A on one side surface, and the test plate A is discharged on the bottom surface. The opening 82c is formed.
A test plate cutting unit 83 is provided inside the dry box 82. FIG. 15 is a schematic perspective view of the test plate cutout unit 83. As shown in the drawing, the test plate cutout unit 83 holds the test plate A by engaging with the flange A3 of the test plate A accommodated in a stacked manner. The claw 83a is used in conjunction with a shutter unit 86, which will be described later, and the stacked test plates A are discharged one by one downward from the bottom. In the figure, reference numeral 83b indicates a sensor for detecting the test plate at the lowest position, and reference numeral 83c indicates a sensor for detecting the test plate immediately before the lowermost position.
The shutter unit 84 is disposed below the dry box 82 and has a shutter 84a that opens and closes an opening 82c of the dry box 82 (see FIG. 16).
The turntable unit 85 can move the turntable 85a, which can be rotated by placing the test plate A, and the turntable 85a in the horizontal direction from the position below the dry box 82 to the spot measurement position T5 shown in FIGS. A horizontal feed mechanism 85b and a lift mechanism 85c that can move the turntable 85a up and down (see FIG. 17).
As shown in FIG. 18, the shooter unit 86 has a pair of conveyors 86 a arranged in a width where the test plate A can be mounted.
The optical measuring means 87 is disposed above the spotting measurement position T5 and optically measures the color reaction of the test plate A on which urine is spotted.
The operation of the analysis mechanism 80 configured as described above will be briefly described.
In the dry box 82, a plurality of test plates A are stacked and accommodated in advance.
At this time, the turntable 85a is positioned below the dry box 82, the shutter 84a of the shutter unit 84 is closed, and the claw 83a of the test plate cutting unit 83 is engaged with the test plate A at the lowest position. It has stopped.
When the apparatus is activated, the claw 83a of the test plate cutting unit 83 releases the test plate A at the lowest position. As a result, the stacked test plates A fall as a whole, and the lowermost test plate A is placed on the shutter 84 a of the shutter unit 84. In this state, the claw 83a of the test plate cutout unit 83 is locked to the test plate that is one before the lowermost position, and the test plate A is held.
At the same time, the lifting mechanism 85c of the turntable unit 85 raises the turntable 85a to above the conveyor 86a of the shooter unit 86.
In this state, the shutter unit 84 opens the shutter 84a, and the test plate at the lowest position held on the shutter 84a is dropped onto the turntable 85a.
When the test plate A is placed on the turntable 85a, the lateral feed mechanism 85b of the turntable unit 85 moves the turntable 85a to the spotting measurement position T5.
At the spotting measurement position T5, the turntable 85a appropriately rotates the test plate A in accordance with the operation of the spotting mechanism 40 to spot the urine on the reagent part A11 of the inspection part A9 at the spotting start position T6. The color reaction of the reagent part A11 spotted by the optical measuring means 87 is measured. This spotting and measuring operation is as described in the embodiment shown in FIG.
After completion of the optical measurement, the turntable 85a is returned to the lower side of the dry box 82 again by the lateral feed mechanism 85b. After the turntable 85a reaches below the dry box 82, the turntable 85a is lowered downward by the lifting mechanism 85c. As a result, the test plate placed on the turntable 85 a is placed on the conveyor 86 a of the shooter unit 86. When the test plate is placed on the conveyor 86a, the shooter unit 86 operates the conveyor 86a to send and discard the test plate in the discarding direction.

(Explanation of the action of the entire device)
Next, the operation of the analyzer configured as described above will be described.
The test plate A is set in the dry box 82 in advance.
First, the user puts the Harun cup 1 in which the urine collected from the patient is accommodated into the rack 11 and sets it in the pre-treatment cup accommodating portion 12. In addition, a test tube rack 21 containing empty test tubes 2 is set in a pre-dispensing test tube housing portion 22.
When the first Harun cup 1 reaches the reading position T1, the Harun cup reading mechanism 51 rotates the Harn cup 1, and reads the patient identification information of the Harn cup 1 during the rotation.
A control device (not shown) checks analysis information such as the presence / absence of a chemical analysis request such as qualitative analysis and quantitative analysis and the number and amount of test tubes necessary for quantitative analysis based on the above-described patient identification information.
When chemical analysis is necessary and the test plate A is not at the spotting measurement position T5, the analysis mechanism 80 is operated to take one test plate A from the dry box 82 onto the turntable 85a. The taken out test plate A is transferred to the spotting measurement position T5.
The control device (not shown) reads the individual identification information from the individual identifier A11 of the test plate A transferred to the spotting measurement position T5 and recognizes the position of the inspection unit A9 where spotting will be performed on the test plate A ( The position of the inspection unit A9 can be recognized by detecting the rotational distance of the turntable 85a), and the information is associated with the patient identification information read from the Harun cup 1 and stored.
On the other hand, after the reading of the patient identification information of the Harun cup 1 is finished, the rack 11 is sent to the post-processing cup housing part 13 side by one Harun cup. In this state, the Harun cup 1 reaches the urine suction position T2, and the next Harun cup 1 reaches the reading position T1.
In parallel with the above-described operation, the test tube rack 21 is pushed out from the pre-dispensing test tube housing portion 22 into the transfer passage 25, and then the top test tube 2 is moved to the labeling and reading position T3. It is transferred to the position where it reaches. When quantitative analysis and / or scrutiny analysis is required, the control device uses a label / print pasting mechanism 60 and a test tube reading mechanism based on the patient identification information read from the Harun cup 1 and the corresponding analysis information. 52 is operated, and a label printed with patient identification information corresponding to the patient identification information of the Harun cup 1 is attached to the test tube 2. The label attaching process to the test tube 2 is performed on the required number of test tubes 2 based on the patient identification information read from the Harun cup 1 and the analysis information corresponding thereto.
The test tube reading mechanism 52 reads the information on the label attached to the test tube 2 and compares it with the patient identification information read from the Harun cup 1.
On the other hand, when the Harun cup 1 reaches the urine suction position T2, the stirring rod of the stirring means 45 is inserted into the urine of the Harun cup 1, and at the same time, the nozzle member 32 of the dispensing mechanism 30 and the nozzle of the spotting mechanism 40 The member 42 is inserted into the urine of the Harun cup 1.
After stirring of the urine in the Harun cup 1 is completed, the stirring bar is cleaned with a suitable cleaning means. At the same time as the stirring is completed, a necessary amount of urine is sucked into each nozzle member 32 and 42.
After sucking urine, the nozzle member 42 of the spotting mechanism moves to the inspection part A9 of the test plate A transferred to the spotting measurement position T5, and cooperates with the turntable 85a to make the reagent part A11 of the inspection part A9. To spot urine.
At the same time, the nozzle member 32 of the dispensing mechanism 30 is lifted by the shaft 31 and moves to the dispensing position T4 to dispense urine into the test tube 2 after labeling. Dispensing urine into the test tube 2 is performed in the necessary amount and in the required number according to the analysis information corresponding to the patient identification information read from the Harun cup 1.
The dispensing process described above is not performed for analysis only. Further, the analysis process is not performed in the case of only the dispensing process.
The test plate A after spotting is rotated by the turntable 85a as described above and used for measurement by the optical measuring means 87.
Since the measurement by the optical measuring means 87 has already been described in the embodiment shown in FIG. 4, the description is omitted here.
The measurement result is stored in association with the patient identification information read from the Harun cup 1.
When the dispensing process and the spotting process are completed, the nozzle member 32 of the dispensing mechanism 30 and the nozzle member 42 of the spotting mechanism 40 are moved to the washing pots 33 and 43, respectively, and are washed with these washing pots 33 and 43. Is done.
While the dispensing process and the spotting process related to the above-described Harun Cup 1 are being performed, the patient identification information of the next Harun Cup 1 is read by the barcode reader 53, and the previous Harun Cup 1 is dispensed and spotted. Then, the next dispensing and spotting process of the Harun cup 1 is performed.

T1 Reading position T2 Suction position T3 Labeling and reading position T4 Dispensing position T5 Spotting measurement position T6 Spotting start position T7 Measurement position

A Test plate A1 Outer wall A2 Disc body A3 Flange A4 Locking part A5 Donut shaped groove A6 Donut shaped protrusion A7 Protruding part A8 Protruding part A9 Inspection part A10 Protruding A11 Reagent part A12 Test paper A13 Label with individual identifier printed

B Rotating means C Spotting mechanism D Optical measuring means

1 Harun Cup 2 Test tube

DESCRIPTION OF SYMBOLS 10 Harun cup supply accommodation mechanism 11 Rack 12 Pre-processing cup accommodating part 13 After-treatment cup accommodating part 14 Transfer means 15 Transfer passage 16 Rail 17 Emergency cup supply unit

20 Test tube supply / accommodating mechanism for dispensing 21 Test tube rack 22 Test tube accommodating portion before dispensing 23 Test tube accommodating portion after dispensing 24 Rack transfer means 25 Transfer passage 26 Leg portion 27 Emergency test tube supply unit

30 Dispensing mechanism 31 Shaft 32 Nozzle member 33 Washing pot

40 Pointing mechanism 41 Shaft 42 Nozzle member 43 Washing pot

45 Stirring means

50 Reading Mechanism 51 Reading Mechanism for Harun Cup 52 Reading Mechanism for Test Tube

60 Label printing and pasting mechanism


80 Analysis Mechanism 81 Frame Unit 82 Dry Box 82a Dehumidifier 82b Door 82c Opening 83 Test Plate Cutting Unit 83a Claw 83b Sensor 83b Sensor 84 Shutter Unit 84a Shutter 85 Turntable Unit 85a Turntable 85b Lateral Feed Mechanism 85c Lifting Mechanism 86a Shutter Unit 86a Conveyor 87 Optical measuring means


T10 spot position T11 measurement position

DESCRIPTION OF SYMBOLS 100 Pre-processing Harun cup accommodation part 101 Post-treatment Harun cup accommodation part 102 Transfer means 103 Harun cup supply accommodation mechanism 104 Pre-treatment test tube accommodation part 105 Post-treatment test tube accommodation part 106 Transfer means 107 Test tube supply accommodation mechanism 108 Qualitative analysis mechanism 109 Test paper

Claims (12)

A disposable test plate used in an analyzer for spotting a sample on a test reagent part and optically measuring a color reaction of the test reagent part,
The test plate comprises a plurality of test portions for one specimen having a plurality of reagent portions on a disposable disc main body, arranged radially at intervals from each other,
A disposable test plate characterized in that an individual identifier obtained by electronically coding identification information capable of identifying individual disposable test plates is provided on the disc body . 2. Each of the inspection parts has a recess arranged radially on a disposable disk with a space between each other, and a plurality of reagent parts are provided at the bottom of the recess. Test plate according to. The disposable test plate according to claim 1 or 2, wherein each of the inspection units has a test paper provided with a plurality of inspection reagent units on a strip. The disposable test plate according to claim 2 or 3, wherein the recess is configured so that the test paper can be detachably attached. On the disc body, a color sample serving as an internal standard for optical measurement is provided,
The disposable test plate according to any one of claims 1 to 4, wherein the individual identifier includes color information of the color sample. The disposable test plate according to any one of claims 1 to 5 , wherein the plate body is configured to be stackable. The plate body has an outer peripheral wall extending downward on an outer periphery thereof;
When stacking multiple disposable test plates, the inner surface of the outer peripheral wall of the upper test plate is in contact with the outer surface of the outer peripheral wall of the lower test plate, and the gap between the upper test plate and the lower test plate is A sealed test plate according to claim 6 , wherein a sealed space is formed. When a plurality of disposable test plates are stacked, each inspection part of the lower test plate is closed by the back surface of the plate body of the upper test plate, and each inspection part is sealed. The disposable test plate according to claim 6 or 7 , wherein a main body is formed. An analyzer using the disposable test plate according to any one of claims 1 to 8 ,
A spotting mechanism for spotting a specimen on a test reagent part provided in the test part;
A reagent part for testing on which a specimen is spotted;
A rotating means for rotating the disposable test plate,
The rotating means is configured to arrange and rotate the disposable test plate so that the spotting position by the spotting mechanism and the measurement position by the optical measuring means are located on the rotation trajectory of each inspection portion of the disposable test plate. Is
The individual identifier provided on the disk body of the test plate located on the rotating means is read, and each analysis result is stored in association with the individual identifier.
An analyzer characterized by being configured as follows . It has a test plate container that houses multiple disposable test plates,
The analyzer according to claim 9 , further comprising transfer means for sequentially taking out the test plates from the test plate container and transferring them to the spotting measurement position. The rotating means rotates the test plate at an arbitrary time interval;
The analyzer according to claim 9 or 10 , wherein the optical measuring means is configured to measure the color reaction of the reagent part for inspection after spotting with time. The rotation means rotates the test plate before use, and the optical measurement means is configured to check whether or not each inspection section of the test plate is usable. The analyzer according to any one of 9 to 11 .

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