JP5719130B2 - 外用貼付剤 - Google Patents
外用貼付剤 Download PDFInfo
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- JP5719130B2 JP5719130B2 JP2010196627A JP2010196627A JP5719130B2 JP 5719130 B2 JP5719130 B2 JP 5719130B2 JP 2010196627 A JP2010196627 A JP 2010196627A JP 2010196627 A JP2010196627 A JP 2010196627A JP 5719130 B2 JP5719130 B2 JP 5719130B2
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Description
図1に、本発明の外用貼付剤の一実施形態を示す。この外用貼付剤1は、重なり合う二枚のシート状の支持体2(2a、2b)における合わせ面間に皮膚外用剤3が挟み込まれたものであり(図1(a)参照)、使用時に重なり合う二枚の支持体2(2a、2b)を分離することによって(図1(b)参照)、分離された各支持体2(2a、2b)において、皮膚外用剤3が露出した貼付面4が形成されるように構成されたものである(図1(c)参照)。即ち、この外用貼付剤1は、本発明第一貼付剤に相当するものである。
図4に、本発明の外用貼付剤の他の実施形態を示す。この外用貼付剤1は、片面同士が重なり合うように折り畳まれた一枚の支持体2における合わせ面間に皮膚外用剤3が挟み込まれたものであり(図4(a)参照)、使用時に折り畳まれた支持体2を展開することによって(図4(b)参照)、展開された支持体2における合わせ面において、皮膚外用剤3が露出した貼付面4が形成されるように構成されたものである(図4(c)参照)。即ち、この外用貼付剤1は、本発明第二貼付剤に相当するものである。
精製水に、保湿剤としてのプロピレングリコール5重量部及びpH調整剤としての水酸化カリウム0.5重量部を加え、70℃に加熱調整することによって水相液を得た。
前記皮膚外用剤の粘度についての試験と同様にして、25℃における粘度が約10000mPa・sとなるように調整された皮膚外用剤を、一の支持体(前記ラミネート不織布と同様の支持体)の不織布面側に、担持量10〜10000g/m2の範囲内となるように塗工し、更に、塗工面を覆うようにして他の支持体を重ね合わせることによって、担持量の異なる皮膚外用剤を挟み込んでなる外用貼付剤を複数種類得た。
前記皮膚外用剤の粘度についての試験と同様にして、25℃における粘度が約10000mPa・sとなるように調整された皮膚外用剤を、一の支持体(前記ラミネート不織布と同様の支持体)の不織布面側に、担持量約500g/m2となるように塗工し、更に、塗工面を覆うようにして他の支持体を重ね合わせることによって外用貼付剤を得た。
2 支持体
3 皮膚外用剤
4 貼付面
5 台座
6 扁平状袋材
Claims (8)
- 重なり合う二枚のシート状の支持体における合わせ面間に皮膚外用剤が挟み込まれてなり、使用時に重なり合う二枚の支持体を分離することによって、分離された各支持体それぞれにおいて、皮膚外用剤が露出した貼付面が形成される外用貼付剤であって、
この外用貼付剤は、
皮膚外用剤の基剤が、水中油滴型乳化性基剤であり、
皮膚外用剤の25℃における粘度が、5000〜500000mPa・s、
重なり合う二枚の支持体における合わせ面間に挟み込まれた皮膚外用剤の担持量が、合わせ面の面積に対して100〜5000g/m2であり、
15〜30℃の温度条件下、重なり合う二枚の支持体がT形剥離されて分離された際に、分離された各支持体において、前記担持量の40〜60%の皮膚外用剤が担持された貼付面が形成されることを特徴とする外用貼付剤。 - 片面同士が重なり合うように折り畳まれた一枚のシート状の支持体における合わせ面間に皮膚外用剤が挟み込まれてなり、使用時に折り畳まれた支持体を展開することによって、展開された支持体において、皮膚外用剤が露出した貼付面が形成される外用貼付剤であって、
この外用貼付剤は、
皮膚外用剤の基剤が、水中油滴型乳化性基剤であり、
皮膚外用剤の25℃における粘度が、5000〜500000mPa・s、
折り畳まれた支持体における合わせ面間に挟みこまれた皮膚外用剤の担持量が、合わせ面の面積に対して100〜5000g/m2であり、
15〜30℃の温度条件下、折り畳まれた支持体がT次剥離されて展開された際に、展開された支持体において、前記担持量の40〜60%の皮膚外用剤が担持された貼付面が形成されることを特徴とする外用貼付剤。 - 請求項1又は2に記載の外用貼付剤において、
支持体が、布基材の片側面に高分子材料からなるフィルムを積層した積層シートであり、この積層シートにおける布基材側の面が合わせ面となる外用貼付剤。 - 請求項1ないし3のいずれか1項に記載の外用貼付剤において、
皮膚外用剤の基剤が、水中油滴型界面活性剤と水とを主体として構成されてなる外用貼付剤。 - 請求項4に記載の外用貼付剤において、
水中油滴型界面活性剤が、モノステアリン酸グリセリン、又はモノステアリン酸ソルビタンから選択される外用貼付剤。 - 請求項1ないし5のいずれか1項に記載の外用貼付剤において、
水が、皮膚外用剤全体に対して、30〜90重量%含有されてなる外用貼付剤。 - 請求項1ないし6のいずれか1項に記載の外用貼付剤において、
合わせ面における周縁部の一部ないし全部には、合わせ面中央部における皮膚外用剤の担持量と比較して、皮膚外用剤の担持量が少ない剥離部が設けられてなる外用貼付剤。 - 請求項7に記載の外用貼付剤において、
剥離部が、合わせ面の周縁部の一部ないし全部を押圧することによって設けられたものである外用貼付剤。
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