JP5714900B2 - 口腔疾患を予防するための組成物および方法 - Google Patents
口腔疾患を予防するための組成物および方法 Download PDFInfo
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Description
歯垢は、最近では“歯の表面にバイオフィルムとしてみられる多様な微生物群落であって、宿主および微生物に由来する細胞外高分子マトリックス内に埋め込まれたもの”と定義されている(Marsh, 2004)。歯垢バイオフィルムは歯肉ラインの上および下(それぞれ歯肉縁上および歯肉縁下)に発生する。酸を産生する歯肉縁上の歯垢は齲歯(むし歯)の原因である。歯肉縁下の歯の表面に形成されて歯肉溝の内張り上皮を覆う歯垢は、歯周感染症(すなわち歯肉炎および歯周炎)の発症をもたらす(Rose et al, 2004)。
アクチノマイセス・ビスコーサス ATCC 43146
アクチノマイセス・オドントリチカス ATCC 17929
カンピロバクター・レクタス ATCC 33238
エンテロコッカス・フェカーリス ATCC 10741
フソバクテリウム・ヌクレアタム ATCC 49256
ミクロモナス(ペプトストレプトコッカス)・ミクロス ATCC 33270
ポルフィロモナス・ジンジバリス ATCC 49417
プレボテラ・インターメディア ATCC 25611
ストレプトコッカス・サングイニス ATCC 10556
ストレプトコッカス・オラーリス ATCC 35037
着香剤を含む口内リンス
着香剤を含まない口内リンス
Difco(商標)中和ブロス(約800mL)
強化TSBYE(約400mL)
人工唾液+5%トリプトン+5%酵母エキス(約2,500mL)(AS+T+Y)
0.147g/L 塩化カルシウム(CaCl2)
0.426g/L リン酸ナトリウム(Na2HPO4)
1.68g/L 炭酸水素ナトリウム(NaHCO3)
90〜50mL遠心管
25mL、10mL、5mLおよび0.1mLピペット
ピペットエイドピペッター
9個の無菌エルレンマイヤーフラスコ
無菌試験管
39−各選択寒天、合計312のプレート用(48時間、前還元したもの)
最適増殖培地および選択寒天(培地を24時間、前還元したもの):
CRブロスおよびCR寒天−カンピロバクター・レクタス
BHIBブロスおよびBHIB pH=9.6寒天−エンテロコッカス・フェカーリス
TSBYEインベルターゼ処理ブロスおよびMSss/MSN寒天−ストレプトコッカス・サングイニスおよびストレプトコッカス・オラーリス
シェードラー(Schaedler)ブロスおよびCVE寒天−フソバクテリウム・ヌクレアタム
PmブロスおよびMSCN寒天−ミクロモナス・ミクロス
PgブロスおよびBPB+MUP寒天−ポルフィロモナス・ジンジバリス
BHIBブロスおよびCFAT+MUP寒天−アクチノマイセス・ビスコーサス
ETSBYE−すべての細菌用
血液寒天
安定化した二酸化塩素リンスの殺菌活性の測定を、歯肉炎、歯周の疾患および健康状態に関連する個々の口腔細菌の懸濁液について実施した。下記の細菌を個々にマイクロタイタープレートアッセイシステムによりアッセイした:ポルフィロモナス・ジンジバリス、プレボテラ・インターメディア、フソバクテリウム・ヌクレアタム、ミクロモナス・ミクロス、アクチノマイセス・ビスコーサス、アクチノマイセス・オドントリチカス、ストレプトコッカス・サングイニス、ストレプトコッカス・オラーリス、カンピロバクター・レクタスおよびエンテロコッカス・フェカーリス。
S. oralis ストレプトコッカス・オラーリス
S. sanguinis ストレプトコッカス・サングイニス
A. viscosus アクチノマイセス・ビスコーサス
C. rectus カンピロバクター・レクタス
F. nucleatum フソバクテリウム・ヌクレアタム
M. micros ミクロモナス・ミクロス
P. gingivalis ポルフィロモナス・ジンジバリス
*−−細菌がフラスコの底に付着したのでA660がきわめて低かった。フラスコの底を無菌ループで掻き取ってそれらを懸濁させると、そのアッセイのCFU/mL数は予想どおりになった;
**−−A660による濃度が2倍に見えたが、標準曲線によればわずかな差があり、したがってこの実験は予め計算したとおりに行なわれた。
Claims (4)
- 口腔内のバイオフィルム環境における歯周細菌を減少および死滅させるための、0.5%〜0.8%(w/v)の範囲の濃度を有する安定化した二酸化塩素の溶液を含有する医薬組成物であって、
医薬組成物で口腔をすすいで、口腔の歯および組織に付着したバイオフィルム内に存在する歯周細菌の増殖に対する殺菌作用を生じさせ、
前記口腔内のバイオフィルムに混合微生物群が存在し、
前記殺菌作用は、前記医薬組成物より遊離する二酸化塩素により生じる、
前記医薬組成物。 - 前記歯周細菌は、口腔のバイオフィルムにおける歯周細菌の複合体の多様な微生物群に存在する嫌気性および好気性細菌である、請求項1に記載の医薬組成物であって、
前記歯周細菌の減少および死滅は、前記歯周細菌の再増殖の阻害による、
前記医薬組成物。 - グラム陰性およびグラム陽性歯周細菌が生息する口腔内のバイオフィルムの多様な微生物環境に生息する該歯周細菌を減少および死滅させるための、0.5%〜0.8%(w/v)の範囲の濃度を有する安定化した二酸化塩素の溶液を含有する医薬組成物であって、
前記医薬組成物で口腔をすすぎ、
前記口腔内のバイオフィルムに混合微生物群が存在し、
前記殺菌作用は、前記医薬組成物より遊離する二酸化塩素により生じる、
前記医薬組成物。 - 口腔に導入した際に歯周疾患に関連する好気性および嫌気性歯周細菌の増殖に対する静菌干渉を生じさせる、請求項3に記載の医薬組成物であって、
前記歯周細菌の減少および死滅は、前記歯周細菌の再増殖の阻害による、
前記医薬組成物。
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ES (2) | ES2682457T3 (ja) |
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-
2007
- 2007-07-09 US US11/774,730 patent/US20090016973A1/en not_active Abandoned
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2008
- 2008-02-27 ES ES14193943.9T patent/ES2682457T3/es active Active
- 2008-02-27 EP EP14193943.9A patent/EP2921174B1/en active Active
- 2008-02-27 JP JP2010516078A patent/JP5714900B2/ja not_active Expired - Fee Related
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- 2008-02-27 WO PCT/US2008/055154 patent/WO2009009163A1/en active Search and Examination
- 2008-02-27 EP EP08743577.2A patent/EP2200441B1/en active Active
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2013
- 2013-10-18 JP JP2013217385A patent/JP6087781B2/ja not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
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ES2682457T3 (es) | 2018-09-20 |
JP2010533189A (ja) | 2010-10-21 |
WO2009009163A1 (en) | 2009-01-15 |
JP6087781B2 (ja) | 2017-03-01 |
HK1143929A1 (en) | 2011-01-21 |
EP2200441A1 (en) | 2010-06-30 |
US20090016973A1 (en) | 2009-01-15 |
CA2623769A1 (en) | 2009-01-09 |
EP2200441B1 (en) | 2014-12-10 |
CA2623769C (en) | 2019-02-12 |
EP2200441A4 (en) | 2011-01-05 |
JP2014040470A (ja) | 2014-03-06 |
ES2543132T3 (es) | 2015-08-14 |
EP2921174A1 (en) | 2015-09-23 |
HK1212598A1 (zh) | 2016-06-17 |
EP2921174B1 (en) | 2018-05-16 |
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