JP5683766B2 - 高い結合親和性を有する免疫結合体 - Google Patents

高い結合親和性を有する免疫結合体 Download PDF

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JP5683766B2
JP5683766B2 JP2001500670A JP2001500670A JP5683766B2 JP 5683766 B2 JP5683766 B2 JP 5683766B2 JP 2001500670 A JP2001500670 A JP 2001500670A JP 2001500670 A JP2001500670 A JP 2001500670A JP 5683766 B2 JP5683766 B2 JP 5683766B2
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antibody
amino acid
residues
mesothelin
seq
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JP2003502030A (ja
JP2003502030A5 (cg-RX-API-DMAC7.html
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イラ パスタン，
イラ パスタン，
パーサ エス． チャウドハリー，
パーサ エス． チャウドハリー，
Original Assignee
ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， リプリゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ
ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， リプリゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2001500670A 1999-05-27 2000-05-26 高い結合親和性を有する免疫結合体 Expired - Lifetime JP5683766B2 (ja)

Applications Claiming Priority (3)

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US16007199P 1999-05-27 1999-05-27
US60/160,071 1999-05-27
PCT/US2000/014829 WO2000073346A1 (en) 1999-05-27 2000-05-26 Immunoconjugates having high binding affinity

Related Child Applications (1)

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JP2011269272A Division JP2012050464A (ja) 1999-05-27 2011-12-08 高い結合親和性を有する免疫結合体

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JP2003502030A JP2003502030A (ja) 2003-01-21
JP2003502030A5 JP2003502030A5 (cg-RX-API-DMAC7.html) 2007-07-12
JP5683766B2 true JP5683766B2 (ja) 2015-03-11

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JP2001500670A Expired - Lifetime JP5683766B2 (ja) 1999-05-27 2000-05-26 高い結合親和性を有する免疫結合体
JP2011269272A Withdrawn JP2012050464A (ja) 1999-05-27 2011-12-08 高い結合親和性を有する免疫結合体
JP2013257556A Withdrawn JP2014050409A (ja) 1999-05-27 2013-12-13 高い結合親和性を有する免疫結合体

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JP2013257556A Withdrawn JP2014050409A (ja) 1999-05-27 2013-12-13 高い結合親和性を有する免疫結合体

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US (1) US7081518B1 (cg-RX-API-DMAC7.html)
EP (2) EP2011801A1 (cg-RX-API-DMAC7.html)
JP (3) JP5683766B2 (cg-RX-API-DMAC7.html)
AT (1) ATE401348T1 (cg-RX-API-DMAC7.html)
AU (1) AU5303700A (cg-RX-API-DMAC7.html)
CA (1) CA2374398C (cg-RX-API-DMAC7.html)
DE (1) DE60039510D1 (cg-RX-API-DMAC7.html)
DK (1) DK1180123T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA01011950A (cg-RX-API-DMAC7.html)
WO (1) WO2000073346A1 (cg-RX-API-DMAC7.html)

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MXPA01011950A (es) 2002-05-06
DE60039510D1 (de) 2008-08-28
EP1180123B1 (en) 2008-07-16
JP2012050464A (ja) 2012-03-15
WO2000073346A1 (en) 2000-12-07
CA2374398A1 (en) 2000-12-07
EP1180123A1 (en) 2002-02-20
CA2374398C (en) 2011-03-15
AU5303700A (en) 2000-12-18
JP2014050409A (ja) 2014-03-20
ATE401348T1 (de) 2008-08-15
JP2003502030A (ja) 2003-01-21
US7081518B1 (en) 2006-07-25
EP2011801A1 (en) 2009-01-07
DK1180123T3 (da) 2008-10-13

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