JP5683272B2 - アグリカナーゼ感受性切断部位を有する潜在関連タンパク質構築物 - Google Patents
アグリカナーゼ感受性切断部位を有する潜在関連タンパク質構築物 Download PDFInfo
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- JP5683272B2 JP5683272B2 JP2010538889A JP2010538889A JP5683272B2 JP 5683272 B2 JP5683272 B2 JP 5683272B2 JP 2010538889 A JP2010538889 A JP 2010538889A JP 2010538889 A JP2010538889 A JP 2010538889A JP 5683272 B2 JP5683272 B2 JP 5683272B2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Applications Claiming Priority (3)
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| GBGB0724556.6A GB0724556D0 (en) | 2007-12-17 | 2007-12-17 | LAtency associated protein construct with aggrecanase sensitive cleavage site |
| GB0724556.6 | 2007-12-17 | ||
| PCT/GB2008/004167 WO2009077755A2 (en) | 2007-12-17 | 2008-12-17 | Latency associated protein construct with aggrecanase sensitive cleavage site |
Publications (3)
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| JP2011507498A JP2011507498A (ja) | 2011-03-10 |
| JP2011507498A5 JP2011507498A5 (enExample) | 2013-02-14 |
| JP5683272B2 true JP5683272B2 (ja) | 2015-03-11 |
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| JP2010538889A Expired - Fee Related JP5683272B2 (ja) | 2007-12-17 | 2008-12-17 | アグリカナーゼ感受性切断部位を有する潜在関連タンパク質構築物 |
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| EP (1) | EP2262540B1 (enExample) |
| JP (1) | JP5683272B2 (enExample) |
| DK (1) | DK2262540T3 (enExample) |
| ES (1) | ES2552018T3 (enExample) |
| GB (1) | GB0724556D0 (enExample) |
| WO (1) | WO2009077755A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3004154A4 (en) * | 2013-06-05 | 2017-01-04 | Ben Gurion University of The Negev Research and Development Authority | IL-1beta-IL-1Ra CHIMERA AND METHODS OF USING THE SAME |
| GB201411506D0 (en) | 2014-06-27 | 2014-08-13 | Univ London Queen Mary | Modified latency associated protein construct |
| JP6516235B2 (ja) * | 2014-10-31 | 2019-05-22 | 国立大学法人富山大学 | キメラタンパク質及びそれを用いたミクログリア活性阻害剤 |
| ES2780274A1 (es) | 2019-02-15 | 2020-08-24 | Consejo Superior De Investig Científicas (Csic) | Cortistatina o un análogo de la misma como agente farmacéuticamente activo en forma latente |
| GB202004679D0 (en) | 2020-03-31 | 2020-05-13 | Stealthyx Therapeutics Ltd | Modified latercy associated protein construct |
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| US4103002A (en) * | 1977-02-08 | 1978-07-25 | Board Of Regents, University Of Florida | Bioglass coated A1203 ceramics |
| US4234972A (en) * | 1978-06-21 | 1980-11-25 | Board Of Regents, State Of Florida | Bioglass coated metal substrate |
| US4725234A (en) * | 1985-08-15 | 1988-02-16 | Ethridge Edwin C | Alveolar bone grafting process with controlled surface active ceramics |
| DE3907663A1 (de) * | 1989-03-09 | 1990-09-13 | Espe Stiftung | Knochenersatzteil aus glasionomerzement |
| FR2651439B1 (fr) * | 1989-09-06 | 1994-09-23 | Fbfc International Sa Nv | Materiau bioreactif pour prothese ou implants composites. |
| US5074916A (en) * | 1990-05-18 | 1991-12-24 | Geltech, Inc. | Alkali-free bioactive sol-gel compositions |
| JP2807752B2 (ja) | 1993-05-17 | 1998-10-08 | ティーディーケイ株式会社 | 結晶化ガラス材 |
| GB9319971D0 (en) | 1993-09-28 | 1993-11-17 | Cookson Group Plc | Cobalt glass compositions for coatings |
| US5679338A (en) * | 1994-05-12 | 1997-10-21 | Osteoarthritis Science, Inc. | Use of IL-4 for inhibition of the breakdown of articular cartilage and other tissues |
| FI101129B (sv) | 1995-01-13 | 1998-04-30 | Vivoxid Oy | Nya bioaktiva glas och deras användning |
| US6224913B1 (en) * | 1996-05-09 | 2001-05-01 | The Trustees Of The University Of Pennsylvania | Conditioning of bioactive glass surfaces in protein containing solutions |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| WO1998017236A1 (en) | 1996-10-23 | 1998-04-30 | Sunstar Inc. | Oral preparations containing biologically active crystallized glass |
| CZ295421B6 (cs) | 1997-03-13 | 2005-08-17 | Saint-Gobain Vitrage | Kompozice na bázi křemičito-sodno-vápenatého skla a jejich použití |
| ATE302621T1 (de) * | 1999-06-14 | 2005-09-15 | Imp College Innovations Ltd | Silberhaltige bioglas-zusammensetzungen, die von sol-gel zuständen abgeleitet werden |
| GB0100551D0 (en) * | 2001-01-09 | 2001-02-21 | Queen Mary & Westfield College | Protein |
| US7141392B2 (en) * | 2001-01-09 | 2006-11-28 | Queen Mary And Westfield College | Latent fusion protein |
| DE10111449A1 (de) * | 2001-03-09 | 2002-09-26 | Schott Glas | Verwendung von bioaktivem Glas in Zahnfüllmaterial |
| WO2004071542A1 (en) | 2003-02-14 | 2004-08-26 | The North West London Hospitals Nhs Trust | Bioactive material for use in stimulating vascularization |
| DE112004000094A5 (de) * | 2003-02-25 | 2008-04-03 | Schott Ag | Antimikrobiell wirkendes Borosilicatglas |
| US6905723B2 (en) * | 2003-05-30 | 2005-06-14 | Depuy Products, Inc. | Strontium-substituted apatite coating |
| CN1292804C (zh) | 2004-03-08 | 2007-01-03 | 西安交通大学 | 含锶纳米磷酸钙生物活性骨水泥的制备工艺 |
| DE102004026432A1 (de) * | 2004-05-29 | 2005-12-22 | Schott Ag | Glaszusammensetzungen als antimikrobieller Zusatz für Dentalmaterialien und deren Verwendung |
| WO2006050829A1 (en) | 2004-11-12 | 2006-05-18 | Dentsply De Trey Gmbh | Dental glass composition |
| WO2007020613A1 (en) | 2005-08-12 | 2007-02-22 | University Of Limerick | A synthetic graft having a glass network |
| DE102006036019A1 (de) | 2006-08-02 | 2008-02-07 | Pemeas Gmbh | Membran-Elektroden-Einheit und Brennstoffzellen mit erhöhter Leistung |
| WO2008090533A2 (en) | 2007-01-26 | 2008-07-31 | University Of Limerick | A bone cement |
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- 2008-12-17 US US12/808,383 patent/US8357515B2/en not_active Expired - Fee Related
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- 2008-12-17 EP EP08863207.0A patent/EP2262540B1/en not_active Not-in-force
- 2008-12-17 WO PCT/GB2008/004167 patent/WO2009077755A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2552018T3 (es) | 2015-11-25 |
| US20100310515A1 (en) | 2010-12-09 |
| WO2009077755A3 (en) | 2009-10-15 |
| JP2011507498A (ja) | 2011-03-10 |
| EP2262540B1 (en) | 2015-08-12 |
| EP2262540A2 (en) | 2010-12-22 |
| GB0724556D0 (en) | 2008-01-30 |
| DK2262540T3 (en) | 2015-10-19 |
| US8357515B2 (en) | 2013-01-22 |
| WO2009077755A2 (en) | 2009-06-25 |
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