JP5681895B2 - Food composition - Google Patents

Description

  The present invention relates to a food composition.

  In recent years, pharmaceuticals, quasi-drugs, cosmetics, foods and drinks for various effects have been developed as awareness of health and beauty increases. In such a background, collagen is blended in a wide variety of products and is widely used as a product that promotes various beauty and effects (for example, Patent Document 1). Here, collagen has a disadvantage that it has a unique odor (for example, collagen derived from pigs has animal odor, and fish-derived collagen has a raw odor). If collagen is contained in food as it is, the flavor and the like deteriorate significantly. There was a problem such as. As a method for solving this problem, a method of adding sucralose as disclosed in Patent Document 2 is known.

JP 2001-252048 A WO00 / 24273 Publication

  However, in the diversification of health foods, in addition to the technique described in Patent Document 2, it has been desired to provide a collagen-containing food that can prevent deterioration of flavor and the like.

  This invention responds to the above-mentioned request, and it aims at providing the food composition which can prevent deterioration of the flavor etc. resulting from containing collagen.

  In order to achieve the above-mentioned object, the food composition according to claim 1 contains a pine bark extract, collagen and a growth factor. In the present invention, the term “collagen” is not limited to a collagen protein, but includes a collagen peptide obtained by hydrolyzing a collagen protein and an atelocollagen obtained by treating a collagen molecule with a protease and removing a telopeptide portion. .

  The food composition according to claim 2 is the food composition according to claim 1, wherein the growth factor is an EGF (Epidmal Growth Factor) -like component contained in a swallow's nest. The EGF-like component refers to a component that exhibits the same action as EGF in the body.

  The food composition according to claim 3 uses a swallow's nest as an EGF-like component in the food composition according to claim 2, and the pine bark extract is added to 1 part by weight of the collagen. .2 parts by weight or more, and 0.04 parts by weight or more of the swallow's nest.

  According to the food composition according to claim 1, in addition to collagen, it contains a pine bark extract and a growth factor, and according to the food composition according to claims 2 and 3, in addition to collagen, Since the pine bark extract and the EGF-like component are contained, there is an effect that the deterioration of the flavor and the like due to the inclusion of the collagen can be prevented.

  Hereinafter, embodiments of the present invention will be described. The present invention is not construed as being limited by the description of the embodiments described later, and various modifications can be made within the scope of the claims.

  The food composition of the present invention is characterized by containing a pine bark extract, collagen and a growth factor. Further, the growth factor contained in the food composition is an EGF (Epideral Growth Factor) -like component contained in the swallow's nest. The food composition uses swallow's nest as an EGF-like component, and contains 0.2 parts by weight or more of pine bark extract with respect to 1 part by weight of collagen, and 0.04 of swallow's nest. It contains at least part by weight.

(About pine bark extract)
The pine bark extract is extracted from the bark of French coastal pine (Pinus Martina), larch, black pine, red pine, Japanese black pine, pine pine, Korean pine, high pine, rhyukyu pine, Utsukushima, Japanese pine, white pine, Canada The product is preferably used. Among these, a bark extract of French coastal pine is preferably used.

  French coastal pine is a marine pine that grows on the Atlantic coast of southern France. The bark of French coastal pine contains organic acids and other physiologically active components in addition to proanthocyanidins, which are flavonoids, as main components. This main component, proanthocyanidins, is known to have a strong antioxidant action to remove active oxygen.

  The pine bark extract is obtained by extracting the above-mentioned pine bark with water and / or an organic solvent. When water is used, warm water or hot water is used. As an organic solvent used for extraction, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, butane, acetone, hexane, cyclohexane, propylene glycol, hydrous ethanol, hydrous propylene glycol, ethyl methyl ketone, Organic solvents acceptable for the production of foods or drugs such as glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible oils and fats, 1,1,1,2-tetrafluoroethane, 1,1,2-trichloroethene Preferably used. These water and organic solvents may be used alone or in combination. In particular, hot water, hydrous ethanol, hydrous propylene glycol and the like are preferably used.

  The extraction method from pine bark is not particularly limited, and for example, a warm extraction method, a supercritical fluid extraction method, or the like is used.

  The supercritical fluid extraction method is a method of performing extraction using a supercritical fluid that is a fluid that exceeds the critical point (critical temperature, critical pressure) of a gas-liquid substance. As the supercritical fluid, carbon dioxide, ethylene, propane, nitrous oxide (laughing gas) or the like is used, and carbon dioxide is preferably used.

  In the supercritical fluid extraction method, an extraction process for extracting a target component with a supercritical fluid and a separation process for separating the target component and the supercritical fluid are performed. In the separation step, any one of extraction separation by pressure change, extraction separation by temperature change, and extraction separation using an adsorbent / absorbent may be performed.

  Moreover, you may perform supercritical fluid extraction by the entrainer addition method. In this method, for example, ethanol, propanol, n-hexane, acetone, toluene, other aliphatic lower alcohols, aliphatic hydrocarbons, aromatic hydrocarbons, and ketones are added to the extraction fluid in an amount of 2 to 20 W / V. %, And by performing supercritical fluid extraction using this fluid, the solubility of the target extract such as OPC (oligomeric proanthocyanidin) and catechins in the extraction solvent is dramatically increased. Or a method for enhancing the selectivity of separation, and obtaining an efficient pine bark extract.

  Since the supercritical fluid extraction method can be operated at a relatively low temperature, it can be applied to substances that are altered or decomposed at high temperatures, the advantage that the extraction fluid does not remain, and the recycling of the solvent is possible. There is an advantage that the process can be omitted and the process becomes simple.

  Extraction from pine bark may be performed by a liquid carbon dioxide batch method, a liquid carbon dioxide reflux method, a supercritical carbon dioxide reflux method, or the like, in addition to the extraction method described above.

  For extraction from pine bark, a plurality of extraction methods may be combined. By combining a plurality of extraction methods, it becomes possible to obtain pine bark extracts having various compositions.

  It is safe to purify the pine bark extract obtained by the above-described extraction by ultrafiltration or column method or batch method using an adsorptive carrier (Diaion HP-20, Sephadex-LH20, chitin, etc.). From the viewpoint of sex.

  Specifically, the pine bark extract contained in the food composition of the present invention is prepared by the following method, but this is illustrative and is not limited to this method.

  1 kg of French coastal pine bark is placed in 3 L of a saturated aqueous solution of sodium chloride and extracted at 100 ° C. for 30 minutes to obtain an extract (extraction process). Thereafter, the extract is filtered, and the resulting insoluble matter is washed with 500 mL of a saturated solution of sodium chloride to obtain a washing solution (washing step). The extract and washing solution are combined to obtain a crude extract of pine bark.

  Next, 250 mL of ethyl acetate is added to the crude extract and the phases are separated, and the process of recovering the ethyl acetate layer is repeated 5 times. The collected ethyl acetate solutions are combined and added directly to 200 g of anhydrous sodium sulfate for dehydration. The ethyl acetate solution is then filtered and the filtrate is concentrated in vacuo until the original volume is reduced to one fifth. Then, the concentrated ethyl acetate solution is poured into 2 L of chloroform, and the precipitate obtained by stirring is collected by filtration. Thereafter, the precipitate is dissolved in 100 mL of ethyl acetate, and then added again to 1 L of chloroform and precipitated for washing twice. By this method, for example, about 5 g of pine bark extract containing 20% by mass or more of proanthocyanidins having a degree of polymerization of 2 to 4 and 5% by mass or more of catechins is obtained. Here, the content of the specific component in the extract is a value based on the dry mass of the extract, and the same applies to the following.

  Pine bark extract contains proanthocyanidins as one of the main active ingredients. Proanthocyanidins refer to a group of compounds consisting of a condensation polymer having a degree of polymerization of 2 or more, with flavan-3-ol and / or flavan-3,4-diol as a structural unit. Proanthocyanidins are powerful antioxidants produced by plants and are intensively contained in plant leaves, bark, fruit peels and seeds. This proanthocyanidin is a substance that cannot be produced in the human body.

  When a pine bark extract containing this proanthocyanidin is ingested, an excellent effect of improving lipid metabolism is obtained. The pine bark extract contains a condensed polymer having a polymerization degree of 2 or more as proanthocyanidins, and further contains catechin and the like. In particular, proanthocyanidins containing a large amount of a condensation polymer having a low degree of polymerization are preferably used. The condensation polymer having a low polymerization degree is preferably a condensation polymer having a polymerization degree of 2 to 30 (2 to 30 mer), more preferably a condensation polymer having a polymerization degree of 2 to 10 (2 to 10 mer). Further, a condensation polymer (2 to 4 mer) having a polymerization degree of 2 to 4 is more preferable. Proanthocyanidins that are condensation polymers having a degree of polymerization of 2 to 4 (2 to 4 mer) are particularly easily absorbed into the body. In the present specification, the polymer having a degree of polymerization of 2 to 4 is referred to as oligomeric proanthocyanidin (hereinafter referred to as “OPC”).

  The pine bark extract contains 2 to 4 masses of proanthocyanidins (that is, OPC), based on the dry mass of the pine bark extract, 15% by mass or more, more preferably 20% by mass or more, and further preferably 30% by mass. More preferably, it is an extract containing the above.

  Further, the pine bark extract is preferably an extract containing pentamer or more proanthocyanidins in an amount of 10% by mass or more, more preferably 15% by mass or more based on the dry mass of the pine bark extract.

  The pine bark extract may further contain catechins. The content of catechins in the pine bark extract is preferably 5% by mass or more, more preferably 10% by mass or more, based on the dry mass of the pine bark extract.

  Catechins can be extracted together with proanthocyanidins (for example, OPC) by the extraction method described above. Catechin is a general term for polyhydroxyflavan-3-ol. As catechins, (+)-catechin (referred to as catechin in a narrow sense), (−)-epicatechin, (+)-gallocatechin, (−)-epigallocatechin, epigallocatechin gallate, epicatechin gallate, afzelechin, etc. It has been known.

  In addition to the above (+)-catechin, gallocatechin, afzelekin, and (+)-catechin or 3-galloyl derivatives of gallocatechin have been isolated from the pine bark extract. Catechins are known to have a carcinogenic inhibitory effect, an active oxygen and free radical scavenging effect, and an antioxidant effect. In addition, catechins are known to have an antidiabetic effect that suppresses an increase in blood sugar. Catechins are poor in water solubility by themselves and have low physiological activity, but in the presence of OPC, catechins have the property of being activated at the same time as water solubility increases. Therefore, catechins work effectively when present together with OPC.

  The catechins are preferably contained in the pine bark extract at 5% by mass or more. Further, it is more preferable that catechins are contained in an amount of 5% by mass or more in a pine bark extract containing 20% by mass or more of OPC and 10% by mass or more of proanthocyanidins of pentamer or more. For example, when the catechin content of the pine bark extract is less than 5% by mass, the catechins may be added so that the content is 5% by mass or more. That is, it is more preferable to use a pine bark extract containing 5% by mass or more of catechins, 20% by mass or more of OPC, and 10% by mass or more of proanthocyanidins of pentamer or more.

(About collagen)
Collagen contained in the food composition of the present invention is a generic term for fibrous hard proteins constituting the animal body, and includes a soluble protein obtained by hydrolyzing the same, The animal can be a land animal or aquatic animal. For example, terrestrial animals such as cattle, pigs, and sheep, and aquatic animals such as fish are preferable. Preferred examples include those obtained by extracting the skeletal proteins of these animals with an aqueous carrier or hydrolyzing with a protease or the like and then extracting the soluble portion. Particularly preferred are those based on fish, hydrolyzed and solubilized. Moreover, as for a preferable molecular weight, an average molecular weight is 10,000 or less, More preferably, it is 5000 or less. This is because if the average molecular weight is too large, the mouth-solubility is inhibited and it may be difficult to swallow. In order to obtain such an average molecular weight collagen, it is preferable to reduce the molecular size by hydrolysis, and to adjust the molecular weight distribution by ultrafiltration or the like as desired. In addition, since such a collagen already has a commercial product for food, it may be used.

(About growth factors)
The growth factor contained in the food composition of the present invention is a general term for endogenous proteins that promote proliferation and differentiation of specific cells in the body. Examples of the growth factor contained in the food composition of the present invention include an EGF-like component (an EGF-like component is a component that exhibits the same action as EGF in the body). As the EGF-like component, an EGF-like component contained in a swallow's nest can be exemplified. In addition, EGF (Epideral Growth Factor) has shown the epidermal growth factor and the epidermal growth factor. The EGF-like component already has a swallow's nest that can be used for food, and may be used as the component by adding it to the food composition.

(About the food composition of the present invention)
The food composition of the present invention contains a pine bark extract, collagen, and a growth factor, and more specifically, contains a pine bark extract, collagen, and an EGF-like component (swallow's nest). The amount of the pine bark extract in the food composition of the present invention is not particularly limited, but it is preferable to contain 0.004 parts by weight or more with respect to 1 part by weight of collagen.

  The amount of collagen in the food composition of the present invention is not particularly limited, but is preferably in the range of 3 to 17% by weight with respect to the whole food composition.

  The amount of swallow's nest in the food composition of the present invention is not particularly limited, but it is preferable to contain 0.00001 part by weight or more with respect to 1 part by weight of collagen.

  The food composition of the present invention includes pine bark extract, collagen, swallow's nest, barley young leaf powder, indigestible dextrin (water-soluble dietary fiber), reduced maltose, green tea powder, mugwort powder, dextrin Vitamins such as extract, black vinegar, apple juice, fructose glucose liquid sugar, oligosaccharide, chicken crown extract, vitamin C and the like can be blended.

  The food composition of the present invention can be provided in an edible form. For example, powder, granule, granule, liquid, paste, cream, tablet, capsule, caplet, soft capsule, tablet, rod, plate, block, pill, solid, gel, It can be formed into a jelly shape, gummi shape, wafer shape, biscuit shape, bowl shape, chewable shape, syrup shape, stick shape or the like and provided as a food. Further, it may be used by adding to water, milk, soy milk, fruit juice drink, whey drink, soft drink, green juice, black vinegar, yogurt or the like. Moreover, you may use the food composition of this invention for the health food which displayed the beauty use, and the food for specific health, for example.

  Examples of the present invention will be described below. It should be noted that the present invention is not construed as being limited to the embodiments described later, and various modifications can be made within the scope of the claims.

(Evaluation of food composition)
The food composition containing pine bark extract, collagen and swallow's nest was subjected to a sensory test together with a comparative object, and the superiority of this food composition was evaluated.

  The sensory test was performed as follows. First, a total of four types of beverages, test beverages and comparative beverages 1 to 3 shown in Table 1, were prepared. Specifically, pine bark extract powder (trade name: Flavangenol, manufactured by Toyo Shinyaku Co., Ltd. ("Flavengenol" is a registered trademark of Toyo Shinyaku Co., Ltd.)), collagen powder, and swallow's nest powder To prepare an aqueous solution containing 0.5% by weight of collagen, 0.1% by weight of flavangenol, and 0.02% by weight of swallow's nest based on the whole beverage. Was used as a test beverage. In other words, the test beverage is an aqueous solution containing 0.2 parts by weight of pine bark extract and 0.04 parts by weight of swallow's nest with respect to 1 part by weight of collagen.

  Moreover, only the collagen was used and the aqueous solution which contains collagen 0.5weight% with respect to the whole drink was prepared, and this was made into the comparative drink 1. Also, using two types of collagen and flavangenol, an aqueous solution containing 0.5 wt% collagen and 0.1 wt% flavangenol was prepared for the whole beverage and compared. It was set as the drink 2. Furthermore, using collagen and swallow's nest, an aqueous solution containing 0.5% by weight of collagen and 0.02% by weight of swallow's nest is prepared with respect to the entire beverage, did.

(Table 1)

  Next, in the sensory test, the test drinks and comparative drinks 1 to 3 were sampled by 6 subjects composed of men and women. Thereafter, the subjects were evaluated on a total of 11 evaluation items of “smell, deliciousness, flavor, sweetness, acidity, salty taste, bitterness, good aftertaste, throat sensation, touch”. In addition, for each of the total 11 evaluation items described above, evaluation was performed using a scoring method based on 5 levels of 1 to 5 points for each subject (1 point is the best evaluation and 5 points is the worst evaluation). . Then, for each evaluation item, the evaluation score of each test was added to obtain a total score for each evaluation item (the lower the total score, the better the evaluation). Table 2 shows the overall score for each evaluation item.

(Table 2)

  As shown in Table 2, the test beverage (food composition containing flavangenol, collagen and swallow's nest) has a total score of 19 or less in all evaluation items, and is compared with comparative beverages 1-3. Therefore, it is a stable overall score with little variation.

  Here, in the food field, even if most of the evaluation items described above have a low overall score (even if it is a good evaluation), if any one of the evaluation items has a high overall score (bad evaluation). If so, the overall evaluation of the food will be poor. For this reason, a stable and low overall score is very important in food. In this respect, the test beverage shows a stable and low overall score as compared with the comparative beverages 1 to 3 as described above, and thus can be said to be very suitable for use in the food field.

  In addition, as shown in Table 2, the test beverage showed a low overall score in six evaluation items of “taste”, “flavor”, “sweet”, “acidity”, “salt”, and “good aftertaste”. Therefore, compared with the comparative drinks 1-3, the good evaluation is shown.

  In particular, as shown in Table 2, the test beverage has an extremely excellent evaluation in terms of flavor as compared with Comparative beverages 1 to 3 because the overall score in the evaluation item of “flavor” is extremely low. This overall score just shows that the combination of collagen, flavangenol and swallow's nest has a marked effect on improving "flavor".

  As described above, according to the food composition containing flavangenol, collagen and swallow's nest (growth factor), it is possible to prevent the deterioration of flavor and the like due to the inclusion of collagen.

  The present invention has been described above based on the embodiments. However, the present invention is not limited to the above-described embodiments, and various modifications and changes can be easily made without departing from the spirit of the present invention. Can be inferred.

  In the above-described embodiments, the food composition is a beverage, but the present invention is not limited to this, and the food composition may be formed in a liquid form other than powder, granules, granules, and paste. Thus, even when the food composition is molded in a form other than liquid, it is easily conceivable that the same result as that shown in Table 2 is obtained.

  In the above-described examples, the swallow's nest was used as the EGF-like component contained in the food composition, but the present invention is not limited to this, and the EGF-like component was previously extracted from the swallow's nest and extracted. An EGF-like component may be contained in the food composition instead of the swallow's nest.

  Moreover, in the Example mentioned above, a test drink (the drink which can prevent deterioration of the flavor etc. resulting from containing collagen) is a pine bark extract 0.1% with respect to 1 weight part of collagen. 2 parts by weight and 0.04 parts by weight of swallow's nest were contained, but the present invention is not limited to this. That is, from the viewpoint of realizing the above-described prevention of deterioration of flavor and the like, 0.2 parts by weight or more of pine bark extract and 0.04 parts by weight or more of swallow's nest are contained with respect to 1 part by weight of collagen. A food composition may be used. In addition, even if it is a food composition of such a prescription, it can be easily imagined that the same result as the result shown in Table 2 is obtained.

  According to the food composition according to claim 1, in addition to collagen, it contains a pine bark extract and a growth factor, and according to the food composition according to claims 2 and 3, in addition to collagen, Further, since it contains a pine bark extract and an EGF-like component, it is possible to prevent deterioration of flavor and the like due to the inclusion of collagen. Therefore, it can be used in industrial fields where it is necessary to prevent this deterioration.

Claims (1)

A food composition containing pine bark extract, collagen and swallow's nest ,
The food composition contains 0.2 parts by weight or more of the pine bark extract and 0.04 parts by weight or more of the swallow's nest with respect to 1 part by weight of the collagen. Food composition.