JP5675773B2 - Ｃｃｒ２の４−アゼチジニル−１−フェニル−シクロヘキサンアンタゴニスト - Google Patents

Ｃｃｒ２の４−アゼチジニル−１−フェニル−シクロヘキサンアンタゴニスト Download PDF

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JP5675773B2
JP5675773B2 JP2012506232A JP2012506232A JP5675773B2 JP 5675773 B2 JP5675773 B2 JP 5675773B2 JP 2012506232 A JP2012506232 A JP 2012506232A JP 2012506232 A JP2012506232 A JP 2012506232A JP 5675773 B2 JP5675773 B2 JP 5675773B2
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alkyl
phenyl
prepared
methyl
azetidin
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Japanese (ja)
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JP2012524111A (ja
JP2012524111A5 (OSRAM
Inventor
ツアン，スーチン
ハフナゲル，ヘザー・ラエ
フー，クイフエン
ジヨンソン，ダナ・エル
スイ，ツイーフア
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
JP2012506232A 2009-04-17 2010-04-15 Ｃｃｒ２の４−アゼチジニル−１−フェニル−シクロヘキサンアンタゴニスト Expired - Fee Related JP5675773B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17030709P 2009-04-17 2009-04-17
US61/170,307 2009-04-17
PCT/US2010/031265 WO2010121046A1 (en) 2009-04-17 2010-04-15 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2

Publications (3)

Publication Number Publication Date
JP2012524111A JP2012524111A (ja) 2012-10-11
JP2012524111A5 JP2012524111A5 (OSRAM) 2013-04-25
JP5675773B2 true JP5675773B2 (ja) 2015-02-25

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JP2012506232A Expired - Fee Related JP5675773B2 (ja) 2009-04-17 2010-04-15 Ｃｃｒ２の４−アゼチジニル−１−フェニル−シクロヘキサンアンタゴニスト

Country Status (14)

Country Link
US (2) US20100267689A1 (OSRAM)
EP (1) EP2419419B1 (OSRAM)
JP (1) JP5675773B2 (OSRAM)
KR (1) KR20120006544A (OSRAM)
CN (1) CN102459227B (OSRAM)
AR (1) AR076328A1 (OSRAM)
AU (1) AU2010236346B2 (OSRAM)
BR (1) BRPI1016189A2 (OSRAM)
CA (1) CA2758934A1 (OSRAM)
ES (1) ES2528625T3 (OSRAM)
MX (1) MX2011010964A (OSRAM)
NZ (1) NZ595432A (OSRAM)
TW (1) TW201102377A (OSRAM)
WO (1) WO2010121046A1 (OSRAM)

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GB201617454D0 (en) * 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
US11304952B2 (en) 2017-09-25 2022-04-19 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor
EA202091325A1 (ru) 2017-11-30 2020-08-28 Лэндос Байофарма, Инк. Способы лечения с помощью лигандов лантионин c-подобного белка 2 и подготовленных с их помощью клеток
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
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GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819961D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
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US20120040960A1 (en) 2012-02-16
MX2011010964A (es) 2011-11-02
TW201102377A (en) 2011-01-16
JP2012524111A (ja) 2012-10-11
AU2010236346B2 (en) 2015-01-22
CA2758934A1 (en) 2010-10-21
NZ595432A (en) 2013-12-20
ES2528625T3 (es) 2015-02-11
BRPI1016189A2 (pt) 2016-04-19
CN102459227B (zh) 2014-08-20
EP2419419A1 (en) 2012-02-22
US20100267689A1 (en) 2010-10-21
AR076328A1 (es) 2011-06-01
US8513229B2 (en) 2013-08-20
AU2010236346A1 (en) 2011-11-03
EP2419419B1 (en) 2014-12-03
WO2010121046A1 (en) 2010-10-21
CN102459227A (zh) 2012-05-16

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