JP5667869B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that analyzes biological samples such as blood and urine, and more particularly to an automatic analyzer that has a function of performing pre-analysis processing of a sample.

  Corresponding to recent metabolic examinations, automatic analyzers for clinical examinations are required to have a function for easily analyzing specific examination items such as hemoglobin A1c. Each company has also started to sell hemoglobin A1c dedicated machines, hemoglobin A1c measurement options, and so on. In the measurement of hemoglobin A1c, it is common to perform normal biochemical analysis after pre-treatment of a collected biological sample by a predetermined process such as hemolysis. The sample pretreatment can be carried out by a conventional method, but it is desirable that it is automatically performed when reproducibility of measurement results and rapid analysis are required. As a method for automating sample pretreatment with a conventional automatic analyzer, a method of performing pretreatment using a reaction vessel on a reaction disk as described in Patent Document 1, for example, is known. In this method, for inspection items that require sample pretreatment, the sample and pretreatment liquid are discharged into a reaction vessel on a reaction disk, and pretreatment is performed. A predetermined amount of the pre-processed sample is sucked, and the sucked pre-processed sample is discharged to another reaction container on the same reaction disk to shift to a normal analysis sequence.

  Moreover, as described in Patent Document 2, an automatic analyzer having a mechanism for performing dedicated sample pretreatment has also been proposed.

JP-A-6-82460 JP-A-8-194004

  However, in the sample pretreatment by the method of Patent Document 1, sample dispensing from the sample storage container to the reaction container, suction of the pretreated sample in the reaction container, and the suctioned pretreated sample to another reaction container Are discharged by the same sample dispensing mechanism, the analysis processing capability decreases when these dispensing operations overlap. In particular, depending on the inspection item, each of the operations described above may require two cycles in the operation cycle time of the apparatus, and the influence thereof becomes very large. Moreover, since the method according to Patent Document 2 requires a dedicated mechanism for preprocessing, the apparatus becomes large.

  SUMMARY OF THE INVENTION An object of the present invention is to provide an automatic analyzer capable of reducing the analytical processing capacity and reducing the size of the apparatus even when pretreatment of a sample is performed using a reaction vessel on a reaction disk. .

  The configuration of the present invention for achieving the above object is as follows.

  A reaction container for reacting a sample and a reagent, a reaction disk in which the reaction containers are arranged in an annular shape, a reaction disk rotating mechanism for rotating the reaction disk, and a predetermined amount of sample is discharged to the reaction container at a sample discharge position In an automatic analyzer comprising a sample dispensing mechanism and a reagent dispensing mechanism that discharges a predetermined amount of reagent to the reaction container at a reagent discharge position, a sample is dispensed into one of the reaction containers by the sample dispensing mechanism. A control mechanism for controlling the reaction disk rotation mechanism, the sample dispensing mechanism, and the reagent dispensing mechanism so that the pretreatment liquid is discharged by the reagent dispensing mechanism into the reaction container from which the sample has been discharged, Furthermore, a pre-treated sample in the reaction vessel from which the pre-treatment liquid has been discharged is sucked by a predetermined amount at the pre-treatment sample suction position, and further placed in a reaction vessel different from the reaction vessel at the pre-treatment sample discharge position. Sample after pretreatment for quantitative dispensing Mechanism, an automatic analyzer having a.

  “Reacting the sample and the reagent” is achieved by “mixing the sample and the reagent” as an operation, and it does not matter whether or not the reaction actually occurs. In other words, it is assumed that the sample and the reagent are mixed and reacted. A reaction vessel is a vessel molded with synthetic resin, glass, etc., and after reacting the sample with the reagent, the reaction solution may be discarded, washed and reused, or once subjected to the reaction. The thing may be a so-called disposable reaction vessel that is discarded and a new reaction vessel is used. A reaction disk is generally a plurality of reaction vessels arranged side by side on a ring-shaped or disk-shaped base, but the plurality of reaction vessels maintain their relative positional relationship. Anything can be used as long as it can be moved. The reaction disk rotating mechanism may be any mechanism as long as the reaction container on the disk can be rotated as a whole (integrally) while maintaining the relative positional relationship between them. In general, a ring-shaped or disk-shaped base is rotated around one axis. The sample dispensing mechanism, the reagent dispensing mechanism, and the pre-treatment sample dispensing mechanism generally include a mechanism for temporarily storing a sample or reagent to be sucked into a dispensing nozzle and discharging the stored sample or reagent. It is provided. In order to suck into the dispensing nozzle or discharge the sucked nozzle, it is common to use a mechanism that changes the pressure in the dispensing nozzle with a pressure changing means such as a syringe pump or a diaphragm. Each dispensing mechanism performs a discharge operation to the reaction container when the reaction disk is stopped.

  The control mechanism for controlling the reaction disk rotating mechanism, the sample dispensing mechanism, and the reagent dispensing mechanism is generally controlled by a programmed computer.

  The above describes the invention from the viewpoint of the hardware mechanism, but it is described as follows from the viewpoint of the discharge position on the reaction disk.

  A reaction disk in which reaction vessels for reacting samples and reagents are arranged in a ring form a sample discharge position for discharging the sample from the sample storage container to the reaction vessel using the sample dispensing mechanism, and a reaction container using the reagent dispensing mechanism. A reagent discharge position for discharging the reagent to the discharged sample and a pre-processed sample suction for sucking the pre-processed sample from the reaction container containing the sample discharged with the pre-process liquid using the pre-processed sample dispensing mechanism An automatic analyzer comprising a position and a pre-processed sample discharge position for discharging the sucked sample to another reaction container on the same reaction disk.

  The reaction disk is repeatedly rotated and stopped as one set. The rotation of the reaction disk uses the number of reaction vessels as a unit of movement, and always moves a fixed amount in each cycle, and the total number of reaction vessels included in the reaction disk. When the same number of cycles elapses, the position of the reaction vessel on the reaction disk is controlled to return to the initial state before the start of the cycle.

  In the case of a normal inspection item that does not require sample pretreatment, first, a predetermined amount of sample is discharged into the reaction container using the sample dispensing mechanism at the sample discharge position on the reaction disk. Thereafter, a predetermined amount of the reagent is discharged into the reaction container from which the sample has been discharged using the reagent dispensing mechanism at the reagent discharge position, and the sample and the reagent are reacted. The absorbance of the reaction solution is measured with a spectrophotometer while the necessary number of cycles elapses, and the obtained measurement data is processed by the apparatus control unit and the result is reported to the operator.

  In the case of an inspection item that requires sample pretreatment, first, a predetermined amount of sample is discharged into the reaction container using the sample dispensing mechanism at the sample discharge position on the reaction disk. Thereafter, a pre-treatment liquid for pre-processing the sample is discharged at a reagent discharge position using the reagent dispensing mechanism, and the sample is pre-processed. After a certain number of cycles have elapsed since the discharge of the pretreatment liquid, the pretreated sample is sucked using the pretreatment sample dispensing mechanism at the pretreated sample suction position, and the pretreated sample that has been further sucked is pretreated. It discharges to another reaction container in a post-sample discharge position. Here, the pre-processed sample discharged at the pre-processed sample discharge position is controlled to return to the sample discharge position after an odd number of cycles from the time when the sample was discharged into the reaction container at the sample discharge position. The analysis order is managed by the apparatus control unit so that the reaction container from which the sample is discharged and the reaction container from which the sample is newly discharged are not the same. The pre-processed sample discharged at the pre-processed sample discharge position shifts to a normal inspection item analysis operation.

  Even when the sample dispensing operation and the pre-processed sample dispensing operation overlap in the same cycle, they can operate in parallel without interfering with each other, and a reduction in analysis processing capability can be prevented. In addition, the apparatus is more compact than when a mechanism for performing pre-processing is used.

It is the figure which showed the structure of the automatic analyzer about one Example of this invention. It is the figure which showed arrangement | positioning of each mechanism around a reaction disk about the Example of FIG. It is the figure which showed the analysis sequence of normal analysis about the Example of FIG. (The first half of the analysis sequence. The second half follows Fig. 4.) It is the figure which showed the analysis sequence of normal analysis about the Example of FIG. (The latter half of the analysis sequence; continued from Figure 3) It is the figure which showed the analysis sequence when the pre-processing of a sample is required about the Example of FIG. The pretreatment time is about 1 minute. It is the figure which showed the analysis sequence when the pre-processing of a sample is required about the Example of FIG. The pretreatment time is about 2.5 minutes. FIG. 3 is a diagram illustrating an analysis sequence in the case of requiring the sample pretreatment with two kinds of pretreatment liquids in the example of FIG. 2. (The first half of the analysis sequence. The second half follows Fig. 8.) FIG. 3 is a diagram illustrating an analysis sequence in the case of requiring the sample pretreatment with two kinds of pretreatment liquids in the example of FIG. 2. (Second half of the analysis sequence; continued from FIG. 7) It is the figure which showed the Example of the automatic analyzer of the structure which can each access to the sample which a sample dispensing mechanism and a pre-processing dispensing mechanism can move on a sample conveyance line. It is the figure which showed the apparatus structure of the conventional automatic analyzer. It is the figure which showed the analysis sequence when the pre-processing of a sample is needed about the conventional automatic analyzer shown in FIG. With respect to the conventional automatic analyzer shown in FIG. 11, the sample dispensing operation in each cycle and the sample after the pretreatment when the analysis requiring the pretreatment of the sample including the advanced dispensing nozzle cleaning is continuously performed. It is the figure which showed the implementation state of dispensing operation | movement. In the embodiment shown in FIG. 2, the sample dispensing operation and the sample dispensing operation after the pretreatment are performed in each cycle when the analysis requiring the sample pretreatment including the advanced dispensing nozzle cleaning is continuously performed. It is the figure which showed the state.

  Embodiments of the present invention will be described in detail with reference to the drawings.

  1 and 2 show the configuration of the automatic analyzer. The automatic analyzer of the present invention includes a reaction disk 2 in which reaction vessels 1 in which a sample and a reagent react are arranged in a ring, a reagent cold box 4 in which a reagent bottle 3 containing various reagents including a pretreatment liquid is installed, a blood collection tube A sample disk 6 on which a sample storage container 5 storing a biological sample is erected is provided. The sample is sucked by the sample dispensing mechanism 7 and discharged to the reaction container at a sample discharge position 13 on the reaction disk. The reagent or the pretreatment liquid is sucked from the reagent bottle by the first reagent dispensing mechanism 8 or the second reagent dispensing mechanism 9 and discharged by a predetermined amount at the first reagent discharging position 14 or the second reagent discharging position 15 on the reaction disk, respectively. Then, mix and react the sample and the reagent. The absorbance of the reaction solution in the reaction vessel is measured with a spectrophotometer 10 installed on the outer periphery of the reaction disk. The pre-treatment sample dispensing mechanism 11 has a structure in which the rotation center axis freely moves with respect to the horizontal plane of the apparatus, and can access a plurality of reaction vessels on the reaction disk. The pre-treatment sample suction position (1) 16 Alternatively, a pre-processed sample is sucked from the pre-process sample suction position (2) 17 by a predetermined amount, and the sucked pre-process sample is further discharged to another reaction container at the pre-process sample discharge position 18. After completion of the analysis, the reaction vessel is washed by the reaction vessel washing mechanism 12 at the reaction vessel washing position 19 and reused.

  Here, in this embodiment, a total of 50 reaction vessels are annularly arranged at equal intervals in the reaction disk, and a cycle with rotation and stop as one set is repeated, and the unit cycle time is 16 seconds. In addition, the rotation of the reaction disk uses the number of reaction vessels as a unit of movement, and always moves a certain amount in each cycle, and the amount of movement is 17 pieces. Note that the sample dispensing mechanism, the first reagent dispensing mechanism, the second reagent dispensing mechanism, and the pretreatment sample dispensing mechanism perform dispensing operation on the reaction container when the reaction disk is stopped, and reaction. The container cleaning mechanism cleans the reaction container when the reaction disk is stopped. The absorbance of the reaction solution is measured when the reaction disk rotates and the reaction vessel crosses the optical axis 20 of the spectrophotometer.

  Details of the analysis sequence will be described with reference to FIGS. 3 to 8 indicate the identification No. of the reaction vessel, and represents the moving state of the reaction vessel for each cycle with the rotation / stop cycle of the reaction disk as a unit of time. The identification No. of the reaction container is assigned in order clockwise with the sample discharge position being the reaction container No. 1 in the initial stop position state of the reaction disk.

  Here, focusing on the reaction vessel No. 1, the analysis sequence will be described.

  An analysis sequence for normal analysis that does not require sample pretreatment will be described below.

<FIGS. 3 and 4> In the case of normal analysis First, in the 0th cycle, a predetermined amount of sample is discharged into the reaction container at the sample discharge position using the sample dispensing mechanism. In the first cycle, a predetermined amount of the first reagent is discharged at the first reagent discharge position using the first reagent dispensing mechanism into the reaction container from which the sample has been discharged, and mixed with the sample. In the first reagent discharge to the 18th cycle, the reaction between the sample and the reagent and the absorbance measurement of the reaction solution using a spectrophotometer are performed. In the 19th cycle after about 5 minutes have elapsed from the start of analysis, a predetermined amount of the second reagent is discharged at the second reagent discharge position using the second reagent dispensing mechanism and mixed with the sample. Note that this operation is not performed when the inspection item set for the sample discharged into the reaction container No. 1 does not require the discharge of the second reagent. From the second reagent discharge to the 37th cycle, the reaction between the sample and the reagent and the absorbance measurement of the reaction solution are performed. The analysis operation is terminated at the 38th cycle when about 10 minutes have elapsed from the start of the analysis, and the operation proceeds to the reaction vessel cleaning operation. The reaction vessel is washed at the reaction vessel washing position using the reaction vessel washing mechanism, and is sequentially performed at the 38th, 41st, and 44th cycles. After the completion of the washing operation of the reaction vessel, the reaction vessel No. 1 returns to the initial stop position before the start of the analysis sequence in the 50th cycle and is used again for the analysis.

  Next, an analysis sequence that requires sample pretreatment will be described. Here, two types of analysis sequences with different preprocessing times are shown.

<Fig. 5> When sample pretreatment is required (pretreatment time = about 1 minute)
First, a predetermined amount of sample is discharged into the reaction container at the sample discharge position using the sample dispensing mechanism in the 0th cycle. In the first cycle, a predetermined amount of pretreatment liquid is discharged at the first reagent discharge position using the first reagent dispensing mechanism into the reaction container from which the sample has been discharged, and mixed with the sample. In the fifth cycle after about 1 minute has elapsed since the pretreatment liquid was discharged, a pre-treated sample was dispensed from the reaction vessel No. 1 at the pre-treated sample body suction position (1) using the pre-treated sample dispensing mechanism. Then, in a sixth cycle, the sucked pre-processed sample is discharged to the reaction container No. 20 at a pre-processed sample discharge position by a predetermined amount. In the seventh cycle, the reaction vessel No. 20 reaches the sample discharge position, but the sample is not discharged, and the pretreated sample discharged to the reaction vessel No. 20 then moves to the analysis sequence for normal analysis. . The reaction vessel No. 1 used for the pretreatment of the sample is not used for analysis after the pretreatment sample is aspirated, and shifts to the reaction vessel washing operation from the 38th cycle. After the cleaning operation is completed, it is used again for analysis.

<Fig. 6> When sample pretreatment is required (pretreatment time = about 2.5 minutes)
First, in the 0th cycle, a predetermined amount of sample is discharged into the reaction container at the sample discharge position using the sample sampling mechanism. In the first cycle, a predetermined amount of pretreatment liquid is discharged at the first reagent discharge position using the first reagent dispensing mechanism into the reaction container from which the sample has been discharged, and mixed with the sample. In the 11th cycle after about 2.5 minutes have passed since the discharge of the pretreatment liquid, the pretreated sample is removed from the reaction vessel No. 1 at the pretreated sample suction position (2) using the pretreated sample dispensing mechanism. A predetermined amount is aspirated, and in the 12th cycle, the pretreated sample that has been aspirated is discharged into the reaction vessel No. 22 at the pretreated sample discharge position. In the thirteenth cycle, the reaction vessel No. 22 reaches the sample discharge position, but the sample is not discharged, and the pre-processed sample discharged to the reaction vessel No. 22 then moves to the analysis sequence for normal analysis. . The reaction vessel No. 1 used for the pretreatment of the sample is not used for analysis after the pretreatment sample is aspirated, and shifts to the reaction vessel washing operation from the 38th cycle. After the cleaning operation is completed, it is used again for analysis.

  By setting the sample pre-treatment sample suction position to an appropriate position, for example, it is possible to cope with pretreatment of a sample to which two kinds of pretreatment liquids need to be added. Details will be described below with reference to FIGS.

<Figs. 7 and 8> When sample pretreatment is required (addition of two types of pretreatment liquid)
In order to cope with the addition of two kinds of pretreatment liquids, a pretreatment post sample suction position (3) is newly added to the position of the reaction vessel No. 10 in the initial stop position state of the reaction disk.

  First, at the 0th cycle, a predetermined amount of sample is discharged to the reaction container at the sample discharge position using the sample dispensing mechanism. In the first cycle, a predetermined amount of the pretreatment liquid (1) is discharged to the reaction container from which the sample has been discharged using the first reagent dispensing mechanism at the first reagent discharge position, and mixed with the sample. In the 19th cycle after about 5 minutes have passed since the start of analysis, a predetermined amount of the pretreatment liquid (2) is discharged at the second reagent discharge position using the second reagent dispensing mechanism and mixed with the sample. In the 23rd cycle, a pre-treated sample is sucked from the reaction vessel No. 1 at the pre-treated sample suction position (3) using the pre-treated sample dispensing mechanism. A predetermined amount of the processed sample is discharged into the reaction container No. 26 at the pre-processed sample discharge position. In the 25th cycle, the reaction vessel No. 26 reaches the sample discharge position, but the sample is not discharged, and the pre-processed sample discharged to the reaction vessel No. 26 then moves to the analysis sequence for normal analysis. . The reaction vessel No. 1 used for the pretreatment of the sample is not used for analysis after the pretreatment sample is aspirated, and shifts to the reaction vessel washing operation from the 38th cycle. After the cleaning operation is completed, it is used again for analysis.

  Equipped with a pre-treatment sample dispensing mechanism as described above, and pre-treatment of the sample can be efficiently performed by setting the pre-treatment sample suction position and the pre-treatment sample discharge position at appropriate positions on the reaction disk. In addition, the preprocessing time can be changed.

  In this embodiment, the pretreatment sample dispensing mechanism sucks the pretreatment sample from the pretreatment sample suction position, and discharges the sucked sample at the pretreatment sample discharge position. The suction position need not be limited to the reaction vessel on the reaction disk. For example, in the apparatus configuration as shown in FIG. 9, the sample storage container moves on the sample transport line 22, and the sample dispensing mechanism and the pre-processed sample dispensing mechanism each access the sample storage container on the transport line. be able to. For this reason, the pre-treatment sample dispensing mechanism can directly suck the sample from the sample storage container and discharge the sucked sample at the pre-treatment sample discharge position. Can be pre-processed. As an advantage of performing the sample dispensing operation by both the sample dispensing mechanism and the pre-processed sample dispensing mechanism, there is a case where multiple cycles are required for the sample dispensing operation. Normally, the sample dispensing operation is completed in one cycle, but depending on the inspection item, an operation time of two cycles or more is required. In such a case, if the sample dispensing operation is performed by both the sample dispensing mechanism and the pre-processed sample dispensing mechanism, it is possible to prevent a decrease in analysis processing capability.

  In this embodiment, the sample discharge position and the pre-processed sample discharge position are set to different reaction container positions on the reaction disk, but the sample dispensing mechanism and the pre-processed sample dispensing mechanism do not physically interfere with each other. By controlling in this way, it is possible to set the same position.

  Here, in order to clarify the effect of the present invention, the difference from the prior art will be described with respect to the analysis processing capability when the sample pretreatment is required.

  First, FIG. 10 and FIG. 11 show an analysis sequence in the case of carrying out the apparatus configuration and sample pretreatment for an embodiment of a conventional automatic analyzer, respectively. As shown in FIG. 10, in the conventional automatic analyzer, each mechanism around the reaction disk and each discharge position on the reaction disk are arranged at the same position as the apparatus configuration in FIG. Not equipped. FIG. 11 is a diagram showing the analysis sequence in the case where sample pretreatment is performed, paying attention to the reaction vessel No. 1. The reaction vessel No. 1 in which the sample is discharged in the 0th cycle is the sample before the sample. When the pre-processed sample suction position 21 is reached in the sixth cycle after the processing is completed, a predetermined amount of the pre-processed sample is sucked using the sample dispensing mechanism, and the pre-processed sample sucked in the seventh cycle. Is discharged into the reaction container No. 20 at the sample discharge position by a predetermined amount. The discharged pretreated sample is then transferred to a normal analysis sequence. As described above, in the conventional automatic analyzer, the sample dispensing mechanism is configured to perform both the sample dispensing operation and the pre-processed sample dispensing operation.

  When a sample is pre-processed by a conventional automatic analyzer, a factor that greatly affects the analysis processing capability is a state in which a specific test item is continuously analyzed, such as hemoglobin A1c measurement. Details will be described below.

  The sample dispensing operation is performed through the dispensing nozzle 23 provided in the sample dispensing mechanism. After the sample dispensing operation, the dispensing nozzle is cleaned in the cleaning tank 24 so as not to affect the analysis result of the next sample. Do. Normally, the sample dispensing operation and the dispensing nozzle cleaning operation are completed in one cycle by adding these two operation times. However, in a specific inspection item such as hemoglobin A1c measurement, a more advanced dispensing nozzle is used. Since cleaning is required, a total of 2 cycles are required for the sample dispensing operation and the subsequent dispensing nozzle cleaning operation (sample dispensing: 1 cycle, dispensing nozzle cleaning: 1 cycle).

  FIGS. 12 and 13 respectively show sample dispensing operations performed in each cycle and sample dispensing after pretreatment in the case where analysis requiring sample pretreatment with advanced dispensing nozzle cleaning is continuously performed. Indicates the implementation status of the operation.

  As shown in FIG. 12, the conventional automatic analyzer performs the sample dispensing operation every four cycles. Originally, the sample dispensing mechanism can perform sample dispensing every two cycles even when sample dispensing that requires high-level dispensing nozzle cleaning is performed continuously. Since sample dispensing after processing is performed by the same dispensing mechanism, it is necessary to control the sample dispensing timing so that the two operations do not overlap, and as a result, the number of sample dispensing must be limited.

  However, in the automatic analyzer of the present invention, as shown in FIG. 13, the sample dispensing operation and the pretreatment sample dispensing operation are performed by two different dispensing mechanisms. Further, the pre-processed sample discharge position is set such that the pre-processed sample discharged at the pre-processed sample discharge position reaches the sample discharge position after an odd number of cycles from the time when the sample is discharged into the reaction container at the sample discharge position. If the sample dispensing operation is performed every two cycles, it can be controlled so that the two operations do not overlap.

  Thus, when the analysis which requires the sample pretreatment with a high degree of dispensing nozzle cleaning is continuously performed, the automatic analyzer of the present invention has twice the analysis processing capacity as compared with the conventional technology. become.

DESCRIPTION OF SYMBOLS 1 Reaction container 2 Reaction disk 3 Reagent bottle 4 Reagent cooler 5 Sample storage container 6 Sample disk 7 Sample dispensing mechanism 8 First reagent dispensing mechanism 9 Second reagent dispensing mechanism 10 Spectrophotometer 11 Pretreatment sample dispensing Mechanism 12 Reaction vessel cleaning mechanism 13 Sample discharge position 14 First reagent discharge position 15 Second reagent discharge position 16 Pre-processed sample suction position (1)
17 Sample suction position after pretreatment (2)
18 Pre-processed sample discharge position 19 Reaction vessel cleaning position 20 Spectrophotometer optical axis position 21 Pre-processed sample suction position (conventional automatic analyzer)
22 Sample transport line 23 Dispensing nozzle 24 Cleaning tank

Claims (6)

A reaction container for reacting a sample and a reagent, a reaction disk in which the reaction containers are arranged in an annular shape, a reaction disk rotating mechanism for rotating the reaction disk, and a sample dispensing mechanism for discharging a predetermined amount of sample to the reaction container And a reagent dispensing mechanism for discharging a predetermined amount of the reagent to the reaction container,
A sample is discharged at one of the reaction containers at a sample discharge position using the sample dispensing mechanism, and a pretreatment liquid is discharged at the reagent discharge position using the reagent dispensing mechanism into the reaction container from which the sample has been discharged. A control mechanism for controlling the reaction disk rotation mechanism, the sample dispensing mechanism, and the reagent dispensing mechanism,
Further, the pretreatment liquid is a predetermined quantity sucked by the preprocessed sample suction position preprocessed sample in the reaction vessel was discharged, yet the to another reaction vessel arranged in the same said on the reaction disk and the reaction vessel An automatic analyzer comprising a pre-processed sample dispensing mechanism for discharging a pre-processed sample by a predetermined amount at a pre-processed sample discharge position provided at a position different from the sample discharge position. The automatic analyzer according to claim 1, wherein
The pre-processed sample dispensing mechanism sucks pre-processed samples from reaction containers at a plurality of reaction container positions on the reaction disk, and sucks them into reaction containers at the same reaction container position on the reaction disk. An automatic analyzer capable of discharging the sample after the pretreatment.   2. The automatic analyzer according to claim 1, wherein the reaction disk repeatedly executes a cycle in which rotation and stop are set as one set, and the rotation of the reaction disk always moves a fixed amount in each cycle with the number of reaction vessels as a moving unit. When the same number of cycles as the total number of reaction vessels on the reaction disk elapses, the position of the reaction vessel on the reaction disk is controlled to return to the initial state before the start of the cycle, and the sample dispensing mechanism, reagent dispensing mechanism and pretreatment are controlled. The post-sample dispensing mechanism performs a dispensing operation on each reaction container when the reaction disk is stopped, and the pre-treated sample discharged at the pre-treated sample discharge position is the sample at the sample discharge position. An automatic analyzer that is controlled to return to the sample discharge position after an odd number of cycles, starting from the time when the sample was discharged into the reaction vessel.   2. The automatic analyzer according to claim 1, wherein the pre-treatment sample dispensing mechanism sucks a predetermined amount of the sample to be measured from a position different from the reaction container position on the reaction disk, and further pre-treats the sucked sample. An automatic analyzer capable of discharging a predetermined amount into a reaction container at a post-sample discharge position. The automatic analyzer according to claim 2,
The pre-processed sample dispensing mechanism includes a first rotating arm that rotates around a first axis, and a second axis that rotates around a second axis provided at an end of the first rotating arm. An automatic analyzer comprising a rotary arm, and a dispensing nozzle for sucking and discharging a sample after pretreatment at the end of the second arm. The automatic analyzer according to claim 2,
The pretreatment sample dispensing mechanism includes a rotating arm that rotates around one axis, and a dispensing nozzle that sucks and discharges a pretreatment liquid at an end of the rotating arm, and further includes the axis, An automatic analyzer comprising: an axis moving mechanism that moves the axes in a direction orthogonal to each other.

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