JP5658272B2 - Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 - Google Patents
Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 Download PDFInfo
- Publication number
- JP5658272B2 JP5658272B2 JP2012543668A JP2012543668A JP5658272B2 JP 5658272 B2 JP5658272 B2 JP 5658272B2 JP 2012543668 A JP2012543668 A JP 2012543668A JP 2012543668 A JP2012543668 A JP 2012543668A JP 5658272 B2 JP5658272 B2 JP 5658272B2
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- phenyl
- quinazoline
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- YHAIRNZJUZWIFQ-UHFFFAOYSA-N C=CCCCC(c1ccc(C2(F)[F][F]2)cc1)=O Chemical compound C=CCCCC(c1ccc(C2(F)[F][F]2)cc1)=O YHAIRNZJUZWIFQ-UHFFFAOYSA-N 0.000 description 1
- AYRSEXWPCCRZSZ-UHFFFAOYSA-N CC(CCC1)C1I Chemical compound CC(CCC1)C1I AYRSEXWPCCRZSZ-UHFFFAOYSA-N 0.000 description 1
- YAGDYJMIKDUXJQ-UHFFFAOYSA-N CC(CCCC1)C1I Chemical compound CC(CCCC1)C1I YAGDYJMIKDUXJQ-UHFFFAOYSA-N 0.000 description 1
- 0 CC1(*)CCCC1 Chemical compound CC1(*)CCCC1 0.000 description 1
- YBHULJYVHAAWKG-JTDNENJMSA-N CCCC(CN)OCC1=CC[C@@H](C)CC1 Chemical compound CCCC(CN)OCC1=CC[C@@H](C)CC1 YBHULJYVHAAWKG-JTDNENJMSA-N 0.000 description 1
- IHPHPGLJYCDONF-UHFFFAOYSA-N CCCNC(C)=O Chemical compound CCCNC(C)=O IHPHPGLJYCDONF-UHFFFAOYSA-N 0.000 description 1
- OHVYRLNUMZHWIK-NTSWFWBYSA-N CO[C@H](COCC1)[C@H]1N Chemical compound CO[C@H](COCC1)[C@H]1N OHVYRLNUMZHWIK-NTSWFWBYSA-N 0.000 description 1
- FMASQTBEJBAFML-UTONKHPSSA-N C[C@@](CCC1)([C@@H]1C1=CC=C(C)[IH]C1)[Zn] Chemical compound C[C@@](CCC1)([C@@H]1C1=CC=C(C)[IH]C1)[Zn] FMASQTBEJBAFML-UTONKHPSSA-N 0.000 description 1
- OKSVNXWXLRDLND-UHFFFAOYSA-N Cc1ccc(C(CCC2)OC2=O)cc1 Chemical compound Cc1ccc(C(CCC2)OC2=O)cc1 OKSVNXWXLRDLND-UHFFFAOYSA-N 0.000 description 1
- VLOVHRKBVSJBGF-UHFFFAOYSA-N NCCC(C=C[I]=C1)=C1N Chemical compound NCCC(C=C[I]=C1)=C1N VLOVHRKBVSJBGF-UHFFFAOYSA-N 0.000 description 1
- UEKVOCXLRLKKDY-NEPJUHHUSA-N NC[C@@H](CCC1)O[C@@H]1c1ccc(C(F)(F)F)cc1 Chemical compound NC[C@@H](CCC1)O[C@@H]1c1ccc(C(F)(F)F)cc1 UEKVOCXLRLKKDY-NEPJUHHUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179567 | 2009-12-17 | ||
| EP09179567.4 | 2009-12-17 | ||
| EP10162624 | 2010-05-12 | ||
| EP10162624.0 | 2010-05-12 | ||
| PCT/EP2010/069550 WO2011073155A1 (en) | 2009-12-17 | 2010-12-13 | Novel antagonists for ccr2 and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514302A JP2013514302A (ja) | 2013-04-25 |
| JP2013514302A5 JP2013514302A5 (https=) | 2014-11-06 |
| JP5658272B2 true JP5658272B2 (ja) | 2015-01-21 |
Family
ID=43532680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543668A Active JP5658272B2 (ja) | 2009-12-17 | 2010-12-13 | Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130143905A1 (https=) |
| EP (1) | EP2513086B1 (https=) |
| JP (1) | JP5658272B2 (https=) |
| WO (1) | WO2011073155A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2687931C (en) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| HUE025547T2 (en) * | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| EP2569298B1 (en) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| EP2576542B1 (en) | 2010-05-25 | 2015-04-22 | Boehringer Ingelheim International GmbH | Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases |
| EP2576538B1 (en) | 2010-06-01 | 2015-10-28 | Boehringer Ingelheim International GmbH | New CCR2 antagonists |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| CA2852160A1 (en) | 2011-10-28 | 2013-05-02 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| CN104086539A (zh) * | 2014-07-17 | 2014-10-08 | 天津炜捷制药有限公司 | 一种利伐沙班的制备方法 |
| MX383744B (es) | 2015-07-02 | 2025-03-14 | Centrexion Therapeutics Corp | Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona. |
| CN114349728A (zh) * | 2020-10-12 | 2022-04-15 | 南京药石科技股份有限公司 | （3r，4r）-4-氨基四氢吡喃-3-醇及其盐的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2371583C (en) * | 1999-05-04 | 2005-09-13 | Schering Corporation | Piperazine derivatives useful as ccr5 antagonists |
| GB0004153D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| CN100519558C (zh) | 2000-10-12 | 2009-07-29 | 贝林格尔英格海姆法玛两合公司 | 结晶单水合物、其制备方法及其在制备药物组合中的用途 |
| AR035700A1 (es) | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
| CZ302786B6 (cs) | 2001-06-22 | 2011-11-09 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Krystalický bezvodý tiotropiumbromid, zpusob jeho výroby a jeho použití pro výrobu léciva pro lécbu asthmatu |
| AU2002363236A1 (en) * | 2001-10-30 | 2003-05-12 | Millennium Pharmaceuticals, Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
| SE0203304D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Coumpounds |
| WO2004074438A2 (en) * | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| WO2006004741A2 (en) * | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| CN101801952A (zh) * | 2007-10-01 | 2010-08-11 | 弗·哈夫曼-拉罗切有限公司 | 用作ccr受体拮抗剂的n-杂环联芳基甲酰胺类化合物 |
| MX2010003868A (es) | 2007-10-09 | 2010-04-27 | Hoffmann La Roche | Cis-imidazolinas quirales. |
| HUE025547T2 (en) * | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
-
2010
- 2010-12-13 US US13/515,852 patent/US20130143905A1/en not_active Abandoned
- 2010-12-13 WO PCT/EP2010/069550 patent/WO2011073155A1/en not_active Ceased
- 2010-12-13 EP EP20100796008 patent/EP2513086B1/en active Active
- 2010-12-13 JP JP2012543668A patent/JP5658272B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2513086A1 (en) | 2012-10-24 |
| EP2513086B1 (en) | 2015-04-29 |
| JP2013514302A (ja) | 2013-04-25 |
| US20130143905A1 (en) | 2013-06-06 |
| WO2011073155A1 (en) | 2011-06-23 |
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