JP5658272B2 - Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 - Google Patents
Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 Download PDFInfo
- Publication number
- JP5658272B2 JP5658272B2 JP2012543668A JP2012543668A JP5658272B2 JP 5658272 B2 JP5658272 B2 JP 5658272B2 JP 2012543668 A JP2012543668 A JP 2012543668A JP 2012543668 A JP2012543668 A JP 2012543668A JP 5658272 B2 JP5658272 B2 JP 5658272B2
- Authority
- JP
- Japan
- Prior art keywords
- amino
- alkyl
- phenyl
- quinazoline
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- YHAIRNZJUZWIFQ-UHFFFAOYSA-N C=CCCCC(c1ccc(C2(F)[F][F]2)cc1)=O Chemical compound C=CCCCC(c1ccc(C2(F)[F][F]2)cc1)=O YHAIRNZJUZWIFQ-UHFFFAOYSA-N 0.000 description 1
- AYRSEXWPCCRZSZ-UHFFFAOYSA-N CC(CCC1)C1I Chemical compound CC(CCC1)C1I AYRSEXWPCCRZSZ-UHFFFAOYSA-N 0.000 description 1
- YAGDYJMIKDUXJQ-UHFFFAOYSA-N CC(CCCC1)C1I Chemical compound CC(CCCC1)C1I YAGDYJMIKDUXJQ-UHFFFAOYSA-N 0.000 description 1
- 0 CC1(*)CCCC1 Chemical compound CC1(*)CCCC1 0.000 description 1
- YBHULJYVHAAWKG-JTDNENJMSA-N CCCC(CN)OCC1=CC[C@@H](C)CC1 Chemical compound CCCC(CN)OCC1=CC[C@@H](C)CC1 YBHULJYVHAAWKG-JTDNENJMSA-N 0.000 description 1
- IHPHPGLJYCDONF-UHFFFAOYSA-N CCCNC(C)=O Chemical compound CCCNC(C)=O IHPHPGLJYCDONF-UHFFFAOYSA-N 0.000 description 1
- OHVYRLNUMZHWIK-NTSWFWBYSA-N CO[C@H](COCC1)[C@H]1N Chemical compound CO[C@H](COCC1)[C@H]1N OHVYRLNUMZHWIK-NTSWFWBYSA-N 0.000 description 1
- FMASQTBEJBAFML-UTONKHPSSA-N C[C@@](CCC1)([C@@H]1C1=CC=C(C)[IH]C1)[Zn] Chemical compound C[C@@](CCC1)([C@@H]1C1=CC=C(C)[IH]C1)[Zn] FMASQTBEJBAFML-UTONKHPSSA-N 0.000 description 1
- OKSVNXWXLRDLND-UHFFFAOYSA-N Cc1ccc(C(CCC2)OC2=O)cc1 Chemical compound Cc1ccc(C(CCC2)OC2=O)cc1 OKSVNXWXLRDLND-UHFFFAOYSA-N 0.000 description 1
- VLOVHRKBVSJBGF-UHFFFAOYSA-N NCCC(C=C[I]=C1)=C1N Chemical compound NCCC(C=C[I]=C1)=C1N VLOVHRKBVSJBGF-UHFFFAOYSA-N 0.000 description 1
- UEKVOCXLRLKKDY-NEPJUHHUSA-N NC[C@@H](CCC1)O[C@@H]1c1ccc(C(F)(F)F)cc1 Chemical compound NC[C@@H](CCC1)O[C@@H]1c1ccc(C(F)(F)F)cc1 UEKVOCXLRLKKDY-NEPJUHHUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09179567.4 | 2009-12-17 | ||
| EP09179567 | 2009-12-17 | ||
| EP10162624.0 | 2010-05-12 | ||
| EP10162624 | 2010-05-12 | ||
| PCT/EP2010/069550 WO2011073155A1 (en) | 2009-12-17 | 2010-12-13 | Novel antagonists for ccr2 and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514302A JP2013514302A (ja) | 2013-04-25 |
| JP2013514302A5 JP2013514302A5 (enExample) | 2014-11-06 |
| JP5658272B2 true JP5658272B2 (ja) | 2015-01-21 |
Family
ID=43532680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543668A Active JP5658272B2 (ja) | 2009-12-17 | 2010-12-13 | Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130143905A1 (enExample) |
| EP (1) | EP2513086B1 (enExample) |
| JP (1) | JP5658272B2 (enExample) |
| WO (1) | WO2011073155A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5603770B2 (ja) | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体拮抗薬およびその使用 |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| ES2674275T3 (es) | 2009-12-17 | 2018-06-28 | Centrexion Therapeutics Corporation | Antagonistas del receptor CCR2 y usos de los mismos |
| JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| EP2731941B1 (en) * | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| US20140329809A1 (en) | 2011-10-28 | 2014-11-06 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| CN104086539A (zh) * | 2014-07-17 | 2014-10-08 | 天津炜捷制药有限公司 | 一种利伐沙班的制备方法 |
| PT3317270T (pt) | 2015-07-02 | 2020-08-24 | Centrexion Therapeutics Corp | (4-((3r,4r)-3-metoxitetrahidro-pirano-4-ilamino)piperidina-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-pirano-2-il)metilamino)pirimidina-4-il)citrato de metanona |
| CN114349728A (zh) * | 2020-10-12 | 2022-04-15 | 南京药石科技股份有限公司 | （3r，4r）-4-氨基四氢吡喃-3-醇及其盐的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK287418B6 (sk) * | 1999-05-04 | 2010-09-07 | Schering Corporation | Farmaceutický prípravok s obsahom CCR5 antagonistov a súprava s obsahom tohto prípravku |
| GB0004153D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| WO2002030928A1 (de) | 2000-10-12 | 2002-04-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Kristallines monohydrat, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels |
| AR035700A1 (es) | 2001-05-08 | 2004-06-23 | Astrazeneca Ab | Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados |
| ME00412B (me) | 2001-06-22 | 2011-10-10 | Boehringer Ingelheim Pharma | Kristalni antiholinergik , postupak za njegovo pripremanje i njegova primjena u proizvodnji lijeka |
| WO2003037271A2 (en) * | 2001-10-30 | 2003-05-08 | Millennium Pharmaceuticals,Inc. | Compounds, pharmaceutical compositions and methods of use therefor |
| SE0203304D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Coumpounds |
| WO2004074438A2 (en) * | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| WO2006004741A2 (en) * | 2004-06-28 | 2006-01-12 | Incyte Corporation | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| RU2010116821A (ru) * | 2007-10-01 | 2011-11-10 | Ф.Хоффманн-Ля Аг (Ch) | N-гетероциклические биарильные карбоксамиды в качестве антагонистов рецептора ccr |
| RU2487127C2 (ru) | 2007-10-09 | 2013-07-10 | Ф.Хоффманн-Ля Рош Аг | Хиральные цис-имидазолины |
| CN102256963B (zh) * | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
-
2010
- 2010-12-13 EP EP20100796008 patent/EP2513086B1/en active Active
- 2010-12-13 JP JP2012543668A patent/JP5658272B2/ja active Active
- 2010-12-13 US US13/515,852 patent/US20130143905A1/en not_active Abandoned
- 2010-12-13 WO PCT/EP2010/069550 patent/WO2011073155A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2513086B1 (en) | 2015-04-29 |
| EP2513086A1 (en) | 2012-10-24 |
| WO2011073155A1 (en) | 2011-06-23 |
| JP2013514302A (ja) | 2013-04-25 |
| US20130143905A1 (en) | 2013-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12209094B2 (en) | CCR2 receptor antagonists and uses thereof | |
| JP5796266B1 (ja) | 新規ｃｃｒ２受容体アンタゴニスト、その製造方法及び薬物としてのその使用 | |
| JP5658272B2 (ja) | Ｃｃｒ２の新規アンタゴニスト及びこれらの使用 | |
| JP5786257B2 (ja) | 新規の選択的ｃｃｒ２拮抗薬 | |
| JP5646736B2 (ja) | 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 | |
| JP5721242B2 (ja) | 新規ｃｃｒ２アンタゴニスト | |
| JP5636094B2 (ja) | Ｃｃｒ２受容体アンタゴニスト | |
| JP5647339B2 (ja) | Ｃｃｒ２アンタゴニスト及びこれらの使用 | |
| JP5786258B2 (ja) | 新規かつ選択的なｃｃｒ２拮抗薬 | |
| HK1178147B (en) | New ccr2 receptor antagonists and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130513 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130513 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140611 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20140612 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140911 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20140911 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20141117 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20141127 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5658272 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |