JP5637822B2 - Multi-chamber container with chemical solution and method for manufacturing the same - Google Patents

Description

  The present invention relates to a multi-chamber container containing a chemical solution and a method for producing the same.

In the state where the amino acid infusion and glucose infusion are mixed with each other, or in the state where the antibiotic and its solution are mixed with each other, there is a risk of deterioration over time. A multi-chamber container having a chemical solution storage chamber is used. This multi-chamber container mixes the chemical solution in the chemical solution storage chamber immediately before use and uses it for infusion.
For example, the multi-chamber container has a partition portion such as a weak seal portion that is peeled off when pressure is applied from the outside, and each chemical solution storage chamber is partitioned liquid-tightly by the partition portion. And just before use, a partition part peels by applying a pressure from the outside, each chemical | medical solution storage chamber is connected, and a chemical | medical solution is mixed. Thereafter, the mixed drug solution is discharged from the discharge port and administered to the patient by infusion or the like.

In this multi-chamber container, forgetting to open the weak seal part, the drug solution that should be originally mixed and dispensed is not mixed, and only one drug solution before mixing may be administered to the patient. In recent years, various techniques have been proposed to ensure mixing prior to administration to a patient.
For example, when the multi-chamber container is folded, the side ends of the multi-chamber container are bonded to each other, and when the folded multi-chamber container is opened, the weak seal portion is peeled off by an impact that peels off the adhesive portion. There has been proposed a method in which a chemical solution is mixed before use (for example, see Patent Document 1).
In addition, the folded surface of the multi-chamber container and the chevron-shaped weak seal portion having the apex portion are bonded at the apex portion, and peeling is started from the apex portion of the weak seal portion when opening the fold, There has been proposed one in which a chemical solution storage chamber communicates with each other to mix each chemical solution (for example, see Patent Document 2).
In addition, an anti-opening member is provided that is attached to the medicine discharge part and closes the opening. When the medicine is mixed, the anti-opening member can be removed, and a piercing needle can be inserted through the opening to administer the medicine. A chamber container has been proposed (see, for example, Patent Document 3).

Design Registration No. 1383528 Japanese Patent No. 4238667 JP 2006-150120 A

  By the way, among the above-described prior arts, the first prior art described is that when the side end portion is fixed by bonding before filling with the chemical solution, the storage chamber expands by filling with the chemical solution, and the peeling direction is applied to the side end portion fixed by the adhesive or the like. The stress of will be added. For example, after filling the first chemical solution, it is necessary to fill the adhesive part so that it does not peel off when the next chemical solution is filled. The degree becomes high. In addition, when the side ends are fixed with an adhesive or the like after filling with the chemical solution, the position of the side end portions having a small area cannot be easily matched because the chemical solution easily moves in the storage chamber. Furthermore, when fixing only the side end, considering that the storage chamber swells due to the chemical solution, it is difficult to maintain the fixed state, and the side end may be peeled off due to impact during transportation. There is. And, since the storage chamber is greatly swollen and the thickness of the trunk portion is increased when the amount of the chemical solution filled in the chemical solution storage portion of the multi-chamber container is high and the thickness of the trunk portion is increased, the difficulty of fixing the side end portion further increases, In addition, there is a high possibility that the side end portion fixed during transportation will be peeled off.

  In addition, among the above-described conventional technologies, the second one, like the first one, is easy to apply a stress directly to the weak seal part when an impact, vibration, etc. are applied during transportation. . Furthermore, since stress due to impact, vibration, or the like is applied to the top of the weak seal portion where stress is likely to concentrate, there is a possibility that the weak seal portion peels and the storage chambers communicate with each other to mix the two chemicals. Furthermore, the weak seal part is designed to be peeled off due to an increase in the internal pressure of the storage chamber so that the storage chambers communicate with each other. However, the weak seal part is erroneously peeled off by an external pulling force. In such a case, the film forming the container body may be broken at the portion where the tensile force is applied, and the chemical solution may flow out.

  Furthermore, among the above-described conventional technologies, the last mentioned one needs to prepare an anti-opening member, so there is a risk that it will not be used when the anti-opening member is removed, and the number of parts increases. There is a problem that the cost increases due to the waste and the waste increases.

  The present invention has been made in view of the above circumstances, and while suppressing an increase in cost due to an increase in the number of parts, the filling amount of the chemical solution is restricted, and the chemical solution is mixed by an impact during transportation. It is an object of the present invention to provide a multi-chamber container with a chemical solution that can reliably prevent the chemical solution from being administered to a patient without being mixed and improve the reliability, and a method for manufacturing the same.

In order to solve the above-described problems, the invention described in claim 1 includes a plurality of storage chambers in which chemical solutions are stored, and the storage chambers are partitioned by a peelable weak seal portion formed in a straight belt shape. In the multi-chamber container containing a chemical solution formed by laminating a plurality of substantially planar flexible films, the outer surfaces of the body portion of the storage chamber inflated by the chemical solution are arranged to face each other. A fixed portion for releasably fixing , and pulling the barrels of the fixed storage chambers in the peeling direction or developing them by their own weight, the internal pressure of the storage chamber rises and the weak seal portion peels off opening be characterized by Rukoto.

  According to a second aspect of the present invention, in the first aspect of the invention, the fixing portion is formed by blocking, an adhesive, a pressure-sensitive adhesive, or an adhesive member provided on the surface of the multi-chamber container, so To fix.

  According to a third aspect of the present invention, in the first or second aspect of the present invention, the weak seal portion may be the storage chamber with respect to a bent portion that is bent when the outer surfaces of the body portion are arranged to face each other. Are arranged so as to be shifted in the arrangement direction.

  According to a fourth aspect of the present invention, in the invention of the third aspect, the folding portion includes a folding assisting portion that facilitates folding.

The invention described in claim 5 is the invention according to any one of claims 1 to 4, wherein the fixing part fixes the outer surfaces of the body part by blocking, and the film is a polyethylene resin. A multilayer film having an outer layer and an inner layer, wherein the melting point of the polyethylene resin of the outer layer is lower than the melting point of the inner layer polyethylene resin.

The invention described in claim 6 is the invention according to any one of claims 1 to 4, wherein the fixing portion fixes the outer surfaces of the body portion by blocking , and the film includes an outer layer and an inner layer. The outer layer resin is a propylene random copolymer or a propylene block copolymer.

  According to a seventh aspect of the present invention, in the method for producing a chemical solution-containing multi-chamber container according to any one of the first to sixth aspects, the outer surfaces of the body portion are arranged to face each other and heated in a state where the outer surfaces are in close contact with each other. The fixing portions are formed by fixing the outer surfaces together by blocking.

  According to an eighth aspect of the present invention, in the method for producing a multi-chamber container containing a chemical solution according to the third or fourth aspect, the outer surfaces of the body portion are arranged to face each other in the vertical direction, and the weak seal portion is the bent portion. It arrange | positions rather than an up-down direction, heats in the state which the said outer surfaces contact | adhered, and fixes the said outer surfaces by blocking, and forms the said fixing | fixed part, It is characterized by the above-mentioned.

According to the first aspect of the present invention, in a state where the outer surfaces of the body portions of the storage chamber are arranged opposite to each other, the outer surfaces are detachably fixed by the fixing portion, thereby fixing a relatively large area. Since it can be used, a necessary and sufficient fixing force can be obtained. Accordingly, it is possible to maintain an initial state in which the body portions are fixed during transportation, and it is possible to prevent the weak seal portion from being peeled off due to an impact during transportation and mixing the chemicals.
In addition, since the necessary and sufficient fixing force is obtained by the fixing part, when a user such as a nurse starts using the chemical solution, by simply pulling and unfolding the torso parts of the fixed storage chamber in the peeling direction, The internal pressure of the storage chamber rises due to the reaction at the time of deployment, the weak seal portion is peeled open, and the adjacent storage chambers communicate with each other to mix the chemicals. Therefore, there is an effect that reliability can be improved by reliably preventing the medicinal solution from being administered to the patient without being mixed, while suppressing an increase in cost due to an increase in the number of parts as in the past.

  According to the second aspect of the present invention, the outer surface of the body portion can be fixed by blocking, an adhesive, a pressure-sensitive adhesive, or an adhesive member provided on the surface of the multi-chamber container, so that the fixing portion is easily formed. There is an effect that can be done.

  According to the third aspect of the invention, since it is possible to prevent stress due to bending from being applied to the weak seal portion, unnecessary peeling of the weak seal portion can be prevented.

  According to the fourth aspect of the present invention, since the folding assist part can be easily folded, it is possible to prevent the folding part from being formed in an unintended place.

  According to the invention described in claim 5, there is an effect that the outer layer of the body portion can be easily fixed by blocking and the fixing portion can be formed while preventing the inner layer from blocking.

  According to the invention described in claim 6, by using a propylene random copolymer or a propylene block copolymer as the resin of the outer layer, it is possible to constitute an inexpensive film having thermoplasticity that is excellent in transparency and flexibility. There is.

  According to the invention described in claim 7, since the outer surfaces of the body portions are opposed to each other and the outer surfaces are in close contact with each other, for example, by heating with a retort or the like, the fixing portion can be formed. There is an effect that it is possible to easily manufacture a highly reliable multi-chamber container with a chemical solution having a fixing portion while reducing the number of manufacturing steps.

  According to the invention described in claim 8, the multi-chamber container containing the chemical solution is usually heated from below, such as being placed in a metal container such as a heating tray, but the weak seal portion is bent. Since the metal container is brought into contact with the portion where the weak seal portion is formed by being arranged below the portion, the metal container is cooled immediately after heating, which is burdened by unnecessary heating to the weak seal portion. There is an effect that can prevent the increase. Moreover, since the heating to a weak seal part can be performed efficiently, the opening strength between storage chambers can be reduced by appropriately reducing the peel strength of the weak seal part by this heating.

It is a perspective view of the multi-chamber container with a chemical | medical solution in 1st Embodiment of this invention. It is sectional drawing which follows the AA line of FIG. It is the arrow view seen from the B direction of FIG. It is an expanded view of the multiple chamber container containing a chemical | medical solution in 1st Embodiment of this invention. It is sectional drawing which shows the pulling direction which peels a fixing | fixed part in the chemical | medical solution containing multi-chamber container of FIG. FIG. 6 is a cross-sectional view illustrating a pulling direction due to a reaction at the time of peeling of the fixed portion of FIG. 5 and a direction in which the pressure of each portion acts. It is sectional drawing which shows the state by which the weak seal part was opened by the reaction at the time of peeling of a fixing | fixed part. It is sectional drawing equivalent to FIG. 2 in 2nd Embodiment of this invention. It is a figure which shows the state which mounted the multiple chamber container containing a chemical | medical solution of FIG. 8 in the metal tray. It is an expanded view equivalent to FIG. 4 in 3rd Embodiment of this invention. It is a side view of the jig | tool of the 1st modification in 3rd Embodiment of this invention. It is an expanded view equivalent to FIG. 4 of the 1st modification in 3rd Embodiment of this invention. It is an expanded view equivalent to FIG. 4 of the 2nd modification in 3rd Embodiment of this invention. It is sectional drawing equivalent to FIG. 2 in the other aspect of 1st-3rd embodiment of this invention.

Next, the chemical solution containing multi-chamber container and the manufacturing method thereof according to the first embodiment of the present invention will be described with reference to the drawings.
FIG. 1 and FIG. 2 show a state (hereinafter simply referred to as a transport state) at the time of transport of the multi-chamber container 1 containing a chemical solution in this embodiment. This multi-chamber container 1 containing a chemical solution is formed by laminating a plurality of, specifically two, films F having substantially planar flexibility by heat sealing, and stores, for example, a chemical solution such as a vitamin agent. A first storage chamber 2 and a second storage chamber 3 for storing a medical solution such as physiological saline or amino acid are provided.

  The multi-chamber container 1 containing the chemical solution is bent so that the outer surfaces of the body portion 4 of the first storage chamber 2 swelled by the chemical solution and the body portion 5 of the second storage chamber 3 swelled by the chemical solution are opposed to each other. It is bent at the part 6. And the fixing | fixed part 10 is formed in the at least one part of the outer surface of the trunk | drum 4 and 5, more specifically the range shown with the dashed-two dotted line in FIG. 3, and the trunk | drum 4 and 5 are fixed so that peeling is mutually possible. Is done. The fixing part 10 is formed by blocking, an adhesive, a pressure-sensitive adhesive, or an adhesive member provided on the surfaces of the body part 4 and the body part 5. Examples of the adhesive member include a hook-and-loop fastener such as an adhesive tape and a magic tape (registered trademark), and a fitting member having a fitting portion (hereinafter, the same applies to the second and third embodiments).

  In the first storage chamber 2, a port 8 for discharging the mixed chemical solution out of the container is attached to the substantially central portion in the width direction of the bottom seal portion 11, which is the edge on the opposite side to the bent portion 6. In the second storage chamber, a circular suspension hole 9 is formed at the edge opposite to the bent portion 6. In addition, what is necessary is just to set the shape of the suspension hole 9 suitably.

  Here, the film F and the port 8 described above are made of a thermoplastic resin, but may be any thermoplastic resin used in the medical field. Examples of the thermoplastic resin used in the medical field include vinyl chloride, ethylene vinyl acetate copolymer, polyolefin, polyamide, polyester, polyethersulfone, cyclic polyolefin, cyclic polyolefin copolymer, ethylene elastomer, and styrene. Elastomers and mixtures of these resins.

  In addition, thermoplastic resins are partially cross-linked for the purpose of improving heat resistance, etc., and in order to actively block, low melting point components such as ultra-low density polyethylene, ethylene elastomer, styrene elastomer are mixed. May be. Of these thermoplastic resins, polyolefin is preferable because it is inexpensive and excellent in transparency and flexibility. Examples of the polyolefin include high-density polyethylene, low-density polyethylene, linear low-density polyethylene, polyethylene-based resins such as ethylene-vinyl acetate copolymer, olefin-based elastomers such as ethylene-butadiene random copolymer, homopolypropylene, and ethylene. Or the propylene random copolymer which consists of an alpha olefin and a propylene, and the polypropylene block copolymer-type resin containing an ethylene propylene copolymer elastomer are mention | raise | lifted.

  Furthermore, the film F may be a single layer film made of one kind of film or a multilayer film in which a plurality of kinds of films are laminated. In the case of a single layer film, since it is excellent in transparency and flexibility, linear low density polyethylene, ethylene propylene random copolymer, ethylene propylene block copolymer, a mixture of polypropylene resin and styrene elastomer, etc. A film is preferred.

  In the case of a multilayer film, when it has an outer layer and an inner layer made of a polyethylene resin, it is preferable that the density of the polyethylene resin in the outer layer is lower than the density of the polyethylene resin in the inner layer. Thereby, since melting | fusing point of the polyethylene-type resin of the outer layer which comprises a container surface becomes lower than melting | fusing point of the polyethylene-type resin of an inner layer, it becomes easy to block the outer surfaces of the trunk | drum 4, 5 from inner surfaces by heating. Furthermore, since the peeling strength of the later-described weak seal portion 7 in which the inner layer surfaces are in close contact with each other is not greatly changed by heating when the outer layer is blocked, the fixing portion 10 can be easily formed.

That is, by using the polyethylene resin film F using the high density polyethylene having the highest density and the highest melting point among the polyethylene resins as the inner layer, various types of low density polyethylene resins are used as the outer layer than the inner layer. This is preferable because it becomes easier. In addition, specific layer configurations include, from the outside, low density polyethylene / linear low density polyethylene, low density polyethylene / linear low density polyethylene / high density polyethylene, linear low density polyethylene / low density polyethylene / Examples thereof include high-density polyethylene, linear low-density polyethylene / linear low-density polyethylene / high-density polyethylene, and the like. The density when measured by the JIS K 7112 D method is 0.905 to 0.930 g / cm ^{3 for} low density polyethylene, 0.900 to 0.940 g / cm ³ for linear low density polyethylene, and high density. It is preferable to use polyethylene having a value of 0.940 to 0.965 g / cm ³ . From the viewpoint of the melting point, a polyethylene resin having a melting point of 123 ° C. or higher, preferably 130 ° C. or higher is preferable for the inner layer, and a polyethylene resin having a melting point of 121 ° C. or lower is preferably used for the outer layer. In addition, melting | fusing point is the value measured based on JISK7121.

  When the film F described above is a multilayer film, a propylene random copolymer or a propylene block copolymer propylene resin may be used for the outer layer. Since the propylene random copolymer partially contains a low melting point component in the resin, the outer surfaces of the film F are likely to be blocked during heating, and the propylene block copolymer contains a low melting point elastomer. For this reason, blocking between the container surfaces tends to occur during heating. Specific examples of the layer structure include those from the outside in the order of propylene random copolymer / propylene block copolymer + styrene elastomer / homopolypropylene.

  The film F described above can be manufactured by a manufacturing method such as T-die molding, water-cooling or air-cooling inflation molding, or laminate molding. From the viewpoint of transparency, T-die molding and water-cooled inflation molding are preferred. In particular, water-cooled inflation molding is preferred because it is easy to avoid contamination with foreign matters and is excellent in hygiene. The film F has a thickness of about 5 to 1000 μm, preferably about 50 to 500 μm. In the case of a two-layer film, since the inner layer is the main layer, the thickness of the inner layer is preferably 70% or more of the total thickness. In the case of a three-layer film, the intermediate layer that occupies other than the inner and outer layers is the main layer, and therefore the thickness of the intermediate layer is preferably 50% or more of the total thickness.

  FIG. 4 shows a state in which the multi-chamber container 1 containing the chemical solution is expanded, more specifically, a state before the body parts 4 and 5 are fixed by the fixing part 10. The first storage chamber 2 and the second storage chamber 3 described above are separated by a weak seal portion 7. The weak seal portion 7 is formed in a belt shape having a constant width across the left and right edges of the multi-chamber container 1 containing a chemical solution. When the internal pressure of at least one of the first storage chamber 2 and the second storage chamber 3 is equal to or higher than a predetermined internal pressure, the weak seal portion 7 is peeled off and opened in the front and back direction in FIG. . When the weak seal portion 7 is peeled off, the first storage chamber 2 and the second storage chamber 3 communicate with each other, and different chemical solutions stored in the first storage chamber 2 and the second storage chamber 3 are mixed. .

  The weak seal portion 7 is a peel strength at a T-type peel per 15 mm width measured at a pulling speed of 100 mm / min in accordance with JIS Z 0238 at a portion welded by a normal heat seal of the film F such as the bottom seal portion 11. Is about 10 N / 15 mm width compared to about 50 N / 15 mm width. And formation of the weak seal | sticker part 7 is formed by adjusting the temperature, pressure, and time at the time of heat-sealing the innermost surfaces of the film F so that it may peel easily compared with a normal heat seal. As another method for forming the weak seal portion 7, the innermost layer resin may be an incompatible resin composition, for example, a film having an easy peel property as a composition of polyethylene and polypropylene. Furthermore, a method of sandwiching and sealing an easy-peel strip film between two flat portions, a method of forming a strong seal portion and a weak seal portion with a specific ratio with a seal bar having specific irregularities, and adhesion It can also be formed by a method in which an inhibitory substance is applied to the seal portion and sealed.

Next, the operation of the above-described multi-chamber container 1 containing a chemical solution will be described with reference to FIGS.
First, the edge of the multi-chamber container 1 containing the chemical solution is pulled in the direction of the white arrow in FIG. 5 and peeled off from the body 4 and the body 5 fixed by the fixing unit 10. Since the fixing force by the fixing part 10 is set to such an extent that the fixing part 10 is not peeled off due to vibration during transportation or the like, it is not easily peeled off due to being caught in the middle during deployment. Therefore, the tensile force in the direction shown by the white arrow in FIG. 6 is applied to the chemical-containing multi-chamber container 1 by the reaction at the moment when all the fixing portions 10 are peeled and the chemical-solution multi-chamber container 1 is deployed. Then, by this tensile force, the two films F forming the first storage chamber 2 and the second storage chamber 3 approach each other in the body 4 and the body 5 (indicated by solid arrows in FIG. 6). As a result, the internal pressure of the first storage chamber 2 and the second storage chamber 3 increases.

  When the internal pressure of the first storage chamber 2 and the second storage chamber 3 rises, particularly the force that the film F in the vicinity of the weak seal portion 7 tends to shift outward (in the direction indicated by the solid arrow in FIG. 6). When the pressure exceeds a predetermined internal pressure set in advance, this force exceeds the fixing force by the weak seal portion 7, the two films F are peeled off, and the weak seal portion 7 is opened. As shown, the first storage chamber 2 and the second storage chamber 3 are communicated with each other. Here, since the fixing force of the fixing portion 10 is substantially proportional to the tensile force caused by the reaction when the fixing portion 10 is peeled off, the fixing force is set to a fixing force corresponding to the sealing force of the weak seal portion 7.

  In addition, in the description of the above-described operation, the example in which the multi-chamber container 1 containing a chemical solution is expanded to the left and right has been described. The multi-chamber container 1 containing a chemical solution is used by hanging a drip stand hook through the suspension hole 9 so that the port 8 is disposed below. When the suspension hole 9 is suspended from the drip stand hook, the bottom seal 11 side where the port 8 is provided moves downward due to the weight of the chemical solution, and the fixing portion 10 is peeled off. After the brake is applied, the fixing portion 10 is peeled off. The weak seal portion 7 is peeled off by an instantaneous reaction that occurs at this time, and the first storage portion 2 and the second storage portion 3 are communicated. In this manner, the first storage unit 2 and the second storage unit 3 can be communicated with each other during a normal series of drip preparation operations.

  In other words, by providing the fixing portion 10 on the outer surface of the body portions 4 and 5, it is possible to fix the fixing portion 10 with a relatively wide area. A large amount of energy is required for peeling. And since the difference of the force at the time of expansion | deployment after peeling can be enlarged, a big reaction is obtained and the weak seal part 7 can be peeled reliably. For example, when a fixing portion having a relatively narrow range is provided, the force is concentrated on the narrow range, which may lead to destruction of the film F. However, such destruction of the film F is prevented. Even if the weak seal portion 7 does not completely peel off and a part of the non-peeled portion remains, it may be used. However, in order to completely peel off the weak seal portion 7, a normal procedure, that is, It is possible to peel off the non-peeled portion by pressing the first storage chamber 2 or the second storage chamber 3 from the outside.

Next, the manufacturing method of the chemical | medical solution containing multi-chamber container 1 of this embodiment is demonstrated, referring drawings. In addition, this manufacturing method demonstrates as an example the case where the fixing | fixed part 10 is formed by blocking.
First, the peripheral edges of the two films F are welded by a normal heat seal, and the band-shaped weak seal portion 7 is formed in the width direction substantially at the center of the film F in the longitudinal direction. Thereby, the two storage chambers 2 and 3 are formed. The storage chambers 2 and 3 are formed with openings (not shown) that communicate with the outside in order to fill the chemical solution. In addition, the port 8 serving as a chemical inlet is sandwiched between the two films F by heat sealing or the like.

Then, the storage chambers 2 and 3 are filled with different chemical solutions to seal the opening. Thereafter, the bent portion 6 is formed by bending the weak seal portion 7 or its vicinity along the weak seal portion 7, and the body portions 4, 5 are arranged opposite to each other and brought into contact with each other. And it heats in this state.
Then, the film F of the bent portion 6 is folded by heating, and the body portions 4 and 5 that are in contact with each other are blocked. Here, the fixing force of the fixing unit 10 is adjusted by adjusting the heating temperature, the heating time, and the like. In addition, since the weak seal part 7 is easy to peel and is the weakest part with respect to external force in the chemical | medical solution containing multi-chamber container 1, in order not to peel the weak seal part 7 at the time of filling with a chemical | medical solution, for example, a weak seal at the time of filling Filling from the side of the 1st storage chamber 2 and the 2nd storage chamber 3 in which the part 7 is clamped with a jig | tool, or force is not easily added to the weak seal part 7 is performed.

  Thereafter, when the heating is stopped and the temperature of the body parts 4 and 5 is lowered, the fixed state of the body parts 4 and 5 due to blocking is maintained. In addition, the heating mentioned above can utilize the retort, for example, the heating of the high pressure steam sterilization process of a chemical | medical solution, etc.

  Therefore, according to the above-described first embodiment, by fixing the outer surfaces of the trunk portions 4 and 5 of the storage chambers 2 and 3 to be opposed to each other by the fixing portion 10, Since a relatively large area can be used for fixing, it is possible to obtain a necessary and sufficient fixing force, and as a result, it is possible to maintain an initial state in which the body parts 4 and 5 are fixed during transportation. Further, it is possible to prevent the weak seal portion 7 from being peeled off due to an impact during transportation and mixing the chemicals.

  Further, the necessary and sufficient fixing force can be obtained by the fixing portion 10, so that when the user such as a nurse starts using the chemical solution, the body portions 4 and 5 of the fixed storage chambers 2 and 3 are peeled from each other. The internal pressure of the storage chambers 2 and 3 rises due to the reaction during deployment, and the weak seal portion 7 is peeled and opened, and the adjacent storage chambers 2 and 3 communicate with each other to mix the chemicals. Therefore, while suppressing an increase in cost due to an increase in the number of parts as in the past, it is possible to reliably prevent the medicinal solution from being administered to the patient without being mixed and improve reliability.

Furthermore, since the outer surfaces of the trunk portions 4 and 5 can be fixed to each other by an adhesive member such as a blocking fastener, an adhesive, a pressure-sensitive adhesive, or a surface fastener provided on the surface of the multi-chamber container, the fixing portion 10 is easily formed. be able to.
In addition, by fixing the melting point of the inner layer of the film F relatively high and lowering the melting point of the outer layer, the outer layers of the body parts 4 and 5 are easily fixed by fixing while preventing the inner layer from blocking. The part 10 can be formed.

And by using a propylene random copolymer or a propylene block copolymer as resin of the outer layer of the film F, the film which has the thermoplasticity which is cheap and is excellent in transparency and a softness | flexibility can be comprised.
In addition, since the outer surfaces of the body portions 4 and 5 are opposed to each other and the outer surfaces are in contact with each other, the fixing portion 10 can be formed simply by heating with, for example, a retort. It is possible to easily manufacture the multi-chamber container 1 with a highly reliable chemical solution provided with the fixing portion 10 while reducing the number of steps.

Next, a chemical solution-containing multi-chamber container according to a second embodiment of the present invention will be described with reference to the drawings. The multi-chamber container containing the chemical solution according to the second embodiment is described only by assigning the same reference numerals to the same portions because the arrangement of the bent portions of the multi-chamber container 1 containing the chemical solution according to the first embodiment is different. .
FIG. 8 shows the transport state of the multi-chamber container 101 containing the chemical solution of this embodiment. This multi-chamber container 101 containing chemical liquids, like the multi-chamber container 1 containing chemical liquids of the first embodiment described above, is bonded by heat sealing a plurality of (two) films F having substantially planar flexibility. For example, the first storage chamber 2 that stores a chemical solution such as a vitamin agent and the second storage chamber 3 that stores a chemical solution such as physiological saline are provided.

  The multi-chamber container 101 containing the chemical solution is bent by the bent portion 6 so that the outer surfaces of the barrel portion 4 and the barrel portion 5 are opposed to each other, and is fixed to at least a part of the outer surfaces of the barrel portions 4 and 5. Part 110 is formed. Similar to the fixing portion 10 of the first embodiment, the fixing portion 110 is configured by blocking, an adhesive, a pressure-sensitive adhesive, or an adhesive member provided on the surface of the trunk portion 4 and the trunk portion 5. 5 is fixed in a peelable manner.

  Furthermore, a port 8 for discharging the mixed chemical solution out of the container is attached to the first storage chamber 2 at the approximate center in the width direction of the bottom seal portion 11 on the side opposite to the bent portion 6. A suspension hole 9 is formed in the storage chamber 3 at the edge opposite to the bent portion 6. In addition, since the film F mentioned above is the same as the thermoplastic resin of 1st Embodiment mentioned above, duplication description is abbreviate | omitted.

  The first storage chamber 2 and the second storage chamber 3 of the multi-chamber container 101 containing the chemical solution are separated by a weak seal portion 107. The weak seal portion 107 is formed in a belt shape having a constant width over the width direction of the multi-chamber container 1 containing a chemical solution, similarly to the weak seal portion 7 described above. The weak seal portion 107 is peeled open when the internal pressure of at least one of the first storage chamber 2 and the second storage chamber 3 is equal to or higher than a predetermined internal pressure. The two storage chambers 3 communicate with each other, and different chemical solutions stored in the first storage chamber 2 and the second storage chamber 3 are mixed.

  By the way, in the multi-chamber container 101 containing the chemical solution of this embodiment, the weak seal portion 107 is arranged on the second storage chamber 3 side with respect to the bent portion 6. For example, when the multi-chamber container 101 containing the chemical solution is placed on a flat surface h such as in a tray so that the second storage chamber 3 is on the lower side in the vertical direction, the portion where the weak seal portion 107 is formed is The flat wall h comes into contact with the outer wall 112 of the second storage chamber 3.

  Next, the manufacturing method of the multi-chamber container 101 containing a chemical | medical solution of this embodiment is demonstrated. The multi-chamber container 101 containing the chemical solution is similar to the multi-chamber container 1 containing the chemical solution according to the first embodiment described above, and the weak seal portion 107 is opened by the reaction when the fixing portion 110 is peeled off. A description of the operation when doing so will be omitted.

  First, the peripheral edges of the two films F are welded by a normal heat seal, and a band-shaped weakly sealed portion 107 is formed so as to cross the substantially longitudinal center of the film F. Thereby, the two storage chambers 2 and 3 are formed. The storage chambers 2 and 3 are formed with openings (not shown) that communicate with the outside in order to fill the chemical solution. In addition, the port 8 serving as a chemical inlet is sandwiched between the two films F by heat sealing or the like.

  Next, the first storage chamber 2 and the second storage chamber 3 are filled with different chemical solutions, respectively, and the opening is sealed. Thereafter, the film F is bent along the weak seal portion 107 to form the bent portion 6 on the first storage chamber 2 side of the weak seal portion 107. At this time, the body portions 4 and 5 are arranged to face each other. Make contact. And in this state, it heats similarly to 1st Embodiment.

  This heating is performed, for example, by high-pressure steam sterilization or the like by placing the chemical-containing multi-chamber container 101 on the metal tray t shown in FIG. At this time, the weak seal portion 107 is placed in contact with the bottom surface b of the metal tray t. By placing in this way, the heat of the metal tray t can be efficiently transmitted to the weak seal portion 107, and the opening strength of the weak seal portion 107 can be appropriately reduced (for example, about 10%). As a result, it is possible to relatively increase the opening strength of the weak seal portion 107 at the time of filling with the chemical solution before performing high-pressure steam sterilization, compared to the opening strength after performing high-pressure steam sterilization. In other words, the opening strength can be adjusted so that it is difficult to open when filling a chemical solution that easily applies a force to peel off the weak seal portion 107 and is easy to open after filling the chemical solution. Further, the film F of the bent portion 6 is folded by heating, and the body portions 4 and 5 are blocked. Although not shown, the metal tray t has a plurality of holes.

  Here, of the heat-sealed portions of the chemical solution containing multi-chamber container 101, the weak seal portion 107 is the portion that is most easily peeled off. For example, when some external force is applied during handling of the chemical solution containing multi-chamber container 101, peeling easily occurs. Therefore, there is a case where a chemical solution to be mixed immediately before use is mixed. In addition, a so-called seal retraction occurs in which a part of the seal at the boundary between the weak seal portion 107 and the first storage chamber 2 and the second storage chamber 3 is peeled off without being mixed until the chemical solution is mixed. The width of the weak seal portion 107 may be partially narrowed. This is because the pressure applied to the first storage chamber 2 and the second storage chamber 3 on both sides of the weak seal portion 107 is applied when the weak seal portion 107 is sealed through the chemical solution.

  Since the bent portion 6 is bent in a state where the inner surfaces of the film F are in contact with each other, when pressure is applied to the chemical solution in the first storage chamber 2, the pressure is relaxed by the portion where the inner surfaces of the bent portion 6 are in contact with each other. Thus, it is possible to prevent pressure from being applied directly when the weak seal portion 107 is sealed on the bent portion 6 side. In addition, although the case where the bending part 6 was formed in the 1st storage chamber 2 side of the weak seal part 107 was demonstrated, you may make it form the bending part 6 in the 2nd storage chamber 3 side of the weak seal part 107. FIG.

  Therefore, according to the multi-chamber container 101 containing the chemical solution of the second embodiment described above, the position of the bent portion 6 and the position of the weak seal portion 107 are shifted, and the stress due to the bending is applied to the weak seal portion 107. Therefore, unnecessary peeling of the weak seal portion 107 can be prevented. Further, when the first storage chamber 2 in which the bent portion 6 is disposed is filled with a chemical solution, it is possible to prevent an impact from being applied to the weak seal portion 107 due to the filling pressure of the chemical solution.

  Further, since the weak seal portion 107 and the bent portion 6 are displaced, pressure is directly applied when the weak seal portion 107 is sealed on the bent portion 6 side by the bent portion 6 in which the inner surfaces are in contact with each other. Therefore, it is possible to prevent the weak seal portion 107 from retreating when the bent portion 6 is sealed. In addition, when the multi-chamber container 101 containing the chemical solution is deployed, the bent portion 6 is extended, and the pressure of the chemical solution due to the reaction during the development is directly applied to both sides of the weak seal portion 107. The part 107 can be reliably peeled and the chemical solution can be mixed.

Next, a chemical solution containing multi-chamber container according to a third embodiment of the present invention will be described with reference to FIGS. In addition, since the multi-chamber container 201 containing the chemical solution according to the third embodiment is configured by adding a configuration for stabilizing the folding position of the bending portion 6 with respect to the multi-chamber container 101 containing the chemical liquid according to the second embodiment, The same parts as those of the second embodiment will be described with the same reference numerals.
FIG. 10 shows a state where the multi-chamber container 201 containing the chemical solution according to this embodiment is developed, more specifically, a state before the body parts 4 and 5 are fixed by the fixing part 110. As shown in FIG. 10, the multi-chamber container 201 containing a chemical solution has a first storage chamber 2 and a second storage chamber 3 that store different chemical solutions. 10 and 12 show an example in which a cylindrical film manufactured by inflation molding that does not require heat sealing is used for the left and right side edges of the multi-chamber container 201 containing a chemical solution.

Between the 1st storage chamber 2 and the 2nd storage chamber 3, the strip | belt-shaped weak seal part 107 is formed over the width direction similarly to 2nd Embodiment. The first storage chamber 2 and the second storage chamber 3 are separated by the weak seal portion 107.
And in the 1st storage chamber 2, the folding auxiliary | assistant part 120 for making it easy to bend in the right-and-left end part of the plan part (it shows with the broken line o in FIG. 10) where the broken line of the bending part 6 is formed, Similarly to the upper and lower edges of the multi-chamber container 201 containing a chemical solution, it is formed by welding by heat sealing.
The folding assisting portion 120 is formed in a substantially triangular shape extending toward the inside of the multi-chamber container 201 containing a chemical solution, and the apexes 121 are arranged to face each other. As a result, when the bent portion 6 is formed by bending the vicinity of the bending auxiliary portion 120, particularly when the first storage chamber 2 is filled with a chemical solution, the bending auxiliary portion 120 is bound. The bent line of the bent portion 6 is easily arranged on the line connecting these vertices.

  Note that the bending auxiliary portion 120 is not limited to the one formed by heat sealing as described above. For example, as in the first modification shown in FIGS. 11 and 12, a jig 210 that is substantially U-shaped in a side view is used as a chemical solution. It is also possible to form a constriction by sandwiching the left and right end portions of the entering multi-chamber container 301 so as not to overlap with the weak seal portion 107 to facilitate bending. In this case, since the jig 210 may be attached, the position of the bent portion 6 can be set stably and easily. 11 and 12 show an example in which the bent portion 6 is provided on the second storage chamber 3 side, it goes without saying that it may be formed on the first storage chamber 2 side.

  Furthermore, as shown in FIG. 13, you may make it provide the notch part 220 notched in the trapezoid shape on both sides of the location which wants to form the bending part 6 of the multi-chamber container 401 containing a chemical | medical solution. At the position where the notch 220 is disposed, the chemical solution-containing multi-chamber container 401 can be easily bent, and the position where the bent portion 6 is formed can be stabilized. FIG. 13 shows a case where the position of the weak seal portion 7 and the position of the bent portion 6 are matched as in the first embodiment, but the position of the weak seal portion 107 as in the second embodiment. When the position of the bent portion 6 is shifted, the position of the notch portion 220 may be shifted from the position of the weak seal portion 7 to the first storage portion 2 or the second storage portion 3 side. Moreover, although the case where the notch part 220 was notched into a trapezoid was demonstrated, it is not restricted to a trapezoid, For example, a triangular shape may be sufficient. Moreover, you may make it provide the bending auxiliary | assistant part 120, the jig | tool 210, and the notch part 220 which were mentioned above only in either one of right and left.

Examples of the present invention will be described below.
<Example 1>
The outer layer / intermediate layer / inner layer of the film F was linear low density polyethylene / linear low density polyethylene / high density polyethylene, respectively, and the thickness [μm] was 25/200/25 in order from the outer layer. The density [g / cm ³ ] was 0.921 / 0.910 / 0.956 in order from the outer layer, and the melting point [° C.] was 121/110/132 in order from the outer layer.
Further, the film F of this example was prepared by water-cooled inflation.
The size of the multi-chamber container 1 containing a chemical solution was 30 cm × 18 cm in length and width, provided with a port 8 at one end and a suspension hole 9 at the other end. The weak seal portion 7 is provided in a straight band shape with a width of 1 cm across the both sides at a position of 18 cm in the longitudinal direction from one end of the port 8, and the weak seal portion 7 is folded as the bent portion 6 at a sterilization temperature of 105 ° C. Heated for 30 minutes in a shower autoclave.
The outer surfaces of the body parts 4 and 5 that were in contact after cooling were blocked and fixed. Although there was resistance when developing the multi-chamber container 1 containing a chemical solution, it was able to be deployed. Simultaneously with the development, the weak seal 7 was peeled off and the chemical solution was mixed. The opening strength of the weak seal portion 7 before and after sterilization was substantially the same.

<Example 2>
A multi-chamber container 201 containing a chemical solution was prepared using the same film 1 as in Example 1 described above, and the bent portion 6 was provided at a position of 15 cm in the longitudinal direction from the side where the port 8 is located. The position of the bent portion 6 is shifted from the weak seal portion 107. The multi-chamber container 201 containing the chemical solution is placed so that the portion where the weak seal portion 107 is formed on the bottom surface b of the metal tray t during heat sterilization, and the shower type high-pressure steam sterilizer is sterilized at 105 ° C. for 30 minutes. I went there. After cooling, the outer surfaces of the body portions 4 and 5 that were in contact with each other were blocked and fixed. Although there was resistance when expanding the multi-chamber container 201 containing the chemical solution, it was possible to expand. Simultaneously with the development, the weak seal 107 was peeled off and the chemical solution was mixed. The opening strength of the weak seal 107 before and after sterilization was reduced by about 10 N after sterilization than before sterilization. The opening strength in Example 2 is the maximum value obtained by using a compression tester (RTC1250A manufactured by Orientec Co., Ltd.) and pressing the storage chamber at a speed of 200 mm / min with a 10 cm × 10 cm flat plate ( The same applies to Example 3 below).

<Example 3>
Using the same film F as in Example 1, the bent portion 6 was provided at a position of 15 cm in the longitudinal direction from the port 8 side shifted from the weak seal portion 107. This was performed in a shower type high-pressure steam sterilizer at a sterilization temperature of 105 ° C. for 30 minutes so that the weak seal 107 came to the bottom surface b of the tray t on which the container was placed during heat sterilization. The outer surfaces of the body portions 4 and 5 that were in contact after cooling were blocked, and the port 8 was fixed, so that the shape did not change before and after sterilization and was fixed. Although there was resistance when expanding the multi-chamber container 201 containing the chemical solution, it was possible to expand. Simultaneously with the development, the weak seal 107 was peeled off and the chemical solution was mixed.
The opening strength of the weak seal portion 107 before and after sterilization was reduced by about 10 N after sterilization than before sterilization.

<Example 4>
The film F was multilayered, and the outer layer / intermediate layer / inner layer = propylene random copolymer / propylene block copolymer + styrene elastomer / homopolypropylene. The thickness [μm] of the film F was 25/200/25 from the outer layer, and the melting point [° C.] was 130/160/160 from the outer layer.
Film F having this structure was prepared by water-cooled inflation. The sterilization temperature was 121 ° C. for 30 minutes using a shower type high-pressure steam sterilizer. The outer surfaces of the body portions 4 and 5 that were in contact after cooling were blocked and fixed. Although there was resistance when developing the multi-chamber container 1 containing a chemical solution, it was able to be deployed. Simultaneously with the development, the weak seal 7 was peeled off and the chemical solution was mixed.

The present invention is not limited to the configuration of each of the above-described embodiments, and the design can be changed without departing from the gist thereof.
For example, in each of the above-described embodiments, the case where the chemical solution filled in the storage chambers 2 and 3 is a vitamin agent and physiological saline has been described. However, the chemical solution is not limited to these vitamin agent and saline. Moreover, although the case where both the chemical | medical solution with which the storage chambers 2 and 3 are filled is a liquid chemical | medical agent was demonstrated, at least one chamber should just be a liquid chemical | medical agent among the storage chambers 2 and 3, for example, a liquid agent, a powder agent, etc. It may be a combination. Moreover, although the case where the storage chambers 2 and 3 are provided has been described, three or more storage chambers may be appropriately provided according to the type of medicine to be mixed.

  In each of the above-described embodiments, the case where the two film F is heat-sealed to form the multi-chamber containers 1, 101, 201, 301, 401, and 501 containing the chemical solution has been described. It is not limited to a sheet, and it may be formed of three or more films.

  And you may make it hold | maintain a conveyance state so that the bent shape of the multi-chamber container 1,101,201,301,401,501 containing a chemical | medical solution may not collapse. As a holding method, a folded multi-chamber container 1, 101, 201, 301, 401, 501 in a folded state is wrapped with a belt-like tape and fixed so as not to move, or a multi-chamber container 1, 101 containing a chemical liquid. , 201, 301, 401, 501 may be held in a state of being transported by being vacuum-packed and folded when further wrapped by outer packaging.

  Moreover, as another aspect of each embodiment described above, for example, as shown in FIG. 14, the above-described suspension hole 9 has a shape into which the port 8 can be inserted, and when the multi-chamber container 501 containing a chemical solution is in a transport state, The suspension hole 9 may be locked to the port 8 through the port 8 through the suspension hole 9. Thereby, the position of the bending part 6 is stabilized, and it can always be made into a fixed shape in the conveyance state. Furthermore, since the multi-chamber container 501 containing the chemical solution is constrained in a fixed shape, the shape is deformed by unexpected force during transportation or the like without performing outer packaging or fixing with a tape or the like. 110 can be prevented from peeling off.

2 First storage room (storage room)
3 Second storage room (storage room)
7,107 Weak seal part 4,5 Body part 6 Bending part 10 Fixing part 120 Bending auxiliary part 210 Jig (Bending auxiliary part)
220 Notch (folding aid)
F film

Claims (8)

It is provided with a plurality of storage chambers for storing chemicals, the storage chambers are separated by a peelable weak seal portion formed in a straight strip shape, and a plurality of substantially planar flexible films are bonded together In a multi-chamber container containing chemicals,
The outer surfaces of the body portions of the storage chamber swelled by the chemical solution are arranged opposite to each other, provided with a fixing portion that fixes the outer surfaces in a peelable manner, and pulls the fixed body portions of the storage chamber in the peeling direction, or chemical solution containing multiple chambers the weak seal portion inner pressure rises in the housing chamber characterized that you peel opened by rolling by its own weight.   The said fixing | fixed part is a multi-chamber container with a chemical | medical solution of Claim 1 which fixes the outer surfaces of the said trunk | drum by blocking, an adhesive agent, an adhesive, or the adhesive member provided in the multi-chamber container surface.   The compound containing the chemical solution according to claim 1 or 2, wherein the weak seal portion is arranged to be shifted in the arrangement direction of the storage chamber with respect to a bent portion that is bent when the outer surfaces of the body portion are arranged to face each other. Chamber container.   The said bending part is a multi-chamber container with a chemical | medical solution of Claim 3 provided with the bending auxiliary | assistant part which makes it easy to bend. The fixing part fixes the outer surfaces of the body part by blocking,
The said film is a multilayer film which has the outer layer and inner layer which consist of a polyethylene-type resin, Comprising: Melting | fusing point of the polyethylene-type resin of an outer layer is lower than melting | fusing point of an inner-layer polyethylene-type resin. Multi-chamber container with chemical solution. The fixing part fixes the outer surfaces of the body part by blocking,
The said film is a multilayer film which has an outer layer and an inner layer, Comprising: The resin of an outer layer is a propylene random copolymer or a propylene block copolymer, The multi-chamber container with a chemical | medical solution as described in any one of Claim 1 thru | or 4 . In the manufacturing method of the chemical | medical solution containing multi-chamber container of Claim 1 thru | or 6,
A plurality of chambers containing a chemical solution, wherein the outer surfaces of the body portion are arranged opposite to each other, heated in a state where the outer surfaces are in contact with each other, and the outer surfaces are fixed by blocking to form the fixing portion. Container manufacturing method. In the manufacturing method of the chemical | medical solution containing multi-chamber container of Claim 3 or 4,
The outer surfaces of the body portions are arranged opposite to each other in the vertical direction, the weak seal portion is arranged below the bent portion in the vertical direction, and the outer surfaces are heated and blocked in a state where the outer surfaces are in close contact with each other. A method for producing a multi-chamber container with a chemical solution, characterized in that the fixed portions are formed by fixing surfaces.

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