JP5607719B2 - 代謝プロファイル - Google Patents

代謝プロファイル Download PDF

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Publication number
JP5607719B2
JP5607719B2 JP2012501376A JP2012501376A JP5607719B2 JP 5607719 B2 JP5607719 B2 JP 5607719B2 JP 2012501376 A JP2012501376 A JP 2012501376A JP 2012501376 A JP2012501376 A JP 2012501376A JP 5607719 B2 JP5607719 B2 JP 5607719B2
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subject
endogenous
biological sample
metabolites
concentration
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JP2012501376A
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Japanese (ja)
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JP2012521551A5 (enExample
JP2012521551A (ja
Inventor
エリク トルビョルン ルンドステット
ニルス ヨハン トリグ
ヨン ロベルト ガブリエルソン
グニラ エクストリューム
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アナマル アクチボラゲット
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Priority claimed from GB0905090A external-priority patent/GB0905090D0/en
Priority claimed from GB0905098A external-priority patent/GB0905098D0/en
Priority claimed from GB0905096A external-priority patent/GB0905096D0/en
Application filed by アナマル アクチボラゲット filed Critical アナマル アクチボラゲット
Publication of JP2012521551A publication Critical patent/JP2012521551A/ja
Publication of JP2012521551A5 publication Critical patent/JP2012521551A5/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2012501376A 2009-03-24 2010-03-24 代謝プロファイル Expired - Fee Related JP5607719B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0905096.4 2009-03-24
GB0905098.0 2009-03-24
GB0905090A GB0905090D0 (en) 2009-03-24 2009-03-24 Biomarkers
GB0905098A GB0905098D0 (en) 2009-03-24 2009-03-24 Use of biomarkers
GB0905090.7 2009-03-24
GB0905096A GB0905096D0 (en) 2009-03-24 2009-03-24 Biomarkers
PCT/GB2010/000557 WO2010109192A1 (en) 2009-03-24 2010-03-24 Metabolic profiles

Publications (3)

Publication Number Publication Date
JP2012521551A JP2012521551A (ja) 2012-09-13
JP2012521551A5 JP2012521551A5 (enExample) 2013-05-09
JP5607719B2 true JP5607719B2 (ja) 2014-10-15

Family

ID=42228305

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012501376A Expired - Fee Related JP5607719B2 (ja) 2009-03-24 2010-03-24 代謝プロファイル

Country Status (6)

Country Link
US (2) US20120108668A1 (enExample)
EP (1) EP2411812B1 (enExample)
JP (1) JP5607719B2 (enExample)
ES (1) ES2432534T3 (enExample)
GB (1) GB2470803A (enExample)
WO (1) WO2010109192A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573993A (zh) * 2009-07-31 2012-07-11 Anamar股份公司 治疗炎症的化合物
JP6198377B2 (ja) * 2012-09-14 2017-09-20 キヤノン株式会社 表示制御装置、表示制御方法、及びプログラム
US20160061812A1 (en) * 2013-03-15 2016-03-03 The University Of Birmingham Diagnosis and Treatment of Arthritic Conditions
CN103675181A (zh) * 2013-12-05 2014-03-26 陈东 气相色谱-质谱检测细胞内外液中有机酸、氨基酸、糖的方法
CN106175684B (zh) * 2016-07-13 2018-12-21 华南师范大学 基于激光光谱技术的人体股骨头病变早期诊断设备及其操作方法
CN109115905A (zh) * 2018-07-31 2019-01-01 苏州旭辉检测有限公司 一种血液样本中鸟氨酸的检测方法
CN111307792A (zh) * 2020-02-20 2020-06-19 江苏大学 一种猪肉食源性致病菌挥发性代谢物的色敏仿生传感检测方法
GB202102105D0 (en) * 2021-02-15 2021-03-31 Novabiotics Ltd Prognostic method
CN115290797A (zh) * 2022-09-13 2022-11-04 贵州医科大学 基于气质联用技术的黑骨藤抗类风湿性关节炎代谢组学研究方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
WO2005094200A2 (en) 2003-06-20 2005-10-13 University Of Florida Biomarkers for differentiating between type 2 and type 2 diabetes
US7700364B2 (en) * 2004-10-12 2010-04-20 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
WO2006066263A1 (en) 2004-12-17 2006-06-22 Entelos, Inc. Assessing insulin resistance using biomarkers
DE602007011592D1 (de) 2006-03-24 2011-02-10 Metanomics Gmbh MITTEL UND VERFAHREN ZUR PROGNOSE ODER DIAGNOSE VON DIABETES typ II
DE102006026173A1 (de) 2006-06-06 2007-12-20 Fachhochschule Südwestfalen Verfahren zur nichtinvasiven Diagnose von Diabetes
AU2007298649B2 (en) 2006-07-28 2012-08-09 Al-Saqqaf, Lamya Prediction and prophylactic treatment of type 1 diabetes
US20090318392A1 (en) 2006-09-14 2009-12-24 Zora Biosciences Oy Biofluid metabolite profiling as a tool for early prediction of autoimmunity and type 1 diabetes risk
CN101796408B (zh) * 2007-06-29 2014-05-07 奎斯特诊断投资公司 用液相层析-质谱法分析体液内的氨基酸

Also Published As

Publication number Publication date
GB201004994D0 (en) 2010-05-12
US20120108668A1 (en) 2012-05-03
GB2470803A (en) 2010-12-08
EP2411812B1 (en) 2013-10-02
US20160018407A1 (en) 2016-01-21
JP2012521551A (ja) 2012-09-13
EP2411812A1 (en) 2012-02-01
ES2432534T3 (es) 2013-12-04
WO2010109192A1 (en) 2010-09-30

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