GB2470803A - Diagnosis and treatment of arthritis - Google Patents

Diagnosis and treatment of arthritis Download PDF

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Publication number
GB2470803A
GB2470803A GB1004994A GB201004994A GB2470803A GB 2470803 A GB2470803 A GB 2470803A GB 1004994 A GB1004994 A GB 1004994A GB 201004994 A GB201004994 A GB 201004994A GB 2470803 A GB2470803 A GB 2470803A
Authority
GB
United Kingdom
Prior art keywords
subject
endogenous metabolites
metabolic profile
biological sample
levels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1004994A
Other languages
English (en)
Other versions
GB201004994D0 (en
Inventor
Erik Torbjoern Lundstedt
Nils Johan Trygg
Jon Robert Gabrielsson
Gunilla Ekstroem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anamar AB
Original Assignee
Anamar AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0905090A external-priority patent/GB0905090D0/en
Priority claimed from GB0905098A external-priority patent/GB0905098D0/en
Priority claimed from GB0905096A external-priority patent/GB0905096D0/en
Application filed by Anamar AB filed Critical Anamar AB
Publication of GB201004994D0 publication Critical patent/GB201004994D0/en
Publication of GB2470803A publication Critical patent/GB2470803A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • G01N33/6812Assays for specific amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/101Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/105Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/24Immunology or allergic disorders
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/56Staging of a disease; Further complications associated with the disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/60Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
GB1004994A 2009-03-24 2010-03-24 Diagnosis and treatment of arthritis Withdrawn GB2470803A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0905090A GB0905090D0 (en) 2009-03-24 2009-03-24 Biomarkers
GB0905098A GB0905098D0 (en) 2009-03-24 2009-03-24 Use of biomarkers
GB0905096A GB0905096D0 (en) 2009-03-24 2009-03-24 Biomarkers

Publications (2)

Publication Number Publication Date
GB201004994D0 GB201004994D0 (en) 2010-05-12
GB2470803A true GB2470803A (en) 2010-12-08

Family

ID=42228305

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1004994A Withdrawn GB2470803A (en) 2009-03-24 2010-03-24 Diagnosis and treatment of arthritis

Country Status (6)

Country Link
US (2) US20120108668A1 (enExample)
EP (1) EP2411812B1 (enExample)
JP (1) JP5607719B2 (enExample)
ES (1) ES2432534T3 (enExample)
GB (1) GB2470803A (enExample)
WO (1) WO2010109192A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573993A (zh) * 2009-07-31 2012-07-11 Anamar股份公司 治疗炎症的化合物
JP6198377B2 (ja) * 2012-09-14 2017-09-20 キヤノン株式会社 表示制御装置、表示制御方法、及びプログラム
US20160061812A1 (en) * 2013-03-15 2016-03-03 The University Of Birmingham Diagnosis and Treatment of Arthritic Conditions
CN103675181A (zh) * 2013-12-05 2014-03-26 陈东 气相色谱-质谱检测细胞内外液中有机酸、氨基酸、糖的方法
CN106175684B (zh) * 2016-07-13 2018-12-21 华南师范大学 基于激光光谱技术的人体股骨头病变早期诊断设备及其操作方法
CN109115905A (zh) * 2018-07-31 2019-01-01 苏州旭辉检测有限公司 一种血液样本中鸟氨酸的检测方法
CN111307792A (zh) * 2020-02-20 2020-06-19 江苏大学 一种猪肉食源性致病菌挥发性代谢物的色敏仿生传感检测方法
GB202102105D0 (en) * 2021-02-15 2021-03-31 Novabiotics Ltd Prognostic method
CN115290797A (zh) * 2022-09-13 2022-11-04 贵州医科大学 基于气质联用技术的黑骨藤抗类风湿性关节炎代谢组学研究方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070088085A1 (en) * 2000-08-07 2007-04-19 Melacure Therapeutics Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
US20070218561A1 (en) * 2004-10-12 2007-09-20 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
WO2009006338A1 (en) * 2007-06-29 2009-01-08 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
WO2005094200A2 (en) 2003-06-20 2005-10-13 University Of Florida Biomarkers for differentiating between type 2 and type 2 diabetes
WO2006066263A1 (en) 2004-12-17 2006-06-22 Entelos, Inc. Assessing insulin resistance using biomarkers
DE602007011592D1 (de) 2006-03-24 2011-02-10 Metanomics Gmbh MITTEL UND VERFAHREN ZUR PROGNOSE ODER DIAGNOSE VON DIABETES typ II
DE102006026173A1 (de) 2006-06-06 2007-12-20 Fachhochschule Südwestfalen Verfahren zur nichtinvasiven Diagnose von Diabetes
AU2007298649B2 (en) 2006-07-28 2012-08-09 Al-Saqqaf, Lamya Prediction and prophylactic treatment of type 1 diabetes
US20090318392A1 (en) 2006-09-14 2009-12-24 Zora Biosciences Oy Biofluid metabolite profiling as a tool for early prediction of autoimmunity and type 1 diabetes risk

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070088085A1 (en) * 2000-08-07 2007-04-19 Melacure Therapeutics Ab Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
US20070218561A1 (en) * 2004-10-12 2007-09-20 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
WO2009006338A1 (en) * 2007-06-29 2009-01-08 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Annals of Rheumatic Diseases 22 (1963) Nettelbladt and Sandell 'Amino-acid content of serum in Rheumatoid Arthritis' 269-272 *
Clinical Rheumatology 25 (2006) Schroecksnadel et al 'Tryptophan degradation increases with stage in patients with rheumatoid arthritis' 334-337 *
Zeitschrift fur Rheumatologie 37 (1978) Partsch et al 'Plasma amino-acid level in Rheumatoid Arthritis and Ankylosing Spondylitis and its variation during age' 105-111 *

Also Published As

Publication number Publication date
GB201004994D0 (en) 2010-05-12
US20120108668A1 (en) 2012-05-03
EP2411812B1 (en) 2013-10-02
US20160018407A1 (en) 2016-01-21
JP5607719B2 (ja) 2014-10-15
JP2012521551A (ja) 2012-09-13
EP2411812A1 (en) 2012-02-01
ES2432534T3 (es) 2013-12-04
WO2010109192A1 (en) 2010-09-30

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