JP5599717B2 - 68Ga系放射性医薬品の比放射能を向上させるための68Ge/68Gaジェネレータ溶出液のFe(III)からの精製 - Google Patents
68Ga系放射性医薬品の比放射能を向上させるための68Ge/68Gaジェネレータ溶出液のFe(III)からの精製 Download PDFInfo
- Publication number
- JP5599717B2 JP5599717B2 JP2010536214A JP2010536214A JP5599717B2 JP 5599717 B2 JP5599717 B2 JP 5599717B2 JP 2010536214 A JP2010536214 A JP 2010536214A JP 2010536214 A JP2010536214 A JP 2010536214A JP 5599717 B2 JP5599717 B2 JP 5599717B2
- Authority
- JP
- Japan
- Prior art keywords
- iii
- hcl
- generator
- eluate
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 title claims description 81
- 239000012217 radiopharmaceutical Substances 0.000 title claims description 12
- 229940121896 radiopharmaceutical Drugs 0.000 title claims description 12
- 230000002799 radiopharmaceutical effect Effects 0.000 title claims description 12
- 238000000746 purification Methods 0.000 title description 30
- 230000000694 effects Effects 0.000 title description 16
- 238000005349 anion exchange Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 25
- XOYLJNJLGBYDTH-UHFFFAOYSA-M chlorogallium Chemical compound [Ga]Cl XOYLJNJLGBYDTH-UHFFFAOYSA-M 0.000 claims description 21
- 239000011347 resin Substances 0.000 claims description 21
- 229920005989 resin Polymers 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims description 16
- 239000008367 deionised water Substances 0.000 claims description 14
- 229910021641 deionized water Inorganic materials 0.000 claims description 14
- 230000000717 retained effect Effects 0.000 claims description 13
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 10
- 238000010828 elution Methods 0.000 claims description 10
- 239000003638 chemical reducing agent Substances 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 8
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052802 copper Inorganic materials 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 229910052719 titanium Inorganic materials 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 230000020477 pH reduction Effects 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 5
- 229910052718 tin Inorganic materials 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 41
- 239000000243 solution Substances 0.000 description 39
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 18
- 150000001768 cations Chemical class 0.000 description 15
- 239000003957 anion exchange resin Substances 0.000 description 14
- 238000000926 separation method Methods 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000010949 copper Substances 0.000 description 12
- 150000002500 ions Chemical class 0.000 description 10
- 238000002600 positron emission tomography Methods 0.000 description 9
- 239000004408 titanium dioxide Substances 0.000 description 9
- 238000004094 preconcentration Methods 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- XOLBLPGZBRYERU-UHFFFAOYSA-N tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 8
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 7
- 229910052733 gallium Inorganic materials 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 125000000129 anionic group Chemical group 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 6
- 239000010936 titanium Substances 0.000 description 6
- 150000001450 anions Chemical class 0.000 description 5
- 239000003729 cation exchange resin Substances 0.000 description 5
- 239000002738 chelating agent Substances 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229920000128 polypyrrole Polymers 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 238000011002 quantification Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- -1 tetrachloride anion Chemical class 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- VXAUWWUXCIMFIM-UHFFFAOYSA-M aluminum;oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Al+3] VXAUWWUXCIMFIM-UHFFFAOYSA-M 0.000 description 4
- 238000005341 cation exchange Methods 0.000 description 4
- 229920001940 conductive polymer Polymers 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 3
- 108090000288 Glycoproteins Proteins 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- 239000012491 analyte Substances 0.000 description 3
- 230000001588 bifunctional effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229920001429 chelating resin Polymers 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000004980 dosimetry Methods 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229940079877 pyrogallol Drugs 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 108010015899 Glycopeptides Proteins 0.000 description 2
- 102000002068 Glycopeptides Human genes 0.000 description 2
- 108010028921 Lipopeptides Proteins 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003637 basic solution Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000002322 conducting polymer Substances 0.000 description 2
- 238000004993 emission spectroscopy Methods 0.000 description 2
- 229910001447 ferric ion Inorganic materials 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000011491 glass wool Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 229910052809 inorganic oxide Inorganic materials 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 239000000700 radioactive tracer Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 1
- 229910010277 boron hydride Inorganic materials 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000010668 complexation reaction Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229960004887 ferric hydroxide Drugs 0.000 description 1
- 229910001448 ferrous ion Inorganic materials 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012477 high molecular weight ligand Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 102000014187 peptide receptors Human genes 0.000 description 1
- 108010011903 peptide receptors Proteins 0.000 description 1
- 229920000767 polyaniline Polymers 0.000 description 1
- 229920002635 polyurethane Chemical group 0.000 description 1
- 239000004814 polyurethane Chemical group 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- UDYFLDICVHJSOY-UHFFFAOYSA-N sulfur trioxide pyridine complex Chemical compound O=S(=O)=O.C1=CC=NC=C1 UDYFLDICVHJSOY-UHFFFAOYSA-N 0.000 description 1
- 239000003447 supported reagent Substances 0.000 description 1
- 229910021654 trace metal Inorganic materials 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G15/00—Compounds of gallium, indium or thallium
- C01G15/003—Preparation involving a liquid-liquid extraction, an adsorption or an ion-exchange
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/04—Processes using organic exchangers
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/80—Compositional purity
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/88—Isotope composition differing from the natural occurrence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99185207P | 2007-12-03 | 2007-12-03 | |
US60/991,852 | 2007-12-03 | ||
PCT/US2008/085095 WO2009102378A2 (en) | 2007-12-03 | 2008-12-01 | Purification of 68ge/68ga generator eluate from fe(iii) intended to improve specific radioactivity of 68ga-based radiopharmaceuticals |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2011505376A JP2011505376A (ja) | 2011-02-24 |
JP2011505376A5 JP2011505376A5 (de) | 2011-12-15 |
JP5599717B2 true JP5599717B2 (ja) | 2014-10-01 |
Family
ID=40957422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010536214A Active JP5599717B2 (ja) | 2007-12-03 | 2008-12-01 | 68Ga系放射性医薬品の比放射能を向上させるための68Ge/68Gaジェネレータ溶出液のFe(III)からの精製 |
Country Status (7)
Country | Link |
---|---|
US (2) | US9487410B2 (de) |
EP (1) | EP2214720B1 (de) |
JP (1) | JP5599717B2 (de) |
CN (1) | CN101970016B (de) |
BR (1) | BRPI0819647A2 (de) |
RU (1) | RU2010120765A (de) |
WO (1) | WO2009102378A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0922492D0 (en) * | 2009-12-23 | 2010-02-03 | Hammersmith Imanet Ltd | Method for obtaining 68GA |
CN102382994B (zh) * | 2011-07-18 | 2013-08-14 | 原子高科股份有限公司 | 一种放射性68Ge溶液的制备方法 |
DE102012208377B4 (de) * | 2012-05-18 | 2015-07-23 | Zentralklinik Bad Berka Gmbh | Satz und Verfahren zur Herstellung eines Radiopharmakons |
DE102012208375B4 (de) | 2012-05-18 | 2015-07-23 | Zentralklinik Bad Berka Gmbh | Satz und Verfahren zur Herstellung eines Radiopharmakons |
DE102012208376C5 (de) * | 2012-05-18 | 2018-02-01 | Zentralklinik Bad Berka Gmbh | Satz und Verfahren zur Herstellung eines Radiopharmakons |
DE102012208378B4 (de) * | 2012-05-18 | 2015-07-23 | Zentralklinik Bad Berka Gmbh | Satz und Verfahren zur Herstellung eines Radiopharmakons |
PL3539138T3 (pl) * | 2016-11-11 | 2021-12-13 | Curium Us Llc | Sposoby generowania germanu-68 ze zmniejszoną ilością części lotnych |
SI3343570T1 (sl) * | 2016-12-27 | 2019-10-30 | Itm Isotopen Tech Muenchen Ag | Generator 68Ge/68Ga |
WO2020028825A1 (en) | 2018-08-03 | 2020-02-06 | Board Of Regents, The University Of Texas System | Method for extraction and purification of 68ga |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2226316T3 (en) * | 2002-05-30 | 2016-04-11 | Scripps Research Inst | Copper catalyzed ligation of azides and acetylenes |
GB0308407D0 (en) | 2003-04-11 | 2003-05-21 | Amersham Plc | Method of obtaining 68 GA |
US7023000B2 (en) * | 2003-05-21 | 2006-04-04 | Triumf | Isotope generator |
AU2007224162A1 (en) | 2006-03-03 | 2007-09-13 | Aveo Pharmaceuticals, Inc. | Processes for synthesizing 7-alkynyl-4-aminoquinazolines and a related intermediate |
-
2008
- 2008-12-01 CN CN2008801189460A patent/CN101970016B/zh active Active
- 2008-12-01 US US12/745,715 patent/US9487410B2/en active Active
- 2008-12-01 EP EP08872351.5A patent/EP2214720B1/de active Active
- 2008-12-01 WO PCT/US2008/085095 patent/WO2009102378A2/en active Application Filing
- 2008-12-01 JP JP2010536214A patent/JP5599717B2/ja active Active
- 2008-12-01 RU RU2010120765/15A patent/RU2010120765A/ru unknown
- 2008-12-01 BR BRPI0819647-8A patent/BRPI0819647A2/pt not_active IP Right Cessation
-
2016
- 2016-09-23 US US15/274,503 patent/US9790097B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9790097B2 (en) | 2017-10-17 |
EP2214720A2 (de) | 2010-08-11 |
WO2009102378A3 (en) | 2009-10-29 |
US20170029287A1 (en) | 2017-02-02 |
US20100275734A1 (en) | 2010-11-04 |
CN101970016A (zh) | 2011-02-09 |
US9487410B2 (en) | 2016-11-08 |
CN101970016B (zh) | 2013-01-02 |
BRPI0819647A2 (pt) | 2015-05-26 |
RU2010120765A (ru) | 2012-01-10 |
WO2009102378A2 (en) | 2009-08-20 |
JP2011505376A (ja) | 2011-02-24 |
EP2214720B1 (de) | 2018-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5599717B2 (ja) | 68Ga系放射性医薬品の比放射能を向上させるための68Ge/68Gaジェネレータ溶出液のFe(III)からの精製 | |
Kolsky et al. | Radiochemical purification of no-carrier-added scandium-47 for radioimmunotherapy | |
Meijs et al. | Production of highly pure no-carrier added 89Zr for the labelling of antibodies with a positron emitter | |
AU663716B2 (en) | Tungsten-188/carrier-free rhenium-188 perrhenic acid generator system | |
JP2002527031A (ja) | テクネチウム―99m生成システム | |
EP3996111A1 (de) | Verfahren zur reinigung von 226ra-haltiger lösung, verfahren zur herstellung eines 226ra-targets und verfahren zur herstellung von 225ac | |
US11986815B2 (en) | Processes and systems for producing and/or purifying gallium-68 | |
Sadeghi et al. | Separation of the no-carrier-added 109 Cd from Ag, Cu and 65 Zn by use of a precipitation and AG1-X8 resin | |
Kmak et al. | Extraction of selenium and arsenic with TOA-impregnated XAD-2 resin from HCl | |
KR20210091224A (ko) | 높은 라듐-228 함량을 갖는 적어도 하나의 생성장치를 제조하는 방법 | |
US8932876B2 (en) | Method and system for purifying charged radioisotopes | |
Chakravarty et al. | An electro-amalgamation approach to produce 175Yb suitable for radiopharmaceutical applications | |
Fonseca et al. | GMP-Automated Purification of Copper-61 Produced in Cyclotron Liquid Targets: Methodological Aspects | |
RU2522892C1 (ru) | Способ получения активной фармацевтической субстанции для синтеза препаратов галлия-68 | |
Sajjad et al. | Autoradiolytic Decomposition of Reductant-free Sodium and 124I 123I-Iodide | |
CN112789691B (zh) | 由含钍-228及其子体的水溶液生产铅-212的方法 | |
Castillo et al. | An adapted purification procedure to improve the quality of 90Y for clinical use | |
CN115029566A (zh) | 一种使用teva-uteva树脂分离钇样品中锆的方法 | |
van der Walt et al. | Separation of 203Pb by ion-exchange chromatography on chelex 100 after production of 203Pb by the Pb (p, xn) 203Bi→ EC. β+ 203Pb nuclear reaction | |
CN116068069A (zh) | 一种制备高纯锆的方法 | |
Wolters | Solid Sorbents for Improved Chemical Separations: Applications in Nuclear Medicine and Environmental Remediation | |
WO2024147853A1 (en) | Method for stacked elution of mother-daughter radionuclides | |
Safavi-Tehrani | Production of High Specific Activity Radioisotopes via the Szilard-Chalmers Method, Using the UC-Irvine TRIGA® Reactor | |
Fadzil et al. | Purification and concentration of gallium-68 via anion exchange method from a SnO2-based column germanium-68/gallium-68 generator | |
Mirzadeh et al. | Technetium-99m generator system |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100604 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20111130 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121109 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131001 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20131226 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140109 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140131 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140207 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140303 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140715 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140813 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5599717 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |