JP5596532B2 - Flying insect repellent, flying insect repellent, and flying insect repellent method - Google Patents

Description

  The present invention relates to a flying pest repellent, and more specifically, a flying pest repellent that suppresses the flying behavior of blood-sucking pests such as mosquitoes and flying pests such as Drosophila, and a flying pest repellent and a flying pest repellent using the same Regarding the method.

  Conventionally, a method of applying a repellent containing diet (N, N-diethyl-toluamide) to the skin surface has been widely used against flying pests such as mosquitoes, moths and chironomids. However, since diet has a somewhat lower volatility compared to ordinary fragrance ingredients, it has a repellent effect on the skin, but a spatial repellent effect could not be expected.

  In addition, as a method for repelling flying insect pests, a component composed of a pyrethroid compound diluted with a petroleum solvent, or solidified in the form of an incense or gel, such as physical properties such as fire, heat, wind, spray, etc. The method of volatilizing by an effective action is known and used.

  On the other hand, it is known that some compounds (for example, monoterpene compounds) contained in plant essential oil exhibit a pest repellent effect. For example, Patent Literature 1 includes, as a pest repellent component (A), citronellal and one or more selected from terpineol, menthol, limonene, geraniol, citronellol, camphene, etc., and the pest repellent component (A) A pest repellent volatilization composition having a citronellal content of 2 to 10% by mass is disclosed.

  However, although this pest repellent volatilization composition urges consideration for natural product orientation and safety, its repellent effect is not always satisfactory. Furthermore, in the United States, candles containing citronella oil as an active ingredient are also commercially available. However, the method of dissipating citronellal using the heat of the candle has poor citronellal volatilization efficiency and cannot provide a practical repellent effect.

JP 2003-201203 A

  An object of the present invention is to provide a flying pest repellent that is highly safe, has a high space repellent effect on flying pests, and can suppress the arrival and blood sucking behavior of pests even at low concentrations.

  In order to solve the above problems, the present inventors have searched for compounds having a repellent effect against flying pests widely, and specific polyether compounds have a high space repellent effect against flying pests, The present inventors completed the present invention by discovering that the effect of repelling pests hardly decreases even when the plastic material is expected to be contacted in use.

（式中、Ｒ_１およびＲ_３は水素原子または低級アルキル基を、Ｒ_２は炭素数１ないし５の分 岐していても良いアルキレン基を示し、ｎは１ないし３の自然数を示す）
で示されるポリエーテル化合物を含有してなる飛翔害虫忌避剤である。 That is, the present invention provides the following chemical formula (I)

(Wherein R ₁ and R ₃ represent a hydrogen atom or a lower alkyl group, R ₂ represents an alkylene group having 1 to 5 carbon atoms which may be branched, and n represents a natural number of 1 to 3)
It is a flying insect repellent containing the polyether compound shown by these.

  The flying pest repellent of the present invention is highly safe, has a high space repellent effect on flying pests, and can suppress the flying of pests and blood sucking behavior even at low concentrations. Further, even when used in a plastic trash can, the adsorption to the plastic can be prevented, and the effect can be exhibited in a small amount. Furthermore, it has a mild odor and can be used in combination with other perfume ingredients.

It is a top view of the flying insect repellent of the present invention. It is drawing which showed the A-A 'cross section of FIG. 1 typically.

  In the present specification, the flying pests are mosquitoes such as Acaeca, Chicaeka, Aedes albopictus, Aedes albopictus, houseflies, mosquito flies, sarcophaga flies, fly flies such as Drosophila, flies, butterflies, butterflies, etc. Examples include flying pests such as chironomids such as sesji chironomid and red chironomid chironomids, and moss such as squid, koiga and noshimemadame. These are pests that approach humans during flight and suck blood from their skin, pests that carry pathogenic bacteria while flying without blood sucking, and pests that themselves cause discomfort to humans . Further, the flying pest repellent of the present invention gives a high space repellent effect to the flying pest, the spatial repellent effect is a range close to the place where the flying pest repellent is applied, for example, This means the effect of keeping flying pests away from the space within 1m.

  The polyether used as an active ingredient in the flying insect repellent of the present invention is represented by the chemical formula (I).

In the formula (I), examples of the lower alkyl group of the groups R ₁ and R ₃ include an optionally branched alkyl group having 1 to 4 carbon atoms, such as a methyl group, an ethyl group, a propyl group, and a butyl group. Groups and the like. Further, the alkylene group having 1 to carbon atoms for group R ₂ 5, may be mentioned methylene group, ethylene group, propylene group, butylene group and the like.

Specific examples of the polyether compound (I) include ethylene glycol (R ₁ , R ₃ = H, R ₂ = ethylene, n = 1), propylene glycol (R ₁ , R ₃ = H, R ₂ = Propylene, n = 1), butylene glycol (R ₁ , R ₃ = H, R ₂ = butylene, n = 1), ethylene glycol monomethyl ether (R ₁ = methyl group, R ₂ = ethylene, R ₃ = H, n = 1), ethylene glycol dimethyl ether (R ₁ , R ₃ = methyl group, R ₂ = ethylene, n = 1), ethylene glycol diethyl ether (R ₁ , R ₃ = ethyl group, R ₂ = ethylene, n = 1) , ethylene glycol monoethyl ether _{(R 1} = ethyl, _{R 2} = _{ethylene, R 3 = H, n =} 1), 3- methoxy-1-butanol _{(R 1 = H, R 2} = butylene, _{R 3} = methyl , N = 1), 1- methoxy-2-butanol _{(R 1 = H, R 2} = butylene, _{R 3} = methyl, n = 1), 1- methoxy-2-propanol _(R 1 = H, R ₂ = Propylene, R ₃ = methyl group, n = 1), 3-methoxy-3-methyl-1-butanol (R ₁ = H, R ₂ = butylene, R ₃ = methyl group, n = 1), diethylene glycol (R ₁ , R ₃ = H, R ₂ = ethylene, n = 2), dipropylene glycol (R ₁ , R ₃ = H, R ₂ = propylene, n = 2), diethylene glycol monomethyl ether (R ₁ = methyl group, R ₂ = ethylene, R ₃ = H, n = 2), dipropylene glycol dimethyl ether (R ₁ , R ₃ = methyl group, R ₂ = propylene, n = 2) and the like. Among these, dipropylene glycol dimethyl ether is particularly preferable in terms of vapor pressure and odor.

  The flying insect repellent of the present invention is used by volatilizing the polyether compound (I), which is an active ingredient. The active ingredient may be heated to evaporate, but it is preferable to evaporate at room temperature in consideration of the alteration of the drug and the volatilization rate.

  In addition, the pharmaceutical form of the flying pest repellent of the present invention can adopt various forms such as liquid, gel, solid, and sheet according to the needs of the use scene, and the active ingredient can be adapted to this. The polyether compound (I) can be blended.

  In the case of a solid form, the polyether compound (I) can be used by being held on a suitable holding body. Examples of the holding body include a shape processed into a nonwoven fabric, a sheet, a film, and the like, and a shape processed into a powder, a tablet mat, and the like. Furthermore, as materials, for example, natural fibers such as pulp, cotton, wool, hemp, silk, synthetic fibers such as polypropylene, polyethylene, polyamide, polyethylene terephthalate, polybutylene terephthalate, polysulfone, rayon, methacrylic acid resin, glass fiber, and zeolite And porous materials such as talc, white carbon, diatomaceous earth, lime, silica gel and activated carbon. The blending amount of the polyether compound (I) in these solid flying insect repellents is about 30 to 70% by mass (hereinafter simply indicated as “%”), preferably 40 to 60%, based on the total amount. It is.

Moreover, what is necessary is just to combine the said polyether compound (I) with a gelatinizer and a solvent, and to make a gel-like body when setting it as a gel-like body. Examples of the gelling agent used for preparing the gel-like body include carrageenan, xanthan gum, gellan gum, gelatin, aluminum octylate,
2-hydroxystearic acid and the like can be mentioned, and the polyether compound (I) may be blended in an amount of about 30 to 70%, preferably 40 to 60%, based on the total amount.

  Further, the liquid-form flying insect repellent may be obtained by simply dissolving or dispersing the polyether compound (I) in a solvent. The solvent used for this may be either aqueous or oily, such as water, alcohols such as methyl alcohol and ethyl alcohol, esters such as diethyl phthalate, isopropyl myristate, butyl stearate, hexane, kerosene, paraffin, etc. And aliphatic hydrocarbons, and aromatic hydrocarbons such as benzene and xylene. The blending amount of the polyether compound (I) in this liquid flying insect repellent is about 30 to 70%, preferably 40 to 60%, based on the total amount.

  In the flying pest repellent of the present invention, the repellent effect against flying pests can be further enhanced by using the polyether compound (I) in combination with other repellent components. Examples of repellent components used in combination include pyrethroids, conventionally known plant essential oils, and compounds contained therein.

  Examples of pyrethroids that can be used in combination include allethrin; 3-allyl-2-methylcyclopent-2-en-4-one-1-yl dl-cis / trans-chrysantemate (Pinamine, Sumitomo Chemical ( ), Dl · d-T80-aresulin; 3-allyl-2-methylcyclopent-2-en-4-one-1-yl d-cis / trans-chrisantemate (Pinamine Forte, Sumitomo Chemical Co., Ltd.) ), Dl · d-T-areslin; 3-allyl-2-methylcyclopent-2-en-4-one-1-yl d-trans-chrysantemate (bioareslin), d · d- D-3-allyl-2-methylcyclopent-2-en-4-one-1-yl d-trans-chrysantemate (esviol), d · d-T80 -Plaretrin; d-2-methyl-4-oxo-3-propargylcyclopent-2-enyl d-cis / trans-chrysantemate (Etoc, Sumitomo Chemical Co., Ltd.), framethrin; 5- (2-propargyl ) -3-furylmethyl chrysanthemate (Pinamine D, Sumitomo Chemical Co., Ltd.), Empentrin; 1-ethynyl-2-methylpent-2-enyl d-cis / trans-Chrysanthemate (Vaperslin, Sumitomo Chemical) ), Terrareslin; 2-allyl-3-methyl-2-cyclopenten-1-one-4-yl-2,2,3,3, tetramethyl-cyclopropanecarboxylate (Noxlin, Sumitomo Chemical ( Co., Ltd.), transfluthrin; 2,3,5,6-tetrafluorobenzyl-2,2-dimethyl-3- (2,2- (Chlorovinyl) cyclopropanecarboxylate (Bayer), profluthrin; (2,3,5,6-tetrafluoro-4-methylphenyl) methyl-2,2-dimethyl-3- (1-propen-1-yl) cyclo And propanecarboxylate (Fairy Tail, Sumitomo Chemical Co., Ltd.). Of these, empentrin, transfluthrin, and profluthrin are preferable in terms of good volatility.

  Meanwhile, conventionally known plant essential oils and components contained in these plant essential oils include, for example, orange oil, cassia oil, grapefruit oil, clove oil, cedarwood oil, citronella oil, cinnamon oil, cinnamon leaf oil, geranium oil, thyme White oil, peppermint oil, hiba oil, pimento oil, fennel oil, penny royal oil, peppermint oil, bergamot oil, lavender oil, roux oil, lemongrass oil, citronellal, tarpineol, menthol, limonene, geraniol, citronellol, citral, l -1 type, or 2 or more types, such as carvone and camphene, can be mentioned.

  In addition, in the flying pest repellent of the present invention, it is needless to say that a stabilizer, an ultraviolet absorber, an antioxidant, a pH adjuster, a fragrance, a pigment and the like may be appropriately blended in addition to the above-described components. .

  Next, a flying pest repellent utilizing a liquid-like flying pest repellent will be described with reference to a drawing showing an embodiment thereof.

  FIG. 1 is a plan view of a flying insect repellent, and FIG. 2 is a schematic sectional view thereof. In the figure, 1 is a flying insect repellent, 2 is a container body, 3 is a gas permeable film, 4 is a recess, and 5 is a flying insect repellent. The flying insect repellent of this embodiment uses a container body 2 in which a sheet is formed in a form having a recess 4 in the center as shown in FIGS. 1 to 2, and contains a liquid flying insect repellent 5 in the recess 4. It is what you do. As this sheet, a resin sheet or a metal sheet such as aluminum can be used.

  The depth and the internal volume of the recess 4 in the above embodiment are not particularly limited because they change according to the amount of the flying insect repellent 5 accommodated therein, but for example, the depth of the recess 4 is about 0.00. It can be appropriately determined according to the amount of the flying insect repellent 5 accommodated from a range of 1 to 20 mm, preferably 1 to 10 mm.

  Moreover, in the said aspect, it is set as the structure where the upper surface of the accommodated recessed part 4 was plugged up with the gas-permeable film 3. Thereby, it is possible to prevent the flying insect repellent 5 from spilling out of the container body 2, and handling such as transportation becomes easy. Moreover, by making the said container body 2 vertical, a liquid level becomes clear and an end point becomes clearer.

  The gas permeable film 3 can be used without any particular limitation as long as the flying pest repellent 5 can be volatilized by allowing the gas to permeate without causing the liquid agent to flow out. Examples of such a gas permeable film 3 include stretched or unstretched polypropylene, polyethylene (for example, linear low density polyethylene, low density polyethylene, etc.), polyethylene terephthalate, polymethylpentene, and the like. These films may be used alone or in combination of two or more. The thickness of the gas permeable film 3 is about 10 to 100 μm, preferably 30 to 70 μm.

  In selecting the gas permeable film 3 to be used, in addition to being a film effective for volatilization of the flying insect repellent 5, for example, a composite film in which two or more kinds of films are bonded can be mentioned. Specifically, for example, a composite film in which the polyethylene or unstretched polypropylene is used as a sealant layer (not shown), and stretched polypropylene, polyethylene terephthalate, and a perforated film (for example, perforated polyethylene terephthalate film) are bonded to the outer surface thereof. Can be mentioned. Here, the sealant layer refers to a film that is directly adhered to the container body 2 and enhances adhesion and liquid tightness with the container body 2. The thickness of the composite film may be in the range of about 10 to 100 μm in thickness of the gas permeable film 3 described above. In addition, you may provide a sealant layer in the upper surface (adhesion surface of a film) of the container body 2 independently.

  Further, in order to prevent the gas permeable film 3 from sticking to the bottom surface of the recess 4 due to the volatilization of the flying insect repellent 5, the inside of the recess 4 is reduced in pressure over time. A mouth (not shown) may be provided to send air to the recess 4 sealed with the gas permeable film 3. Such an air inlet can be provided in a part of the gas permeable film 3, for example.

  The flying pest repellent of the present invention thus obtained should be installed in various scenes such as garbage bins, triangle corners, etc. generated in ordinary households, restaurants, camping, barbecue, etc. Is possible. And by using this flying insect repellent, mosquitoes such as mosquitoes, chikaeka, human mosquitoes, mosquito mosquitoes, house flies, flies flies, scabs flies, fly flies such as Drosophila flies, flies, flies, flies, etc. It is possible to eliminate flying insects such as chironomids, chironomids such as sesji chironomid and akamushi chironika, and mosses such as moths, koiga, and mosquitoes.

  EXAMPLES Hereinafter, although an Example demonstrates this invention further in detail, this invention is not restrict | limited at all by the said Example.

Example 1
Knockdown effect test 1:
At the mixing ratio shown in Table 1, the present invention product 1 and comparative product 1 were prepared and then the container (housing part shown in figure 1-3: polyester, closed film: polyethylene, an opening area 7.67Cm ² ) Was filled with 3.2 ml, and the opening was closed with a drug-permeable film. Further, this was housed in a case having an opening on one side to obtain a flying insect repellent.

  The flying pest repellent filled and stored with Invention Products 1 and 2 and Comparative Product 1 was evaluated for the knockdown effect against Drosophila melanogaster by the following method. In addition, as a comparative product 2, a commercially available earth (not manufactured by Earth Pharmaceutical) was used. The results are shown in Table 2.

( Test method )
Twenty test insects (Drosophila melanogaster) were placed in a glass container with a lid having a capacity of 10.5 L, and attached to the back of the lid filled with the sample with double-sided tape so that the opening was on the top. After that, the number of knockdowns was counted by observing the state of the test insects. The time required for half of the test insects to be knocked down (hereinafter referred to as “KT50”) and 90% required for the knockdown. The measured time (hereinafter referred to as “KT90”) was measured.

  From the above results, the flying insect repellent using the products 1 and 2 of the present invention has a shorter time for both KT50 and KT90 than those using the comparative product 1, and is as high as the commercially available comparative product 2. It was found that a knockdown effect was exhibited.

Example 2
Knockdown effect test 2:
The same test as in Example 1 was performed using a polypropylene container (11.6 L) instead of the glass container with a cover of 10.5 L in Example 1. In addition, as a comparative product 2, a commercially available earth (not manufactured by Earth Pharmaceutical) was used. The results are shown in Table 3.

  From the above results, it can be seen that the flying insect repellent using the products 1 and 2 of the present invention has a shorter time for both KT50 and KT90 than those using the comparative product 1, and shows a high knockdown effect. It was. On the other hand, Comparative Product 2 had an excellent knockdown effect in Example 1, but Example 2 did not show a knockdown effect. This is presumed that the active ingredient of the comparative product 2 was adsorbed by the plastic in the plastic container and was no longer effective. On the other hand, it turns out that this invention product shows the outstanding knockdown effect irrespective of the kind of container.

Example 3
Repellent effect test:
Two 8 tatami constant temperature test chambers (room temperature 25 ± 2 ° C., humidity 40 ± 10%) were prepared, and a polypropylene trash can was installed in each room. In the trash bin, we added yeast and old liquor that had been matured for two days by adding yeast as the source of the test insects. In one room (treatment area), a flying insect repellent using the product 1 of the present invention was attached to the inside of a trash can lid (made of glass), and the gap of the lid was opened by 1 cm. In the other room (untreated section), nothing was attached to the lid of the trash box, and the gap between the lids was similarly opened by 1 cm. Similarly, experiments were conducted on flying insect repellents using the product 2 of the present invention and the comparative product 1. Thirty minutes after applying the flying insect repellent using the products 1 and 2 of the present invention and the flying insect repellent using the comparative product 1, 50 test insects were released in both rooms. The number of test insects that approached the trash can was counted for each elapsed time, and the repelling rate was calculated using the following formula. The results are shown in Table 4.

  As is clear from the above results, the flying insect repellent using the product 1 of the present invention has a repelling rate of 66.7 to 80% continuously from the start of measurement until 24 hours have passed. Even after 24 hours, it had a repelling rate of 70% or more. The average repelling rate for 24 hours was 72.2%. Similarly, the flying insect repellent using the product 2 of the present invention has a repelling rate of 70 to 89.5% continuously from the start of measurement until 24 hours have passed, and 24 hours have passed. Later, it had a repelling rate of nearly 90%. The average repelling rate for 24 hours was 77.2%.

On the other hand, the flying insect repellent using the comparative product 1 had only a repellent rate of 40% to 50%, and the average repellent rate after 24 hours was about 50%. From these results, it was found that the products 1 and 2 of the present invention have an excellent repellent effect against Drosophila melanogaster.

  The flying pest repellent of the present invention is highly safe, has a high space repellent effect on flying pests, and can suppress the flying of insects and blood sucking behavior even at low concentrations. Moreover, even if it is used in a plastic trash can etc., there is almost no adsorption to the plastic, and the effect can be exhibited with a small amount. Furthermore, it has a mild odor and can be used by mixing with other perfume ingredients and other repellent ingredients such as pyrethroids, plant essential oils or compounds contained therein.

  Therefore, the present invention can be advantageously used in the fields of insect repellent and sanitary environment improvement.

DESCRIPTION OF SYMBOLS 1 ...... Flying insect repellent 2 ...... Container body 3 ... Gas-permeable film 4 ...... Recessed 5 ...... Flying insect repellent

Claims (8)

A flying insect repellent containing dipropylene glycol dimethyl ether .   The flying insect repellent according to claim 1, which is volatilized to act.   The flying insect repellent according to claim 1 or 2, further comprising a pyrethroid.   Furthermore, orange oil, cassia oil, grapefruit oil, clove oil, cedarwood oil, citronella oil, cinnamon oil, cinnamon leaf oil, geranium oil, thyme white oil, peppermint oil, hiba oil, pimento oil, fennel oil, penny royal oil, The flying insect repellent according to claim 1 or 2, comprising one or more plant essential oils selected from peppermint oil, bergamot oil, lavender oil, roux oil and lemongrass oil.   The flying insect repellent according to claim 1 or 2, further comprising one or more compounds selected from citronellal, terpineol, menthol, limonene, geraniol, citronellol, citral, l-carvone and camphene.   6. A flying insect repellent comprising: the flying insect repellent according to any one of claims 1 to 5 housed in a container having an upper surface opening; and the opening is closed with a gas permeable film.   The flying insect repellent according to claim 6, which is used after evaporating at room temperature. A method for repelling flying insects, comprising volatilizing or spraying the flying insect repellent according to any one of claims 1 to 5 in an environment where the flying insects fly.

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