JP5566105B2 - 感染症に対する候補薬 - Google Patents
感染症に対する候補薬 Download PDFInfo
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- JP5566105B2 JP5566105B2 JP2009526572A JP2009526572A JP5566105B2 JP 5566105 B2 JP5566105 B2 JP 5566105B2 JP 2009526572 A JP2009526572 A JP 2009526572A JP 2009526572 A JP2009526572 A JP 2009526572A JP 5566105 B2 JP5566105 B2 JP 5566105B2
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- plasminogen
- bacterial
- infection
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
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| PCT/SE2007/050585 WO2008026999A2 (en) | 2006-08-28 | 2007-08-28 | Candidates against infection |
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| JP2010502600A JP2010502600A (ja) | 2010-01-28 |
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| JP2009526572A Expired - Fee Related JP5566105B2 (ja) | 2006-08-28 | 2007-08-28 | 感染症に対する候補薬 |
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| EP (1) | EP2056864B1 (https=) |
| JP (1) | JP5566105B2 (https=) |
| KR (1) | KR101517626B1 (https=) |
| CN (2) | CN101563100B (https=) |
| AU (1) | AU2007290881B2 (https=) |
| CA (1) | CA2662101C (https=) |
| DK (1) | DK2056864T3 (https=) |
| EA (1) | EA016250B1 (https=) |
| ES (1) | ES2451015T3 (https=) |
| MX (1) | MX2009002226A (https=) |
| WO (1) | WO2008026999A2 (https=) |
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| US9107864B2 (en) | 2004-06-07 | 2015-08-18 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| US8501198B2 (en) | 2004-06-07 | 2013-08-06 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| ES2453496T3 (es) | 2006-08-28 | 2014-04-08 | Omnio Healer Ab | Diana farmacológica novedosa de prevención y tratamiento de enfermedad periodontal, mejora de la cicatrización de heridas periodontales y promoción de la salud oral |
| KR20120050442A (ko) | 2009-07-10 | 2012-05-18 | 쓰롬보제닉스 엔.브이. | 플라스미노겐 및 플라스민의 변이체 |
| US20120189609A1 (en) | 2009-08-28 | 2012-07-26 | Thrombogenics Nv | Improvement to trabeculectomy |
| RU2421192C1 (ru) * | 2010-03-09 | 2011-06-20 | Винера Гумаровна Нафикова | Способ лечения хронического бактериального конъюнктивита |
| SG187201A1 (en) * | 2010-07-26 | 2013-02-28 | Qu Biolog Inc | Immunogenic anti-inflammatory compositions |
| EP2661493B1 (en) | 2011-01-05 | 2016-03-30 | ThromboGenics N.V. | Plasminogen and plasmin variants |
| JP6000353B2 (ja) | 2011-08-12 | 2016-09-28 | スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ | プラスミノーゲンおよびプラスミンの変異体 |
| CN102507707B (zh) * | 2011-10-12 | 2015-10-21 | 山东大学 | 一种检测龈沟液中蛋白裂解酶含量的方法 |
| US10251946B2 (en) | 2014-05-02 | 2019-04-09 | Qu Biologics Inc. | Anti-microbial immunomodulation |
| TWI801331B (zh) * | 2015-11-03 | 2023-05-11 | 美商波麥堤克生物治療股份有限公司 | 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法 |
| DK3391902T5 (da) | 2015-12-18 | 2024-09-23 | Talengen Int Ltd | Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati |
| CA3008475C (en) * | 2015-12-18 | 2024-06-04 | Talengen International Limited | Method for preventing and treating hepatic tissue injury and related disorders thereof |
| JP6793748B2 (ja) * | 2015-12-18 | 2020-12-02 | タレンゲン インターナショナル リミテッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ | 放射性および化学的損傷を予防及び治療するための方法 |
| CN106890321A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种用于预防和治疗宫颈糜烂的方法 |
| CN108463235A (zh) * | 2015-12-18 | 2018-08-28 | 泰伦基国际有限公司 | 一种用于预防和治疗宫颈糜烂的方法 |
| DK3395354T3 (da) | 2015-12-18 | 2024-06-03 | Talengen Int Ltd | Plasminogen til anvendelse i behandling af diabetisk nefropati |
| CN108463240A (zh) | 2015-12-18 | 2018-08-28 | 泰伦基国际有限公司 | 一种预防或治疗糖尿病性视网膜病变的方法 |
| ES2982294T3 (es) | 2015-12-18 | 2024-10-15 | Talengen Int Ltd | Plasminógeno para su uso en el tratamiento o prevención de lesiones nerviosas por diabetes mellitus |
| TWI746581B (zh) * | 2016-12-15 | 2021-11-21 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備預防和治療脂質腎損傷之藥劑上的用途 |
| JP7213552B2 (ja) * | 2016-12-15 | 2023-01-27 | タレンゲン インターナショナル リミテッド | 肝の繊維化を予防及び治療するための方法 |
| CN108210900A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗肥胖症的药物及其用途 |
| JP7168990B2 (ja) | 2016-12-15 | 2022-11-10 | タレンゲン インターナショナル リミテッド | 肥満症を予防および治療するための方法および薬物 |
| TWI677348B (zh) | 2016-12-15 | 2019-11-21 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種改善心臟病變的方法 |
| CN110198732A (zh) * | 2016-12-15 | 2019-09-03 | 泰伦基国际有限公司 | 一种促进胰岛素受体底物-2表达的方法 |
| WO2018107686A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种治疗动脉粥样硬化及其并发症的方法 |
| JP7242057B2 (ja) * | 2016-12-15 | 2023-03-20 | タレンゲン インターナショナル リミテッド | 薬物性腎損傷を予防及び治療するための方法 |
| CA3067890A1 (en) | 2017-06-19 | 2018-12-27 | Talengen International Limited | Method for regulating and controling glp-1/glp-1r and drug |
| TWI868051B (zh) * | 2017-06-23 | 2025-01-01 | 美商波麥堤克生物治療股份有限公司 | 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療 |
| CN107496911A (zh) * | 2017-10-20 | 2017-12-22 | 滕敏子 | 一种外科手术后用于防肿胀、抗感染的愈合剂 |
| EP3883598A1 (en) * | 2018-11-19 | 2021-09-29 | Nordmark IP GmbH | Ancrod for the treatment or prophylaxis of endocarditis |
| WO2021025043A1 (ja) * | 2019-08-07 | 2021-02-11 | 学校法人東京歯科大学 | 判別方法、蛍光測定装置および検査薬 |
| CN111742887A (zh) * | 2019-12-19 | 2020-10-09 | 广西医科大学第一附属医院 | 放疗后分泌性中耳炎树鼩模型的建立方法 |
| US20230081922A1 (en) * | 2020-02-11 | 2023-03-16 | Talengen International Limited | Method and drug for treating viral pneumonia |
| WO2021180068A1 (zh) * | 2020-03-09 | 2021-09-16 | 泰伦基国际有限公司 | 一种治疗2019新型冠状病毒引发疾病的方法和药物 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
| CN115845036B (zh) * | 2023-02-20 | 2023-05-09 | 滨州益洁口腔有限公司 | 用于口腔种植体牙龈组织的蛋白酶及制备方法 |
| WO2025017211A1 (en) * | 2023-07-20 | 2025-01-23 | Katholieke Universiteit Leuven | Treatment of staphylococcal abscesses |
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| US3023143A (en) * | 1959-10-14 | 1962-02-27 | American Cyanamid Co | Process for preparing a veterinary composition |
| AT402367B (de) | 1990-10-11 | 1997-04-25 | Immuno Ag | Pharmazeutische zubereitung auf basis von lys-plasminogen |
| US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US5792835A (en) | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
| US5397578A (en) * | 1994-03-29 | 1995-03-14 | Tovarischestvo S Ogranichennoi Otvetstvennostiju "Taurus" | Method of treatment of chronic purulent inflammations of ear in children |
| US6372473B1 (en) | 1997-05-28 | 2002-04-16 | Human Genome Sciences, Inc. | Tissue plasminogen activator-like protease |
| US6420622B1 (en) * | 1997-08-01 | 2002-07-16 | 3M Innovative Properties Company | Medical article having fluid control film |
| JP2003513682A (ja) | 1998-07-24 | 2003-04-15 | ファーマカル、バイオテクノロジーズ、インコーポレーテッド | 骨組織復元システムおよび方法 |
| AU3862900A (en) | 1999-03-01 | 2000-09-21 | Uab Research Foundation | Porous tissue scaffolding materials and uses thereof |
| US20030026794A1 (en) * | 2001-07-31 | 2003-02-06 | Howard Fein | Selective enzyme treatment of skin conditions |
| US7067492B2 (en) * | 2001-09-06 | 2006-06-27 | Omnio Ab | Method of promoting healing of a tympanic membrane perforation |
| NZ533029A (en) * | 2001-11-26 | 2006-05-26 | Genentech Inc | Composition useful for removal of fibrin-bound blood clot from a catheter comprises water, a plasminogen activator and an alcohol |
| MXPA04007585A (es) * | 2002-02-06 | 2005-09-20 | N Zyme Biotec Gmbh | Metodo para la produccion de proteinas recombinantes en microorganismos. |
| CN1420126A (zh) | 2002-07-10 | 2003-05-28 | 牛勃 | 一种重组人纤溶酶原Kringle5突变体蛋白rhPK－5的制备方法 |
| ES2453496T3 (es) | 2006-08-28 | 2014-04-08 | Omnio Healer Ab | Diana farmacológica novedosa de prevención y tratamiento de enfermedad periodontal, mejora de la cicatrización de heridas periodontales y promoción de la salud oral |
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| CN101573134B (zh) | 2013-03-06 |
| CN101573134A (zh) | 2009-11-04 |
| US20130149321A1 (en) | 2013-06-13 |
| EP2056864B1 (en) | 2013-12-11 |
| JP2010502600A (ja) | 2010-01-28 |
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| US8318661B2 (en) | 2012-11-27 |
| AU2007290881A1 (en) | 2008-03-06 |
| DK2056864T3 (en) | 2014-03-10 |
| EA016250B1 (ru) | 2012-03-30 |
| US20100099600A1 (en) | 2010-04-22 |
| KR20090059122A (ko) | 2009-06-10 |
| KR101517626B1 (ko) | 2015-05-07 |
| EA200970233A1 (ru) | 2009-08-28 |
| EP2056864A2 (en) | 2009-05-13 |
| CN101563100B (zh) | 2013-08-07 |
| CA2662101C (en) | 2015-07-07 |
| WO2008026999A3 (en) | 2008-05-22 |
| MX2009002226A (es) | 2009-09-07 |
| US10729750B2 (en) | 2020-08-04 |
| ES2451015T3 (es) | 2014-03-26 |
| AU2007290881B2 (en) | 2013-03-07 |
| CA2662101A1 (en) | 2008-03-06 |
| US20160243204A1 (en) | 2016-08-25 |
| CN101563100A (zh) | 2009-10-21 |
| EP2056864A4 (en) | 2012-01-25 |
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