JP5549034B2 - Hair restorer - Google Patents

Description

  The present invention relates to a hair growth agent, and more specifically, a hair growth agent comprising a particulate material having nano-sized magnetic ultrafine particles as a core and an active ingredient coated on the magnetic ultrafine particles.

  Traditionally, alopecia is a state in which hair does not grow in spite of the fact that the person himself expects hair to grow, and is commonly referred to as baldness. Is. The method of hair removal varies depending on the age and living environment, but there are many people who suffer from thinning hair. In recent years, interest in hair has become stronger regardless of age or sex. Therefore, various hair growth agents, hair growth agents, hair nourishing agents, and hair thickeners (hereinafter collectively referred to as hair growth agents) have been developed.

  In general, hair growth repeats growth and loss according to a periodic hair cycle (growth phase-regression phase-resting phase). In this hair cycle, since a new hair follicle is formed from the rest period to the growth period, this period is considered to be the most important for hair growth. In addition, it is considered that hair papilla cells play an important role in the division of hair matrix cells during this period.

  Therefore, various hair growth agents for promoting blood circulation to hair papilla cells and promoting division of hair matrix cells have been reported so far (for example, Patent Documents 1 to 3 below).

Japanese Patent Laid-Open No. 10-194935 JP-A-8-40835 International Publication No. 2006/095778 Pamphlet

  The hair restorer disclosed in Patent Document 1 promotes blood circulation of hair papilla cells and promotes the division of hair matrix cells, such as blood circulation promoters, anti-inflammatory agents, female hormones and the like. Synthetic drug ingredients and extracts from dokudami, mugwort, aloe etc. are blended.

  The hair growth agent disclosed in Patent Document 2 is a blood circulation promoter that promotes blood circulation of hair papilla cells, such as dl-α-tocopherol acetate, pyridoxine dicaprylate, biotin, nicotinic acid, and derivatives thereof (nicotinic acid benzyl ester). Tolazoline hydrochloride, glyceryl glycyrrhetinate, assembly extract, hypericum extract, toki extract, nematode extract, capsicum tincture and the like are blended.

  The hair restorer disclosed in Patent Document 3 encloses a herbal component having a hair-growth effect in a biocompatible polymer to form particles with a nano-unit size. And the said particle | grain is penetrate | infiltrated into the scalp deep part from a pore or a scalp surface, and the hair-growth effect is aimed at by releasing the said herbal medicine component in a scalp deep part.

However, the hair-growth effect in the hair-growth agents disclosed in Patent Documents 1 and 2 is not always satisfactory. That is, in the hair restorer disclosed in Patent Documents 1 and 2, the active ingredients (blood circulation promoter, etc.) contained in the hair restorer are directly applied to the scalp,
It did not penetrate effectively into the scalp, that is, the permeability of the active ingredient was not sufficient.

  Moreover, the hair growth agent currently disclosed by the said patent document 3 is a particle diameter of 30 nanometers-300 nanometers, and releases the said herbal medicine component in the scalp deep part. However, it is generally known that only particles having a particle size of the order of 10 nanometers (several tens of nanometers) can penetrate into the scalp due to the accumulation of sebum in the scalp. In other words, the hair restorer disclosed in Patent Document 3 may not be able to effectively penetrate into the scalp with nanoparticles encapsulating herbal ingredients having a hair-growth effect, and as a result, the hair-growth effect is sufficient. Could not get to.

  Therefore, it has been desired to develop a hair-restoring agent having a higher effect of penetrating an active ingredient having a hair-growth effect into the scalp and a sustained release effect of the active ingredient inside the scalp.

  The present invention has been made in view of the above circumstances, and the object of the present invention is to provide a hair restorer having a higher effect of penetrating an active ingredient having a hair-growth effect into the scalp and a sustained release effect inside the scalp. There is to do.

In order to achieve the above object, the present invention has the following features. That is, the first invention is a hair restorer, a magnetic ultrafine particle serving as a nucleus, the surface of which is coated with an inorganic oxide film, and a hydrophilic film layer formed on the surface of the magnetic ultrafine particle, The layer of active ingredient for hair growth formed on the layer of hydrophilic film and the layer of water-soluble polymer formed on the layer of active ingredient for hair growth are multilayer coated in this order, and the hydrophilic film consists of lecithin. , water-soluble polymer is characterized by LIPIDURE-NR der Rukoto.

According to a second invention, in the first invention, the magnetic ultrafine particles are composed of magnetite ultrafine particles.

  A third invention is characterized in that, in the first or second invention, the active ingredient for hair growth is at least one selected from the group consisting of tocopherol acetate, carrot extract, cherry extract, and loquat leaf extract. .

  The hair-growth agent according to the present invention can obtain an excellent hair growth effect by solving the problem that the active ingredient does not effectively penetrate into the scalp, that is, the penetration effect of the active ingredient is not sufficient.

  Further, when magnetite ultrafine particles are used as the ultrafine particles, the hair restorer according to the present invention can be produced at low cost.

Further, since there is a hydrophilic film layer made of lecithin between the surface of the ultrafine particles and the layer of the hair-growth active ingredient, the layer of hair-growth active ingredient easily adheres to the magnetic ultrafine particles. Furthermore, since the layer of the water-soluble polymer composed of LIPIDURE-NR is further formed on the layer of the hair-growth active ingredient, the layer of the hair-growth active ingredient can be stabilized.

The figure which showed the preparation procedures of the hair restorer which concerns on this invention The figure which showed a mode that the layer was formed in the surface of a magnetic body ultrafine particle at the process 5 and the process 6 of FIG. An example of the back of a mouse The figure which shows the result of having observed the back hair which grew on the back part with the electron microscope (Example) The figure which shows the result of having observed the back hair which grew on the back part with the electron microscope (comparative example 1)

  As a result of intensive studies, the present applicant has focused on nano-sized magnetic ultrafine particles and succeeded in coating the magnetic ultrafine particles with an active ingredient having a hair-growing effect. The magnetic ultrafine particles coated with an active ingredient having a hair-growth effect effectively penetrate into the scalp, release the active ingredient having the hair-growth effect, promote blood circulation of hair papilla cells, and divide hair matrix cells. It was found that high hair growth effect can be obtained as a result. In addition, in this description, nano size means several nanometers-several tens of nanometers.

  That is, the hair-restoring agent according to the present invention is a hair-restoring agent containing a particulate substance having nano-sized magnetic ultrafine particles as a core and the magnetic ultrafine particles coated with an active ingredient.

  In the following description, an active ingredient having a hair-growth effect is simply referred to as an active ingredient, the nano-sized magnetic ultrafine particles are simply referred to as magnetic ultrafine particles, and magnetic ultrafine particles coated with the active ingredients are referred to as magnetic ultrafine particles. It is simply called particulate matter.

  Hereinafter, the present invention will be described in detail, but these descriptions do not limit the present invention. Accordingly, it goes without saying that various improvements and modifications can be made without departing from the scope of the present invention.

<Production of hair restorer>
First, the production procedure of the hair restorer according to the present invention will be described.

  Hereinafter, the procedure for producing the hair restorer according to the present invention will be described with reference to the drawings. FIG. 1 is a diagram showing a procedure for producing a hair restorer according to the present invention.

  First, a solution A was prepared by adding glycyrrhetinic acid or a salt thereof and a surfactant cooled to a temperature of 0 ° C. to 5 ° C. and stirring for about 5 minutes in an appropriately sized container (FIG. 1). Step 1).

  Specific examples of the glycyrrhetinic acids or salts thereof include glycyrrhizic acid, sodium glycyrrhizinate, dipotassium glycyrrhizinate, ammonium glycyrrhizinate, and stearyl glycyrrhizinate.

  On the other hand, an aqueous solution in which one type, preferably a plurality of types of active ingredients, was added to an appropriately sized container was prepared. Specifically, the aqueous solution was sufficiently stirred at room temperature (25 ° C. to 30 ° C.) for about 10 minutes to prepare Solution B (Step 2 in FIG. 1).

  And the solution A prepared at the said process 1 and the solution B prepared at the said process 2 were mixed in arbitrary ratios, and it was set as the mixed solution. And the said mixed solution was fully stirred for about 10 minutes at normal temperature (25 degreeC-30 degreeC) (process 3 of FIG. 1).

Thereafter, magnetic ultrafine particles were added to the mixed solution prepared in the above step 3 to obtain a mixed solution containing magnetic ultrafine particles. The magnetic ultrafine particle-containing mixed solution was sufficiently stirred at room temperature for about 10 minutes (step 4 in FIG. 1).

  On the other hand, ion-exchanged water is added to an appropriately sized container, and then the ion-exchange is performed so that LIPIDURE (registered trademark) -NR (water-soluble polymer manufactured by NOF Corporation) is 10% by mass to 25% by mass. Dissolved in water. And the solution C was prepared by fully stirring the said solution (process 5 of FIG. 1).

  Finally, while maintaining the magnetic ultrafine particle-containing mixed solution prepared in Step 4 at about 50 ° C. to 60 ° C., a predetermined amount of the solution C is mixed at an arbitrary interval with the magnetic ultrafine particle-containing mixed solution. And stirred for about 30 minutes (step 6 in FIG. 1).

  Through the above-described steps, the hair-growth agent according to the present invention, that is, the particulate substance in which the nano-sized magnetic ultrafine particles are used as the core and the magnetic ultrafine particles are coated with the active ingredient is produced. The manner in which a layer is formed on the surface of the magnetic ultrafine particles in Step 4 and Step 6 of FIG. 1 will be described below with reference to the drawings.

  FIG. 2 is a diagram showing a state in which a layer is formed on the surface of the magnetic ultrafine particles in Step 4 and Step 6 of FIG.

  In step 4 of FIG. 1, first, a hydrophilic film 2 is formed on the surface of the magnetic ultrafine particles 1 (FIGS. 2A to 2B). Thereafter, the active ingredient film 3 is coated on the surface of the hydrophilic film 2 (FIGS. 2B to 2C). The active ingredient film 3 corresponds to an example of a first layer recited in the claims.

  Further, in step 6 of FIG. 1, the solution C is dropped to form a composite ultrafine particle (water-soluble polymer) film 4 so as to cover the active ingredient film 3. In addition, the hair restorer according to the present invention produced through the above steps, that is, the average particle diameter of the particulate matter having nano-sized magnetic ultrafine particles as the core and the magnetic ultrafine particles coated with the active ingredient Is about 10 nanometers to several tens of nanometers.

  In Step 6 of FIG. 1, the solution C is dropped because the surface of the hydrophilic film 2 is coated by coating the surface of the active ingredient film 3 with the composite ultrafine particle (water-soluble polymer) film 4. This is because the film 3 of the active ingredient coated on is stabilized.

  Here, the magnetic ultrafine particles, the surfactant, and the active ingredient used in each step of FIG. 1 will be described in detail.

(Ultrafine magnetic material)
The magnetic ultrafine particles are magnetic ultrafine particles in which the surface of the fine particles is coated with an inorganic oxide film. The magnetic ultrafine particles are produced as follows. First, an aqueous solution of mixed iron chlorides (Fe, Co, Ni, Mn, Cu, Zn, etc.) is stirred under specified conditions, suction filtered using a suction funnel, washed several times with pure water and sodium And magnetite ultrafine particles are prepared by removing chlorine ions. An appropriate amount of a metal salt (silicate, ethyl ethyl salt of titanium, etc.) is added to the solution in which the magnetite ultrafine particles are dispersed, and the mixture is stirred under predetermined conditions, whereby an inorganic oxide film is formed on the surface of the magnetite ultrafine particles. Coated magnetic ultrafine particles can be obtained. The fine particles may be magnetic nanoparticles having magnetism, for example, NiCo nanoparticles and ND ₄ MnF ₃ nanoparticles.

(Surfactant)
The surfactant used in Step 1 in FIG. 1 is specifically a natural surfactant, and more specifically egg yolk lecithin, milk-derived lecithin, and soybean-derived lecithin. The surfactant has both a hydrophilic group (carboxy group, sulfone group, ammonium group, hydroxyl group, etc.) and a hydrophobic group (sometimes called a lipophilic group; long chain hydrocarbon group, etc.). It may be an amphiphilic natural surfactant and is not limited to egg yolk lecithin, milk-derived lecithin, or soybean-derived lecithin.

(Active ingredient)
The active ingredient blended in step 2 in FIG. 1 is an ingredient called a blood circulation promoter or a cell activator. Specifically, the active ingredients used in step 2 of FIG. 1 are tocopherol acetate, carrot extract, cherry extract, and loquat leaf extract. More specifically, in the solution B, the tocopherol acetate is about 0.1% by mass to 5% by mass, the carrot extract is about 0.5% by mass to about 15% by mass, the cherry extract is about 15% by mass to about 60% by mass, The loquat leaf extract contains about 0.5% by mass to 18% by mass, respectively.

  In addition to the above active ingredients, an ingredient having an anti-inflammatory effect, that is, an anti-inflammatory agent, may be preferably blended in an amount of about 0.01% to 5% by weight. Examples of the anti-inflammatory agent include glycyrrhetinic acid and derivatives thereof, licorice extract, diphenhydramine hydrochloride, sicon extract, age extract, hydrocortisone acetate, and the like.

  In addition, the active ingredient which can be mix | blended by the process 2 of FIG. 1 is not restricted to a tocopherol, a carrot extract, a cherry tree extract, and a loquat leaf extract, It promotes blood circulation or activates a cell. Anything is possible.

  For example, vitamins and salts thereof, amino acids and salts thereof, panthenol derivatives, carpronium chloride, oryzanol, camphor, tocopherol, linolenic acid ester, nicotinic acid, methyl nicotinate, benzyl nicotinate, butoxyethyl nicotinate, nicotinic acid ester , Tocopherol nicotinic acid, tocopherol nicotinic acid ester, inositol hexanicotinic acid ester, tocopherol linolenic acid ester, nonanoic acid vanillylamide, tocopherol succinate, dextran sulfate sodium, acetylcholine, assembly extract, red pepper tincture, cantalis tincture, ginger tincture, ginseng , Chixetsu carrot, cephalanthin, cerretin, nicorandil, pinacidil, garlic extract, tow Extract, gentian extract, iodized garlic extract, licorice, minoxidil, nematode, chixet carrot, ginger, diou, aloe, spironolactone, hinokitiol, hinokiol, Korean carrot, peach seed, white drug, antifungal, prosthetic fat, yellow Camellia, safflower, photosensitive element 101, photosensitive element 201, photosensitive element 301, photosensitive element 401, and the like can also be blended in step 2 of FIG.

  In addition, the active ingredient which can be mix | blended at the process 2 of FIG. 1 will not be limited to each component mentioned above, if it is a various component which has a hair growth, hair growth, hair nourishing, and a hair thickening effect. In other words, what has been described above is merely an example of active ingredients that may be used in step 2 of FIG. Therefore, as long as the safety to the living body is not impaired, bactericides, anti-androgen hormone agents, sebum secretion inhibitors, immunosuppressants, antihistamines, local stimulants, keratin softeners, anti-apoptotic agents, etc. Any kind of drug having a hair nourishing and hair thickening effect can also be blended as an active ingredient in step 2 of FIG.

Moreover, in the actual use scene of the hair restorer according to the present invention, a dosage form (solution, emulsion, cream, gel, tic, shampoo, spray, Mousse, pack, etc.). Therefore, as long as the effects of the present invention are not impaired, water, lower alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), Monohydric alcohol (ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, isoprene glycol), acetonitrile, esters (ethyl acetate, butyl acetate, etc.), carbonized Hydrogens (hexane, heptane, liquid paraffin, etc.), ethers (ethyl ether, propyl ether, etc.), fragrances, preservatives, antioxidants, ultraviolet absorbers, dyes, fragrances and the like may be appropriately blended.

  Next, the present invention will be described in more detail based on examples and comparative examples.

<Evaluation of hair growth>
The back hair of an 8 week old C3H mouse (male) acclimated for 2 weeks was shaved with an electric clipper, and the back hair was further shaved with an electric shaver after 1 day, and the skin was exposed. The hair was evaluated.

Example: 0.1 ml of hair restorer prepared by the method described in FIG. 1 was applied to the exposed mouse skin once a day.
Comparative Example 1: 0.1 ml of a plant extract (mixed solution of tocopherol acetate, carrot extract, cherry extract and loquat leaf extract) was applied to the exposed mouse skin once a day. That is, 0.1 ml of the solution B prepared in Step 2 of FIG. 1 was applied once a day.
Comparative Example 2: 0.1 ml of distilled water was applied to the exposed mouse skin once a day.

  For each of Example, Comparative Example 1 and Comparative Example 2, a set of 5 mice was taken, and the back of the mouse was photographed before hair growth evaluation, 14 days after the start of evaluation, 30 days after the start of evaluation, and 60 days after the start of evaluation. .

  FIG. 3 shows an example of a back photograph of a mouse before hair growth evaluation, 14 days after the start of evaluation, 30 days after the start of evaluation, and 60 days after the start of evaluation for each of Example, Comparative Example 1 and Comparative Example 2. First, in comparison with Comparative Example 1 and Comparative Example 2 in FIG. 3, in the case of applying a plant extract compared to the case of applying only distilled water, the effect of hair growth is slightly greater when applying the plant extract. Obtained. However, as is clear from the comparison between the example of FIG. 3 and Comparative Example 1, when the hair restorer according to the present invention is used, an excellent hair restoring effect can be obtained as compared with the case where the plant extract is simply applied. did it. That is, Comparative Example 1 is an example assuming a conventional hair restorer, which is merely applied with a plant extract (blood circulation promoter that promotes blood circulation of hair papilla cells), and the hair restorer according to the present invention. Compared with, the effect of penetration of active ingredients into the scalp is small. In other words, in the hair restorer according to the present invention, the active ingredient effectively penetrates into the scalp, the active ingredient acts locally within the scalp, promotes blood circulation to the hair papilla cells, and the hair matrix cells divide. It is thought that this is because of the promotion.

<Observation of hair bulb>
Next, the back hairs that grew on the back of the mouse according to the example (after 30 days) and the mouse according to Comparative Example 1 (after 30 days) were observed with an electron microscope. The results are shown in FIG. 4 and FIG. 4B is an enlarged view of a portion surrounded by a solid line in FIG. 4A. Similarly, FIG. 5B is an enlarged view of a portion surrounded by a solid line in FIG.

As is clear from a comparison between FIG. 4B and FIG. 5B, the hair of the back hair that grew in the mouse according to the example was the back hair that had been haired in the mouse according to Comparative Example 1. The bulge was larger than the hairballs. Also according to these results, the hair restorer according to the present invention effectively penetrates into the scalp, the active ingredient acts locally in the scalp, promotes blood circulation to hair papillae cells, and hair matrix cells This is thought to be due to the promotion of division.

  From the above results, by coating the magnetic ultrafine particles with an active ingredient having a hair-growth effect, the effect of penetration of the active ingredient into the scalp and the sustained release effect of the active ingredient are applied directly to the skin. It was shown to be higher. That is, the hair restorer according to the present invention obtains an excellent hair growth and hair growth effect by solving the problem that the active ingredient does not effectively penetrate into the scalp, that is, the penetration effect of the active ingredient is not sufficient. I was able to.

  The hair growth agent according to the present invention promotes blood circulation to hair papilla cells, promotes hair matrix cell division, and promotes hair growth, hair growth, hair growth, hair growth, hair growth agent, hair growth agent, hair growth agent, hair increase. It is useful as an agent.

DESCRIPTION OF SYMBOLS 1 ... Magnetic ultrafine particle 2 ... Hydrophilic film 3 ... Active ingredient film 4 ... Composite ultrafine particle (water-soluble polymer) film

Claims (3)

A hair restorer,
Magnetic ultrafine particles that become the core, coated with an inorganic oxide film on the surface,
A hydrophilic film layer formed so as to cover the surface of the magnetic ultrafine particles;
A layer of a hair-growth active ingredient formed so as to cover the layer of the hydrophilic film;
The layer of the water-soluble polymer formed so as to cover the layer of the hair-growth active ingredient is multilayer coated in this order ,
The hydrophilic membrane is made of lecithin,
The water-soluble polymer is characterized by LIPIDURE (TM) -NR der Rukoto, hair tonic.   The hair restoring agent according to claim 1, wherein the magnetic ultrafine particles are composed of magnetite ultrafine particles.   The hair restoring agent according to claim 1 or 2, wherein the hair restoring active ingredient is at least one selected from the group consisting of tocopherol acetate, carrot extract, cherry extract, and loquat leaf extract.

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