JP5548875B2 - 抗真菌剤 - Google Patents
抗真菌剤 Download PDFInfo
- Publication number
- JP5548875B2 JP5548875B2 JP2011522975A JP2011522975A JP5548875B2 JP 5548875 B2 JP5548875 B2 JP 5548875B2 JP 2011522975 A JP2011522975 A JP 2011522975A JP 2011522975 A JP2011522975 A JP 2011522975A JP 5548875 B2 JP5548875 B2 JP 5548875B2
- Authority
- JP
- Japan
- Prior art keywords
- pyran
- dimethylpropyl
- phenanthro
- propano
- dodecahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(C)[C@@](C)[C@@](C)(CC[C@@](*)([C@@]1(C)C(C=C2[C@](C[C@]3*)(*(C)O*[C@]4(C)[C@]3O*)[C@]4(CC3)I)=*)[C@]23I=C)[C@@]1C(*)=O Chemical compound CC(C)[C@@](C)[C@@](C)(CC[C@@](*)([C@@]1(C)C(C=C2[C@](C[C@]3*)(*(C)O*[C@]4(C)[C@]3O*)[C@]4(CC3)I)=*)[C@]23I=C)[C@@]1C(*)=O 0.000 description 9
- SGKWTTFCOUQDER-UHFFFAOYSA-N C[n]1ncnc1[Re] Chemical compound C[n]1ncnc1[Re] SGKWTTFCOUQDER-UHFFFAOYSA-N 0.000 description 2
- VTUUHTGTUIJRSA-LLVKDONJSA-N CC(C)(C)OC(N1[C@@](C)(CO)CCC1)=O Chemical compound CC(C)(C)OC(N1[C@@](C)(CO)CCC1)=O VTUUHTGTUIJRSA-LLVKDONJSA-N 0.000 description 1
- REMIEVWXRMFNTF-KUQLLVEASA-N CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1OC)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)(C)C)NC)[C@H]3C(O)=O Chemical compound CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1OC)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)(C)C)NC)[C@H]3C(O)=O REMIEVWXRMFNTF-KUQLLVEASA-N 0.000 description 1
- UWBUBNWCTMMVCA-GOLKHQQMSA-N CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1OC)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)C)N)[C@H]3C(O)=O Chemical compound CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1OC)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)C)N)[C@H]3C(O)=O UWBUBNWCTMMVCA-GOLKHQQMSA-N 0.000 description 1
- UUICCXLHVHRHNH-POWZRTNLSA-N CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1[n]4ncnc4)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)C)N)[C@H]3C(O)=O Chemical compound CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1[n]4ncnc4)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)C)N)[C@H]3C(O)=O UUICCXLHVHRHNH-POWZRTNLSA-N 0.000 description 1
- FRJLPXJOUOWWIC-UHWJHWJMSA-N CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1[n]4ncnc4C(NC)=O)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)(C)C)NC)[C@H]3C(CO)=O Chemical compound CC(C)[C@@H](C)[C@@](C)(CC[C@](C)([C@H]1CC2)[C@@]3(C)CC=C1[C@](C[C@H]1[n]4ncnc4C(NC)=O)([C@H](C)OC4)[C@@H]2[C@]4(C)[C@H]1OC[C@@](C)(C(C)(C)C)NC)[C@H]3C(CO)=O FRJLPXJOUOWWIC-UHWJHWJMSA-N 0.000 description 1
- NHTKJBCNJJVEAN-YRNVUSSQSA-N CN(C)/C=N/C(c1ccncc1)=O Chemical compound CN(C)/C=N/C(c1ccncc1)=O NHTKJBCNJJVEAN-YRNVUSSQSA-N 0.000 description 1
- VFQXVTODMYMSMJ-UHFFFAOYSA-N NC(c1ccncc1)=O Chemical compound NC(c1ccncc1)=O VFQXVTODMYMSMJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dentistry (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13610108P | 2008-08-12 | 2008-08-12 | |
| US61/136,101 | 2008-08-12 | ||
| PCT/US2009/004560 WO2010019204A1 (en) | 2008-08-12 | 2009-08-07 | Antifungal agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530593A JP2011530593A (ja) | 2011-12-22 |
| JP2011530593A5 JP2011530593A5 (enExample) | 2012-12-20 |
| JP5548875B2 true JP5548875B2 (ja) | 2014-07-16 |
Family
ID=41669133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522975A Active JP5548875B2 (ja) | 2008-08-12 | 2009-08-07 | 抗真菌剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8188085B2 (enExample) |
| EP (1) | EP2326181A4 (enExample) |
| JP (1) | JP5548875B2 (enExample) |
| CN (2) | CN104877001B (enExample) |
| AU (1) | AU2009282474B2 (enExample) |
| CA (1) | CA2731941C (enExample) |
| WO (1) | WO2010019204A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103180301B (zh) | 2010-08-26 | 2015-11-25 | 拜耳知识产权有限责任公司 | 5-碘代三唑衍生物 |
| DK3247711T3 (da) | 2015-01-19 | 2022-05-09 | Scynexis Inc | Hidtil ukendte salte og polymorfer af scy-078 |
| KR20240110109A (ko) | 2017-04-10 | 2024-07-12 | 싸이넥시스, 인크. | 조합하여 사용되는 항진균제 |
| WO2019028034A1 (en) | 2017-08-04 | 2019-02-07 | Scynexis, Inc. | Antifungal agents with enhanced activity in acidic ph |
| BR112020013448A2 (pt) * | 2018-01-02 | 2020-12-01 | Scynexis, Inc. | composição injetável, métodos para tratar uma infecção fúngica e para preparar uma composição injetável. |
| US12053486B2 (en) | 2018-03-09 | 2024-08-06 | Therazure LLC | Compositions for the treatment of infections in feet |
| WO2020160316A1 (en) | 2019-01-30 | 2020-08-06 | Scynexis, Inc. | Triterpenoid antifungals for the treatment of fungal osteo-articular infections |
| JP7581219B2 (ja) | 2019-02-27 | 2024-11-12 | サイネクシス，インコーポレーテッド | ニューモシスチス属種（Ｐｎｅｕｍｏｃｙｓｔｉｓ ｓｐｐ．）肺炎を治療又は予防するためのトリテルペノイド系抗真菌薬 |
| WO2020232037A1 (en) | 2019-05-16 | 2020-11-19 | Scynexis, Inc. | Antifungal agents, like ibrexafungerp for candida auris decolonization |
| WO2021092349A1 (en) | 2019-11-08 | 2021-05-14 | Scynexis, Inc. | Lipid-based formulations of scy-078 salts |
| US20220409651A1 (en) * | 2019-11-15 | 2022-12-29 | The Research Foundation For The State University Of New York | Anti-fungal compositions and methods for using same |
| CN118724779B (zh) * | 2024-06-05 | 2025-09-23 | 浙江瑞博制药有限公司 | 一种醛基化合物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3834062B2 (ja) | 1996-01-31 | 2006-10-18 | メルク エンド カンパニー インコーポレーテッド | 抗真菌剤 |
| US5756472A (en) | 1996-01-31 | 1998-05-26 | Merck & Co., Inc. | Antifungal agent obtained from hormonema |
| HUP0303249A3 (en) * | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| FR2824324B1 (fr) * | 2001-05-04 | 2003-08-15 | Aventis Pharma Sa | Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques |
| AU2002253456A1 (en) | 2002-04-17 | 2003-10-27 | Ranbaxy Laboratories Limited | Azole derivatives as antifungal agents |
| ES2402659T3 (es) * | 2006-04-03 | 2013-05-07 | Merck Sharp & Dohme Corp. | Derivados de enfumafungina como agentes antifúngicos |
-
2009
- 2009-08-07 US US12/461,318 patent/US8188085B2/en active Active
- 2009-08-07 AU AU2009282474A patent/AU2009282474B2/en active Active
- 2009-08-07 CA CA2731941A patent/CA2731941C/en active Active
- 2009-08-07 WO PCT/US2009/004560 patent/WO2010019204A1/en not_active Ceased
- 2009-08-07 JP JP2011522975A patent/JP5548875B2/ja active Active
- 2009-08-07 EP EP09806945A patent/EP2326181A4/en not_active Withdrawn
- 2009-08-07 CN CN201510182454.XA patent/CN104877001B/zh active Active
- 2009-08-07 CN CN200980140485.1A patent/CN102176827B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009282474B2 (en) | 2014-03-20 |
| WO2010019204A1 (en) | 2010-02-18 |
| CA2731941A1 (en) | 2010-02-18 |
| CA2731941C (en) | 2016-09-27 |
| EP2326181A4 (en) | 2012-11-28 |
| CN102176827A (zh) | 2011-09-07 |
| CN102176827B (zh) | 2015-05-20 |
| EP2326181A1 (en) | 2011-06-01 |
| US8188085B2 (en) | 2012-05-29 |
| HK1214271A1 (zh) | 2016-07-22 |
| CN104877001A (zh) | 2015-09-02 |
| AU2009282474A1 (en) | 2010-02-18 |
| US20100113439A1 (en) | 2010-05-06 |
| JP2011530593A (ja) | 2011-12-22 |
| CN104877001B (zh) | 2020-07-03 |
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| Publication | Publication Date | Title |
|---|---|---|
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| EP2326172B1 (en) | Antifungal agents | |
| JP5548876B2 (ja) | 抗真菌剤 | |
| KR20190133251A (ko) | 조합하여 사용되는 항진균제 | |
| JP7562542B2 (ja) | 真菌性骨－関節感染症を治療するためのトリテルペノイド系抗真菌薬 | |
| HK1214271B (zh) | 抗真菌製劑 | |
| HK1158017B (en) | Antifungal agents | |
| HK40022879B (en) | Antifungal agents used in combination | |
| HK40022879A (en) | Antifungal agents used in combination |
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