AU2009282474B2 - Antifungal agents - Google Patents

Antifungal agents Download PDF

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Publication number
AU2009282474B2
AU2009282474B2 AU2009282474A AU2009282474A AU2009282474B2 AU 2009282474 B2 AU2009282474 B2 AU 2009282474B2 AU 2009282474 A AU2009282474 A AU 2009282474A AU 2009282474 A AU2009282474 A AU 2009282474A AU 2009282474 B2 AU2009282474 B2 AU 2009282474B2
Authority
AU
Australia
Prior art keywords
propano
dodecahydro
tetramethyl
phenanthro
pyran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2009282474A
Other languages
English (en)
Other versions
AU2009282474A1 (en
Inventor
James Apgar
Mark L. Greenlee
Brian Haid Heasley
Ahmed Mamai
Dongfang Meng
Kingsley Nelson
Gregory James Pacofsky
Dann L. Parker Jr.
Donald Sperbeck
Kenneth James Wildonger
Robert Wilkening
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scynexis Inc
Original Assignee
SCYNEXIS Inc
Scynexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009282474(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by SCYNEXIS Inc, Scynexis Inc filed Critical SCYNEXIS Inc
Publication of AU2009282474A1 publication Critical patent/AU2009282474A1/en
Assigned to SCYNEXIS, INC. reassignment SCYNEXIS, INC. Request for Assignment Assignors: MERCK SHARP & DOHME CORP., SCYNEXIS, INC.
Application granted granted Critical
Publication of AU2009282474B2 publication Critical patent/AU2009282474B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2009282474A 2008-08-12 2009-08-07 Antifungal agents Active AU2009282474B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13610108P 2008-08-12 2008-08-12
US61/136,101 2008-08-12
PCT/US2009/004560 WO2010019204A1 (en) 2008-08-12 2009-08-07 Antifungal agents

Publications (2)

Publication Number Publication Date
AU2009282474A1 AU2009282474A1 (en) 2010-02-18
AU2009282474B2 true AU2009282474B2 (en) 2014-03-20

Family

ID=41669133

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009282474A Active AU2009282474B2 (en) 2008-08-12 2009-08-07 Antifungal agents

Country Status (7)

Country Link
US (1) US8188085B2 (enExample)
EP (1) EP2326181A4 (enExample)
JP (1) JP5548875B2 (enExample)
CN (2) CN102176827B (enExample)
AU (1) AU2009282474B2 (enExample)
CA (1) CA2731941C (enExample)
WO (1) WO2010019204A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201390241A1 (ru) 2010-08-26 2013-07-30 Байер Интеллектуэль Проперти Гмбх Производные 5-йодтриазола
US10174074B2 (en) 2015-01-19 2019-01-08 Scynexis, Inc. Salts and polymorphs of SCY-078
MX2019012116A (es) 2017-04-10 2019-11-21 Scynexis Inc Agentes antifungicos utilizados en combinacion.
DK3661503T3 (da) 2017-08-04 2022-12-12 Scynexis Inc Svampedræbende midler med forbedret aktivitet i surt PH
MX2020006992A (es) 2018-01-02 2020-09-09 Scynexis Inc Composiciones inyectables de antifungicos triterpenoides encapsulados en liposomas.
US12053486B2 (en) 2018-03-09 2024-08-06 Therazure LLC Compositions for the treatment of infections in feet
EA202192107A1 (ru) * 2019-01-30 2021-10-21 Сайнексис, Инк. Тритерпеноидные фунгициды для лечения грибковых костно-суставных инфекций
JP7581219B2 (ja) 2019-02-27 2024-11-12 サイネクシス，インコーポレーテッド ニューモシスチス属種（Ｐｎｅｕｍｏｃｙｓｔｉｓ ｓｐｐ．）肺炎を治療又は予防するためのトリテルペノイド系抗真菌薬
CN113905733A (zh) 2019-05-16 2022-01-07 西尼克斯公司 用于消除耳念珠菌移生的如依贝瑞芬赫普的抗真菌剂
WO2021092349A1 (en) 2019-11-08 2021-05-14 Scynexis, Inc. Lipid-based formulations of scy-078 salts
WO2021097411A1 (en) * 2019-11-15 2021-05-20 The Research Foundation For The State University Of New York Anti-fungal compositions and methods for using same
CN118724779B (zh) * 2024-06-05 2025-09-23 浙江瑞博制药有限公司 一种醛基化合物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7230023B2 (en) * 2001-02-22 2007-06-12 Sankyo Company, Limited Water-soluble triazole fungicide
US20080009504A1 (en) * 2006-04-03 2008-01-10 Balkovec James M Antifungal agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) * 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
AU703925B2 (en) 1996-01-31 1999-04-01 Scynexis, Inc. Antifungal agent
FR2824324B1 (fr) * 2001-05-04 2003-08-15 Aventis Pharma Sa Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques
EP1497281A4 (en) 2002-04-17 2005-11-02 Ranbaxy Lab Ltd AZOLE DERIVATIVES AS ANTIFUNGAL AGENTS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7230023B2 (en) * 2001-02-22 2007-06-12 Sankyo Company, Limited Water-soluble triazole fungicide
US20080009504A1 (en) * 2006-04-03 2008-01-10 Balkovec James M Antifungal agents

Also Published As

Publication number Publication date
HK1214271A1 (zh) 2016-07-22
EP2326181A4 (en) 2012-11-28
CA2731941C (en) 2016-09-27
CN104877001B (zh) 2020-07-03
US8188085B2 (en) 2012-05-29
WO2010019204A1 (en) 2010-02-18
EP2326181A1 (en) 2011-06-01
AU2009282474A1 (en) 2010-02-18
CN104877001A (zh) 2015-09-02
US20100113439A1 (en) 2010-05-06
CA2731941A1 (en) 2010-02-18
CN102176827A (zh) 2011-09-07
JP5548875B2 (ja) 2014-07-16
JP2011530593A (ja) 2011-12-22
CN102176827B (zh) 2015-05-20

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ GREENLEE, MARK L.; WILKENING, ROBERT; APGAR, JAMES; SPERBECK, DONALD; WILDONGER, KENNETH JAMES; MENG, DONGFANG; PARKER JR., DAN L.; PACOFSKY, GREGORY JAMES; HEASLEY, BRIAN HAID; MAMAI, AHMED AND NELSON, KINGSLEY

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ GREENLEE, MARK L.; WILKENING, ROBERT; APGAR, JAMES; SPERBECK, DONALD; WILDONGER, KENNETH JAMES; MENG, DONGFANG; PARKER, DANN L., JR.; PACOFSKY, GREGORY JAMES; HEASLEY, BRIAN HAID; MAMAI, AHMED AND NELSON, KINGSLEY

PC1 Assignment before grant (sect. 113)

Owner name: SCYNEXIS, INC.

Free format text: FORMER APPLICANT(S): SCYNEXIS, INC.; MERCK SHARP & DOHME CORP.

FGA Letters patent sealed or granted (standard patent)