CA2731941C - Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase - Google Patents

Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase Download PDF

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Publication number
CA2731941C
CA2731941C CA2731941A CA2731941A CA2731941C CA 2731941 C CA2731941 C CA 2731941C CA 2731941 A CA2731941 A CA 2731941A CA 2731941 A CA2731941 A CA 2731941A CA 2731941 C CA2731941 C CA 2731941C
Authority
CA
Canada
Prior art keywords
pyran
propano
phenanthro
dodecahydro
tetramethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2731941A
Other languages
English (en)
French (fr)
Other versions
CA2731941A1 (en
Inventor
Mark L. Greenlee
Robert Wilkening
James Apgar
Donald Sperbeck
Kenneth James Wildonger
Dongfang Meng
Dann L. Parker
Gregory James Pacofsky
Brian Haid Heasley
Ahmed Mamai
Kingsley Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scynexis Inc
Original Assignee
Scynexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2731941(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scynexis Inc filed Critical Scynexis Inc
Publication of CA2731941A1 publication Critical patent/CA2731941A1/en
Application granted granted Critical
Publication of CA2731941C publication Critical patent/CA2731941C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2731941A 2008-08-12 2009-08-07 Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase Active CA2731941C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13610108P 2008-08-12 2008-08-12
US61/136,101 2008-08-12
PCT/US2009/004560 WO2010019204A1 (en) 2008-08-12 2009-08-07 Antifungal agents

Publications (2)

Publication Number Publication Date
CA2731941A1 CA2731941A1 (en) 2010-02-18
CA2731941C true CA2731941C (en) 2016-09-27

Family

ID=41669133

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2731941A Active CA2731941C (en) 2008-08-12 2009-08-07 Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase

Country Status (7)

Country Link
US (1) US8188085B2 (enExample)
EP (1) EP2326181A4 (enExample)
JP (1) JP5548875B2 (enExample)
CN (2) CN104877001B (enExample)
AU (1) AU2009282474B2 (enExample)
CA (1) CA2731941C (enExample)
WO (1) WO2010019204A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103180301B (zh) 2010-08-26 2015-11-25 拜耳知识产权有限责任公司 5-碘代三唑衍生物
DK3247711T3 (da) 2015-01-19 2022-05-09 Scynexis Inc Hidtil ukendte salte og polymorfer af scy-078
KR20240110109A (ko) 2017-04-10 2024-07-12 싸이넥시스, 인크. 조합하여 사용되는 항진균제
WO2019028034A1 (en) 2017-08-04 2019-02-07 Scynexis, Inc. Antifungal agents with enhanced activity in acidic ph
BR112020013448A2 (pt) * 2018-01-02 2020-12-01 Scynexis, Inc. composição injetável, métodos para tratar uma infecção fúngica e para preparar uma composição injetável.
US12053486B2 (en) 2018-03-09 2024-08-06 Therazure LLC Compositions for the treatment of infections in feet
WO2020160316A1 (en) 2019-01-30 2020-08-06 Scynexis, Inc. Triterpenoid antifungals for the treatment of fungal osteo-articular infections
JP7581219B2 (ja) 2019-02-27 2024-11-12 サイネクシス，インコーポレーテッド ニューモシスチス属種（Ｐｎｅｕｍｏｃｙｓｔｉｓ ｓｐｐ．）肺炎を治療又は予防するためのトリテルペノイド系抗真菌薬
WO2020232037A1 (en) 2019-05-16 2020-11-19 Scynexis, Inc. Antifungal agents, like ibrexafungerp for candida auris decolonization
WO2021092349A1 (en) 2019-11-08 2021-05-14 Scynexis, Inc. Lipid-based formulations of scy-078 salts
US20220409651A1 (en) * 2019-11-15 2022-12-29 The Research Foundation For The State University Of New York Anti-fungal compositions and methods for using same
CN118724779B (zh) * 2024-06-05 2025-09-23 浙江瑞博制药有限公司 一种醛基化合物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3834062B2 (ja) 1996-01-31 2006-10-18 メルク エンド カンパニー インコーポレーテッド 抗真菌剤
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
HUP0303249A3 (en) * 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
FR2824324B1 (fr) * 2001-05-04 2003-08-15 Aventis Pharma Sa Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques
AU2002253456A1 (en) 2002-04-17 2003-10-27 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
ES2402659T3 (es) * 2006-04-03 2013-05-07 Merck Sharp & Dohme Corp. Derivados de enfumafungina como agentes antifúngicos

Also Published As

Publication number Publication date
AU2009282474B2 (en) 2014-03-20
WO2010019204A1 (en) 2010-02-18
CA2731941A1 (en) 2010-02-18
EP2326181A4 (en) 2012-11-28
CN102176827A (zh) 2011-09-07
CN102176827B (zh) 2015-05-20
EP2326181A1 (en) 2011-06-01
US8188085B2 (en) 2012-05-29
HK1214271A1 (zh) 2016-07-22
JP5548875B2 (ja) 2014-07-16
CN104877001A (zh) 2015-09-02
AU2009282474A1 (en) 2010-02-18
US20100113439A1 (en) 2010-05-06
JP2011530593A (ja) 2011-12-22
CN104877001B (zh) 2020-07-03

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Effective date: 20140718