CA2731941C - Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase - Google Patents
Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase Download PDFInfo
- Publication number
- CA2731941C CA2731941C CA2731941A CA2731941A CA2731941C CA 2731941 C CA2731941 C CA 2731941C CA 2731941 A CA2731941 A CA 2731941A CA 2731941 A CA2731941 A CA 2731941A CA 2731941 C CA2731941 C CA 2731941C
- Authority
- CA
- Canada
- Prior art keywords
- pyran
- propano
- phenanthro
- dodecahydro
- tetramethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13610108P | 2008-08-12 | 2008-08-12 | |
| US61/136,101 | 2008-08-12 | ||
| PCT/US2009/004560 WO2010019204A1 (en) | 2008-08-12 | 2009-08-07 | Antifungal agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2731941A1 CA2731941A1 (en) | 2010-02-18 |
| CA2731941C true CA2731941C (en) | 2016-09-27 |
Family
ID=41669133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2731941A Active CA2731941C (en) | 2008-08-12 | 2009-08-07 | Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8188085B2 (enExample) |
| EP (1) | EP2326181A4 (enExample) |
| JP (1) | JP5548875B2 (enExample) |
| CN (2) | CN102176827B (enExample) |
| AU (1) | AU2009282474B2 (enExample) |
| CA (1) | CA2731941C (enExample) |
| WO (1) | WO2010019204A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103180301B (zh) | 2010-08-26 | 2015-11-25 | 拜耳知识产权有限责任公司 | 5-碘代三唑衍生物 |
| PT3247711T (pt) * | 2015-01-19 | 2022-05-16 | Scynexis Inc | Novos sais e polimorfos de scy-078 |
| JP7263313B2 (ja) * | 2017-04-10 | 2023-04-24 | サイネクシス，インコーポレーテッド | 併用される抗真菌剤 |
| PL3661503T3 (pl) | 2017-08-04 | 2023-01-09 | Scynexis, Inc. | Środki przeciwgrzybicze o zwiększonej aktywności przy kwasowym odczynie ph |
| JP7378401B2 (ja) * | 2018-01-02 | 2023-11-13 | サイネクシス，インコーポレーテッド | リポソームの中にカプセル化されたトリテルペノイド抗真菌薬の注射可能な組成物 |
| US12053486B2 (en) | 2018-03-09 | 2024-08-06 | Therazure LLC | Compositions for the treatment of infections in feet |
| MA54866A (fr) * | 2019-01-30 | 2022-05-04 | Scynexis Inc | Antifongiques triterpénoïdes pour le traitement d'infections ostéoarticulaires fongiques |
| AU2020228036B2 (en) | 2019-02-27 | 2025-08-07 | Scynexis, Inc. | Triterpenoid antifungals for the treatment or prevention of Pneumocystis spp. pneumonia |
| AU2020276595B2 (en) | 2019-05-16 | 2025-12-04 | Scynexis, Inc. | Antifungal Agents for Candida Auris Decolonization |
| WO2021092349A1 (en) | 2019-11-08 | 2021-05-14 | Scynexis, Inc. | Lipid-based formulations of scy-078 salts |
| WO2021097411A1 (en) * | 2019-11-15 | 2021-05-20 | The Research Foundation For The State University Of New York | Anti-fungal compositions and methods for using same |
| CN118724779B (zh) * | 2024-06-05 | 2025-09-23 | 浙江瑞博制药有限公司 | 一种醛基化合物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756472A (en) * | 1996-01-31 | 1998-05-26 | Merck & Co., Inc. | Antifungal agent obtained from hormonema |
| DE69718141T2 (de) | 1996-01-31 | 2003-08-21 | Merck & Co., Inc. | Fungizid |
| HUP0303249A3 (en) * | 2001-02-22 | 2007-03-28 | Sankyo Co | Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them |
| FR2824324B1 (fr) * | 2001-05-04 | 2003-08-15 | Aventis Pharma Sa | Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques |
| AU2002253456A1 (en) | 2002-04-17 | 2003-10-27 | Ranbaxy Laboratories Limited | Azole derivatives as antifungal agents |
| ES2402659T3 (es) | 2006-04-03 | 2013-05-07 | Merck Sharp & Dohme Corp. | Derivados de enfumafungina como agentes antifúngicos |
-
2009
- 2009-08-07 WO PCT/US2009/004560 patent/WO2010019204A1/en not_active Ceased
- 2009-08-07 JP JP2011522975A patent/JP5548875B2/ja active Active
- 2009-08-07 EP EP09806945A patent/EP2326181A4/en not_active Withdrawn
- 2009-08-07 CA CA2731941A patent/CA2731941C/en active Active
- 2009-08-07 AU AU2009282474A patent/AU2009282474B2/en active Active
- 2009-08-07 CN CN200980140485.1A patent/CN102176827B/zh active Active
- 2009-08-07 CN CN201510182454.XA patent/CN104877001B/zh active Active
- 2009-08-07 US US12/461,318 patent/US8188085B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009282474A1 (en) | 2010-02-18 |
| US8188085B2 (en) | 2012-05-29 |
| CN102176827B (zh) | 2015-05-20 |
| EP2326181A4 (en) | 2012-11-28 |
| CN102176827A (zh) | 2011-09-07 |
| JP5548875B2 (ja) | 2014-07-16 |
| AU2009282474B2 (en) | 2014-03-20 |
| CN104877001A (zh) | 2015-09-02 |
| JP2011530593A (ja) | 2011-12-22 |
| EP2326181A1 (en) | 2011-06-01 |
| HK1214271A1 (zh) | 2016-07-22 |
| WO2010019204A1 (en) | 2010-02-18 |
| CA2731941A1 (en) | 2010-02-18 |
| CN104877001B (zh) | 2020-07-03 |
| US20100113439A1 (en) | 2010-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140718 |
|
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| U00 | Fee paid |
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| U11 | Full renewal or maintenance fee paid |
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| MPN | Maintenance fee for patent paid |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250724 |
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| U11 | Full renewal or maintenance fee paid |
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