JP5518479B2 - Aβ関連障害の処置のための方法およびその組成物 - Google Patents

Aβ関連障害の処置のための方法およびその組成物 Download PDF

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JP5518479B2
JP5518479B2 JP2009534630A JP2009534630A JP5518479B2 JP 5518479 B2 JP5518479 B2 JP 5518479B2 JP 2009534630 A JP2009534630 A JP 2009534630A JP 2009534630 A JP2009534630 A JP 2009534630A JP 5518479 B2 JP5518479 B2 JP 5518479B2
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modulator
disease
activity
protein
peptide
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JP2010507666A5 (https=
JP2010507666A (ja
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マーク・フラジョレット
ポール・グリーンガード
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ザ ロックフェラー ユニヴァーシティ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2009534630A 2006-10-25 2007-10-24 Aβ関連障害の処置のための方法およびその組成物 Expired - Fee Related JP5518479B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85433306P 2006-10-25 2006-10-25
US60/854,333 2006-10-25
PCT/US2007/022519 WO2008066626A2 (en) 2006-10-25 2007-10-24 METHODS FOR THE TREATMENT OF Aβ RELATED DISORDERS AND COMPOSITIONS THEREFOR

Related Child Applications (1)

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JP2014076376A Division JP2014193865A (ja) 2006-10-25 2014-04-02 Aβ関連障害の処置のための方法およびその組成物

Publications (3)

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JP2010507666A JP2010507666A (ja) 2010-03-11
JP2010507666A5 JP2010507666A5 (https=) 2010-12-09
JP5518479B2 true JP5518479B2 (ja) 2014-06-11

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JP2009534630A Expired - Fee Related JP5518479B2 (ja) 2006-10-25 2007-10-24 Aβ関連障害の処置のための方法およびその組成物
JP2014076376A Pending JP2014193865A (ja) 2006-10-25 2014-04-02 Aβ関連障害の処置のための方法およびその組成物
JP2016124720A Pending JP2017014197A (ja) 2006-10-25 2016-06-23 Aβ関連障害の処置のための方法およびその組成物

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JP2014076376A Pending JP2014193865A (ja) 2006-10-25 2014-04-02 Aβ関連障害の処置のための方法およびその組成物
JP2016124720A Pending JP2017014197A (ja) 2006-10-25 2016-06-23 Aβ関連障害の処置のための方法およびその組成物

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Country Link
US (1) US9532980B2 (https=)
EP (1) EP2077838B1 (https=)
JP (3) JP5518479B2 (https=)
ES (1) ES2425179T3 (https=)
WO (1) WO2008066626A2 (https=)

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WO2009146301A1 (en) 2008-05-27 2009-12-03 Yale University TARGETING TGF-β AS A THERAPY FOR ALZHEIMER'S DISEASE
WO2010003023A2 (en) * 2008-07-01 2010-01-07 Zacharon Pharmaceuticals, Inc. Heparan sulfate inhibitors
WO2010065917A1 (en) 2008-12-05 2010-06-10 The Regents Of The University Of California Methods of treating neurological disorders
US9414409B2 (en) 2012-02-06 2016-08-09 Samsung Electronics Co., Ltd. Method and apparatus for transmitting/receiving data on multiple carriers in mobile communication system
WO2014007367A1 (ja) * 2012-07-05 2014-01-09 国立大学法人東京大学 同一試料中の2種の物質を検出又は測定する方法
RU2016132574A (ru) 2014-01-09 2018-02-12 Интра-Селлулар Терапиз, Инк. Органические соединения
WO2018133835A1 (en) * 2017-01-20 2018-07-26 National Institute Of Biological Sciences, Beijing Nucleoside analogue regulating mammalian circadian rhythm
JP7506473B2 (ja) * 2019-12-20 2024-06-26 ポッカサッポロフード&ビバレッジ株式会社 アミロイドβ蓄積抑制剤
CN113234664B (zh) * 2021-05-11 2024-05-10 澳门大学 一种胰腺祖细胞的制备方法及其应用

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US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
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US6288089B1 (en) 1998-12-21 2001-09-11 Michael Zawada Use of kinase inhibitors for treating neurodegenerative diseases
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WO2005105987A1 (en) * 2004-04-28 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with casein kinase 1, delta, isoform 2 (csnk1d iso 2)

Also Published As

Publication number Publication date
ES2425179T3 (es) 2013-10-11
EP2077838A4 (en) 2010-10-27
US9532980B2 (en) 2017-01-03
JP2017014197A (ja) 2017-01-19
WO2008066626A2 (en) 2008-06-05
WO2008066626A3 (en) 2008-12-11
US20100143361A1 (en) 2010-06-10
EP2077838B1 (en) 2013-04-03
EP2077838A2 (en) 2009-07-15
JP2014193865A (ja) 2014-10-09
JP2010507666A (ja) 2010-03-11

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