JP5487111B2 - 癌の治療のためのカンプトテシンの水和結晶性エステル - Google Patents
癌の治療のためのカンプトテシンの水和結晶性エステル Download PDFInfo
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- JP5487111B2 JP5487111B2 JP2010531264A JP2010531264A JP5487111B2 JP 5487111 B2 JP5487111 B2 JP 5487111B2 JP 2010531264 A JP2010531264 A JP 2010531264A JP 2010531264 A JP2010531264 A JP 2010531264A JP 5487111 B2 JP5487111 B2 JP 5487111B2
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- cancer
- camptothecin
- crystalline
- hydrate
- crystalline camptothecin
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- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
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- 239000001488 sodium phosphate Substances 0.000 description 1
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
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- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
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- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/923,727 US7572803B2 (en) | 2007-10-25 | 2007-10-25 | Hydrated crystalline esters of camptothecin |
| US11/923,727 | 2007-10-25 | ||
| PCT/US2008/081047 WO2009055633A1 (en) | 2007-10-25 | 2008-10-24 | Hydrated crystalline esters of camptothecin for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500841A JP2011500841A (ja) | 2011-01-06 |
| JP2011500841A5 JP2011500841A5 (OSRAM) | 2011-10-13 |
| JP5487111B2 true JP5487111B2 (ja) | 2014-05-07 |
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Country Status (11)
| Country | Link |
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| US (1) | US7572803B2 (OSRAM) |
| EP (1) | EP2205605B1 (OSRAM) |
| JP (1) | JP5487111B2 (OSRAM) |
| KR (1) | KR20100082358A (OSRAM) |
| CN (1) | CN101730701B (OSRAM) |
| BR (1) | BRPI0816584A2 (OSRAM) |
| CA (1) | CA2703054C (OSRAM) |
| ES (1) | ES2396222T3 (OSRAM) |
| MX (1) | MX2010004332A (OSRAM) |
| RU (1) | RU2483071C2 (OSRAM) |
| WO (1) | WO2009055633A1 (OSRAM) |
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| US20130121921A1 (en) | 2011-11-11 | 2013-05-16 | The Christus Stehlin Foundation For Cancer Research | Rodent Therapeutic Model And Methods |
| US9387257B2 (en) * | 2014-01-17 | 2016-07-12 | Academia Sinica | Lung cancer specific peptides for targeted drug delivery and molecular imaging |
| US9675609B2 (en) | 2015-11-11 | 2017-06-13 | Cao Pharmaceuticals Inc. | Nano- and micro-sized particles of 20-camptothecin or derivative thereof and pharmaceutical compositions containing same, and treatment of cancers therewith |
| US20220395497A1 (en) * | 2019-11-20 | 2022-12-15 | Vivacitas Oncology, Inc. | Cancer Treatment Using Camptothecin Derivatives |
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|---|---|---|---|---|
| US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
| US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
| US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6407118B1 (en) * | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
| US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US5922877A (en) * | 1997-08-05 | 1999-07-13 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| USRE38408E1 (en) * | 1997-08-05 | 2004-01-27 | The Stehlin Foundation For Cancer Research | Methods of preparing and purifying 9-nitro-20-camptothecin |
| US6228855B1 (en) * | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
| US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
| US6699875B2 (en) * | 2002-05-06 | 2004-03-02 | The Stehlin Foundation For Cancer Research | Cascade esters of camptothecins and methods of treating cancer using these compounds |
| US6703399B2 (en) * | 2002-05-06 | 2004-03-09 | The Stehlin Foundation For Cancer Research | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
| KR101095382B1 (ko) * | 2003-02-25 | 2011-12-16 | 가부시키가이샤 야쿠르트 혼샤 | 이리노테칸 염산염의 결정다형의 제조방법 |
| TWI333492B (en) * | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
| WO2007035709A2 (en) * | 2005-09-20 | 2007-03-29 | Scinopharm Singapore Pte, Ltd. | Novel crystal forms of irinotecan hydrochloride |
-
2007
- 2007-10-25 US US11/923,727 patent/US7572803B2/en active Active
-
2008
- 2008-10-24 EP EP08841603A patent/EP2205605B1/en not_active Not-in-force
- 2008-10-24 CA CA2703054A patent/CA2703054C/en active Active
- 2008-10-24 BR BRPI0816584-0A2A patent/BRPI0816584A2/pt not_active IP Right Cessation
- 2008-10-24 KR KR1020107011223A patent/KR20100082358A/ko not_active Ceased
- 2008-10-24 CN CN200880013536XA patent/CN101730701B/zh not_active Expired - Fee Related
- 2008-10-24 MX MX2010004332A patent/MX2010004332A/es active IP Right Grant
- 2008-10-24 JP JP2010531264A patent/JP5487111B2/ja not_active Expired - Fee Related
- 2008-10-24 WO PCT/US2008/081047 patent/WO2009055633A1/en not_active Ceased
- 2008-10-24 RU RU2010120810/04A patent/RU2483071C2/ru not_active IP Right Cessation
- 2008-10-24 ES ES08841603T patent/ES2396222T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101730701B (zh) | 2013-05-29 |
| ES2396222T3 (es) | 2013-02-20 |
| US20090111845A1 (en) | 2009-04-30 |
| CA2703054C (en) | 2017-08-22 |
| RU2483071C2 (ru) | 2013-05-27 |
| RU2010120810A (ru) | 2011-11-27 |
| BRPI0816584A2 (pt) | 2015-03-03 |
| CN101730701A (zh) | 2010-06-09 |
| KR20100082358A (ko) | 2010-07-16 |
| MX2010004332A (es) | 2010-05-20 |
| EP2205605A1 (en) | 2010-07-14 |
| CA2703054A1 (en) | 2009-04-30 |
| JP2011500841A (ja) | 2011-01-06 |
| WO2009055633A1 (en) | 2009-04-30 |
| EP2205605B1 (en) | 2012-11-21 |
| US7572803B2 (en) | 2009-08-11 |
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