JP5453438B2 - ドライパウダー吸入器 - Google Patents

ドライパウダー吸入器 Download PDF

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Publication number
JP5453438B2
JP5453438B2 JP2011530042A JP2011530042A JP5453438B2 JP 5453438 B2 JP5453438 B2 JP 5453438B2 JP 2011530042 A JP2011530042 A JP 2011530042A JP 2011530042 A JP2011530042 A JP 2011530042A JP 5453438 B2 JP5453438 B2 JP 5453438B2
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JP
Japan
Prior art keywords
dose container
piercing
dose
actuator
dry powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011530042A
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English (en)
Japanese (ja)
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JP2012504456A (ja
JP2012504456A5 (https=
Inventor
ルイス，スコット
ガウ，アンドリュー
タックウェル，ジョン
ビアード，グレッグ
Original Assignee
オリエル・セラピューティクス，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by オリエル・セラピューティクス，インコーポレイテッド filed Critical オリエル・セラピューティクス，インコーポレイテッド
Publication of JP2012504456A publication Critical patent/JP2012504456A/ja
Publication of JP2012504456A5 publication Critical patent/JP2012504456A5/ja
Application granted granted Critical
Publication of JP5453438B2 publication Critical patent/JP5453438B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0075—Mechanical counters having a display or indicator on a disc
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Medicinal Preparation (AREA)
JP2011530042A 2008-10-01 2009-09-25 ドライパウダー吸入器 Expired - Fee Related JP5453438B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10183208P 2008-10-01 2008-10-01
US61/101,832 2008-10-01
PCT/US2009/005338 WO2010039202A2 (en) 2008-10-01 2009-09-25 Dry powder inhalers with rotating piercing mechanisms and related devices and methods

Publications (3)

Publication Number Publication Date
JP2012504456A JP2012504456A (ja) 2012-02-23
JP2012504456A5 JP2012504456A5 (https=) 2013-08-22
JP5453438B2 true JP5453438B2 (ja) 2014-03-26

Family

ID=42074060

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011530042A Expired - Fee Related JP5453438B2 (ja) 2008-10-01 2009-09-25 ドライパウダー吸入器

Country Status (7)

Country Link
US (1) US8646446B2 (https=)
EP (1) EP2328645B1 (https=)
JP (1) JP5453438B2 (https=)
CA (1) CA2732827C (https=)
ES (1) ES2561899T3 (https=)
MX (1) MX2011003245A (https=)
WO (1) WO2010039202A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5328776B2 (ja) * 2007-06-01 2013-10-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 小出し器具
GB2489383A (en) 2009-12-30 2012-09-26 Vijayan Thirumalai Anandampillai An improved dry powder inhaler
USD641076S1 (en) * 2010-03-26 2011-07-05 Oriel Therapeutics, Inc. Dry powder inhaler
WO2014070769A1 (en) 2012-10-29 2014-05-08 The University Of North Carolina At Chapel Hill Methods and compositions for treating mucosal tissue disorders
USD855792S1 (en) * 2013-01-30 2019-08-06 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Inhaler device
WO2014151329A1 (en) * 2013-03-15 2014-09-25 Aerodesigns, Inc. Particles for aerosolizing apparatus
US20140377130A1 (en) 2013-03-15 2014-12-25 David A. Edwards Systems, methods and articles to provide olfactory sensations
UA29750S (uk) * 2013-11-22 2015-07-10 Гленмарк Фармас& Інгалятор
USD804015S1 (en) * 2013-12-23 2017-11-28 Glenmark Pharmaceuticals Limited Inhaler
USD755950S1 (en) * 2014-05-19 2016-05-10 Vectura Delivery Devices Limited Inhaler
USD767114S1 (en) * 2015-03-18 2016-09-20 Amneal Pharmaceuticals Company Gmbh Inhalation device
USD769439S1 (en) * 2015-03-18 2016-10-18 Amneal Pharmaceuticals Company Gmbh Inhalation device
WO2017011867A1 (en) * 2015-07-20 2017-01-26 Medical Developments International Limited Inhaler device for inhalable liquids
MX395190B (es) * 2015-11-06 2025-03-25 Boehringer Ingelheim Int Sistema con nebulizador y recipiente.
US12337064B2 (en) 2018-09-05 2025-06-24 Sensory Cloud, Inc. Formulations and compositions for ortho- and/or retro-nasal delivery and associated systems, methods and articles
WO2021121448A1 (de) * 2019-12-18 2021-06-24 Markus Mezger Inhalator
USD989282S1 (en) * 2020-06-08 2023-06-13 Merxin Ltd. Inhaler
CN114558211B (zh) * 2020-11-27 2025-09-09 长风药业股份有限公司 药物吸入装置和使用在其中的泡罩条
US20250082872A1 (en) * 2021-01-28 2025-03-13 Iconovo Ab Dry powder inhaler
CN115105695B (zh) * 2022-06-02 2023-05-16 宁波职业技术学院 一种哮喘呼吸器及哮喘呼吸器的使用方法
CN115487068B (zh) * 2022-10-31 2025-10-31 首都医科大学宣武医院 一种适配装置及带适配装置的医用容器

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2828005A (en) * 1954-11-02 1958-03-25 Maurine E Ricke Dispenser
GB873410A (en) 1958-11-11 1961-07-26 Frank T Bartolomeo Smoking simulating device
US4307734A (en) 1980-06-23 1981-12-29 B & B Inventors & Marketers, Inc. Snuff dispenser
US4778054A (en) 1982-10-08 1988-10-18 Glaxo Group Limited Pack for administering medicaments to patients
GB2129691B (en) 1982-10-08 1987-08-05 Glaxo Group Ltd Devices for administering medicaments to patients
AU591152B2 (en) 1985-07-30 1989-11-30 Glaxo Group Limited Devices for administering medicaments to patients
US5138138A (en) 1988-02-03 1992-08-11 Stihler Electronic Medizintechnische Gerate Prod. Und Vertriebs-Gmbh Heating system for an operating table
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SK280968B6 (sk) 1990-03-02 2000-10-09 Glaxo Group Limited Balenie medikamentu na použite v inhalačnom prístroji
UA26230A (uk) 1990-03-02 1999-07-19 Глексо Груп Лімітед Іhгалятор для спільhого використаhhя з лікувальhим блоком і лікувальhий блок
GB9012870D0 (en) 1990-06-08 1990-08-01 Glaxo Group Ltd Device
US5327883A (en) 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5337740A (en) 1991-08-01 1994-08-16 New England Pharmaceuticals, Inc. Inhalation devices
US5394868A (en) 1992-06-25 1995-03-07 Schering Corporation Inhalation device for powdered medicaments
AU4066693A (en) 1992-12-23 1994-07-19 Bernhard Hugemann Compacted drug body for use in the mechanical generation of inhalable active-substance particles
FI954098A7 (fi) 1993-03-03 1995-09-01 Tenax Corp Kuivajauheen inhalaattorin lääkeaineen kantolaite
EP0652022B1 (en) 1993-05-12 1999-01-27 Teijin Limited Device and method for dispensing powdered medicine in multiple doses
US5533502A (en) 1993-05-28 1996-07-09 Vortran Medical Technology, Inc. Powder inhaler with aerosolization occurring within each individual powder receptacle
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
SK282117B6 (sk) 1993-12-18 2001-11-06 Merck Patent Gesellschaft Mit Beschr�Nkter Haftung Zariadenie na rozdeľovanie jednotlivých dávok časticovitého materiálu
NZ293163A (en) 1994-09-21 1998-09-24 Inhale Therapeutic Syst Inhalation medicament disperser, aerosol from high pressure gas entrainment of fluidised powder drawn from receptacle feed tube
DE19500764C2 (de) 1995-01-13 2001-09-27 Sofotec Gmbh & Co Kg Vorrichtung zum Verabreichen von Medikamenten in fester, in einem Luftstrom fein verteilter Form
JP3792743B2 (ja) 1995-01-26 2006-07-05 株式会社リコー トナー充填方法及び装置
US5622166A (en) 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
US5921237A (en) 1995-04-24 1999-07-13 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
FR2738152B1 (fr) 1995-09-04 1998-01-23 Tebro Dispositif de pre-dosage de produit pulverulent pour un distributeur de produit
HUP9901575A3 (en) 1996-04-29 1999-11-29 Dura Pharmaceuticals Inc San D Methods of dry powder inhalation
GB9616047D0 (en) 1996-07-31 1996-09-11 Glaxo Group Ltd Medicament carrier with agglomerated large medicament particles and related method of manufacture thereof
US5794613A (en) * 1997-01-09 1998-08-18 Sepracor, Inc. Multiple-dose dispenser for dry powder inhalers
DE19704849B4 (de) 1997-02-08 2011-02-17 Ing. Erich Pfeiffer Gmbh Austragvorrichtung für Medien
US6006747A (en) * 1997-03-20 1999-12-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5947169A (en) 1997-04-01 1999-09-07 Xerox Corporation Oscillating valve for powders
US5909829A (en) 1997-04-01 1999-06-08 Xerox Corporation Vibratory filler for powders
US6116238A (en) 1997-12-02 2000-09-12 Dura Pharmaceuticals, Inc. Dry powder inhaler
US20010007853A1 (en) 1998-01-08 2001-07-12 Dimarchi Richard Dennis Method for administering monomeric insulin analogs
NL1008031C2 (nl) 1998-01-15 1999-07-21 Pharmachemie Bv Inrichting voor het inhaleren van medicament.
GB2340758A (en) 1998-08-21 2000-03-01 Bespak Plc Drug dispensing system
JP2002535048A (ja) * 1999-01-22 2002-10-22 グラクソ グループ リミテッド 吸入装置
GB9902493D0 (en) 1999-02-05 1999-03-24 Glaxo Group Ltd Inhalation device
US6445941B1 (en) 1999-03-12 2002-09-03 Thomas G. Hampton Method and apparatus for non-invasively detecting, measuring, and recording electrocardiograms in conscious animals
US6328033B1 (en) 1999-06-04 2001-12-11 Zohar Avrahami Powder inhaler
GB9920839D0 (en) 1999-09-04 1999-11-10 Innovata Biomed Ltd Inhaler
US6880555B1 (en) 1999-10-12 2005-04-19 Shl Medical Ab Inhaler
GB9924415D0 (en) 1999-10-16 1999-12-15 Glaxo Group Ltd Medicament pack
AU1752601A (en) 1999-11-11 2001-06-06 Dura Pharmaceuticals, Inc. Dry powder inhaler
US6810872B1 (en) 1999-12-10 2004-11-02 Unisia Jecs Corporation Inhalant medicator
US7069929B2 (en) 2000-02-01 2006-07-04 Quadrant Technologies Limited Dry powder inhaler
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US6668827B2 (en) 2000-05-16 2003-12-30 Nektar Therapeutics Systems devices and methods for opening receptacles having a powder to be fluidized
PE20020066A1 (es) 2000-06-23 2002-02-23 Norton Healthcare Ltd Deposito de dosis medidas previamente para inhalador de polvo seco accionado por la respiracion
WO2002053216A2 (en) 2001-01-08 2002-07-11 Cipla Limited An improved device for metered administration of medicament by inhalation
US6626173B2 (en) 2001-01-08 2003-09-30 Iep Pharmaceutical Devices Inc. Dry powder inhaler
ITPG20010036A1 (it) 2001-07-24 2003-01-24 Marco Cecchini Cartuccia autoforante per erogatori di polvere secche inalatorie
JP4261351B2 (ja) 2001-09-19 2009-04-30 アドヴェント ファーマセウティカルズ プロプライエタリー リミテッド 吸入器
US7931022B2 (en) 2001-10-19 2011-04-26 Respirks, Inc. Method and apparatus for dispensing inhalator medicament
GB0201677D0 (en) 2002-01-25 2002-03-13 Glaxo Group Ltd Medicament dispenser
EP1467790A1 (en) 2002-01-25 2004-10-20 Glaxo Group Limited Medicament dispenser
US6591832B1 (en) 2002-02-21 2003-07-15 Saint-Gobain Calmar Inc. Dry powder dispenser
US6889690B2 (en) * 2002-05-10 2005-05-10 Oriel Therapeutics, Inc. Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages
GB0225621D0 (en) 2002-11-02 2002-12-11 Glaxo Group Ltd Medicament carrier
BR0316428A (pt) * 2002-11-20 2005-10-11 Sun Pharmaceutical Ind Ltd Inalador de pó seco
GB0303870D0 (en) 2003-02-20 2003-03-26 Norton Healthcare Ltd Pre-metered dose magazine for breath-actuated dry powder inhaler
GB0315509D0 (en) 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
GB2407042B (en) 2003-10-17 2007-10-24 Vectura Ltd Inhaler
US20070221218A1 (en) * 2003-10-27 2007-09-27 Warden Jeffrey A Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods
GB0402694D0 (en) 2004-02-06 2004-03-10 Glaxo Group Ltd A fluid dispenser
PL1730676T3 (pl) 2004-02-16 2014-04-30 Glaxo Group Ltd Licznik do stosowania z dozownikiem leku
JP4592701B2 (ja) 2004-08-12 2010-12-08 帝人ファーマ株式会社 供給装置のカウンタ機構及びカウンタ機構を備えた供給装置
WO2006031775A2 (en) 2004-09-13 2006-03-23 Oriel Therapeutics, Inc. Dry powder inhalers that inhibit agglomeration, related devices and methods
JP2006130143A (ja) 2004-11-08 2006-05-25 Hitachi Ltd 吸入式投薬器及び薬剤カートリッジ
US7987845B2 (en) * 2006-01-31 2011-08-02 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
US8037880B2 (en) 2006-04-07 2011-10-18 The University Of Western Ontario Dry powder inhaler
EP1844805A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH & Co.KG Inhalator
EP1844806A1 (de) 2006-04-13 2007-10-17 Boehringer Ingelheim Pharma GmbH Medikamenten-Ausgabevorrichtung, Medikamentenmagazin dafür, und Verfahren zur Entnahme eines Medikaments aus einer Medikamentenkammer
WO2008039182A1 (en) 2006-09-26 2008-04-03 Glaxo Group Limited Drug carrier in blister pack form
CA2688689C (en) 2007-05-16 2015-06-30 Mystic Pharmaceuticals, Inc. Combination unit dose dispensing containers
US8887722B2 (en) 2008-09-26 2014-11-18 Oriel Therapeutics, Inc. Inhaler mechanisms with radially biased piercers and related methods
WO2010036839A2 (en) 2008-09-26 2010-04-01 Oriel Therapeutics, Inc. Inhalers with airway disks having discrete airway channels and related disks and methods

Also Published As

Publication number Publication date
MX2011003245A (es) 2011-04-26
WO2010039202A3 (en) 2010-07-08
JP2012504456A (ja) 2012-02-23
ES2561899T3 (es) 2016-03-01
CA2732827C (en) 2016-10-11
EP2328645A4 (en) 2012-04-18
US20110186047A1 (en) 2011-08-04
US8646446B2 (en) 2014-02-11
CA2732827A1 (en) 2010-04-08
EP2328645B1 (en) 2015-11-11
EP2328645A2 (en) 2011-06-08
WO2010039202A2 (en) 2010-04-08

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