CA2732827C - Dry powder inhalers with rotating piercing mechanisms and related devices and methods - Google Patents
Dry powder inhalers with rotating piercing mechanisms and related devices and methods Download PDFInfo
- Publication number
- CA2732827C CA2732827C CA2732827A CA2732827A CA2732827C CA 2732827 C CA2732827 C CA 2732827C CA 2732827 A CA2732827 A CA 2732827A CA 2732827 A CA2732827 A CA 2732827A CA 2732827 C CA2732827 C CA 2732827C
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- Prior art keywords
- piercing
- dose container
- dry powder
- actuator
- piercing member
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/007—Mechanical counters
- A61M15/0071—Mechanical counters having a display or indicator
- A61M15/0075—Mechanical counters having a display or indicator on a disc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Control And Other Processes For Unpacking Of Materials (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10183208P | 2008-10-01 | 2008-10-01 | |
| US61/101,832 | 2008-10-01 | ||
| PCT/US2009/005338 WO2010039202A2 (en) | 2008-10-01 | 2009-09-25 | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2732827A1 CA2732827A1 (en) | 2010-04-08 |
| CA2732827C true CA2732827C (en) | 2016-10-11 |
Family
ID=42074060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2732827A Expired - Fee Related CA2732827C (en) | 2008-10-01 | 2009-09-25 | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8646446B2 (https=) |
| EP (1) | EP2328645B1 (https=) |
| JP (1) | JP5453438B2 (https=) |
| CA (1) | CA2732827C (https=) |
| ES (1) | ES2561899T3 (https=) |
| MX (1) | MX2011003245A (https=) |
| WO (1) | WO2010039202A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20090136A1 (es) * | 2007-06-01 | 2009-03-11 | Boehringer Ingelheim Int | Dispositivo dispensador |
| GB2489383A (en) | 2009-12-30 | 2012-09-26 | Vijayan Thirumalai Anandampillai | An improved dry powder inhaler |
| USD641076S1 (en) * | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
| WO2014070769A1 (en) | 2012-10-29 | 2014-05-08 | The University Of North Carolina At Chapel Hill | Methods and compositions for treating mucosal tissue disorders |
| USD855792S1 (en) * | 2013-01-30 | 2019-08-06 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Inhaler device |
| EP2968637A2 (en) | 2013-03-15 | 2016-01-20 | Vapor Communications, Inc. | Systems, methods and articles to provide olfactory sensations |
| WO2014151329A1 (en) * | 2013-03-15 | 2014-09-25 | Aerodesigns, Inc. | Particles for aerosolizing apparatus |
| UA29750S (uk) * | 2013-11-22 | 2015-07-10 | Гленмарк Фармас& | Інгалятор |
| USD804015S1 (en) * | 2013-12-23 | 2017-11-28 | Glenmark Pharmaceuticals Limited | Inhaler |
| USD755950S1 (en) * | 2014-05-19 | 2016-05-10 | Vectura Delivery Devices Limited | Inhaler |
| USD769439S1 (en) * | 2015-03-18 | 2016-10-18 | Amneal Pharmaceuticals Company Gmbh | Inhalation device |
| USD767114S1 (en) * | 2015-03-18 | 2016-09-20 | Amneal Pharmaceuticals Company Gmbh | Inhalation device |
| AU2016297678B2 (en) * | 2015-07-20 | 2020-10-08 | Medical Developments International Limited | Inhaler device for inhalable liquids |
| EP3370810B1 (en) * | 2015-11-06 | 2019-12-18 | Boehringer Ingelheim International GmbH | System with nebulizer and container |
| EP3846825A4 (en) | 2018-09-05 | 2022-11-02 | Sensory Cloud, LLC | FORMULATIONS AND COMPOSITIONS FOR ORTHO- AND/OR RETRO-NASAL DELIVERY AND RELATED SYSTEMS, METHODS AND ARTICLES |
| DE112019007971A5 (de) * | 2019-12-18 | 2022-09-22 | Markus Mezger | Inhalator |
| USD989282S1 (en) * | 2020-06-08 | 2023-06-13 | Merxin Ltd. | Inhaler |
| CN114558211B (zh) * | 2020-11-27 | 2025-09-09 | 长风药业股份有限公司 | 药物吸入装置和使用在其中的泡罩条 |
| EP4284474B1 (en) * | 2021-01-28 | 2026-04-29 | Iconovo AB | Dry powder inhaler |
| CN115105695B (zh) * | 2022-06-02 | 2023-05-16 | 宁波职业技术学院 | 一种哮喘呼吸器及哮喘呼吸器的使用方法 |
| CN115487068B (zh) * | 2022-10-31 | 2025-10-31 | 首都医科大学宣武医院 | 一种适配装置及带适配装置的医用容器 |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2828005A (en) * | 1954-11-02 | 1958-03-25 | Maurine E Ricke | Dispenser |
| GB873410A (en) | 1958-11-11 | 1961-07-26 | Frank T Bartolomeo | Smoking simulating device |
| US4307734A (en) * | 1980-06-23 | 1981-12-29 | B & B Inventors & Marketers, Inc. | Snuff dispenser |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| DK172541B1 (da) * | 1982-10-08 | 1998-12-07 | Glaxo Group Ltd | Apparat til administrering af medikamenter til patienter og en medikamentpakning til brug i apparatet |
| DE3682457D1 (de) * | 1985-07-30 | 1991-12-19 | Glaxo Group Ltd | Geraet zur verabreichung von medikamenten an patienten. |
| JPH03502410A (ja) * | 1988-02-03 | 1991-06-06 | シュティーラー エレクトロニック メディツィンテクニーシュ ゲレーテ プロドゥクツィオン‐ウント フェルトリープス‐ゲー・エム・ベー・ハー | 手術台用の加熱装置 |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| SK280968B6 (sk) * | 1990-03-02 | 2000-10-09 | Glaxo Group Limited | Balenie medikamentu na použite v inhalačnom prístroji |
| US6536427B2 (en) * | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
| YU48707B (sh) * | 1990-03-02 | 1999-07-28 | Glaxo Group Limited | Aparat za inhaliranje - inhalator |
| GB9012870D0 (en) | 1990-06-08 | 1990-08-01 | Glaxo Group Ltd | Device |
| US5327883A (en) * | 1991-05-20 | 1994-07-12 | Dura Pharmaceuticals, Inc. | Apparatus for aerosolizing powdered medicine and process and using |
| US5337740A (en) * | 1991-08-01 | 1994-08-16 | New England Pharmaceuticals, Inc. | Inhalation devices |
| US5394868A (en) * | 1992-06-25 | 1995-03-07 | Schering Corporation | Inhalation device for powdered medicaments |
| WO1994014490A1 (de) | 1992-12-23 | 1994-07-07 | Bernhard Hugemann | Verfestigter arzneistoffvorrat für die mechanische erzeugung inhalierbarer wirkstoffpartikel |
| BR9405842A (pt) | 1993-03-03 | 1996-01-16 | Tenax Corp | Portador de medicamento |
| KR100244690B1 (ko) * | 1993-05-12 | 2000-02-15 | 야스이 쇼사꾸 | 분말상 약제 멀티도스 시약장치 |
| US5533502A (en) * | 1993-05-28 | 1996-07-09 | Vortran Medical Technology, Inc. | Powder inhaler with aerosolization occurring within each individual powder receptacle |
| US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
| CA2179202C (en) * | 1993-12-18 | 2006-06-06 | Stephen William Eason | Powder inhalator |
| CZ289029B6 (cs) * | 1994-09-21 | 2001-10-17 | Inhale Therapeutic Systems | Způsob aerosolizace práąku, zejména práąkového léku a zařízení k provádění tohoto způsobu |
| DE19500764C2 (de) | 1995-01-13 | 2001-09-27 | Sofotec Gmbh & Co Kg | Vorrichtung zum Verabreichen von Medikamenten in fester, in einem Luftstrom fein verteilter Form |
| JP3792743B2 (ja) * | 1995-01-26 | 2006-07-05 | 株式会社リコー | トナー充填方法及び装置 |
| US5921237A (en) * | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| US5622166A (en) * | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
| US6209538B1 (en) * | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| FR2738152B1 (fr) * | 1995-09-04 | 1998-01-23 | Tebro | Dispositif de pre-dosage de produit pulverulent pour un distributeur de produit |
| HUP9901575A3 (en) * | 1996-04-29 | 1999-11-29 | Dura Pharmaceuticals Inc San D | Methods of dry powder inhalation |
| GB9616047D0 (en) * | 1996-07-31 | 1996-09-11 | Glaxo Group Ltd | Medicament carrier with agglomerated large medicament particles and related method of manufacture thereof |
| US5794613A (en) * | 1997-01-09 | 1998-08-18 | Sepracor, Inc. | Multiple-dose dispenser for dry powder inhalers |
| DE19704849B4 (de) * | 1997-02-08 | 2011-02-17 | Ing. Erich Pfeiffer Gmbh | Austragvorrichtung für Medien |
| US6006747A (en) | 1997-03-20 | 1999-12-28 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| US5909829A (en) * | 1997-04-01 | 1999-06-08 | Xerox Corporation | Vibratory filler for powders |
| US5947169A (en) * | 1997-04-01 | 1999-09-07 | Xerox Corporation | Oscillating valve for powders |
| US6116238A (en) * | 1997-12-02 | 2000-09-12 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| US20010007853A1 (en) * | 1998-01-08 | 2001-07-12 | Dimarchi Richard Dennis | Method for administering monomeric insulin analogs |
| NL1008031C2 (nl) | 1998-01-15 | 1999-07-21 | Pharmachemie Bv | Inrichting voor het inhaleren van medicament. |
| GB2340758A (en) | 1998-08-21 | 2000-03-01 | Bespak Plc | Drug dispensing system |
| EP1144035B1 (en) * | 1999-01-22 | 2005-10-12 | Glaxo Group Limited | Inhalation device |
| GB9902493D0 (en) | 1999-02-05 | 1999-03-24 | Glaxo Group Ltd | Inhalation device |
| US6445941B1 (en) * | 1999-03-12 | 2002-09-03 | Thomas G. Hampton | Method and apparatus for non-invasively detecting, measuring, and recording electrocardiograms in conscious animals |
| US6328033B1 (en) * | 1999-06-04 | 2001-12-11 | Zohar Avrahami | Powder inhaler |
| GB9920839D0 (en) * | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
| AU1068401A (en) * | 1999-10-12 | 2001-04-23 | Shl Medical Ab | Inhaler |
| GB9924415D0 (en) | 1999-10-16 | 1999-12-15 | Glaxo Group Ltd | Medicament pack |
| AU1752601A (en) | 1999-11-11 | 2001-06-06 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| US6810872B1 (en) * | 1999-12-10 | 2004-11-02 | Unisia Jecs Corporation | Inhalant medicator |
| US7069929B2 (en) * | 2000-02-01 | 2006-07-04 | Quadrant Technologies Limited | Dry powder inhaler |
| US6948494B1 (en) * | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
| US6668827B2 (en) * | 2000-05-16 | 2003-12-30 | Nektar Therapeutics | Systems devices and methods for opening receptacles having a powder to be fluidized |
| AR028746A1 (es) * | 2000-06-23 | 2003-05-21 | Norton Health Care Ltd | Cartucho de dosis previamente medidas para inhalador de polvo seco accionado por la respiracion, el inhalador y un metodo de provision de dosis previamente medidas de polvo seco |
| WO2002053216A2 (en) | 2001-01-08 | 2002-07-11 | Cipla Limited | An improved device for metered administration of medicament by inhalation |
| US6626173B2 (en) | 2001-01-08 | 2003-09-30 | Iep Pharmaceutical Devices Inc. | Dry powder inhaler |
| ITPG20010036A1 (it) | 2001-07-24 | 2003-01-24 | Marco Cecchini | Cartuccia autoforante per erogatori di polvere secche inalatorie |
| CN1313171C (zh) * | 2001-09-19 | 2007-05-02 | 埃德文特药物有限公司 | 吸入器 |
| US7931022B2 (en) * | 2001-10-19 | 2011-04-26 | Respirks, Inc. | Method and apparatus for dispensing inhalator medicament |
| JP2005527260A (ja) * | 2002-01-25 | 2005-09-15 | グラクソ グループ リミテッド | 薬剤ディスペンサ |
| GB0201677D0 (en) * | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
| US6591832B1 (en) * | 2002-02-21 | 2003-07-15 | Saint-Gobain Calmar Inc. | Dry powder dispenser |
| US6889690B2 (en) * | 2002-05-10 | 2005-05-10 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages |
| GB0225621D0 (en) * | 2002-11-02 | 2002-12-11 | Glaxo Group Ltd | Medicament carrier |
| WO2004045487A2 (en) | 2002-11-20 | 2004-06-03 | Sun Pharmaceutical Industries Limited | Dry powder inhaler |
| GB0303870D0 (en) * | 2003-02-20 | 2003-03-26 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
| GB0315509D0 (en) * | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
| GB2407042B (en) * | 2003-10-17 | 2007-10-24 | Vectura Ltd | Inhaler |
| US20070221218A1 (en) * | 2003-10-27 | 2007-09-27 | Warden Jeffrey A | Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods |
| GB0402694D0 (en) * | 2004-02-06 | 2004-03-10 | Glaxo Group Ltd | A fluid dispenser |
| DK1730676T3 (da) * | 2004-02-16 | 2013-11-04 | Glaxo Group Ltd | Tælleenhed til anvendelse med en medikamentfordeler |
| NZ553181A (en) | 2004-08-12 | 2010-08-27 | Teijin Pharma Ltd | Counter mechanism of feeder and feeder having counter mechanism |
| CA2616997C (en) * | 2004-09-13 | 2014-12-23 | Oriel Therapeutics, Inc. | Dry powder inhalers that inhibit agglomeration, related devices and methods |
| JP2006130143A (ja) * | 2004-11-08 | 2006-05-25 | Hitachi Ltd | 吸入式投薬器及び薬剤カートリッジ |
| WO2007089477A2 (en) * | 2006-01-31 | 2007-08-09 | Oriel Therapeutics, Inc. | Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods |
| US8037880B2 (en) * | 2006-04-07 | 2011-10-18 | The University Of Western Ontario | Dry powder inhaler |
| EP1844806A1 (de) * | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH | Medikamenten-Ausgabevorrichtung, Medikamentenmagazin dafür, und Verfahren zur Entnahme eines Medikaments aus einer Medikamentenkammer |
| EP1844805A1 (de) | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH & Co.KG | Inhalator |
| WO2008039182A1 (en) | 2006-09-26 | 2008-04-03 | Glaxo Group Limited | Drug carrier in blister pack form |
| EP2164799B1 (en) * | 2007-05-16 | 2018-12-26 | Mystic Pharmaceuticals, Inc. | Combination unit dose dispensing containers |
| WO2010036355A2 (en) * | 2008-09-26 | 2010-04-01 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially biased piercers and related methods |
| MX2011003244A (es) * | 2008-09-26 | 2011-04-28 | Oriel Therapeutics Inc | Inhaladores con discos de vias aereas con canales de vias aereas discretas y discos y metodos relacionados. |
-
2009
- 2009-09-25 WO PCT/US2009/005338 patent/WO2010039202A2/en not_active Ceased
- 2009-09-25 EP EP09818090.4A patent/EP2328645B1/en not_active Not-in-force
- 2009-09-25 MX MX2011003245A patent/MX2011003245A/es active IP Right Grant
- 2009-09-25 CA CA2732827A patent/CA2732827C/en not_active Expired - Fee Related
- 2009-09-25 US US13/054,809 patent/US8646446B2/en not_active Expired - Fee Related
- 2009-09-25 ES ES09818090.4T patent/ES2561899T3/es active Active
- 2009-09-25 JP JP2011530042A patent/JP5453438B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2561899T3 (es) | 2016-03-01 |
| JP2012504456A (ja) | 2012-02-23 |
| EP2328645A4 (en) | 2012-04-18 |
| US20110186047A1 (en) | 2011-08-04 |
| US8646446B2 (en) | 2014-02-11 |
| EP2328645A2 (en) | 2011-06-08 |
| WO2010039202A3 (en) | 2010-07-08 |
| WO2010039202A2 (en) | 2010-04-08 |
| JP5453438B2 (ja) | 2014-03-26 |
| CA2732827A1 (en) | 2010-04-08 |
| MX2011003245A (es) | 2011-04-26 |
| EP2328645B1 (en) | 2015-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140728 |
|
| MKLA | Lapsed |
Effective date: 20210927 |