JP5422130B2 - Infectious disease prevention composition, food and drink containing it, and feed - Google Patents
Infectious disease prevention composition, food and drink containing it, and feed Download PDFInfo
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Description
本発明は、抗ウイルス作用、抗菌作用及び免疫増強作用を有し感染症を予防することができる感染症予防組成物と、該感染症予防組成物を含有する飲食物及び飼餌料に関するものである。 The present invention relates to an infectious disease preventive composition that has an antiviral action, an antibacterial action, and an immune enhancing action, and can prevent infectious diseases, and foods and drinks and foods containing the infectious disease preventing composition. .
近年、種々の感染症が確認されており、これら感染症が猛威をふるっている。この感染症を予防するために、長年、飲食物として使用されていて安全性が確認されている材料を起源とする感染症予防物質が求められている。 In recent years, various infectious diseases have been confirmed, and these infectious diseases are becoming violent. In order to prevent this infectious disease, there has been a demand for an infectious disease preventive substance originating from a material that has been used for food and drink for many years and has been confirmed to be safe.
このような感染症を予防できる物質としては、例えば、哺乳動物消化管粘膜へのＨｅｌｉｃｏｂａｃｔｅｒ種の感染の予防および／または治療用の経口製剤であって、少なくとも１種類のキサントフィルの予防上および／または治療上の有効量を含んでなる、経口製剤がある（特許文献１参照）。 Examples of substances capable of preventing such infectious diseases include oral preparations for the prevention and / or treatment of Helicobacter species infection of the mammalian gastrointestinal mucosa, for the prevention of at least one xanthophyll and / or There is an oral formulation comprising a therapeutically effective amount (see Patent Document 1).
抗ウイルス作用を有し感染症を予防することができる物質としては、例えば、フコイダン又はプロアントシアニジンを有効成分として含有して、ウィルス増殖阻害作用を有することを特徴とする、抗ウィルス組成物（特許文献２参照）や、アラメからアルコール抽出した物質を主成分とすることを特徴とする抗ウイルス物質（特許文献３参照）がある。 As a substance that has an antiviral action and can prevent infectious diseases, for example, an antiviral composition containing a fucoidan or proanthocyanidin as an active ingredient and having a virus growth-inhibiting action (patented) There is an antiviral substance (refer to Patent Document 3) characterized in that the main component is a substance extracted with alcohol from arame.
また、感染症を予防できるという物質ではないが、抗ウイルス作用を有する物質としては、例えば、同一出願人による、次の性質：（１）グルコース、ガラクトース、キシロース、マンノース及びグルクロン酸を含む多糖類であり、（２）硫酸基を持たず、（３）フェノール硫酸反応において４８０ｎｍに吸収を示し、そして（４）ゲル濾過法により測定した分子量が５万〜３０万である；を有し、ノストックの熱湯抽出物から精製されることを特徴とする抗ウイルス性多糖類物質（ノストフランｎｏｓｔｏｆｌａｎ）がある（特許文献４参照）。 Moreover, although it is not a substance that can prevent infectious diseases, examples of the substance having an antiviral action include the following properties by the same applicant: (1) polysaccharides including glucose, galactose, xylose, mannose and glucuronic acid And (2) no sulfate group, (3) absorption at 480 nm in the phenol-sulfuric acid reaction, and (4) a molecular weight measured by gel filtration is 50,000 to 300,000. There is an antiviral polysaccharide substance (nostoflan nostoflan) characterized by being purified from hot water extract of stock (see Patent Document 4).
この特許文献４の技術に用いられているノストックは、食用として用いることができる藍藻の一種であり、これら食用の藍藻は古来より重用され、その食経験から安全性が確認されているものである。 Nostock used in the technology of Patent Document 4 is a kind of cyanobacteria that can be used for food, and these edible cyanobacteria have been used since ancient times, and their safety has been confirmed from their dietary experience. is there.
また、前記食用藍藻における生理作用としては、コレステロール低下作用、抗ウイルス作用及び抗菌作用が報告されており、これら作用を有する薬剤または食品等として利用することが期待されている。 Moreover, as a physiological action in the edible cyanobacteria, a cholesterol lowering action, an antiviral action and an antibacterial action have been reported, and it is expected to be used as a drug or food having such actions.
ところで、抗ウイルス作用や抗菌作用は、感染症予防の一つとして利用できるものと考えることができるようにも思われるが、しかしながら、実際には、前記抗ウイルス作用や抗菌作用はウイルスや病原菌への直接作用によるものであり、実際に体内に侵入したウイルスや病原菌に対しての抑制作用はほとんど期待できないものである。 By the way, it seems that antiviral action and antibacterial action can be considered as one of the prevention of infectious diseases. However, in actuality, however, the antiviral action and antibacterial action are effective against viruses and pathogens. Therefore, it can hardly be expected to suppress the virus and pathogens that actually enter the body.
従って、すでに飲食物として使用されており安全が確認されている材料に由来する物質から感染症を予防できる物質を得るということに解決しなければならない課題を有している。 Therefore, it has the subject which must be solved in obtaining the substance which can prevent an infectious disease from the substance derived from the material which has been already used as food and drink and the safety | security is confirmed.
本発明者らは上記の課題を解決するため種々検討した結果、食用藍藻の抽出物が、顕著な感染症予防効果を有すると言う全く新しい知見を得、本発明を完成させた。つまり、上記した従来例の課題を解決する具体的手段として本発明に係る第１の発明として、藍藻綱のノストック属の髪菜もしくはイシクラゲまたはアファノテーケ属のスイゼンジノリのうち少なくとも１種以上の抽出物を含有していることを特徴とする感染症予防組成物を提供するものである。 As a result of various studies to solve the above-mentioned problems, the present inventors have obtained a completely new finding that an extract of edible cyanobacteria has a remarkable effect of preventing infectious diseases, and completed the present invention. That is, as a first invention according to the present invention as a specific means for solving the problems of the above-described conventional examples, at least one extract of a cyanobacterium Nostock genus hair or jellyfish or an Aphanoteke genus Suisinori It is intended to provide an infectious disease preventive composition characterized by containing.
この第１の発明において、前記髪菜から得られた抽出物の含有量が０．１％〜５％であり、前記イシクラゲから得られた抽出物の含有量が１％〜５％であり、前記スイゼンジノリから得られた抽出物の含有量が０．５％〜５％であることを特徴とする請求項１に記載の感染症予防組成物を付加的な要件として含むものである。 In this first invention, the content of the extract obtained from the hair vegetable is 0.1% to 5%, and the content of the extract obtained from the medusa is 1% to 5%, The infectious disease prevention composition according to claim 1, wherein the content of the extract obtained from the suizendinori is 0.5% to 5%, as an additional requirement.
また、第２及び第３の発明として、前記第１の発明に係る感染症予防組成物を含有し感染症予防に用いられる飲食物及び飼餌料を提供するものである。
In addition, as the second and third inventions, the present invention provides foods and drinks that contain the infectious disease preventing composition according to the first invention and are used for infectious disease prevention .
本発明に係る感染症予防組成物は、藍藻綱のノストック属の髪菜もしくはイシクラゲまたはアファノテーケ属のスイゼンジノリのうち少なくとも１種以上の抽出物を含有しているため、抗ウイルス作用、抗菌作用及び免疫増強作用の作用を有すると共に、感染症予防作用を有し、長年の食経験から既にその安全性が確認されている飲食可能な藍藻を用いた感染症予防組成物を提供できるようになるという優れた効果を奏する。
また、前記感染症予防組成物を含有する飲食物及び飼餌料にすることにより、前記感染症予防組成物がもつ作用を有する飲食物及び飼餌料を提供できるようになるという優れた効果を奏する。
The composition for preventing infectious diseases according to the present invention contains at least one or more extracts of the cyanobacterium Nostock rape or Ishijelly or Afanoteke suizenjinori, and thus has an antiviral action, an antibacterial action, and It has the effect of enhancing immunity and has the effect of preventing infectious diseases, and it will be possible to provide a composition for preventing infectious diseases using eatable cyanobacteria whose safety has already been confirmed from many years of eating experience. Excellent effect.
Moreover, the food-drinks and feed which have the effect | action which the said infection prevention composition has can be show | played by making it into the food-drinks and feed containing the said infection-control composition.
次に、本発明を具体的な実施の形態に基づいて詳しく説明する。
本発明の実施の形態に係る感染症予防組成物は、藍藻綱（Ｃｙａｎｏｐｈｙｃｅａｅ）のノストック属（Ｎｏｓｔｏｃ）の髪菜（Ｎ．ｆｌａｇｅｌｌｉｆｏｒｍｅ）もしくはイシクラゲ（Ｎ．ｃｏｍｍｕｎｅ）またはアファノテーケ属（Ａｐｈａｎｏｔｈｅｃｅ）のスイゼンジノリ（Ａ．ｓａｃｒｕｍ）のうち少なくとも１種以上の抽出物を含有している組成物である。
Next, the present invention will be described in detail based on specific embodiments.
The composition for preventing infection according to an embodiment of the present invention includes a hairy vegetable ( N. flagelliform ) or a jellyfish ( N. commune ) or a sphenus genus ( Aphanothece ) of Cyanophyceae, Nostoc. It is a composition containing at least one extract of ( A. sacrum ).
これら食用利用が可能な藍藻から感染症予防組成物を抽出する方法としては、例えば、熱湯または極性の高いアルコール等の溶剤を用いることによって抽出作業を行うことができる。 As a method for extracting the composition for preventing infection from these edible cyanobacteria, for example, extraction can be performed by using a solvent such as hot water or highly polar alcohol.
これら藍藻から抽出される感染症予防組成物における含有量としては、前記髪菜が０．１％〜５％の範囲であり、前記イシクラゲが１％〜５％の範囲であり、前記スイゼンジノリが０．５％〜５％の範囲であることが好ましい。これは、各藍藻におけるそれぞれの最低濃度未満の含有量（配合量）では有効な感染症予防効果を得ることができず、一方、それぞれの最高濃度（５％）より高い場合には感染症予防効果はあるがコストパフォーマンスが悪く、また５％以上の濃度にした場合に得られる効果が比例関係にならないことから、製造上の利用に適さないという意味である。そのため、コストパフォーマンスを考慮しないのであれば、各藍藻において５％以上の濃度にすることを完全に除外するというものではない。 The content of the composition for preventing infections extracted from these cyanobacteria is in the range of 0.1% to 5% for the hair vegetables, in the range of 1% to 5% for the medusa, and 0 It is preferably in the range of 5% to 5%. This means that if the content (mixing amount) of each cyanobacteria is less than the minimum concentration, an effective infection prevention effect cannot be obtained, whereas if it is higher than the maximum concentration (5%), infection prevention is possible. This means that although there is an effect, the cost performance is poor and the effect obtained when the concentration is 5% or more does not have a proportional relationship, it is not suitable for use in production. Therefore, if the cost performance is not taken into account, it is not completely excluded to make the concentration of 5% or more in each cyanobacteria.
本発明においては、さらに、前記感染症予防組成物を含んで成る飲食物、特に感染症予防作用を有する機能性食品を提供する。本発明はさらに、前記感染症予防組成物を含んで成る飼餌料を提供する。 The present invention further provides a food or drink comprising the infectious disease preventing composition, particularly a functional food having an infectious disease preventing action. The present invention further provides a feed comprising the composition for preventing infection.
本発明に用いる藍藻綱のノストック属の髪菜もしくはイシクラゲ、またはアファノテーケ属のスイゼンジノリからなる食用藍藻は、天然由来のものを用いても良いが、安定供給の観点から人工栽培したものを用いても良い。 The edible cyanobacteria composed of the Nodosa genus hairy vegetables or Ishikurage of the cyanobacteria class used in the present invention, or the Aphanoteke genus Suizenjinori may be naturally derived, but those artificially cultivated from the viewpoint of stable supply Also good.
このノストック属の髪菜を人工栽培する方法としては、例えば、特開２００７−２５９７３８号公報（髪菜細胞の培養と髪菜多糖の抽出をリンクさせて行うための方法）に記載された技術等を用いることができる。この技術を用いることによって、イシクラゲの人工栽培を行うこともできる。 As a method for artificially cultivating the hair stock of the genus Nostock, for example, a technique described in Japanese Patent Application Laid-Open No. 2007-259738 (a method for linking the cultivation of hair vegetable cells and the extraction of hair vegetable polysaccharides). Etc. can be used. By using this technique, artificial cultivation of Ishijellyfish can be performed.
また、スイゼンジノリについては、人工栽培法が現在のところ確立されていないことから、例えば、福岡県黄金川に生育するスイゼンジノリを採取、乾燥して市販されている商品等を用いることができる。 In addition, since no artificial cultivation method has been established for suizendinori, it is possible to use, for example, a commercial product obtained by collecting, drying, and drying suizenjinori that grows in the Golden River in Fukuoka Prefecture.
（実施例１〜３）
次に、本発明に係る感染症予防組成物をより具体的な実施例を用いて説明するが、本発明は以下の実施例になんら限定されるものではない。この実施例１においては、髪菜、イシクラゲ及びスイゼンジノリの各食用藍藻乾燥藻体１００ｇを熱湯（９５−１００℃）で３回抽出した（１回目３Ｌ、２回目、３回目２Ｌ）のち、ろ過により藻体を除去した。得られた熱湯抽出物（感染症予防組成物）は約６００ｍＬになるまで減圧濃縮したのち、凍結乾燥により乾燥した。
(Examples 1-3)
Next, although the infectious disease prevention composition which concerns on this invention is demonstrated using a more concrete Example, this invention is not limited to a following example at all. In this Example 1, 100 g of each dried cyanobacterium alga edible body of hair vegetables, icing jellyfish and suizenjinori were extracted three times with hot water (95-100 ° C.) (first time 3 L, second time, second time 2 L) and then filtered. Algal bodies were removed. The obtained hot water extract (infection prevention composition) was concentrated under reduced pressure to about 600 mL, and then dried by freeze-drying.
これら髪菜、イシクラゲ及びスイゼンジノリから得られた熱湯抽出物については、それぞれが感染症予防組成物として利用可能なものであるが、この実施例においては、更に、これら食用藍藻熱湯抽出物を精製水に、髪菜は０．２５％（実施例１）、イシクラゲは２．５％（実施例２）、スイゼンジノリは１％（実施例３）となるように懸濁したものを感染症予防組成物として用いた。なお、これら分量で配合した感染症予防組成物を用いても良い。 About the hot water extract obtained from these kana, jellyfish and suizenjinori, each can be used as an infectious disease prevention composition. In this example, these edible cyanobacter hot water extracts are further purified water. In addition, a composition for preventing infection is prepared by suspending so that the hair vegetables are 0.25% (Example 1), the jellyfish is 2.5% (Example 2), and the water lily is 1% (Example 3). Used as. Infectious disease prevention compositions formulated in these amounts may be used.
（試験例１）
この試験例１においては、前記実施例１〜３の感染症予防組成物に対して、感染症予防作用を確認するための試験を行った。この試験例１の方法は、５週齢のオスｄｄＹマウスに、０．２ｍＬを７日間強制経口投与した。また、水を投与したものを対照群（比較例１）とした。
(Test Example 1)
In Test Example 1, a test for confirming the infectious disease preventing action was performed on the infectious disease preventing compositions of Examples 1 to 3. In the method of Test Example 1, 0.2 mL was forcibly orally administered to 5-week-old male ddY mice for 7 days. Moreover, what administered water was made into the control group (comparative example 1).
投与終了後に、リステリア菌（Ｌｉｓｔｅｒｉａ ｍｏｎｏｃｙｔｏｇｅｎｅｓ）を腹腔内接種し、接種３日後に脾臓を取り出し、ＰＢＳ（リン酸緩衝液）を加えてホモジナイズした。得られたホモジネートを適宜希釈し、寒天培地に塗布し、３７℃、２４時間培養し、出現したリステリア菌のコロニー数を測定した。なお、リステリア菌はグラム陽性、鞭毛を持つ無芽胞の短桿菌（０．４〜０．５×０．５〜２．０μｍ）で、病原性を持つ。 After the administration, Listeria monocytogenes was intraperitoneally inoculated, and 3 days after the inoculation, the spleen was taken out and PBS (phosphate buffer) was added and homogenized. The obtained homogenate was appropriately diluted, applied to an agar medium, cultured at 37 ° C. for 24 hours, and the number of colonies of Listeria monocytogenes appeared was measured. The Listeria monocytogenes is a gram-positive, flagellate, non-spore short bacillus (0.4 to 0.5 × 0.5 to 2.0 μm) and has pathogenicity.
この試験例１の結果を図１に示す。この図１においては、脾臓中のリステリア菌コロニー数を図示した。いずれの感染症予防組成物にも、感染抵抗性が認められた。各感染症予防組成物の水への懸濁度合いが異なったため、調製した被験試料濃度が異なった。そのため、感染症予防組成物間での感染抵抗性の強度の違いは比較できなかった。この結果から、食用藍藻熱水抽出物（感染症予防組成物）には、感染症予防作用が認められた。 The results of Test Example 1 are shown in FIG. In FIG. 1, the number of Listeria monocytogenes colonies in the spleen is shown. Infection resistance was recognized in all the infection prevention compositions. Since the degree of suspension of each infectious disease prevention composition in water was different, the prepared test sample concentrations were different. Therefore, the difference in the intensity of infection resistance between infectious disease prevention compositions could not be compared. From this result, the edible cyanobacteria hot water extract (infectious disease prevention composition) was confirmed to have an infectious disease prevention effect.
（実施例４）
この実施例４においては、飲食品配合例として、各食用藍藻熱水抽出物（感染症予防組成物）の粉末をココアや紅茶、ドリンク剤やドリンク用錠剤などに混ぜて飲みやすいようにするか、ふりかけやハンバーグなどに混ぜて食べやすいようにする形で飲食物に３％含ませて用いた。また、シソ油などの食用油脂に懸濁し、ソフトカプセルに封入し、健康補助食品を作製した。
Example 4
In this Example 4, as an example of blending foods and drinks, the powder of each edible cyanobacteria hot water extract (infection prevention composition) should be mixed with cocoa, tea, drinks, tablets for drinks, etc. It was used by adding 3% to foods and drinks so that it could be mixed with sprinkles or hamburgers to make it easier to eat. In addition, it was suspended in edible oils and fats such as perilla oil and sealed in soft capsules to prepare health supplements.
（実施例５）
この実施例５においては、飼餌料の配合例として、各食用藍藻熱水抽出物を飼餌に配合する場合は、その粉末を穀類、ぬか、ふすま類、魚油粗類、または植物油粗類などに混ぜて用いた。固形物の添加濃度は５％とした。
(Example 5)
In this Example 5, as an example of blending feed, when each edible cyanobacteria hot water extract is blended in the feed, the powder is used for cereals, bran, bran, fish oil crude, or vegetable oil crude. Used by mixing. The solid concentration was 5%.
なお、本発明に係る感染症予防組成物が予防できる感染症としては、例えば、インフルエンザ、風邪、はしか及びＡＩＤＳ等のウイルス起源の感染症、並びに食中毒（黄色ブドウ球菌、サルモネラ菌等）、結核、赤痢、チフス及びリステリア症等の細菌（病原菌）起源の感染症が例として挙げらる。 Infectious diseases that can be prevented by the composition for preventing infection according to the present invention include, for example, influenza, cold, measles and AIDS-derived infectious diseases, food poisoning (S. aureus, Salmonella, etc.), tuberculosis, Examples include infections of bacterial (pathogenic) origin such as dysentery, typhoid and listeriosis.
本発明は、ノストック属の髪菜もしくはイシクラゲまたはアファノテーケ属のスイゼンジノリから選択される食用藍藻のうち少なくとも１種以上の抽出物をから成る感染症予防飲食物、飼餌料、特に感染症予防効果を有する機能性飲食物として適用できる。 The present invention provides an infection-preventing food, food, and particularly an infection-preventing effect comprising at least one extract of an edible cyanobacteria selected from hair stocks of the genus Nostock or icing jellyfish or suizeninori of the genus Afanoteke. It can be applied as a functional food or drink.
Claims (3)
前記髪菜から得られた抽出物の含有量が０．１％〜５％であり、
前記イシクラゲから得られた抽出物の含有量が１％〜５％であり、
前記スイゼンジノリから得られた抽出物の含有量が０．５％〜５％であること
を特徴とする感染症予防組成物。 A composition comprising an extract of the cyanobacterium Nosoto of the cyanobacterium and the extract of Ishi jellyfish and Afanotheque suizenjinori in the following amounts ,
The content of the extract obtained from the hair vegetables is 0.1% to 5%,
The content of the extract obtained from the jellyfish is 1% to 5%,
A composition for preventing infectious diseases, wherein the content of the extract obtained from the suizendinori is 0.5% to 5% .
を特徴とする飲食物。 A food or drink comprising the infectious disease prevention composition according to claim 1 and used for infectious disease prevention .
を特徴とする飼餌料。 A feed comprising the infectious disease prevention composition according to claim 1 and used for infectious disease prevention .
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