JP5394238B2 - 短時間作用型ベンゾジアゼピンの塩およびその多型形態 - Google Patents

短時間作用型ベンゾジアゼピンの塩およびその多型形態 Download PDF

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JP5394238B2
JP5394238B2 JP2009518957A JP2009518957A JP5394238B2 JP 5394238 B2 JP5394238 B2 JP 5394238B2 JP 2009518957 A JP2009518957 A JP 2009518957A JP 2009518957 A JP2009518957 A JP 2009518957A JP 5394238 B2 JP5394238 B2 JP 5394238B2
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salt
esylate
salt according
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compound
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JP2009542787A5 (enExample
JP2009542787A (ja
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ゲイリー スチュワート ティルブルック，
ルイザ ジェーン キュービット，
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パイオン ユーケー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009518957A 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびその多型形態 Active JP5394238B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0613693.1 2006-07-10
GBGB0613693.1A GB0613693D0 (en) 2006-07-10 2006-07-10 Benzodiazepine salts (3)
PCT/GB2007/002583 WO2008007081A1 (en) 2006-07-10 2007-07-10 Short-acting benzodiazepine salts and their polymorphic forms

Publications (3)

Publication Number Publication Date
JP2009542787A JP2009542787A (ja) 2009-12-03
JP2009542787A5 JP2009542787A5 (enExample) 2011-08-04
JP5394238B2 true JP5394238B2 (ja) 2014-01-22

Family

ID=36926778

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009518957A Active JP5394238B2 (ja) 2006-07-10 2007-07-10 短時間作用型ベンゾジアゼピンの塩およびその多型形態

Country Status (9)

Country Link
US (1) US8642588B2 (enExample)
EP (1) EP2089378B1 (enExample)
JP (1) JP5394238B2 (enExample)
AT (1) ATE461927T1 (enExample)
CA (1) CA2657369C (enExample)
DE (1) DE602007005515D1 (enExample)
ES (1) ES2343444T3 (enExample)
GB (1) GB0613693D0 (enExample)
WO (1) WO2008007081A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170091770A (ko) 2006-07-10 2017-08-09 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN102964349A (zh) * 2011-08-31 2013-03-13 江苏恒瑞医药股份有限公司 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途
CN104968348B (zh) 2012-05-22 2018-04-17 Paion英国有限公司 包含短效苯二氮杂*类化合物的组合物
DK2891494T3 (da) 2012-08-31 2023-10-23 Paion Uk Ltd Fremgangsmåde til administration af hypnotisserende/beroligende midler
AR094963A1 (es) * 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN103202815B (zh) * 2013-05-05 2014-09-24 李友香 治疗精神疾病的注射剂
CN103232454A (zh) * 2013-05-05 2013-08-07 王元青 治疗精神疾病的药物
CN104146970A (zh) * 2013-05-05 2014-11-19 王元青 治疗精神疾病的冻干粉针剂
CN103230595B (zh) * 2013-05-05 2014-10-08 李友香 治疗精神疾病的组合物
CN106632342B (zh) * 2015-08-07 2019-01-25 成都倍特药业有限公司 苯并二氮杂*衍生物的2-萘磺酸盐及晶型和它们的制备方法
WO2017178663A1 (en) 2016-04-14 2017-10-19 Paion Uk Limited Orally inhaled and nasal benzodiazepines
CN108503644B (zh) * 2016-12-09 2019-06-14 成都倍特药业有限公司 一种苯并二氮杂*衍生物的氢溴酸盐及其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4724237A (en) 1984-06-26 1988-02-09 Merck & Co., Inc. 2-substituted-aminomethyl-1,4-benzodiazepines
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
CA2143246C (en) * 1994-03-16 2000-08-22 Thierry Godel Imidazodiazepines
US5834464A (en) * 1994-11-18 1998-11-10 Merck & Co., Inc. Imidazolinobenzodiazepines
WO1996020941A1 (de) 1995-01-06 1996-07-11 F. Hoffmann-La Roche Ag Hydroxymethyl-imidazodiazepine und deren ester
AU4382896A (en) 1995-02-02 1996-08-21 F. Hoffmann-La Roche Ag Acetylimidazobenzodiazepines
GB9911152D0 (en) 1999-05-14 1999-07-14 Glaxo Group Ltd Short-acting benzodiazepines
US7160880B1 (en) * 1999-05-14 2007-01-09 Cenes Limited Short-acting benzodiazepines
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
KR20170091770A (ko) 2006-07-10 2017-08-09 파이온 유케이 리미티드 속효형 벤조디아제핀 염 및 이의 중합체 형태

Also Published As

Publication number Publication date
US20100075955A1 (en) 2010-03-25
CA2657369C (en) 2014-12-09
ES2343444T3 (es) 2010-07-30
EP2089378A1 (en) 2009-08-19
JP2009542787A (ja) 2009-12-03
DE602007005515D1 (de) 2010-05-06
CA2657369A1 (en) 2008-01-17
EP2089378B1 (en) 2010-03-24
GB0613693D0 (en) 2006-08-16
US8642588B2 (en) 2014-02-04
WO2008007081A1 (en) 2008-01-17
ATE461927T1 (de) 2010-04-15

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