JP5345842B2 - プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ - Google Patents

プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ Download PDF

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Publication number
JP5345842B2
JP5345842B2 JP2008517594A JP2008517594A JP5345842B2 JP 5345842 B2 JP5345842 B2 JP 5345842B2 JP 2008517594 A JP2008517594 A JP 2008517594A JP 2008517594 A JP2008517594 A JP 2008517594A JP 5345842 B2 JP5345842 B2 JP 5345842B2
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Prior art keywords
phenyl
pyrazol
chloro
group
compound
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Expired - Fee Related
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JP2008517594A
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English (en)
Japanese (ja)
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JP2008546754A5 (enExample
JP2008546754A (ja
Inventor
ニール・トーマス・トンプソン
ロバート・ジョージ・ボイル
イアン・コリンズ
ミシェル・ドーン・ガレット
ジョン・フランシス・ライオンズ
カイラ・メリオム・トンプソン
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The Institute of Cancer Research: Royal Cancer Hospital
Cancer Research Technology Ltd
Astex Therapeutics Ltd
Original Assignee
The Institute of Cancer Research: Royal Cancer Hospital
Cancer Research Technology Ltd
Astex Therapeutics Ltd
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Application filed by The Institute of Cancer Research: Royal Cancer Hospital, Cancer Research Technology Ltd, Astex Therapeutics Ltd filed Critical The Institute of Cancer Research: Royal Cancer Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008517594A 2005-06-23 2006-06-21 プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ Expired - Fee Related JP5345842B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US69336705P 2005-06-23 2005-06-23
US69330905P 2005-06-23 2005-06-23
US69331405P 2005-06-23 2005-06-23
US69331505P 2005-06-23 2005-06-23
US69349205P 2005-06-23 2005-06-23
US60/693,309 2005-06-23
US60/693,314 2005-06-23
US60/693,492 2005-06-23
US60/693,367 2005-06-23
US60/693,315 2005-06-23
PCT/GB2006/002297 WO2006136837A2 (en) 2005-06-23 2006-06-21 Pharmaceutical combinations comprising pyrazole derivatives as protein kinase modulators

Publications (3)

Publication Number Publication Date
JP2008546754A JP2008546754A (ja) 2008-12-25
JP2008546754A5 JP2008546754A5 (enExample) 2009-08-06
JP5345842B2 true JP5345842B2 (ja) 2013-11-20

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JP2008517594A Expired - Fee Related JP5345842B2 (ja) 2005-06-23 2006-06-21 プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ

Country Status (4)

Country Link
US (1) US8541461B2 (enExample)
EP (1) EP1933832A2 (enExample)
JP (1) JP5345842B2 (enExample)
WO (1) WO2006136837A2 (enExample)

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Also Published As

Publication number Publication date
US8541461B2 (en) 2013-09-24
EP1933832A2 (en) 2008-06-25
WO2006136837A2 (en) 2006-12-28
WO2006136837A3 (en) 2007-02-15
US20100166699A1 (en) 2010-07-01
JP2008546754A (ja) 2008-12-25

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