JP5335784B2 - 単分散液滴の生成 - Google Patents
単分散液滴の生成 Download PDFInfo
- Publication number
- JP5335784B2 JP5335784B2 JP2010514110A JP2010514110A JP5335784B2 JP 5335784 B2 JP5335784 B2 JP 5335784B2 JP 2010514110 A JP2010514110 A JP 2010514110A JP 2010514110 A JP2010514110 A JP 2010514110A JP 5335784 B2 JP5335784 B2 JP 5335784B2
- Authority
- JP
- Japan
- Prior art keywords
- fluid
- cavity
- droplets
- jet
- droplet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012530 fluid Substances 0.000 claims description 81
- 238000000034 method Methods 0.000 claims description 29
- 239000002131 composite material Substances 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 6
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 14
- 239000007788 liquid Substances 0.000 description 14
- 239000000839 emulsion Substances 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 239000006185 dispersion Substances 0.000 description 9
- 239000002245 particle Substances 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- -1 silver halide Chemical class 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000005202 decontamination Methods 0.000 description 1
- 230000003588 decontaminative effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 150000001247 metal acetylides Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000007908 nanoemulsion Substances 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
- B01F25/4337—Mixers with a diverging-converging cross-section
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Nozzles (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0712863.0 | 2007-07-03 | ||
| GBGB0712863.0A GB0712863D0 (en) | 2007-07-03 | 2007-07-03 | Monodisperse droplet generation |
| PCT/GB2008/002217 WO2009004314A1 (en) | 2007-07-03 | 2008-06-27 | Monodisperse droplet generation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010531730A JP2010531730A (ja) | 2010-09-30 |
| JP2010531730A5 JP2010531730A5 (enExample) | 2011-08-11 |
| JP5335784B2 true JP5335784B2 (ja) | 2013-11-06 |
Family
ID=38421116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514110A Expired - Fee Related JP5335784B2 (ja) | 2007-07-03 | 2008-06-27 | 単分散液滴の生成 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8302880B2 (enExample) |
| EP (1) | EP2164617B1 (enExample) |
| JP (1) | JP5335784B2 (enExample) |
| CN (1) | CN101687152B (enExample) |
| GB (1) | GB0712863D0 (enExample) |
| WO (1) | WO2009004314A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006096571A2 (en) | 2005-03-04 | 2006-09-14 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
| EP2286125B1 (en) * | 2008-05-16 | 2015-07-08 | President and Fellows of Harvard College | Valves and other flow control in fluidic systems including microfluidic systems |
| ES2427619T3 (es) * | 2008-09-18 | 2013-10-31 | Technische Universiteit Eindhoven | Procedimiento para preparar emulsiones mono-dispersadas |
| EP2411133B1 (en) | 2009-03-25 | 2013-12-18 | Eastman Kodak Company | Droplet generator |
| WO2011028764A2 (en) | 2009-09-02 | 2011-03-10 | President And Fellows Of Harvard College | Multiple emulsions created using jetting and other techniques |
| FR2958186A1 (fr) | 2010-03-30 | 2011-10-07 | Ecole Polytech | Dispositif de formation de gouttes dans un circuit microfluide. |
| CN101994162A (zh) * | 2010-12-10 | 2011-03-30 | 江南大学 | 微流体静电纺丝装置 |
| BR112013029729A2 (pt) | 2011-05-23 | 2017-01-24 | Basf Se | controle de emulsões, incluindo emulsões múltiplas |
| BR112014000141A2 (pt) | 2011-07-06 | 2017-06-13 | Harvard College | emulsões múltiplas e técnicas para a formação de emulsões múltiplas |
| US8602535B2 (en) | 2012-03-28 | 2013-12-10 | Eastman Kodak Company | Digital drop patterning device and method |
| US8939551B2 (en) | 2012-03-28 | 2015-01-27 | Eastman Kodak Company | Digital drop patterning device and method |
| US8936354B2 (en) | 2012-03-28 | 2015-01-20 | Eastman Kodak Company | Digital drop patterning device and method |
| US8936353B2 (en) | 2012-03-28 | 2015-01-20 | Eastman Kodak Company | Digital drop patterning device and method |
| GB2502058B (en) * | 2012-05-14 | 2014-08-06 | Schlumberger Holdings | Determining interfacial tension between first and second immiscible liquids |
| GB2513310B (en) | 2013-04-22 | 2015-09-16 | Schlumberger Holdings | Determination of interfacial or surface tension |
| RU2703858C2 (ru) | 2014-12-12 | 2019-10-22 | Дженерал Электрик Компани | Устройство и способ кондиционирования потока жирного газа |
| CN107405633A (zh) * | 2015-05-22 | 2017-11-28 | 香港科技大学 | 基于高深宽比诱导生成液滴的液滴发生器 |
| CN105498869B (zh) * | 2015-11-27 | 2017-06-09 | 中国石油大学(华东) | 一种微纳米液滴制备方法 |
| DE102017105194A1 (de) * | 2017-03-10 | 2018-09-13 | Little Things Factory Gmbh | Fokussiereinrichtung, Tropfengenerator und Verfahren zum Erzeugen einer Vielzahl von Tröpfchen |
| CN107029640B (zh) * | 2017-05-23 | 2023-04-21 | 中国科学技术大学 | 基于液驱流动聚焦射流扰动的微液滴主动制备装置及方法 |
| AU2019321552A1 (en) * | 2018-08-17 | 2021-03-11 | The Regents Of The University Of California | Monodispersed particle-triggered droplet formation from stable jets |
| CN111841439A (zh) * | 2020-08-19 | 2020-10-30 | 中国科学技术大学 | 一种高通量制备均匀单乳液滴的装置及方法 |
| CN112844895B (zh) * | 2021-01-03 | 2021-08-17 | 清华大学 | 一种控制液体射流破碎的装置 |
| CN114749219B (zh) * | 2022-03-30 | 2023-06-02 | 北京航空航天大学 | 集成压电式均匀液滴发生器 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61138529A (ja) * | 1984-12-10 | 1986-06-26 | Idemitsu Petrochem Co Ltd | サイズ用乳化液の製造方法 |
| GB9406255D0 (en) * | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
| US5873523A (en) * | 1996-02-29 | 1999-02-23 | Yale University | Electrospray employing corona-assisted cone-jet mode |
| CA2315048A1 (en) | 1997-12-17 | 1999-06-24 | Universidad De Sevilla | Device and method for creating spherical particles of uniform size |
| CA2314919A1 (en) * | 1997-12-17 | 1999-06-24 | Alfonso Ganan Calvo | Device and method for aeration of fluids |
| SE522494C2 (sv) * | 1999-01-26 | 2004-02-10 | Kvaerner Pulping Tech | Apparat för att införa ett första fluidum i ett andra fluidum som strömmar i en rörledning |
| EP1169121B1 (en) | 1999-04-06 | 2012-10-31 | E Ink Corporation | Methods for producing droplets for use in capsule-based electrophoretic displays |
| EP1334347A1 (en) | 2000-09-15 | 2003-08-13 | California Institute Of Technology | Microfabricated crossflow devices and methods |
| JP2006507921A (ja) * | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| AU2004229440B2 (en) * | 2003-04-10 | 2010-08-12 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| EP2662136A3 (en) * | 2003-08-27 | 2013-12-25 | President and Fellows of Harvard College | Method for handling and mixing droplets |
| EP1742979A4 (en) | 2004-04-23 | 2008-05-21 | Eugenia Kumacheva | METHOD FOR PRODUCING POLYMER PARTICLES OF SELECTED SIZE, MOLD, MORPHOLOGY AND COMPOSITION |
| US7759111B2 (en) * | 2004-08-27 | 2010-07-20 | The Regents Of The University Of California | Cell encapsulation microfluidic device |
| US20060234051A1 (en) * | 2005-01-27 | 2006-10-19 | Zhang Wendy W | System and method of obtaining entrained cylindrical fluid flow |
| US20070054119A1 (en) * | 2005-03-04 | 2007-03-08 | Piotr Garstecki | Systems and methods of forming particles |
| WO2006096571A2 (en) | 2005-03-04 | 2006-09-14 | President And Fellows Of Harvard College | Method and apparatus for forming multiple emulsions |
| DE102005048259B4 (de) | 2005-10-07 | 2007-09-13 | Landesstiftung Baden-Württemberg | Vorrichtung und Verfahren zur Erzeugung eines Gemenges von zwei ineinander unlösbaren Phasen |
| JP4713397B2 (ja) * | 2006-01-18 | 2011-06-29 | 株式会社リコー | 微小流路構造体及び微小液滴生成システム |
| JP2008100182A (ja) * | 2006-10-20 | 2008-05-01 | Hitachi Plant Technologies Ltd | 乳化装置および微粒子製造装置 |
-
2007
- 2007-07-03 GB GBGB0712863.0A patent/GB0712863D0/en not_active Ceased
-
2008
- 2008-06-27 CN CN2008800232872A patent/CN101687152B/zh not_active Expired - Fee Related
- 2008-06-27 EP EP08762513A patent/EP2164617B1/en not_active Not-in-force
- 2008-06-27 JP JP2010514110A patent/JP5335784B2/ja not_active Expired - Fee Related
- 2008-06-27 WO PCT/GB2008/002217 patent/WO2009004314A1/en not_active Ceased
- 2008-06-27 US US12/664,941 patent/US8302880B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2164617B1 (en) | 2013-03-27 |
| JP2010531730A (ja) | 2010-09-30 |
| CN101687152B (zh) | 2013-02-06 |
| CN101687152A (zh) | 2010-03-31 |
| WO2009004314A1 (en) | 2009-01-08 |
| US8302880B2 (en) | 2012-11-06 |
| EP2164617A1 (en) | 2010-03-24 |
| GB0712863D0 (en) | 2007-08-08 |
| US20100170957A1 (en) | 2010-07-08 |
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