JP5323680B2 - 結腸直腸細胞増殖性疾患を検出するための方法および核酸 - Google Patents
結腸直腸細胞増殖性疾患を検出するための方法および核酸 Download PDFInfo
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Engineering & Computer Science (AREA)
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- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
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- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
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- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2006/014131 WO2006113466A2 (en) | 2005-04-15 | 2006-04-17 | Methods and nucleic acids for analyses of cellular proliferative disorders |
| USPCT/US2006/014131 | 2006-04-17 | ||
| EP06090119.6 | 2006-06-27 | ||
| EP06090119 | 2006-06-27 | ||
| PCT/EP2007/003380 WO2007118704A2 (en) | 2006-04-17 | 2007-04-17 | Methods and nucleic acids for the detection of colorectal cell proliferative disorders |
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| JP2013123304A Division JP5846693B2 (ja) | 2006-04-17 | 2013-06-12 | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 |
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| JP2009533066A JP2009533066A (ja) | 2009-09-17 |
| JP2009533066A5 JP2009533066A5 (enrdf_load_stackoverflow) | 2011-04-28 |
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| JP2009505769A Expired - Fee Related JP5323680B2 (ja) | 2006-04-17 | 2007-04-17 | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 |
| JP2013123304A Expired - Fee Related JP5846693B2 (ja) | 2006-04-17 | 2013-06-12 | 結腸直腸細胞増殖性疾患を検出するための方法および核酸 |
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| EP1877577A2 (en) | 2005-04-15 | 2008-01-16 | Epigenomics Inc. | Methods and nucleic acids for analyses of cellular proliferative disorders |
| WO2008122447A2 (en) * | 2007-04-10 | 2008-10-16 | Epigenomics Ag | Dna methylation assay for the diagnosis or prognosis of medical conditions |
| EP2616556B1 (en) * | 2010-09-13 | 2018-12-26 | Clinical Genomics Pty Ltd | Epigenetic markers of colorectal cancers and diagnostic methods using the same |
| FR2967165B1 (fr) * | 2010-11-04 | 2014-10-10 | Assist Publ Hopitaux De Paris | Methode de depistage du cancer colorectal |
| CN103732759A (zh) * | 2011-07-08 | 2014-04-16 | 表观基因组股份有限公司 | 用于确定癌症对象之预后的方法和核酸 |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| CN104046680B (zh) * | 2013-03-11 | 2016-04-06 | 苏州承美生物科技有限公司 | 甲基化dna检测方法 |
| EP3152333B1 (en) | 2014-06-04 | 2019-09-11 | Quest Diagnostics Investments Incorporated | Methylated markers for colorectal cancer |
| EP3521448A4 (en) * | 2016-09-29 | 2020-07-29 | Hanumat Co., Ltd. | PROCESS FOR DETERMINING THE RISK OF APPEARANCE OF SPORADIC COLON CANCER |
| WO2018087129A1 (en) * | 2016-11-08 | 2018-05-17 | Region Nordjylland, Aalborg University Hospital | Colorectal cancer methylation markers |
| US11884980B2 (en) * | 2018-11-28 | 2024-01-30 | Bioscreening & Diagnostics Llc | Method for detection of traumatic brain injury |
| CN111826441A (zh) * | 2019-04-23 | 2020-10-27 | 博尔诚（北京）科技有限公司 | 用于体外检测消化道五癌的体系，在该体系中使用的组合物，以及包含该组合物的试剂盒 |
| CN112195243A (zh) * | 2020-09-22 | 2021-01-08 | 北京华大吉比爱生物技术有限公司 | 一种检测多基因甲基化的试剂盒及其应用 |
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| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5457183A (en) | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US5667976A (en) * | 1990-05-11 | 1997-09-16 | Becton Dickinson And Company | Solid supports for nucleic acid hybridization assays |
| US5245022A (en) | 1990-08-03 | 1993-09-14 | Sterling Drug, Inc. | Exonuclease resistant terminally substituted oligonucleotides |
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| DK0724646T3 (da) * | 1991-01-04 | 2001-09-03 | Univ Washington | DNA sekvenser knyttet til isoleret fragilt X syndrom |
| US5565552A (en) | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| US5364787A (en) * | 1992-03-23 | 1994-11-15 | Idaho Research Foundation | Genes and enzymes involved in the microbial degradation of pentachlorophenol |
| US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| JPH09506253A (ja) | 1993-11-30 | 1997-06-24 | マクギル・ユニヴァーシティ | Ｄｎａメチルトランスフェラーゼの阻害 |
| US5597696A (en) | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| US5514758A (en) | 1994-09-30 | 1996-05-07 | The Goodyear Tire & Rubber Company | Process for making latex for high performance masking tape |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| AU7829398A (en) | 1997-06-09 | 1998-12-30 | University Of Southern California | A cancer diagnostic method based upon dna methylation differences |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| US7700324B1 (en) | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| US5958773A (en) | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| US6331393B1 (en) | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| US6783933B1 (en) * | 1999-09-15 | 2004-08-31 | The Johns Hopkins University School Of Medicine | CACNA1G polynucleotide, polypeptide and methods of use therefor |
| WO2005000087A2 (en) * | 2003-06-03 | 2005-01-06 | Chiron Corporation | Gene products differentially expressed in cancerous colon cells and their methods of use ii |
| US20050064401A1 (en) * | 2000-09-01 | 2005-03-24 | Alexander Olek | Diagnosis of illnesses or predisposition to certain illnesses |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| WO2003042661A2 (en) * | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
| US8101359B2 (en) | 2002-10-01 | 2012-01-24 | Epigenomics Ag | Method for determining risk of relapse of breast cancer following tamoxifen adjuvant therapy |
| WO2004074441A2 (en) * | 2003-02-19 | 2004-09-02 | Government Of The United States Of America Represented By The Secretary Department Of Health And Human Services | Amplification or overexpression of mll septin-like fusion (msf) and septin9 and methods related thereto |
| ATE494390T1 (de) * | 2003-06-23 | 2011-01-15 | Epigenomics Ag | Verfahren und nukleinsäuren zur analyse von störungen der proliferation von kolonzellen |
| WO2005001141A2 (en) * | 2003-06-23 | 2005-01-06 | Epigenomics Ag | Methods and nucleic acids for analyses of colorectal cell proliferative disorders |
| WO2005123945A2 (en) * | 2004-06-21 | 2005-12-29 | Epigenomics Ag | Epigenetic markers for the treatment of breast cancer |
| US20090298054A1 (en) * | 2004-07-18 | 2009-12-03 | Epigenomics Ag | Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders |
| EP1877577A2 (en) * | 2005-04-15 | 2008-01-16 | Epigenomics Inc. | Methods and nucleic acids for analyses of cellular proliferative disorders |
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- 2007-04-17 CA CA2649777A patent/CA2649777C/en active Active
- 2007-04-17 AU AU2007237444A patent/AU2007237444B2/en not_active Ceased
- 2007-04-17 EP EP11009931.4A patent/EP2479283B1/en not_active Not-in-force
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| ES2587068T3 (es) | 2016-10-20 |
| CA2649777C (en) | 2018-08-14 |
| JP2009533066A (ja) | 2009-09-17 |
| JP2013230153A (ja) | 2013-11-14 |
| WO2007118704A3 (en) | 2008-04-24 |
| US20220260570A1 (en) | 2022-08-18 |
| EP2484778A2 (en) | 2012-08-08 |
| JP5846693B2 (ja) | 2016-01-20 |
| CA2649777A1 (en) | 2007-10-25 |
| EP2479283B1 (en) | 2016-06-22 |
| AU2007237444A1 (en) | 2007-10-25 |
| EP2479283A1 (en) | 2012-07-25 |
| EP2484778A3 (en) | 2012-10-10 |
| AU2007237444B2 (en) | 2013-05-23 |
| WO2007118704A2 (en) | 2007-10-25 |
| EP2013360A2 (en) | 2009-01-14 |
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