JP5303225B2 - Gray hair improver - Google Patents

Description

  The present invention relates to a gray hair improving material having an action of making gray hair dark, and more specifically, increasing melanocytes and further maintaining, improving and promoting the activity of melanocyte stimulating factor to activate melanocytes and blackening gray hair The present invention relates to a gray hair improving agent comprising polyphosphoric acid having an excellent action.

Conventionally, as an anti-hair whitening agent having an action of turning gray hair into black hair, an extract of okogi (patent document 1), malotilate (dithiol derivative) (non-patent document 1), basic fibroblast growth factor (b-FGF) Or angiogenin (patent document 2), ω-alkoxycarbonylalkyltrialkylammonium (patent document 3), armature extract (patent document 4), salamander extract (patent document 5), pepper extract (non-patent document 2) ) Etc. are known.
JP 60-178805 A JP-A-8-208440 Japanese Patent Laid-Open No. 7-316048 JP 58-99417 A JP 11-79951 A Cosmetic Society Journal, Vol.21, No.3 (1997) Biol.Pharm.Bull., 27,1611-1616 (2004)

  However, the effects of these anti-whitening agents are not always sufficient, and there are almost no commercially available products. The cause of gray hair is the decrease and inactivation of melanocytes in the hair follicle, and it is thought that inactivation of melanocytes is related to various melanocyte stimulating factors, but the mechanism is still unclear. There are many unclear points.

  An object of the present invention is to provide a gray hair improving agent having excellent white hair improvement and prevention effects.

  As a result of intensive studies, the present inventor has found that polyphosphoric acid has an excellent white hair improvement and prevention action, and has completed the present invention.

  That is, the present invention provides a gray hair improving agent containing polyphosphoric acid. In addition, the present invention provides the polyphosphoric acid to an okogi extract, malotilate (dithiol derivative), basic fibroblast growth factor (b-FGF), angiogenin, ω-alkoxycarbonylalkyltrialkylammonium, amacha extract, Provided is a gray hair improving agent comprising at least one anti-white hair agent selected from the group consisting of a salmon extract and a pepper extract.

  The white hair improving agent of the present invention has excellent white hair improving and preventing effects. That is, by using the gray hair improving agent of the present invention, melanocytes in the scalp are activated, the improvement of white hair is promoted, and the generation of white hair is suppressed.

Examples of the polyphosphoric acid used in the present invention include linear condensed polyphosphoric acid obtained by dehydration condensation of orthophosphoric acid, side-chain polyphosphoric acid having an organic group introduced in the side chain, cyclic polyphosphoric acid, etc. The composition formula is represented by H _{(n + 2)} P _n O _{(3n + 1)} (n is an integer of 2 or more), and as shown in Formula 1, two or more PO ₄ tetrahedra share a vertex oxygen atom and A linear condensed polyphosphoric acid having a chain-like structure is preferred.

  n is an integer of 2 or more.

  n is an integer of at least 2 or more, preferably 5 to 5000, and more preferably 15 to 5000. That is, the polyphosphoric acid of the present invention is preferably a polyphosphoric acid having an average chain length of 15 or more.

  Also included within the scope of the present invention are polyphosphates in which the hydrogen of the polyphosphate is replaced with a metal cation. Examples of metal ions that form salts with polyphosphoric acid include sodium, potassium, magnesium, calcium, and the like.

As an example, sodium polyphosphate in which hydrogen is replaced by sodium ion in Formula 1 is shown below as Formula 2. Sodium polyphosphate represented by the formula 2 is a compound represented by the chemical composition formula Na _{(n + 2)} P _n O _{(3n + 1)} (n is an integer of 2 or more).

  n is an integer of 2 or more.

  There is no restriction | limiting in particular in the manufacturing method of polyphosphoric acid, Polyphosphoric acid can be manufactured by the arbitrary manufacturing methods well-known at the time of this application. For example, as a method for obtaining medium-long chain polyphosphoric acid having an average chain length of 15 or more, there is a method using hexametaphosphate which is inexpensive and easily available. In this method, first, hexametaphosphate is dissolved in water so as to be 0.1 to 10% by weight, preferably 10% by weight. In this hexametaphosphoric acid aqueous solution, 87-100% ethanol, preferably 96% ethanol, is added in an amount of 1/10 to 1/3 of the total liquid volume after mixing the hexametaphosphoric acid solution and ethanol. Add in an amount to give a volume ratio of 2: 1 to 9: 1. The mixed solution is sufficiently stirred, and the resulting precipitate is separated from the aqueous solution component using a separation method such as centrifugation or filter filtration. The precipitate thus separated is medium-long chain polyphosphoric acid. The polyphosphoric acid is subsequently washed with 70% ethanol and then dried. The average chain length of polyphosphoric acid obtained by such a separation operation is 60 to 70, and 10 or less short-chain polyphosphoric acid is hardly contained.

The concentration of polyphosphoric acid used as a white hair improving agent is, for example, 1 × 10 ⁻⁷ to 50% by weight, preferably 0.01 to 10% by weight in the white hair improving agent. If the content of polyphosphoric acid is less than 1 × 10 ⁻⁷ wt%, the effect of improving gray hair cannot be obtained, and if the content of polyphosphoric acid exceeds 50 wt%, formulation problems arise.

The present invention may also be a gray hair improving agent obtained by mixing polyphosphoric acid with various substances already known as anti-whitening agents. Known anti-whitening agents include, but are not limited to, for example, okogi extract, malotilate (dithiol derivative), fibroblast growth factor, angiogenin, ω-alkoxycarbonylalkyltrialkylammonium, amacha extract, salamander extract And a group consisting of pepper extract. The anti-whitening agent may be used in combination of two or more types of anti-whitening agents. The blending amount of the anti-whitening agent in the gray hair improving agent is, for example, 1 × 10 ⁻⁷ to 50% by weight, preferably 0.001 to 10% by weight.

In addition to the above-mentioned components, the gray hair improving agent of the present invention includes a cell activator (pantothenic acid and derivatives thereof, photosensitizer 301, carrot extract, biotin, mononitroguaiacol, allantoin, pentadecanoic acid glyceride, chlorella extract, Royal jelly, beech extract, α-hydroxy acid, mucin, silk sulfate hydrolyzate, seaweed extract, diisopropylamine dichloroacetate, retinol, γ-amino-β-hydroxybutyric acid, steroid derivative, pear seed extract, nicotinic alcohol Organic acid salt, Coleus-Forscolli extract, yeast extract, oat extract, camcum extract, bifidobacteria extract, Citrus plant extract, bryonolic acid, γ-aminobutyric acid, moon peach extract, hibiscus extract Products), blood flow promoters (acetylcholine, carpronium chloride, assembly extract) , Pepper, tincture, hinokitiol, cephalanthin, benzyl nicotinate, garlic extract, toki extract, gentian extract, γ-oryzanol, licorice extract, minoxidil, nematode extract, chixet ginseng extract, ginger extract Extract, aloe extract, ginkgo biloba extract, spironolactone, vitamin B ₆ hydrochloride, D-camphor, DL-camphor, DL-α-tocopherol, garlic iodide extract, DL-α-tocopherol linoleate, inositol hexa Nicotinic acid ester, vitamin E derivative, sodium dextran sulfate, nicotinic acid, DL-α-tocopherol nicotinic acid ester, butoxyethyl nicotinate, methyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol succinate, DL-α-acetic acid acetate Tocopherol, Octylphthalide, cantalis tincture, ginger tincture, etc.), moisturizer (glycerin, propylene glycol, hyaluronic acid, sodium pyrrolidonecarboxylate, chondroitin sulfate, mini sasanishiki extract, cordyceps extract, saffron extract, mucin, etc.), skin irritation Agents (L-menthol, peppermint oil, benzyl nicotinate, nonyl acid vanillamide, camphor, etc.), female hormones (estrone, estradiol, ethinyl estradiol, etc.), female hormone-like substances (soy extract, soybean milk fermentation liquor, licorice extract, Licorice leaf extract, isoflavones, daidzein, genistein, etc.), amino acids (cystine, cysteine, methionine, serine, etc.), vitamins, keratolytic agents (salicylic acid, resorcin, lactic acid, glycolic acid, etc.), percutaneous absorption promotion Agents (alcohols such as ethanol and isopropanol, polyhydric alcohols such as propylene glycol, polyethylene glycol and glycerin, pyrrolidones, hyaluronic acid, urea derivatives, salicylic acid and other moisturizing / softening agents, dimethylformamide, dimethyl sulfoxide, dimethylacetamide An aprotic solvent such as a medium chain fatty acid ester, propylene glycol oleate, lecithin, isopropyl myristate, and the like, surfactant, azone, azone analogue, cyclic urea, etc.). The blending amount of these additional components in the gray hair improving agent is, for example, 1 × 10 ⁻⁷ to 50% by weight, preferably 0.001 to 10% by weight.

In addition, the gray hair improving agent of the present invention includes oil (squalane, liquid paraffin, polybutene, silicone, jojoba oil, camellia oil, etc.), surfactant (polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid). Esters, glycerin fatty acid esters, polyglycerin fatty acid esters, etc.), polyhydric alcohols (propylene glycol, 1,3-butylene glycol, isoprene glycol, dipropylene glycol, sorbitol, maltitol, glycerin, etc.), antioxidants (dibutylhydroxytoluene) , Isopropyl gallate, tocopherol, etc.), sequestering agent (edetate, ethylenediaminetetraacetate or its salt, alanine, sodium citrate, gluconic acid, tartaric acid, etc.) , Anti-inflammatory agents (glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, licorice extract, carbenoxolone disodium, guaiazulene, diphenhydramine hydrochloride, sicon extract, agez extract, hydrocortisone acetate, prednisolone, etc.), preservatives (parabens, chlorhexidine gluconate) Sorbic acid, benzalkonium chloride, chlorxylenol, trichlorocarbanilide, halocarban, mononitroguaiacol, Photosensitizer 201, salicylic acid, etc.), water-soluble polymers, dyes, fragrances, and the like can be appropriately blended. The blending amount of these additional components in the gray hair improving agent is, for example, 1 × 10 ⁻⁷ to 50% by weight, preferably 0.001 to 10% by weight.

  The white hair improving agent of the present invention may be used once to several times a day (for example, 2 to 6 times) by applying an appropriate amount to the scalp and a site where improvement of white hair is expected.

  Moreover, the dosage form of the gray hair improving agent of this invention is not specifically limited, It can provide as hair tonic, hair lotion, hair cream, aerosol, ointment, etc.

  Hereinafter, the present invention will be described in detail based on examples.

<White hair improvement effect test>
Since various factors are involved in gray hair and various physiologically active factors act on melanocytes in a complex manner, the following actual use test was conducted.

1. Preparation of white hair improving agent Sodium polyphosphate used was a 20 w / v% aqueous sodium polyphosphate solution. The composition of the 20 w / v% sodium polyphosphate aqueous solution is shown in Table 1 below. At this time, polyphosphoric acid Na exists as polyphosphoric acid having an average chain length of 45 and 65 (n = 45 and 65). In addition, since ethanol used when separating sodium polyphosphate is left, it can be changed depending on conditions such as operation scale and temperature.

A white hair improving agent was prepared by blending the raw material components described in Table 2 below. Specifically, after dissolving the component C shown in Table 2 in the component A, the component B, which is the active ingredient of the present invention, was added thereto and stirred to dissolve uniformly. As a basic fibroblast growth factor (b-FGF) that is an anti-whitening agent, a reagent (human fibroblast growth factor b (rhFGFb)) manufactured by Biosource International was used. The prepared gray hair improving agent was provided as a hair tonic. In Table 2, the blending amount is shown in an amount converted into solid content including sodium polyphosphate. Components A and C were all commercially available.

2. White hair alopecia and / or thinning hair patients (35-70 years old, male to female ratio 1: 1) who visited the clinic for evaluation test of gray hair improver 50 people randomly divided into 5 groups, twice daily in the morning and evening on the head The coating was applied for 6 consecutive months, and then evaluated according to the following criteria. Judgments were made by clinician doctors, and the number of people in each case was shown.

A: Blackening or browning of the hair root is 5 or more out of 10 gray hairs ○: 3 to 4 △: 1-2 in the same ×: Invalid
3. Experimental result

4). As is clear from the discussion table 3, the hair tonic with only the base of Comparative Example 1 (no component B) showed no improvement effect on gray hair. In addition, the hair tonic containing the anti-white hair agent b-FGF of Comparative Example 2 was not sufficient in improving the white hair even though the water-soluble polyhydric alcohol was added and b-FGF was stabilized.

  On the other hand, in Example 1, a sufficient white hair improving effect was recognized by blending sodium polyphosphate having an average chain length of 45 (n = 45).

  Next, in Example 2, sodium polyphosphate having an average chain length of 65 (n = 65) having a higher degree of polymerization than in Example 1 was blended, and a higher white hair improvement effect than in Example 1 was obtained. The reason for this is not necessarily clear, but it is likely that polyphosphoric acid having a high degree of polymerization takes time to be completely decomposed in the scalp, and the physiological action of polyphosphoric acid is considered to have been sustained.

  Finally, in Example 3, b-FGF (basic fibroblast growth factor) was blended with sodium polyphosphate having an average chain length of 45 (n = 45), and a higher white hair improvement effect than in Example 1 was obtained. It was. The reason is probably that b-FGF, which is a known anti-whitening agent, is stabilized by polyphosphoric acid and the binding to cells is strengthened, and its physiological effect is enhanced. That is, polyphosphate promotes the effect of a physiologically active factor such as b-FGF to proliferate melanocytes and, as a result, stabilizes or enhances the function of a plurality of melanocyte stimulating factors, thereby indirectly inducing melanocytes. It is thought to activate and improve gray hair.

  As described above, the present invention reduces and inactivates the melanocytes in the hair root portion, performs the proliferation and activation of melanocytes by the activation action of the bioactive factor by polyphosphoric acid, and exhibits an excellent improvement effect on gray hair, It was possible to provide a gray hair improving agent having excellent safety. Further, by using polyphosphoric acid and an anti-whitening agent in combination, it was possible to obtain a more excellent whitening agent.

Claims (8)

  A gray hair improving agent containing polyphosphoric acid.   The gray hair improving agent according to claim 1, wherein the polyphosphoric acid is a linear condensed polyphosphoric acid.   The gray hair improving agent according to claim 1 or 2, wherein the polyphosphoric acid is a polyphosphate.   The gray hair improving agent according to claim 1 or 2, wherein the polyphosphoric acid is sodium polyphosphate.   To the polyphosphoric acid, okogi extract, malotilate (dithiol derivative), basic fibroblast growth factor (b-FGF), angiogenin, ω-alkoxycarbonylalkyltrialkylammonium, amacha extract, salamander extract, and The gray hair improving agent according to any one of claims 1 to 4, wherein at least one anti-whitening agent selected from the group consisting of pepper extract is mixed.   The gray hair improving agent according to any one of claims 1 to 4, wherein the polyphosphoric acid is mixed with basic fibroblast growth factor (b-FGF). The gray hair improving agent according to any one of claims 1 to 6, wherein the polyphosphoric acid is contained in an amount of 1 x ^10-7 to 50% by weight.   The gray hair improving agent according to any one of claims 1 to 7, wherein the polyphosphoric acid is polyphosphoric acid having an average chain length of 15 or more.