JP5269803B2 - デング熱の4種の血清型に対する免疫付与のプロトコル - Google Patents
デング熱の4種の血清型に対する免疫付与のプロトコル Download PDFInfo
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- JP5269803B2 JP5269803B2 JP2009538758A JP2009538758A JP5269803B2 JP 5269803 B2 JP5269803 B2 JP 5269803B2 JP 2009538758 A JP2009538758 A JP 2009538758A JP 2009538758 A JP2009538758 A JP 2009538758A JP 5269803 B2 JP5269803 B2 JP 5269803B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0655255 | 2006-12-01 | ||
| FR0655255A FR2909286B1 (fr) | 2006-12-01 | 2006-12-01 | Methode d'immunisation contre les 4 serotypes de la dengue |
| PCT/FR2007/052431 WO2008065315A1 (fr) | 2006-12-01 | 2007-11-30 | Methode d'immunisation contre les 4 serotypes de la dengue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511022A JP2010511022A (ja) | 2010-04-08 |
| JP2010511022A5 JP2010511022A5 (enExample) | 2010-10-28 |
| JP5269803B2 true JP5269803B2 (ja) | 2013-08-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009538758A Expired - Fee Related JP5269803B2 (ja) | 2006-12-01 | 2007-11-30 | デング熱の4種の血清型に対する免疫付与のプロトコル |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7718359B2 (enExample) |
| EP (1) | EP2099483B1 (enExample) |
| JP (1) | JP5269803B2 (enExample) |
| KR (1) | KR20090087890A (enExample) |
| CN (1) | CN101541344A (enExample) |
| AR (1) | AR064009A1 (enExample) |
| AU (1) | AU2007327367B2 (enExample) |
| BR (1) | BRPI0718927A2 (enExample) |
| CA (1) | CA2668570A1 (enExample) |
| FR (1) | FR2909286B1 (enExample) |
| IL (2) | IL198466A (enExample) |
| MX (1) | MX2009004223A (enExample) |
| MY (1) | MY180698A (enExample) |
| TW (1) | TWI400249B (enExample) |
| WO (1) | WO2008065315A1 (enExample) |
| ZA (1) | ZA200902540B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1924280A4 (en) * | 2005-08-10 | 2008-12-10 | Acambis Inc | VACCINATION AGAINST DENGUE VIRUS INFECTION |
| FR2903605A1 (fr) * | 2006-07-12 | 2008-01-18 | Sanofi Pasteur Sa | Methode d'immunisation contre les quatres serotypes de la dengue |
| FR2906724B1 (fr) * | 2006-10-04 | 2009-03-20 | Sanofi Pasteur Sa | Methode d'immunisation contre les 4 serotypes de la dengue. |
| MX2010008799A (es) | 2008-03-05 | 2010-09-07 | Sanofi Pasteur | Proceso para estabilizar una composicion de vacuna que contiene adyuvante. |
| EP2143440A1 (fr) * | 2008-07-09 | 2010-01-13 | Sanofi Pasteur | Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués |
| CN102449172A (zh) * | 2009-06-01 | 2012-05-09 | 伊维拉根公司 | 施用针对登革病毒的疫苗的组合物和方法 |
| CA2770888C (en) * | 2009-08-31 | 2020-04-14 | Gen-Probe Incorporated | Dengue virus assay |
| EP2353609A1 (en) * | 2010-02-04 | 2011-08-10 | Sanofi Pasteur | Immunization compositions and methods |
| WO2012088041A1 (en) | 2010-12-20 | 2012-06-28 | Genvec, Inc. | Adenoviral vector-based dengue fever vaccine |
| MY168959A (en) | 2012-07-24 | 2019-01-28 | Sanofi Pasteur | Vaccine compositions for the prevention of dengue virus infection |
| WO2014016362A1 (en) | 2012-07-24 | 2014-01-30 | Sanofi Pasteur | Vaccine compositions for prevention against dengue virus infection |
| BR112015012515B1 (pt) | 2012-11-30 | 2023-04-11 | Sanofi Pasteur | Uso de antígenos, construções de ácido nucleico ou vetores virais capazes de expressar uma partícula do tipo vírus (vlp) da dengue e de uma vacina contra sarampo, uma vacina contra caxumba e uma vacina contra rubéola |
| US9861692B2 (en) * | 2013-06-21 | 2018-01-09 | Merck Sharp & Dohme Corp. | Dengue virus vaccine compositions and methods of use thereof |
| TWI852899B (zh) | 2014-09-02 | 2024-08-21 | 法商賽諾菲巴斯德公司 | 疫苗組合物 |
| EP3316905A1 (en) | 2015-07-03 | 2018-05-09 | Sanofi Pasteur | Concomitant dengue and yellow fever vaccination |
| US10004795B2 (en) | 2015-09-08 | 2018-06-26 | Fundacao Butantan | Process for preparing an attenuated tetravalent dengue vaccine |
| JP7313345B2 (ja) | 2017-10-05 | 2023-07-24 | サノフィ・パスツール | デング熱に対するブースターワクチン接種のための組成物 |
| ES2908304T3 (es) | 2018-09-05 | 2022-04-28 | Takeda Vaccines Inc | Dosis unitaria de vacuna contra el dengue y administración de la misma |
| PH12022550261A1 (en) | 2019-08-16 | 2023-06-26 | Takeda Vaccines Inc | Methods for preventing dengue and hepatitis a |
| WO2021174059A1 (en) | 2020-02-27 | 2021-09-02 | Takeda Vaccines, Inc. | Method for removing host cell dna from virus preparation |
| WO2023147337A2 (en) | 2022-01-25 | 2023-08-03 | Takeda Vaccines, Inc. | Large-scale flaviviral vaccine production and manufacture |
| US20250177511A1 (en) | 2022-02-15 | 2025-06-05 | Takeda Vaccines, Inc. | Dengue vaccine batch mixing process |
| WO2023215383A1 (en) | 2022-05-04 | 2023-11-09 | Takeda Vaccines, Inc. | Computer-based determination of flavivirus infectivity |
| EP4375381A1 (en) | 2022-11-18 | 2024-05-29 | Takeda Vaccines, Inc. | A method for determining the proportion of a live, attenuated flavivirus having a nucleotide sequence comprising at least one attenuation locus in a formulation |
| EP4626574A1 (en) | 2022-11-29 | 2025-10-08 | Takeda Vaccines, Inc. | Large-scale flaviviral vaccine production and manufacture |
| WO2025072259A1 (en) | 2023-09-25 | 2025-04-03 | Takeda Vaccines, Inc. | Coadministration of tetravalent dengue vaccine with hpv vaccine |
| WO2025122855A1 (en) | 2023-12-08 | 2025-06-12 | Takeda Vaccines, Inc. | A method for determining the concentration of residual vero cell genomic dna in a sample containing virus obtained from production in vero cells |
Family Cites Families (16)
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|---|---|---|---|---|
| CA2332786A1 (en) | 1998-05-29 | 1999-12-02 | Epimmune Inc. | Identification of broadly reactive dr restricted epitopes |
| DE60041250D1 (de) * | 1999-03-26 | 2009-02-12 | Us Army | Multivalenter dengue-virus impfstoff |
| AU4040400A (en) | 1999-03-26 | 2000-10-16 | Walter Reed Army Institute Of Research | Attenuated dengue-4 virus vaccine |
| US6632663B1 (en) | 1999-09-22 | 2003-10-14 | Aventis Pasteur Limited | DNA immunization against chlamydia infection |
| WO2001060847A2 (en) * | 2000-02-16 | 2001-08-23 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Avirulent, immunogenic flavivirus chimeras |
| EP1159969A1 (fr) | 2000-05-30 | 2001-12-05 | Aventis Pasteur | Vaccine composition |
| ATE412738T1 (de) * | 2000-05-30 | 2008-11-15 | Univ Mahidol | Attenuierte stammen von denguevirus und ihre verwendungen in impfstoffzusammensetzungen |
| AU2003239932A1 (en) * | 2002-05-31 | 2003-12-19 | Acambis, Inc. | Tetravalent dengue vaccines |
| CA2519953C (en) * | 2003-03-24 | 2016-01-05 | The Scripps Research Institute | Dna vaccine against tumor growth and methods of use thereof |
| MX2007015872A (es) * | 2005-06-17 | 2008-04-21 | Sanofi Pasteur | Cepa atenuada del serotipo 2 del dengue. |
| CA2611934C (en) * | 2005-06-17 | 2015-11-03 | Sanofi Pasteur | Dengue serotype 1 attenuated strain |
| EP1924280A4 (en) * | 2005-08-10 | 2008-12-10 | Acambis Inc | VACCINATION AGAINST DENGUE VIRUS INFECTION |
| US7968102B2 (en) * | 2006-01-13 | 2011-06-28 | Sanofi Pasteur S.A. | Dengue chimeric viruses |
| AR061197A1 (es) * | 2006-06-07 | 2008-08-13 | Sanofi Pasteur | Cepas del virus 3 del dengue vivas atenuadas |
| FR2903605A1 (fr) * | 2006-07-12 | 2008-01-18 | Sanofi Pasteur Sa | Methode d'immunisation contre les quatres serotypes de la dengue |
| FR2906724B1 (fr) * | 2006-10-04 | 2009-03-20 | Sanofi Pasteur Sa | Methode d'immunisation contre les 4 serotypes de la dengue. |
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2006
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- 2007-11-30 WO PCT/FR2007/052431 patent/WO2008065315A1/fr not_active Ceased
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|---|---|
| IL198466A0 (en) | 2011-08-01 |
| AU2007327367A1 (en) | 2008-06-05 |
| WO2008065315A1 (fr) | 2008-06-05 |
| CN101541344A (zh) | 2009-09-23 |
| US7718359B2 (en) | 2010-05-18 |
| MX2009004223A (es) | 2009-04-30 |
| TW200829599A (en) | 2008-07-16 |
| AU2007327367B2 (en) | 2013-05-09 |
| BRPI0718927A2 (pt) | 2014-04-08 |
| KR20090087890A (ko) | 2009-08-18 |
| EP2099483A1 (fr) | 2009-09-16 |
| JP2010511022A (ja) | 2010-04-08 |
| ZA200902540B (en) | 2010-07-28 |
| IL198466A (en) | 2014-01-30 |
| CA2668570A1 (en) | 2008-06-05 |
| FR2909286B1 (fr) | 2012-06-08 |
| TWI400249B (zh) | 2013-07-01 |
| MY180698A (en) | 2020-12-07 |
| FR2909286A1 (fr) | 2008-06-06 |
| AR064009A1 (es) | 2009-03-04 |
| EP2099483B1 (fr) | 2013-12-25 |
| US20080131460A1 (en) | 2008-06-05 |
| IL230052A0 (en) | 2014-01-30 |
| US20100239612A1 (en) | 2010-09-23 |
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