JP5254792B2 - 重症筋無力症の治療方法 - Google Patents
重症筋無力症の治療方法 Download PDFInfo
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Description
WO2004/106369に開示されているように、EV576は、ヒメダニ類のOrthinodoros moubataの唾液腺抽出物を用いて、古典的溶血アッセイ(図3)により補体阻害活性があることが判明した唾液腺抽出物フラクションをSDS−PAGE及びRP−HPLCに付すことにより精製した。
ラットにおける125I標識rEV576の血清中β半減期は約30〜38時間であった。
実験1
実験的自己免疫性重症筋無力症(EAMG)は、ピドレスデン(Piddlesden)らの文献(前述)の方法に従い雌性ルイスラットにおいて誘起した。
rEV576はEAMGの慢性モデルを用いて更に分析した。このモデルにおいて、動物はアセチルコリン受容体タンパク質−フロイント完全アジュバント(CFA)の投与を受けており、約30日に亘って自己抗体を生成する。このモデルは、症状の発現と進行が比較的遅いヒトの状態を模倣する。
Claims (18)
- 重症筋無力症を治療又は予防するための医薬の製造における、補体C5に結合する剤の治療又は予防に有効な量の使用であって、前記剤は、補体C5がC5コンベルターゼによって補体C5aと補体C5b−9とに分解されるのを防ぐ作用をする、図2のアミノ酸配列の19〜168番アミノ酸、又は図2のアミノ酸配列の1〜168番アミノ酸を含む若しくはそれから構成されるタンパク質である、補体C5に結合する剤の使用。
- 前記剤はIC500.2mg/mL未満でC5に結合する、請求項1に記載の使用。
- 前記剤は吸血性節足動物に由来する、請求項1又は2に記載の使用。
- 前記剤は、請求項1に記載のタンパク質をコードする核酸分子である、請求項1〜3のいずれか1項に記載の使用。
- 前記核酸分子は、図2のヌクレオチド配列の53〜507番塩基を含むか又はそれから構成される、請求項4に記載の使用。
- 前記核酸分子は、図2のヌクレオチド配列の1〜507番塩基を含むか又はそれから構成される、請求項5に記載の使用。
- 前記剤の被験体は哺乳類である、請求項1〜6のいずれか1項に記載の使用。
- 前記哺乳類がヒトである、請求項7に記載の使用。
- 前記剤は、被験体内において全ての利用可能なC5に結合するのに十分な用量で投与される、請求項1〜8のいずれか1項に記載の使用。
- 前記剤は、体重減少及び/又は筋力低下を抑制するのに十分な用量で投与される、請求項1〜9のいずれか1項に記載の使用。
- 前記剤は1mg/kg〜15mg/kgの用量で投与される、請求項1〜10のいずれか1項に記載の使用。
- 前記剤は13mg/kgの単回用量で腹腔内投与される、請求項1〜11のいずれか1項に記載の使用。
- 前記剤は、13mg/kgの用量で腹腔内投与された後、12時間毎に4mg/kgの用量で投与される、請求項12に記載の使用。
- C5に結合する前記剤は、重症筋無力症の治療のための他の薬物の投与も伴う治療計画の一部として投与される、請求項1〜13のいずれか1項に記載の使用。
- 前記他の薬物は、抗コリンエステラーゼ剤、又は免疫抑制薬である、請求項14に記載の使用。
- 前記抗コリンエステラーゼ剤が、ネオスチグミン又はピリドスチグミンであり、前記免疫抑制薬が、プレドニゾン、サイクロスポリン又はアザチオプリンである請求項15に記載の使用。
- C5に結合する前記剤は、他の薬物と同時に、順次的に又は別々に投与される、請求項14〜16のいずれか1項に記載の使用。
- 前記重症筋無力症は軽度の重症筋無力症又は重度の重症筋無力症である、請求項1〜17のいずれか1項に記載の使用。
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GBGB0518443.7A GB0518443D0 (en) | 2005-09-09 | 2005-09-09 | Method of treating myasthenia gravis |
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PCT/GB2006/003265 WO2007028968A1 (en) | 2005-09-09 | 2006-09-05 | Method of treating myasthenia gravis |
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JP2009508819A JP2009508819A (ja) | 2009-03-05 |
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GB0518443D0 (en) | 2005-09-09 | 2005-10-19 | Evolutec Ltd | Method of treating myasthenia gravis |
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NZ614351A (en) * | 2008-11-10 | 2015-05-29 | Alexion Pharma Inc | Methods and compositions for treating complement-associated disorders |
PL2521562T3 (pl) | 2010-01-08 | 2020-04-30 | Volution Immuno Pharmaceuticals Sa | Ev576 do zastosowania w leczeniu zakażeń wirusowych dróg oddechowych |
EP2720708A4 (en) | 2011-06-20 | 2015-10-14 | Univ Saint Louis | AIMING AT THE NEUROMUSCULAR END PLATE FOR TREATMENT PURPOSES |
AU2012272706B2 (en) | 2011-06-22 | 2017-07-06 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
LT2817329T (lt) | 2012-02-20 | 2019-04-10 | Swedish Orphan Biovitrum Ab (Publ) | Polipeptidai, prisijungiantys prie žmogaus komplemento c5 |
SG11201602679VA (en) | 2013-08-28 | 2016-05-30 | Swedish Orphan Biovitrum Ab Publ | Stable polypeptides binding to human complement c5 |
PT3039033T (pt) | 2013-08-28 | 2019-09-06 | Affibody Ab | Polipéptidos de ligação com um scaffold mutado |
GB201410116D0 (en) * | 2014-06-06 | 2014-07-23 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
WO2016198133A1 (en) * | 2015-06-08 | 2016-12-15 | Volution Immuno Pharmaceuticals Sa | Ornithodoros moubata complement inhibitor for use in the treatment of acute graft versus host disease |
GB201602802D0 (en) | 2016-02-17 | 2016-03-30 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
KR20190008225A (ko) * | 2016-05-13 | 2019-01-23 | 델노바 인코퍼레이티드 | 화학적 신경차단으로 인한 부작용의 치료 |
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US20200054611A1 (en) | 2017-01-09 | 2020-02-20 | Gt Biopharma, Inc. | Use and composition for treating myasthenia gravis and other myasthenic syndromes |
US20200000756A1 (en) * | 2017-01-24 | 2020-01-02 | Gt Biopharma, Inc. | Neostigmine combination and compositions |
US11730792B2 (en) | 2017-04-21 | 2023-08-22 | Volution Immuno Pharmaceuticals Sa | Coversin (OmCI) for the treatment of autoimmune blistering diseases: bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA) |
GB201706406D0 (en) | 2017-04-21 | 2017-06-07 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
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WO2020053206A1 (en) | 2018-09-10 | 2020-03-19 | Volution Immuno Pharmaceuticals Sa | Coversin for use in the treatment of rheumatic diseases |
GB201905810D0 (en) | 2019-04-25 | 2019-06-05 | Volution Immuno Pharmaceuticals Sa | Method of treatment |
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CN101340926A (zh) | 2009-01-07 |
CA2621697A1 (en) | 2007-03-15 |
GB0518443D0 (en) | 2005-10-19 |
CN114555013A (zh) | 2022-05-27 |
CA2621697C (en) | 2017-08-29 |
CN103505721A (zh) | 2014-01-15 |
EP4048171A1 (en) | 2022-08-31 |
JP2009508819A (ja) | 2009-03-05 |
US9192648B2 (en) | 2015-11-24 |
ES2542853T3 (es) | 2015-08-12 |
EP1931372B1 (en) | 2015-04-29 |
WO2021080910A1 (en) | 2021-04-29 |
DK1931372T3 (en) | 2015-05-26 |
NZ566789A (en) | 2011-11-25 |
EP1931372A1 (en) | 2008-06-18 |
WO2007028968A9 (en) | 2008-06-12 |
WO2007028968A1 (en) | 2007-03-15 |
US20200282018A1 (en) | 2020-09-10 |
US20160166640A1 (en) | 2016-06-16 |
EP4048171A4 (en) | 2023-11-22 |
US20090209459A1 (en) | 2009-08-20 |
AU2006288985B2 (en) | 2011-09-29 |
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