JP5247474B2 - Cd44の表面発現を証明する細胞の細胞障害性媒介 - Google Patents
Cd44の表面発現を証明する細胞の細胞障害性媒介 Download PDFInfo
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- JP5247474B2 JP5247474B2 JP2008556619A JP2008556619A JP5247474B2 JP 5247474 B2 JP5247474 B2 JP 5247474B2 JP 2008556619 A JP2008556619 A JP 2008556619A JP 2008556619 A JP2008556619 A JP 2008556619A JP 5247474 B2 JP5247474 B2 JP 5247474B2
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- antibody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2884—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6897—Pre-targeting systems with two or three steps using antibody conjugates; Ligand-antiligand therapies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70585—CD44
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Crystallography & Structural Chemistry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/364,013 US7947496B2 (en) | 1999-10-08 | 2006-02-28 | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US11/364,013 | 2006-02-28 | ||
PCT/CA2007/000281 WO2007098575A1 (en) | 2006-02-28 | 2007-02-23 | Cytotoxicity mediation of cells evidencing surface expression of cd44 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013029374A Division JP2013165710A (ja) | 2006-02-28 | 2013-02-18 | Cd44の表面発現を証明する細胞の細胞障害性媒介 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009529497A JP2009529497A (ja) | 2009-08-20 |
JP2009529497A5 JP2009529497A5 (da) | 2012-07-12 |
JP5247474B2 true JP5247474B2 (ja) | 2013-07-24 |
Family
ID=38458603
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008556619A Expired - Fee Related JP5247474B2 (ja) | 2006-02-28 | 2007-02-23 | Cd44の表面発現を証明する細胞の細胞障害性媒介 |
JP2013029374A Pending JP2013165710A (ja) | 2006-02-28 | 2013-02-18 | Cd44の表面発現を証明する細胞の細胞障害性媒介 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013029374A Pending JP2013165710A (ja) | 2006-02-28 | 2013-02-18 | Cd44の表面発現を証明する細胞の細胞障害性媒介 |
Country Status (16)
Country | Link |
---|---|
US (3) | US7947496B2 (da) |
EP (2) | EP2508536A1 (da) |
JP (2) | JP5247474B2 (da) |
CN (2) | CN101432307B (da) |
AU (1) | AU2007219656B2 (da) |
CA (1) | CA2643708A1 (da) |
CY (1) | CY1115212T1 (da) |
DK (1) | DK1989233T3 (da) |
ES (1) | ES2444408T3 (da) |
HK (1) | HK1120527A1 (da) |
NZ (1) | NZ570776A (da) |
PL (1) | PL1989233T3 (da) |
PT (1) | PT1989233E (da) |
SI (1) | SI1989233T1 (da) |
TW (1) | TW200731987A (da) |
WO (1) | WO2007098575A1 (da) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013165710A (ja) * | 2006-02-28 | 2013-08-29 | F Hoffmann La Roche Ag | Cd44の表面発現を証明する細胞の細胞障害性媒介 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050100542A1 (en) * | 1999-10-08 | 2005-05-12 | Young David S. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US20090004103A1 (en) * | 1999-10-08 | 2009-01-01 | Young David S F | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US20080124327A1 (en) * | 1999-10-08 | 2008-05-29 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US8048416B2 (en) * | 1999-10-08 | 2011-11-01 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US7419792B2 (en) * | 1999-10-08 | 2008-09-02 | Arius Research Inc. | Laminin Receptor 1 Precursor Protein (37LRP) epitope delineated by an Hepatocellular carcinoma specific antibody |
US8071072B2 (en) * | 1999-10-08 | 2011-12-06 | Hoffmann-La Roche Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
CN101663049A (zh) * | 2007-03-09 | 2010-03-03 | 霍夫曼-拉罗奇有限公司 | 证明cd44表面表达的细胞的细胞毒性介导 |
EP2009028A1 (en) * | 2007-06-27 | 2008-12-31 | Monoclonal Antibodies Therapeutics | Combination of a conventional anti-cancer treatment with anti-CD44 antibody administration for treating solid tumors |
CA2793838C (en) | 2010-03-19 | 2019-09-17 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Integrin interaction inhibitors for the treatment of cancer |
WO2012129335A2 (en) * | 2011-03-21 | 2012-09-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc | Hyd1 peptides for relapsed cancer |
WO2013035824A1 (ja) | 2011-09-07 | 2013-03-14 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞の分離 |
WO2015048477A1 (en) | 2013-09-27 | 2015-04-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
CN109402064B (zh) * | 2018-11-05 | 2021-05-14 | 湖南省肿瘤医院 | 杂交瘤细胞株及其产生的单克隆抗体和应用 |
CN112569351B (zh) * | 2020-12-16 | 2021-10-15 | 南通大学 | Cd44抗体在制备治疗帕金森疾病的药物中的应用 |
CN114250200A (zh) * | 2021-12-23 | 2022-03-29 | 蚌埠医学院 | 一种非小细胞肺癌脑转移和脊髓转移的动物模型构建方法 |
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US486158A (en) | 1892-11-15 | John cook | ||
US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4828991A (en) * | 1984-01-31 | 1989-05-09 | Akzo N.V. | Tumor specific monoclonal antibodies |
EP0266032A1 (en) | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modified fibrinolytic enzyme |
NZ222509A (en) * | 1986-11-19 | 1993-03-26 | Oncogen | Hybridoma cell line producing antibodies binding to tumour-associated mucin antigen |
US4861581A (en) * | 1986-12-05 | 1989-08-29 | Cancer Biologics, Inc. | Detection of necrotic malignant tissue and associated therapy |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
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DE69229254T2 (de) * | 1991-10-30 | 1999-09-23 | Idemitsu Kosan Co | Verfahren zur Herstellung von menschlichen Lymphozyten und menschlichen Antikörpern; und so hergestellte Antikörper |
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IL105008A0 (en) * | 1992-03-13 | 1993-07-08 | Yeda Res & Dev | Double transfectants of mhc genes as cellular vaccines for immunoprevention of tumor metastasis |
CA2149635A1 (en) | 1992-11-20 | 1994-06-09 | David Tarin | Peptide corresponding to cd44 exon 6, antibodies specific for said peptide and use of these antibodies for diagnosis of tumors |
US5879898A (en) * | 1992-11-20 | 1999-03-09 | Isis Innovation Limited | Antibodies specific for peptide corresponding to CD44 exon 6, and use of these antibodies for diagnosis of tumors |
ATE244888T1 (de) * | 1993-02-05 | 2003-07-15 | Epigen Inc | Humanes carcinoma-antigen (hca), hca antikörper, hca immunoassays, aufzeichnungsmethoden und therapy |
US5693322A (en) * | 1993-03-11 | 1997-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Enhanced intercellular interaction by associational antibody molecules |
EP0703989B1 (en) | 1993-06-18 | 1997-11-05 | Oy Biotie Therapies | COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44v6 |
WO1995020401A1 (en) | 1994-01-31 | 1995-08-03 | Trustees Of Boston University | Polyclonal antibody libraries |
UA58482C2 (uk) * | 1994-06-08 | 2003-08-15 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Моноклональне антитіло vff-18 проти сd44v6 і його фрагменти |
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US6180357B1 (en) * | 1999-10-08 | 2001-01-30 | Arius Research, Inc. | Individualized patient-specific anti-cancer antibodies |
US20050100542A1 (en) * | 1999-10-08 | 2005-05-12 | Young David S. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
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US7189397B2 (en) | 1999-10-08 | 2007-03-13 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of CD44 |
US6657048B2 (en) * | 1999-10-08 | 2003-12-02 | Arius Research, Inc. | Individualized anti-cancer antibodies |
US20040001789A1 (en) * | 1999-10-08 | 2004-01-01 | Young David S. F. | Cytotoxicity mediation of cells evidencing surface expression of gp96 or precursors thereof |
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YU91403A (sh) | 2001-05-18 | 2006-05-25 | Boehringer Ingelheim International Gmbh. | Antitela specifična za cd44v6 |
US20030103985A1 (en) * | 2001-05-18 | 2003-06-05 | Boehringer Ingelheim International Gmbh | Cytotoxic CD44 antibody immunoconjugates |
CA2471206A1 (en) | 2001-12-21 | 2003-07-10 | Arius Research, Inc. | Individualized anti-cancer antibodies |
US7399835B2 (en) * | 2004-02-26 | 2008-07-15 | Arius Research Inc. | Cancerous disease modifying antibodies |
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US7348413B2 (en) * | 2004-02-26 | 2008-03-25 | Arius Research Inc. | Cancerous disease modifying antibodies |
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2006
- 2006-02-28 US US11/364,013 patent/US7947496B2/en not_active Expired - Fee Related
- 2006-05-18 TW TW095117643A patent/TW200731987A/zh unknown
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2007
- 2007-02-23 JP JP2008556619A patent/JP5247474B2/ja not_active Expired - Fee Related
- 2007-02-23 PL PL07701821T patent/PL1989233T3/pl unknown
- 2007-02-23 PT PT77018216T patent/PT1989233E/pt unknown
- 2007-02-23 ES ES07701821.6T patent/ES2444408T3/es active Active
- 2007-02-23 EP EP12174631A patent/EP2508536A1/en not_active Withdrawn
- 2007-02-23 AU AU2007219656A patent/AU2007219656B2/en not_active Ceased
- 2007-02-23 SI SI200731391T patent/SI1989233T1/sl unknown
- 2007-02-23 WO PCT/CA2007/000281 patent/WO2007098575A1/en active Application Filing
- 2007-02-23 DK DK07701821.6T patent/DK1989233T3/da active
- 2007-02-23 EP EP07701821.6A patent/EP1989233B1/en not_active Not-in-force
- 2007-02-23 CA CA002643708A patent/CA2643708A1/en not_active Abandoned
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- 2007-02-23 CN CN2013100529947A patent/CN103197067A/zh active Pending
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2008
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2009
- 2009-01-20 HK HK09100600.3A patent/HK1120527A1/xx not_active IP Right Cessation
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2011
- 2011-08-15 US US13/210,183 patent/US20120107233A1/en not_active Abandoned
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013165710A (ja) * | 2006-02-28 | 2013-08-29 | F Hoffmann La Roche Ag | Cd44の表面発現を証明する細胞の細胞障害性媒介 |
Also Published As
Publication number | Publication date |
---|---|
PT1989233E (pt) | 2014-02-11 |
CN101432307A (zh) | 2009-05-13 |
AU2007219656A1 (en) | 2007-09-07 |
AU2007219656B2 (en) | 2013-02-07 |
EP1989233B1 (en) | 2013-11-06 |
US20060216233A1 (en) | 2006-09-28 |
CN103197067A (zh) | 2013-07-10 |
TW200731987A (en) | 2007-09-01 |
US20120107233A1 (en) | 2012-05-03 |
CY1115212T1 (el) | 2017-01-04 |
EP1989233A1 (en) | 2008-11-12 |
JP2013165710A (ja) | 2013-08-29 |
WO2007098575A1 (en) | 2007-09-07 |
DK1989233T3 (da) | 2014-01-13 |
ES2444408T3 (es) | 2014-02-24 |
CA2643708A1 (en) | 2007-09-07 |
CN101432307B (zh) | 2013-06-12 |
US7947496B2 (en) | 2011-05-24 |
US20080274049A1 (en) | 2008-11-06 |
HK1120527A1 (en) | 2009-04-03 |
EP2508536A1 (en) | 2012-10-10 |
JP2009529497A (ja) | 2009-08-20 |
SI1989233T1 (sl) | 2014-02-28 |
PL1989233T3 (pl) | 2014-04-30 |
NZ570776A (en) | 2011-03-31 |
EP1989233A4 (en) | 2010-05-05 |
US8017117B2 (en) | 2011-09-13 |
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