JP5198001B2 - Stabilized solid formulation - Google Patents
Stabilized solid formulation Download PDFInfo
- Publication number
- JP5198001B2 JP5198001B2 JP2007164835A JP2007164835A JP5198001B2 JP 5198001 B2 JP5198001 B2 JP 5198001B2 JP 2007164835 A JP2007164835 A JP 2007164835A JP 2007164835 A JP2007164835 A JP 2007164835A JP 5198001 B2 JP5198001 B2 JP 5198001B2
- Authority
- JP
- Japan
- Prior art keywords
- water
- granules
- solid preparation
- preparation according
- soluble polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007787 solid Substances 0.000 title claims description 50
- 239000000203 mixture Substances 0.000 title claims description 8
- 238000009472 formulation Methods 0.000 title claims description 7
- 238000002360 preparation method Methods 0.000 claims description 49
- 239000003814 drug Substances 0.000 claims description 45
- 229940079593 drug Drugs 0.000 claims description 44
- 239000008187 granular material Substances 0.000 claims description 42
- 239000010410 layer Substances 0.000 claims description 24
- 229920003169 water-soluble polymer Polymers 0.000 claims description 24
- 150000001720 carbohydrates Chemical class 0.000 claims description 22
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 claims description 19
- 239000004480 active ingredient Substances 0.000 claims description 17
- 239000011247 coating layer Substances 0.000 claims description 17
- 229930006000 Sucrose Natural products 0.000 claims description 16
- 239000005720 sucrose Substances 0.000 claims description 16
- -1 copolyvidone Polymers 0.000 claims description 15
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 14
- 239000004386 Erythritol Substances 0.000 claims description 11
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 11
- 235000019414 erythritol Nutrition 0.000 claims description 11
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 11
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- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 7
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 6
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- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 6
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 6
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- 239000008101 lactose Substances 0.000 claims description 6
- 235000010449 maltitol Nutrition 0.000 claims description 6
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- 239000000594 mannitol Substances 0.000 claims description 6
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 6
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- 239000000600 sorbitol Substances 0.000 claims description 6
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- 239000000811 xylitol Substances 0.000 claims description 6
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 6
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- 239000006188 syrup Substances 0.000 claims description 5
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- 229920002472 Starch Polymers 0.000 claims description 4
- 229940069328 povidone Drugs 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims 2
- 241000978776 Senegalia senegal Species 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- IDBYLPRJLWSMAI-UHFFFAOYSA-M sodium;1,2,3,3a,4,5,6,7,8,8a-decahydroazulene-1-sulfonate Chemical compound [Na+].C1CCCCC2C(S(=O)(=O)[O-])CCC21 IDBYLPRJLWSMAI-UHFFFAOYSA-M 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 49
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- 239000000843 powder Substances 0.000 description 28
- 238000002425 crystallisation Methods 0.000 description 25
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 15
- 239000000243 solution Substances 0.000 description 14
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 13
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 11
- 239000011812 mixed powder Substances 0.000 description 10
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 9
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- 239000008213 purified water Substances 0.000 description 9
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
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- 230000006641 stabilisation Effects 0.000 description 8
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- IELOKBJPULMYRW-NJQVLOCASA-N D-alpha-Tocopheryl Acid Succinate Chemical compound OC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C IELOKBJPULMYRW-NJQVLOCASA-N 0.000 description 7
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- 229960001661 ursodiol Drugs 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は、結晶水を失うと不安定化する薬物を含有する固形製剤において、その含量および外観の安定化に関する。 The present invention relates to the stabilization of the content and appearance of a solid preparation containing a drug that is destabilized when water of crystallization is lost.
薬物の不安定化機構は様々である。その中のひとつとして、薬物中の結晶水を失うと不安定化する薬物があることが知られている。しかし、その安定化には一般的な方法は未だ確立されておらず、その薬物に適した安定化方法の模索がなされているのが現状である。例えば、アズレンスルホン酸ナトリウムは1/2水和物、あるいは1水和物として存在していることが知られており、熱等により、結晶水を失い、不安定化することが知れられている(非特許文献1)。その安定化には、例えば、高分子化合物と一緒に噴霧乾燥あるいは凍結乾燥する方法(特許文献1および2)や2軸エクストルーダーにより処理することによる安定化方法(非特許文献1)などが提示されている。しかし、これらの方法は、固形製剤を製造するには、特別な機器を必要としたり、方法が煩雑であるなどの理由により、結晶水を失うと不安定化する薬物を固形製剤化するのにこれらの方法を用いることは、汎用的に工業化できにくかった。そのため、通常の固形製剤製造方法(例えば、流動層造粒機を用い、打錠用顆粒を製造し、打錠し、素錠を得る。その素錠にコーティングを施し、コーティング錠とする等)の範疇での安定化が望まれていた。
また、治療効果の増大のために、結晶水を失うと不安定化する薬物に他の薬物を配合した配合剤を製造する場合、上記の高分子化合物と一緒に噴霧乾燥あるいは凍結乾燥する方法や2軸エクストルーダーによる方法などを用いると、他の薬物が分解、変色し、安定な製剤が製造できない場合がある。特にビタミン類の中で、ビタミンC類は水分、金属等の存在下で熱により着色変化を起こし易く、ビタミンE類は低融点化合物であるため、熱により溶融、軟化が起こり、外観変化を起こし易い。そのため、結晶水を失うと不安定化する薬物にビタミン類として、特にビタミンC類、ビタミンE類を配合した場合は結晶水を失うと不安定化する薬物含量の安定化を達成しても、外観変化を起こし、外観不安定化を招くことがあった。
In addition, in order to increase the therapeutic effect, in the case of producing a compounding agent in which another drug is blended with a drug that is destabilized when crystallization water is lost, a method of spray drying or freeze-drying together with the above polymer compound, When a method using a biaxial extruder is used, other drugs may be decomposed and discolored, and a stable preparation may not be produced. Among vitamins, vitamin C is susceptible to color change due to heat in the presence of moisture, metals, etc., and vitamin E is a low melting point compound, so it melts and softens due to heat and changes appearance. easy. Therefore, when vitamins are added to the drugs that are destabilized when the crystal water is lost, especially when vitamins C and E are blended, the stabilization of the drug content that is destabilized when the crystal water is lost can be achieved. Appearance changes may occur, leading to appearance instability.
本発明の目的は、水溶性高分子、更には糖質を用いることにより、結晶水を失うと不安定化する薬物の含量のみならず外観も安定化された固形製剤を、通常の固形製剤で用いる製造法である流動層造粒機、転動流動層造粒機、遠心流動型造粒機、押し出し造粒機、攪拌造粒機のいずれか1つまたは2つ以上を用いる方法により提供することにある。 The object of the present invention is to use a water-soluble polymer, and also a saccharide, to obtain a solid preparation having a stabilized appearance as well as a content of a drug that becomes unstable when water of crystallization is lost. Provided by a method using any one or more of fluidized bed granulator, rolling fluidized bed granulator, centrifugal fluidized granulator, extrusion granulator, and agitation granulator, which is a production method to be used. There is.
本発明者らは、上記の目的を達成するために鋭意検討した結果、結晶水を失うと不安定化する薬物を含有する固形製剤において、水溶性高分子、更には糖質を用いることにより、薬物の含量のみならず外観も安定化された固形製剤を製造できることを見出した。
本発明においては、通常の固形製剤で用いる製造法である、流動層造粒機、転動流動層造粒機、遠心流動型造粒機、押し出し造粒機、攪拌造粒機のいずれか1つ、場合によれば2つ以上の機器により、主薬を含む細粒または顆粒(以下、本明細書において、これらを「顆粒」と称する)を調製し、その顆粒、またはその顆粒を打錠することにより得られる素錠をコーティングすることにより得られる顆粒剤、錠剤またはこれらをカプセルに充填したカプセル剤等の固形製剤を提供することができる。
すなわち、本発明は、
(1)結晶水を失うと不安定化する薬物および水溶性高分子を含有する顆粒または細粒を含有する主薬層と、該主薬層上に形成された水溶性高分子および糖質を含有する被覆層とを有する安定化された固形製剤;
(2)さらに、主薬層と被覆層の間に水溶性高分子を含有する中間被膜層を有する上記(1)記載の固形製剤;
(3)顆粒または細粒が、さらに糖質を含有することを特徴とする上記(1)または(2)記載の固形製剤;
(4)結晶水を失うと不安定化する薬物の20℃における水に対する溶解度が、0.1w/w%以上である上記(1)〜(3)のいずれか1に記載の固形製剤;
(5)結晶水を失うと不安定化する薬物が、アズレンスルホン酸ナトリウムである上記(4)記載の固形製剤;
(6)水溶性高分子が、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、ポビドン、コポリビドン、ポリビニルアルコール、アラビアゴムおよびプルランからなる群から選ばれる1種以上である上記(1)〜(3)のいずれか1に記載の固形製剤;
(7)糖質が、エリスリトール、マルチトール、粉末還元麦芽糖水アメ、マンニトール、精製白糖、白糖、トレハロース、ソルビトール、キシリトールおよび乳糖からなる群から選ばれる1種以上である上記(1)〜(3)のいずれか1に記載の固形製剤;
(8)結晶水を失うと不安定化する薬物の含有量が、製剤全量の10重量%以下である上記(1)〜(3)のいずれか1に記載の固形製剤;
(9)結晶水を失うと不安定化する薬物1重量部に対し、水溶性高分子を1〜100重量部含有する上記(1)〜(3)のいずれか1に記載の固形製剤;
(10)結晶水を失うと不安定化する薬物1重量部に対し、糖質を1〜1000重量部含有する上記(1)〜(3)のいずれか1に記載の固形製剤;
(11)錠剤または顆粒剤、または該錠剤もしくは顆粒剤を含有するカプセル剤である上記(1)〜(3)のいずれか1に記載の固形製剤;
(12)結晶水を失うと不安定化する薬物および水溶性高分子を溶解した溶液を用いて顆粒または細粒を調製し、次いで該顆粒または細粒を用いて製造することを特徴とする上記(1)または(2)記載の固形製剤の製造方法;および
(13)結晶水を失うと不安定化する薬物、水溶性高分子および糖質を溶解した溶液を用いて顆粒または細粒を調製し、次いで該顆粒または細粒を用いて製造することを特徴とする上記(3)記載の固形製剤の製造方法を提供する。
As a result of intensive studies to achieve the above object, the present inventors have used a water-soluble polymer, and further a saccharide, in a solid preparation containing a drug that becomes unstable when crystallization water is lost. It has been found that a solid preparation having a stabilized appearance as well as a drug content can be produced.
In the present invention, any one of a fluidized bed granulator, a rolling fluidized bed granulator, a centrifugal fluidized granulator, an extrusion granulator, and an agitation granulator, which is a production method used in a normal solid preparation. In some cases, two or more devices are used to prepare fine granules or granules containing the active ingredient (hereinafter referred to as “granules”), and the granules or the granules are compressed into tablets. Thus, it is possible to provide a solid preparation such as a granule, a tablet obtained by coating an uncoated tablet obtained by this method, or a capsule filled with these.
That is, the present invention
(1) Contains a main drug layer containing granules or fine granules containing a drug and a water-soluble polymer that are destabilized when crystallization water is lost, and a water-soluble polymer and a saccharide formed on the main drug layer. A stabilized solid formulation having a coating layer;
(2) The solid preparation according to (1), further comprising an intermediate coating layer containing a water-soluble polymer between the active ingredient layer and the coating layer;
(3) The solid preparation according to (1) or (2) above, wherein the granules or fine granules further contain a saccharide;
(4) The solid preparation according to any one of the above (1) to (3), wherein the drug destabilized when losing crystal water has a water solubility at 20 ° C. of 0.1 w / w% or more;
(5) The solid preparation according to the above (4), wherein the drug that is destabilized when crystallization water is lost is sodium azulenesulfonate;
(6) Any of the above (1) to (3), wherein the water-soluble polymer is at least one selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, povidone, copolyvidone, polyvinyl alcohol, gum arabic and pullulan 1. Solid preparation according to 1;
(7) The above (1) to (3), wherein the saccharide is at least one selected from the group consisting of erythritol, maltitol, powdered reduced maltose water candy, mannitol, purified sucrose, sucrose, trehalose, sorbitol, xylitol and lactose. ) Any one of the solid preparations;
(8) The solid preparation according to any one of the above (1) to (3), wherein the content of the drug that becomes unstable when crystallization water is lost is 10% by weight or less of the total amount of the preparation;
(9) The solid preparation according to any one of (1) to (3) above, which contains 1 to 100 parts by weight of a water-soluble polymer with respect to 1 part by weight of a drug that becomes unstable when water of crystallization is lost;
(10) The solid preparation according to any one of (1) to (3) above, which contains 1 to 1000 parts by weight of a saccharide with respect to 1 part by weight of a drug that becomes unstable when water of crystallization is lost;
(11) The solid preparation according to any one of (1) to (3) above, which is a tablet or granule, or a capsule containing the tablet or granule;
(12) A granule or a fine particle is prepared using a solution in which a drug that is destabilized when water of crystallization is lost and a water-soluble polymer are dissolved, and then produced using the granule or the fine particle (1) A method for producing a solid preparation according to (2); and (13) Preparation of granules or fine granules using a solution in which a drug, a water-soluble polymer and a sugar that are destabilized when water of crystallization is lost are dissolved. Then, the method for producing a solid preparation according to the above (3), which is produced using the granules or fine granules, is provided.
本発明によれば、水溶性高分子により、更には糖質により、結晶水を失うと不安定化する薬物の含量のみならず外観も安定化された固形製剤を、通常の固形製剤で用いる製造法である流動層造粒機、転動流動層造粒機、遠心流動型造粒機、押し出し造粒機、攪拌造粒機のいずれか1つまたは2つ以上を用いることにより提供することができる。 According to the present invention, a solid preparation having a stabilized appearance as well as a content of a drug that is destabilized by loss of water of crystallization due to a water-soluble polymer, and further to a saccharide, is used in a normal solid preparation. It can be provided by using any one or two or more of fluidized bed granulator, rolling fluidized bed granulator, centrifugal fluidized granulator, extrusion granulator, and agitation granulator. it can.
本発明に係る固形製剤は、結晶水を失うと不安定化する薬物および水溶性高分子を含有する顆粒または細粒を含有する主薬層と、該主薬層上に形成された水溶性高分子および糖質を含有する被覆層とを有する安定化された固形製剤であり、さらに該固形製剤の主薬層には糖質が含まれていてもよく、また主薬層と被覆層の間に中間皮膜層を有していてもよい。ここで、明細書において、「結晶水を失うと不安定化する」とは、薬物中の結晶水を失うことにより、結晶構造が変化、不安定化し、分解することをいう。従って、「安定化された」とは、結晶水を失うと不安定化する薬物からの結晶水の離脱を抑制することによって、固形製剤中に含まれる活性成分の含量変化や外観の変化が抑制されていることをいう。 The solid preparation according to the present invention comprises an active ingredient layer containing granules or fine granules containing a drug and a water-soluble polymer that are destabilized when crystallization water is lost, a water-soluble polymer formed on the active ingredient layer, and A stabilized solid preparation having a saccharide-containing coating layer, and the active ingredient layer of the solid preparation may contain a saccharide, and an intermediate coating layer between the active ingredient layer and the coating layer. You may have. Here, in the specification, “being destabilized when water of crystallization is lost” means that the crystal structure is changed, destabilized and decomposed by losing water of crystallization in the drug. Therefore, “stabilized” suppresses changes in the content and appearance of active ingredients contained in solid preparations by inhibiting the release of water of crystallization from drugs that become unstable when water is lost. It means being done.
本発明における結晶水を失うと不安定化する薬物としては、例えば、アズレンスルホン酸ナトリウム、プラステロン硫酸ナトリウム、アンピシリン三水和物、セフィキシム三水和物等が挙げられる。製剤化の観点より、本発明における結晶水を失うと不安定化する薬物の20℃における水に対する溶解度が0.1w/w%以上であるもの、好ましくは1w/w%以上であるもの、例えばアズレンスルホン酸ナトリウムなどが好ましい。
本発明における結晶水を失うと不安定化する薬物の固形製剤中の含有率は、服用する固形製剤の大きさ、量の観点より、固形製剤全量の10重量%以下であり、好ましくは、5重量%以下である。
Examples of the drug that is destabilized when water of crystallization is lost in the present invention include sodium azulene sulfonate, sodium plasterone sulfate, ampicillin trihydrate, cefixime trihydrate, and the like. From the viewpoint of formulation, a drug that is destabilized when water of crystallization is lost in the present invention has a solubility in water at 20 ° C. of 0.1 w / w% or more, preferably 1 w / w% or more, for example, Sodium azulene sulfonate is preferred.
In the present invention, the content of the drug that is destabilized when the crystal water is lost in the solid preparation is 10% by weight or less of the total amount of the solid preparation from the viewpoint of the size and amount of the solid preparation to be taken, preferably 5%. % By weight or less.
また、本発明の主薬層には、結晶水を失うと不安定化する薬物以外に、他の活性成分が含まれていてもよい。このような活性成分としては、特に限定されないが、たとえば、ビタミン類、制酸剤、健胃薬、消化剤、止瀉剤、鎮痛鎮痙剤、粘膜修復剤等を配合することができる。
該ビタミン類としては、ビタミンCとして、アスコルビン酸、アスコルビン酸カルシウム、アスコルビン酸ナトリウムが挙げられる。また、ビタミンEとして、コハク酸dl−α―トコフェロールカルシウム、コハク酸d−α―トコフェロール、酢酸d−α―トコフェロールが挙げられる。また、L-システイン、ビタミンB1類(塩酸チアミン、硝酸チアミン、塩酸フルスルチアミン、塩酸ジセチアミン、オクトチアミン、シコチアミン、ビスイブチアミン、ビスベンチアミン、ベンフォチアミン)、ビタミンB2類(リボフラビン、リン酸リボフラビン、酪酸リボフラビン)、ビタミンB6類(塩酸ピリドキシン、リン酸ピリドキサール)、ビタミンB12類(シアノコバラミン、酢酸ヒドロキソコバラミン、メコバラミン)、パントテン酸カルシウム、パントテン酸カルシウムタイプS、ニコチン酸、ニコチン酸アミド、ガンマーオリザノール、オロチン酸、グルクロノラクトン、グルクロン酸アミド、ヨクイニン、ヘスペリジン、ビオチン、コンドロイチン硫酸ナトリム等が挙げられる。
制酸剤としては、乾燥水酸化アルミニウムゲル、ケイ酸アルミン酸マグネシウム、ケイ酸マグネシウム、合成ヒドロタルサイト、酸化マグネシウム、水酸化アルミナマグネシウム、水酸化アルミニウムゲル、水酸化アルミニウム・炭酸水素ナトリウム共沈生成物、水酸化アルミニウム・炭酸マグネシウム混合乾燥ゲル、水酸化アルミニウム・炭酸マグネシウム・炭酸カルシウム共沈生成物、水酸化マグネシウム、炭酸水素ナトリウム、炭酸マグネシウム、沈降炭酸カルシウム、メタケイ酸アルミン酸マグネシウム、無水リン酸水素カルシウム、リン酸水素カルシウム、アミノ酢酸、ジヒドロキシアルミニウムアミノアセテート、ロートエキス等が挙げられる。
健胃薬としては、アロエ、ウイキョウ、ウコン、オウバク、オウレン、加工大蒜、コウジン、コウボク、ショウキョウ、センブリ、ケイヒ、ダイオウ、チクセツニンジン、チンピ、トウヒ、ニガキ、ニンジン、ハッカ、ホップ、ウイキョウ油、ケイヒ油、ショウキョウ油、トウヒ油、ハッカ油、レモン油、l−メントール、塩酸ベタイン、塩化カルニチン、乾燥酵母等が挙げられる。
消化剤としては、でんぷん消化酵素、たん白消化酵素、脂肪消化酵素、繊維素消化酵素、ウルソデスオキシコール酸、胆汁末等が挙げられる。
止瀉剤としては、アクリノール、塩化ベルべリン、グアヤコール、クレオソート、次サリチル酸ビスマス、次硝酸ビスマス、次炭酸ビスマス、次没食子酸ビスマス、タンニン酸、カオリン、ペクチン、薬用炭、乳酸カルシウム、沈降炭酸カルシウム、リン酸水素カルシウム等が挙げられる。
鎮痛鎮痙剤としては、塩酸パパベリン、アミノ安息香酸エチル等が挙げられる。
粘膜修復剤としては、アルジオキサ、L-グルタミン、銅クロロフィリンカリウム、銅クロロフィリンナトリウム、メチルメチオニンスルホニウムクロライド、ジメチルポリシロキサン等が挙げられる。
In addition, the active ingredient layer of the present invention may contain other active ingredients in addition to the drug that becomes unstable when water of crystallization is lost. Examples of such active ingredients include, but are not limited to, vitamins, antacids, gastric agents, digestives, antipruritics, analgesic / spasmodic agents, mucosal repair agents, and the like.
Examples of the vitamins include vitamin C, ascorbic acid, calcium ascorbate, and sodium ascorbate. Examples of vitamin E include dl-α-tocopherol calcium succinate, d-α-tocopherol succinate, and d-α-tocopherol acetate. In addition, L-cysteine, vitamin B1 (thiamine hydrochloride, thiamine nitrate, fursultiamine hydrochloride, discetiamine hydrochloride, octothiamine, chicotiamine, bisivethiamine, bisbenchamine, benfotiamine), vitamin B2 (riboflavin, phosphate) Riboflavin, riboflavin butyrate), vitamin B6 (pyridoxine hydrochloride, pyridoxal phosphate), vitamin B12 (cyanocobalamin, hydroxocobalamin acetate, mecobalamin), calcium pantothenate, calcium pantothenate type S, nicotinic acid, nicotinamide, gamma oryzanol Orotic acid, glucuronolactone, glucuronic acid amide, yocuinine, hesperidin, biotin, chondroitin sulfate sodium and the like.
As antacids, dry aluminum hydroxide gel, magnesium aluminate silicate, magnesium silicate, synthetic hydrotalcite, magnesium oxide, magnesium hydroxide alumina, aluminum hydroxide gel, aluminum hydroxide / sodium bicarbonate co-precipitation Product, aluminum hydroxide / magnesium carbonate mixed dry gel, aluminum hydroxide / magnesium carbonate / calcium carbonate coprecipitation product, magnesium hydroxide, sodium hydrogen carbonate, magnesium carbonate, precipitated calcium carbonate, magnesium metasilicate aluminate, anhydrous phosphoric acid Calcium hydrogen, calcium hydrogen phosphate, aminoacetic acid, dihydroxyaluminum aminoacetate, funnel extract and the like can be mentioned.
As a stomachic medicine, aloe, fennel, turmeric, duck, auren, processed daikon, kojin, kokuboku, gyoen, assembly, keihi, daiou, chikutsujinjin, chimpi, spruce, nigaki, carrot, peppermint, hop, fennel oil, Examples include cinnamon oil, pepper oil, spruce oil, peppermint oil, lemon oil, l-menthol, betaine hydrochloride, carnitine chloride, and dry yeast.
Examples of the digestive agent include starch digestive enzyme, protein digestive enzyme, fat digestive enzyme, fibrin digestive enzyme, ursodeoxycholic acid, bile powder and the like.
Antidiarrheal agents include acrinol, berberine chloride, guaiacol, creosote, bismuth subsalicylate, bismuth hyponitrite, bismuth subcarbonate, bismuth subgallate, tannic acid, kaolin, pectin, medicinal charcoal, calcium lactate, precipitated calcium carbonate And calcium hydrogen phosphate.
Examples of the analgesic and antispasmodic agent include papaverine hydrochloride and ethyl aminobenzoate.
Examples of the mucosal repairing agent include aldioxa, L-glutamine, copper chlorophyllin potassium, copper chlorophyllin sodium, methylmethionine sulfonium chloride, dimethylpolysiloxane and the like.
本発明で使用することができる水溶性高分子としては、20℃における水への溶解度が1w/w%以上の高分子であり、好ましくは3w/w%以上の高分子、更に好ましくは5w/w%以上の高分子が好ましい。具体的には、水溶性高分子としては、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、ポビドン、コポリビドン、ポリビニルアルコール、アラビアゴム、およびプルランから選ばれる1つまたは2つ以上を用いることが好ましい。
その配合量は、結晶水を失うと不安定化する薬物1重量部に対して1〜100重量部で、好ましくは、1〜50重量部である。
The water-soluble polymer that can be used in the present invention is a polymer having a solubility in water at 20 ° C. of 1 w / w% or more, preferably 3 w / w% or more, more preferably 5 w / w. A polymer of w% or more is preferred. Specifically, as the water-soluble polymer, it is preferable to use one or two or more selected from hydroxypropylcellulose, hydroxypropylmethylcellulose, povidone, copolyvidone, polyvinyl alcohol, gum arabic, and pullulan.
The blending amount is 1 to 100 parts by weight, preferably 1 to 50 parts by weight, with respect to 1 part by weight of the drug that becomes unstable when crystallization water is lost.
本発明で使用することができる糖質としては、エリスリトール、マルチトール、粉末還元麦芽糖水アメ、マンニトール、精製白糖、白糖、トレハロース、ソルビトール、キシリトール、乳糖、還元麦芽糖水アメ、ブドウ糖、麦芽糖、ラクチトール等が挙げられるが、そのなかでも、糖質として、エリスリトール、マルチトール、粉末還元麦芽糖水アメ、マンニトール、精製白糖、白糖、トレハロース、ソルビトール、キシリトール、乳糖のいずれか1つまたは2つ以上を用いることが好ましい。
その配合量は、結晶水を失うと不安定化する薬物1重量部に対して1〜1000重量部で、好ましくは、1〜500重量部である。
Examples of sugars that can be used in the present invention include erythritol, maltitol, powdered reduced maltose syrup, mannitol, purified sucrose, sucrose, trehalose, sorbitol, xylitol, lactose, reduced maltose syrup, glucose, maltose, lactitol, etc. Among them, erythritol, maltitol, powdered reduced maltose water candy, mannitol, refined sucrose, sucrose, trehalose, sorbitol, xylitol, lactose should be used as the saccharide. Is preferred.
The amount is 1 to 1000 parts by weight, preferably 1 to 500 parts by weight, based on 1 part by weight of the drug that becomes unstable when crystallization water is lost.
本発明の固形製剤としては、例えば、顆粒剤(コーティングされた顆粒剤も含む)、錠剤(例、素錠、糖衣錠、薄層糖衣錠、フィルムコーティング錠、チュアブル錠、口腔内速崩壊錠、積層錠、有核錠、徐放錠)、カプセル剤(硬カプセル剤、軟カプセル剤)、粉末吸入剤などが挙げられる。
本発明の固形製剤は、通常配合される薬理学的に許容される担体等を用いて、常法により製造することができる。特に、通常用いられる流動層造粒法、転動流動層造粒法、遠心流動型造粒法、押し出し造粒法、攪拌造粒法のいずれか1つまたは2つ以上を用いて製造することができる。すなわち、結晶水を失うと不安定化する薬物等の活性成分と担体等の添加剤を用いて本発明の固形製剤の主薬層に相当する核粒(顆粒、素錠など)を製造し、該核粒をコーティング剤でコーティングすることによって製造することができる。また、このようにして得られた顆粒剤や、または錠剤が小型のものである場合は、これらのものをカプセルに充填することによってカプセル剤としてもよい。
核粒の製造法としては、たとえば、結晶水を失うと不安定化する薬物等の活性成分、水溶性高分子および糖質を溶解した溶液を用いて顆粒または細粒を調製し、次いで得られた顆粒または細粒と添加剤を混合し、打錠して素錠を製造する方法などが挙げられる。更には、その他の製造方法として、当該薬物を溶液とし、その溶液中に水溶性高分子を配合し(更に糖質を配合してもよい)、その溶液を糖質、セルロース類、無機物等の賦形剤、あるいは当該薬物を含まない顆粒、細粒、素錠などの核粒、核錠に、コーティングする方法もある。
Examples of the solid preparation of the present invention include, for example, granules (including coated granules), tablets (eg, uncoated tablets, sugar-coated tablets, thin-layer sugar-coated tablets, film-coated tablets, chewable tablets, intraoral quick disintegrating tablets, laminated tablets. , Dry-coated tablets, sustained-release tablets), capsules (hard capsules, soft capsules), powder inhalants and the like.
The solid preparation of the present invention can be produced by a conventional method using a pharmacologically acceptable carrier or the like that is usually blended. In particular, it is produced using any one or two or more of fluidized bed granulation method, rolling fluidized bed granulation method, centrifugal fluidized granulation method, extrusion granulation method and stirring granulation method which are usually used. Can do. That is, a core particle (granule, uncoated tablet, etc.) corresponding to the main drug layer of the solid preparation of the present invention is produced using an active ingredient such as a drug that becomes unstable when water of crystallization is lost and an additive such as a carrier. It can be produced by coating the core particles with a coating agent. Moreover, when the granule obtained in this way or a tablet is small, it is good also as a capsule by filling these into a capsule.
As a method for producing a core particle, for example, a granule or a fine particle is prepared using a solution in which an active ingredient such as a drug that becomes unstable when water of crystallization is lost, a water-soluble polymer and a sugar are dissolved, and then obtained And the like, and the like, and the like. Furthermore, as another production method, the drug is used as a solution, a water-soluble polymer is blended in the solution (a saccharide may be further blended), and the solution is mixed with saccharides, celluloses, inorganic substances, etc. There is also a method of coating a core particle or core tablet such as an excipient or a granule, fine particle or uncoated tablet that does not contain the drug.
本発明の固形製剤の製造に用いられる薬理学的に許容される担体としては、製剤素材として慣用される各種有機または無機担体物質が挙げられ、例えば賦形剤、結合剤、崩壊剤、滑沢剤、流動化剤、界面活性剤等が挙げられる。また、必要に応じて、抗酸化剤、矯味剤、着色剤、香料等の添加物を用いることもできる。
賦形剤としては、例えば、エリスリトール、マルチトール、粉末還元麦芽糖水アメ、マンニトール、精製白糖、白糖、トレハロース、ソルビトール、キシリトール、乳糖、還元麦芽糖水アメ、ブドウ糖、麦芽糖、ラクチトール、コーンスターチ、結晶セルロース、粉末セルロース、リン酸一水素カルシウム、リン酸水素カルシウム、無水リン酸水素カルシウム、乳酸カルシウム、沈降炭酸カルシウム等が挙げられる。
結合剤としては、例えば、ヒドロキシプロピルセルロース、α化デンプン、ショ糖、ゼラチン、アラビアゴム粉末、メチルセルロース、ヒドロキシプロピルメチルセルロース、カルボキシメチルセルロース、カルボキシメチルセルロースナトリウム、ポリビニルピロリドン、ポリビニルアルコール、結晶セルロース、デキストリン、プルランなどが挙げられる。
崩壊剤としては、クロスカルメロースナトリウム、低置換度ヒドロキシプロピルセルロース、カルメロースカルシウム、コーンスターチ、カルボキシメチルスターチナトリウム、ヒドロキシプロピルスターチ、部分α化デンプン、クロスポビドン等が挙げられる。
滑沢剤としては、例えば、ステアリン酸マグネシウム、ステアリン酸カルシウム、ショ糖脂肪酸エステル、タルク、マクロゴール6000等が挙げられる。
流動化剤としては、例えば、軽質無水ケイ酸、含水二酸化ケイ素、カオリン等が挙げられる。
界面活性剤としては、例えばポリソルベート(ポリソルベート80など)、ポリオキシエチレン・ポリオキシプロピレン共重合物、ラウリル硫酸ナトリウムなどなどが挙げられる。
抗酸化剤としては、例えばアスコルビン酸ナトリウム、L−システイン、亜硫酸ナトリウムなどが挙げられる。
矯味剤としては、例えばクエン酸、アスコルビン酸、酒石酸、リンゴ酸、アスパルテーム、アセスルファムカリウム、ソーマチン、サッカリンナトリウム、グリチルリチン二カリウム、グルタミン酸ナトリウム、5’−イノシン酸ナトリウム、5’−グアニル酸ナトリウムなどが挙げられる。
着色剤としては、例えばリボフラビン、ビタミンB12、酸化チタン、黄色三二酸化鉄、三二酸化鉄、食用赤色2号、食用赤色3号、食用赤色102号、食用赤色104号、食用赤色105号、食用赤色106号、食用黄色4号、食用黄色5号、食用緑色3号、食用青色1号、食用青色2号、銅クロロフィルナトリウム、銅クロロフィル等などが挙げられる。
香料としては、例えばl−メントール、ハッカ油、ユーカリ油、オレンジ油、チョウジ油、テレビン油、ウイキョウ油、バニリン等が挙げられる。
Examples of the pharmacologically acceptable carrier used in the production of the solid preparation of the present invention include various organic or inorganic carrier substances commonly used as a preparation material, such as excipients, binders, disintegrants, lubricants. Agents, fluidizing agents, surfactants and the like. Moreover, additives, such as an antioxidant, a corrigent, a coloring agent, and a fragrance | flavor, can also be used as needed.
Excipients include, for example, erythritol, maltitol, powdered reduced maltose water candy, mannitol, purified sucrose, sucrose, trehalose, sorbitol, xylitol, lactose, reduced maltose water candy, glucose, maltose, lactitol, corn starch, crystalline cellulose, Examples thereof include powdered cellulose, calcium monohydrogen phosphate, calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, calcium lactate, and precipitated calcium carbonate.
Examples of the binder include hydroxypropylcellulose, pregelatinized starch, sucrose, gelatin, gum arabic powder, methylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, crystalline cellulose, dextrin, pullulan and the like. Is mentioned.
Examples of the disintegrant include croscarmellose sodium, low-substituted hydroxypropyl cellulose, carmellose calcium, corn starch, carboxymethyl starch sodium, hydroxypropyl starch, partially pregelatinized starch, crospovidone and the like.
Examples of the lubricant include magnesium stearate, calcium stearate, sucrose fatty acid ester, talc, macrogol 6000, and the like.
Examples of the fluidizing agent include light anhydrous silicic acid, hydrous silicon dioxide, kaolin and the like.
Examples of the surfactant include polysorbate (polysorbate 80 and the like), polyoxyethylene / polyoxypropylene copolymer, sodium lauryl sulfate and the like.
Examples of the antioxidant include sodium ascorbate, L-cysteine, sodium sulfite and the like.
Examples of the corrigent include citric acid, ascorbic acid, tartaric acid, malic acid, aspartame, acesulfame potassium, thaumatin, sodium saccharin, glycyrrhizin dipotassium, sodium glutamate, 5'-sodium inosinate, and 5'-sodium guanylate. .
Examples of the colorant include riboflavin, vitamin B12, titanium oxide, yellow ferric oxide, ferric oxide, edible red No. 2, edible red No. 3, edible red No. 102, edible red No. 104, edible red No. 105, and edible red. No. 106, Edible Yellow No. 4, Edible Yellow No. 5, Edible Green No. 3, Edible Blue No. 1, Edible Blue No. 2, Copper Chlorophyll Sodium, Copper Chlorophyll and the like can be mentioned.
Examples of the fragrances include l-menthol, peppermint oil, eucalyptus oil, orange oil, clove oil, turpentine oil, fennel oil, and vanillin.
本発明における主薬層を被覆する被覆層は、糖質を含む被覆層であれば材質は特に制限はない。このような糖質として、例えば、精製白糖、白糖、エリスリトール、トレハロース、マルチトール、粉末還元麦芽糖水アメ、マンニトール、ソルビトール、キシリトール、乳糖等が挙げられる。これらの糖質を1種以上用いて、糖衣、あるいは薄層糖衣(例えば、特開2002−179559参照)を施すことにより本発明の固形製剤は安定化される。
本発明における主薬層のコーティング方法としては、予め当該薬物を含有する顆粒、細粒、素錠などの核粒を製造し、その核粒にコーティングを施す方法がある。その他には、当該薬物に直接コーティングする方法もある。
本発明で用いる糖質を含む被覆層としては、精製白糖等の糖質を用いた糖衣、エリスリトール等の糖質を用いた薄層糖衣であれば特に制限はない。そして、コーティングに用いる糖質以外に必要とあれば、コーティング液に賦形剤、結合剤、滑剤、着色剤、香料等を配合してもよい。
コーティング液に用いる賦形剤としては、コムギデンプン、コメデンプン、トウモロコシデンプン、バレイショデンプン、沈降炭酸カルシウム、カオリン、含水二酸化ケイ素、ケイ酸カルシウム、リン酸水素カルシウム、無水リン酸水素カルシウム等が挙げられる。
コーティング液に用いる結合剤としては、アラビアゴム末、ヒドロキシプロピルセルロース(HPC)、ヒドロキシプロピルメチルセルロース(HPMC)、メチルセルロース、ヒドロキシエチルセルロース、カルボキシメチルエチルセルロース、ポビドン(PVP)、ポリビニルアルコール(PVA)、プルラン、デキストリン、アルファー化デンプン、ヒドロキシプロピルスターチ、トラガント末、結晶セルロース、低置換度ヒドロキシプロピルセルロース(L-HPC)等が挙げられる。
コーティング液に用いる滑剤としては、タルク、軽質無水ケイ酸、マクロゴール6000、ステアリン酸マグネシウム、ステアリン酸カルシウム、ショ糖脂肪酸エステル等が挙げられる。
コーティング液に用いる着色剤としては、リボフラビン、ビタミンB12、酸化チタン、黄色三二酸化鉄、三二酸化鉄、食用赤色2号、食用赤色3号、食用赤色102号、食用赤色104号、食用赤色105号、食用赤色106号、食用黄色4号、食用黄色5号、食用緑色3号、食用青色1号、食用青色2号、銅クロロフィルナトリウム、銅クロロフィル等が挙げられる。
コーティング液に用いる香料としては、l−メントール、ハッカ油、ユーカリ油、オレンジ油、チョウジ油、テレビン油、ウイキョウ油、バニリン等が挙げられる。
また、本発明の固形製剤においては、被覆層のコーティング時、あるいは高湿度下保存時に、主薬が被覆層へ混入する場合があるので、それを防ぐ目的として主薬層と被覆層の間に中間被膜層を設けてもよい。このような目的を達成する限り、中間被膜層の材質は限定されない。例えば、上記被覆層と同様のコーティング基材を用いることができるが、水溶性高分子が含まれることが好ましい。
The coating layer for coating the active ingredient layer in the present invention is not particularly limited as long as it is a coating layer containing a saccharide. Examples of such saccharides include purified sucrose, sucrose, erythritol, trehalose, maltitol, powdered reduced maltose syrup, mannitol, sorbitol, xylitol, and lactose. The solid preparation of the present invention is stabilized by applying sugar coating or thin-layered sugar coating (for example, see JP-A-2002-179559) using one or more of these sugars.
As a method for coating the active ingredient layer in the present invention, there is a method in which core particles such as granules, fine particles, and uncoated tablets containing the drug are produced in advance, and the core particles are coated. In addition, there is a method of directly coating the drug.
The coating layer containing a saccharide used in the present invention is not particularly limited as long as it is a sugar coating using a sugar such as refined sucrose or a thin sugar coating using a sugar such as erythritol. And if necessary other than the saccharide used for coating, an excipient, a binder, a lubricant, a colorant, a fragrance and the like may be blended in the coating solution.
Excipients used in the coating liquid include wheat starch, rice starch, corn starch, potato starch, precipitated calcium carbonate, kaolin, hydrous silicon dioxide, calcium silicate, calcium hydrogen phosphate, anhydrous calcium hydrogen phosphate, and the like. .
Binders used in the coating solution include gum arabic powder, hydroxypropylcellulose (HPC), hydroxypropylmethylcellulose (HPMC), methylcellulose, hydroxyethylcellulose, carboxymethylethylcellulose, povidone (PVP), polyvinyl alcohol (PVA), pullulan, dextrin , Pregelatinized starch, hydroxypropyl starch, tragacanth powder, crystalline cellulose, low-substituted hydroxypropylcellulose (L-HPC) and the like.
Examples of the lubricant used in the coating liquid include talc, light anhydrous silicic acid, macrogol 6000, magnesium stearate, calcium stearate, sucrose fatty acid ester, and the like.
Coloring agents used in the coating liquid include riboflavin, vitamin B12, titanium oxide, yellow ferric oxide, ferric oxide, edible red No. 2, edible red No. 3, edible red No. 102, edible red No. 104, and edible red No. 105. Edible red No. 106, edible yellow No. 4, edible yellow No. 5, edible green No. 3, edible blue No. 1, edible blue No. 2, copper chlorophyll sodium, copper chlorophyll and the like.
Examples of the fragrance used in the coating liquid include l-menthol, peppermint oil, eucalyptus oil, orange oil, clove oil, turpentine oil, fennel oil, and vanillin.
In the solid preparation of the present invention, the active ingredient may be mixed into the coating layer during coating of the coating layer or during storage under high humidity. Therefore, in order to prevent this, an intermediate film is formed between the active ingredient layer and the coating layer. A layer may be provided. As long as such an object is achieved, the material of the intermediate coating layer is not limited. For example, a coating substrate similar to the above coating layer can be used, but it is preferable that a water-soluble polymer is included.
本発明において用いられる流動層造粒機、転動流動層造粒機、遠心流動型造粒機、押し出し造粒機、攪拌造粒機に制限はなく、例えば、パウレック社、フロイント産業社、不二パウダル社の機器を用いればよい。 There are no restrictions on the fluidized bed granulator, rolling fluidized bed granulator, centrifugal fluidized granulator, extrusion granulator, and agitation granulator used in the present invention, for example, Paulek, Freund Sangyo, Two Powdal equipment may be used.
以下に実施例を挙げて本発明をさらに詳しく説明するが、本発明はこれらに限定されるものではない。
実施例1
アスコルビン酸カルシウム 1800g、コハク酸d−α―トコフェロール150g、結晶セルロース(セオラスKG802)354g、ケイ酸カルシウム(フローライトRE)36gにアズレンスルホン酸ナトリウム12g、HPC-L 144g、エリスリトール240gを精製水2256gに溶解させた水溶液を流動層造粒機(MP-10、パウレック)にて噴霧し、造粒した。得られた造粒末を整粒機(パワーミル、昭和機械化工)にて整粒し、整粒末を得た。整粒末2371.2g、L-システイン624g、結晶セルロース(セオラスKG802)145.6g、低置換度ヒドロキシプロピルセルロース(L-HPC, LH31)156g、ステアリン酸マグネシウム 31.2gを混合機(タンブラー混合機(15L)、昭和化学機械)にて混合し、混合末を得た。得られた混合末をロータリー式打錠機(コレクト12HUK、菊水製作所)にて、直径8.8mmの臼と曲率半径7mmのR面をもつ杵を用い、重量320mg、厚み5.54mmの素錠を得た。
得られた素錠300gをコーティング機(ハイコーターMINI、フロイント産業)に仕込み、ヒドロキシプロピルメチルセルロース(TC-5MW)90g、タルク10gを精製水900gに溶解、懸濁させたコーティング液を素錠に噴霧し、1錠あたり6mgコーティングし、アンダーコーティング(UC)錠を得た。続いて、UC錠に、エリスリトール530g、タルク280g、酸化チタン20g、結晶セルロース(アビセルPH-F20)50g、アラビアゴム末120gを精製水1500gに溶解、懸濁させたコーティング液を噴霧し、1錠あたり114mgコーティングし、ビルドアップコーティング(BC)錠を得た。続いてBC錠に、エリスリトール360g、ポリエチレングリコール6000(PEG6000)40gを精製水600gに溶解させたコーティング液を用い、1錠あたり15mgコーティングし、シロップコーティング(SC)錠を得た。SC錠に、カルナウバロウ、セラックパール、ヒマシ油、エタノール、n−ヘキサンを溶解させた艶出液を注液、乾燥し、艶出したシュガーレス薄層糖衣錠を得た。
The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.
Example 1
1800 g of calcium ascorbate, 150 g of d-α-tocopherol succinate, 354 g of crystalline cellulose (Theorus KG802), 36 g of calcium silicate (florite RE), 12 g of sodium azulenesulfonate, 144 g of HPC-L, 240 g of erythritol to 2256 g of purified water The dissolved aqueous solution was sprayed with a fluidized bed granulator (MP-10, Paulek) and granulated. The obtained granulated powder was sized with a sizing machine (Power Mill, Showa Mechanics) to obtain a sized powder. Mixer (Tumbler mixer (15L)) 2371.2g of sized powder, 624g of L-cysteine, 145.6g of crystalline cellulose (Theolas KG802), 156g of low-substituted hydroxypropylcellulose (L-HPC, LH31), 31.2g of magnesium stearate , Showa Chemical Machinery Co., Ltd.) to obtain a mixed powder. Using a rotary tableting machine (Correct 12HUK, Kikusui Seisakusho), the resulting mixed powder is used to obtain an uncoated tablet with a weight of 320 mg and a thickness of 5.54 mm using a pestle with a 8.8 mm diameter mortar and a radius of curvature of 7 mm. It was.
300 g of the resulting uncoated tablets are charged into a coating machine (Hi-coater MINI, Freund Sangyo), and 90 g of hydroxypropylmethylcellulose (TC-5MW) and 10 g of talc are dissolved and suspended in 900 g of purified water and sprayed onto the uncoated tablets. Then, 6 mg was coated per tablet to obtain an undercoating (UC) tablet. Subsequently, UC tablets were sprayed with a coating solution in which 530 g of erythritol, 280 g of talc, 20 g of titanium oxide, 50 g of crystalline cellulose (Avicel PH-F20), and 120 g of gum arabic powder were dissolved and suspended in 1500 g of purified water. A 114 mg coating was obtained to obtain a build-up coating (BC) tablet. Subsequently, 15 mg per tablet was coated on BC tablets using a coating solution in which 360 g of erythritol and 40 g of polyethylene glycol 6000 (PEG 6000) were dissolved in 600 g of purified water to obtain syrup-coated (SC) tablets. A glaze solution in which carnauba wax, shellac pearl, castor oil, ethanol, and n-hexane were dissolved was poured into an SC tablet and dried to obtain a glazeless sugarless thin-coated sugar-coated tablet.
実施例2
アスコルビン酸カルシウム 1800g、コハク酸d−α―トコフェロール150g、結晶セルロース(セオラスKG802)354g、ケイ酸カルシウム(フローライトRE)36gにアズレンスルホン酸ナトリウム12g、PVPK90 144g、エリスリトール240gを精製水2256gに溶解させた水溶液を流動層造粒機(MP-10、パウレック)にて噴霧し、造粒した。得られた造粒末を整粒機(パワーミル、昭和機械化工)にて整粒し、整粒末を得た。整粒末2371.2g、L-システイン624g、結晶セルロース(セオラスKG802)145.6g、低置換度ヒドロキシプロピルセルロース(L-HPC, LH31)156g、ステアリン酸マグネシウム 31.2gを混合機(タンブラー混合機(15L)、昭和化学機械)にて混合し、混合末を得た。得られた混合末をロータリー式打錠機(コレクト12HUK、菊水製作所)にて、直径8.8mmの臼と曲率半径7mmのR面をもつ杵を用い、重量320mg、厚み5.54mmの素錠を得た。
得られた素錠に実施例1と同じくシュガーレス薄層糖衣を施し、シュガーレス薄層糖衣錠を得た。
Example 2
Dissolve 1800 g of calcium ascorbate, 150 g of d-α-tocopherol succinate, 354 g of crystalline cellulose (Theorus KG802), 36 g of calcium silicate (FLORITE RE), 12 g of sodium azulenesulfonate, 144 g of PVPK90, and 240 g of erythritol in 2256 g of purified water. The aqueous solution was sprayed with a fluidized bed granulator (MP-10, Paulek) and granulated. The obtained granulated powder was sized with a sizing machine (Power Mill, Showa Mechanics) to obtain a sized powder. Mixer (Tumbler mixer (15L)) 2371.2g of sized powder, 624g of L-cysteine, 145.6g of crystalline cellulose (Theolas KG802), 156g of low-substituted hydroxypropylcellulose (L-HPC, LH31), 31.2g of magnesium stearate , Showa Chemical Machinery Co., Ltd.) to obtain a mixed powder. Using a rotary tableting machine (Correct 12HUK, Kikusui Seisakusho), the resulting mixed powder is used to obtain an uncoated tablet with a weight of 320 mg and a thickness of 5.54 mm using a pestle with a 8.8 mm diameter mortar and a radius of curvature of 7 mm. It was.
The obtained uncoated tablets were subjected to sugarless thin-layer sugar coating as in Example 1 to obtain sugarless thin-layer sugar-coated tablets.
実施例3
アスコルビン酸カルシウム 1800g、コハク酸d−α―トコフェロール150g、結晶セルロース(セオラスKG802)354g、ケイ酸カルシウム(フローライトRE)36gにアズレンスルホン酸ナトリウム12g、HPC-L 144gを精製水2256gに溶解させた水溶液を流動層造粒機(MP-10、パウレック)にて噴霧し、造粒した。得られた造粒末を整粒機(パワーミル、昭和機械化工)にて整粒し、整粒末を得た。整粒末2163.2g、L-システイン624g、結晶セルロース(セオラスKG802)145.6g、低置換度ヒドロキシプロピルセルロース(L-HPC, LH31)156g、ステアリン酸マグネシウム 31.2gを混合機(タンブラー混合機(15L)、昭和化学機械)にて混合し、混合末を得た。得られた混合末をロータリー式打錠機(コレクト12HUK、菊水製作所)にて、直径8.8mmの臼と曲率半径7mmのR面をもつ杵を用い、重量300mg、厚み5.26mmの素錠を得た。
得られた素錠に実施例1と同じくシュガーレス薄層糖衣を施し、シュガーレス薄層糖衣錠を得た。
Example 3
1800 g of calcium ascorbate, 150 g of d-α-tocopherol succinate, 354 g of crystalline cellulose (Theorus KG802), 36 g of calcium silicate (florite RE), 12 g of sodium azulenesulfonate and 144 g of HPC-L were dissolved in 2256 g of purified water. The aqueous solution was sprayed with a fluidized bed granulator (MP-10, Paulek) and granulated. The obtained granulated powder was sized with a sizing machine (Power Mill, Showa Mechanics) to obtain a sized powder. Mixer (Tumbler mixer (15L)) 2163.2g of sized powder, 624g of L-cysteine, 145.6g of crystalline cellulose (Theolas KG802), 156g of low-substituted hydroxypropylcellulose (L-HPC, LH31), 31.2g of magnesium stearate , Showa Chemical Machinery Co., Ltd.) to obtain a mixed powder. Using a rotary tableting machine (Correct 12HUK, Kikusui Seisakusho), the resulting mixed powder is used to obtain an uncoated tablet with a weight of 300 mg and a thickness of 5.26 mm using a pestle with a diameter of 8.8 mm and a radius of curvature of 7 mm. It was.
The obtained uncoated tablets were subjected to sugarless thin-layer sugar coating as in Example 1 to obtain sugarless thin-layer sugar-coated tablets.
実施例4
アスコルビン酸カルシウム 1800g、コハク酸d−α―トコフェロール150g、結晶セルロース(セオラスKG802)354g、ケイ酸カルシウム(フローライトRE)36gにアズレンスルホン酸ナトリウム12g、PVPK90 144gを精製水2256gに溶解させた水溶液を流動層造粒機(MP-10、パウレック)にて噴霧し、造粒した。得られた造粒末を整粒機(パワーミル、昭和機械化工)にて整粒し、整粒末を得た。整粒末2163.2g、L-システイン624g、結晶セルロース(セオラスKG802)145.6g、低置換度ヒドロキシプロピルセルロース(L-HPC, LH31)156g、ステアリン酸マグネシウム 31.2gを混合機(タンブラー混合機(15L)、昭和化学機械)にて混合し、混合末を得た。得られた混合末をロータリー式打錠機(コレクト12HUK、菊水製作所)にて、直径8.8mmの臼と曲率半径7mmのR面をもつ杵を用い、重量300mg、厚み5.29mmの素錠を得た。
得られた素錠に実施例1と同じくシュガーレス薄層糖衣を施し、シュガーレス薄層糖衣錠を得た。
Example 4
An aqueous solution prepared by dissolving 1800 g of calcium ascorbate, 150 g of d-α-tocopherol succinate, 354 g of crystalline cellulose (Theorus KG802), 36 g of calcium silicate (FLORITE RE), 12 g of sodium azulenesulfonate and 144 g of PVPK90 in 2256 g of purified water It sprayed with the fluid bed granulator (MP-10, Paulek), and granulated. The obtained granulated powder was sized with a sizing machine (Power Mill, Showa Mechanics) to obtain a sized powder. Mixer (Tumbler mixer (15L)) 2163.2g of sized powder, 624g of L-cysteine, 145.6g of crystalline cellulose (Theolas KG802), 156g of low-substituted hydroxypropylcellulose (L-HPC, LH31), 31.2g of magnesium stearate , Showa Chemical Machinery Co., Ltd.) to obtain a mixed powder. Use the rotary powder press (Collect 12HUK, Kikusui Seisakusho Co., Ltd.) to obtain an uncoated tablet with a weight of 300mg and a thickness of 5.29mm using a pestle with a diameter of 8.8mm and a radius of curvature of 7mm. It was.
The obtained uncoated tablets were subjected to sugarless thin-layer sugar coating as in Example 1 to obtain sugarless thin-layer sugar-coated tablets.
比較例1
アズレンスルホン酸ナトリウム12g、アスコルビン酸カルシウム 1800g、コハク酸d−α―トコフェロール150g、結晶セルロース(セオラスKG802)354g、ケイ酸カルシウム(フローライトRE)36gにHPC-L 144gを精製水2256gに溶解させた水溶液を流動層造粒機(MP-10、パウレック)にて噴霧し、造粒した。得られた造粒末を整粒機(パワーミル、昭和機械化工)にて整粒し、整粒末を得た。整粒末2163.2g、L-システイン624g、結晶セルロース(セオラスKG802)145.6g、低置換度ヒドロキシプロピルセルロース(L-HPC, LH31)156g、ステアリン酸マグネシウム 31.2gを混合機(タンブラー混合機(15L)、昭和化学機械)にて混合し、混合末を得た。得られた混合末をロータリー式打錠機(コレクト12HUK、菊水製作所)にて、直径8.8mmの臼と曲率半径7mmのR面をもつ杵を用い、重量300mg、厚み5.26mmの素錠を得た。
Comparative Example 1
Sodium azulene sulfonate 12g, calcium ascorbate 1800g, d-α-tocopherol succinate 150g, crystalline cellulose (Theorus KG802) 354g, calcium silicate (florite RE) 36g, HPC-L 144g was dissolved in purified water 2256g The aqueous solution was sprayed with a fluidized bed granulator (MP-10, Paulek) and granulated. The obtained granulated powder was sized with a sizing machine (Power Mill, Showa Mechanics) to obtain a sized powder. Mixer (Tumbler mixer (15L)) 2163.2g of sized powder, 624g of L-cysteine, 145.6g of crystalline cellulose (Theolas KG802), 156g of low-substituted hydroxypropylcellulose (L-HPC, LH31), 31.2g of magnesium stearate , Showa Chemical Machinery Co., Ltd.) to obtain a mixed powder. Using a rotary tableting machine (Correct 12HUK, Kikusui Seisakusho), the resulting mixed powder is used to obtain an uncoated tablet with a weight of 300 mg and a thickness of 5.26 mm using a pestle with a diameter of 8.8 mm and a radius of curvature of 7 mm. It was.
比較例2
アズレンスルホン酸ナトリウム12g、アスコルビン酸カルシウム 1800g、コハク酸d−α―トコフェロール150g、結晶セルロース(セオラスKG802)354g、ケイ酸カルシウム(フローライトRE)36gにPVPK90 144gを精製水2256gに溶解させた水溶液を流動層造粒機(MP-10、パウレック)にて噴霧し、造粒した。得られた造粒末を整粒機(パワーミル、昭和機械化工)にて整粒し、整粒末を得た。整粒末2163.2g、L-システイン624g、結晶セルロース(セオラスKG802)145.6g、低置換度ヒドロキシプロピルセルロース(L-HPC, LH31)156g、ステアリン酸マグネシウム 31.2gを混合機(タンブラー混合機(15L)、昭和化学機械)にて混合し、混合末を得た。得られた混合末をロータリー式打錠機(コレクト12HUK、菊水製作所)にて、直径8.8mmの臼と曲率半径7mmのR面をもつ杵を用い、重量300mg、厚み5.29mmの素錠を得た。
Comparative Example 2
An aqueous solution in which 144 g of PVPK90 was dissolved in 2256 g of purified water in 12 g of sodium azulene sulfonate, 1800 g of calcium ascorbate, 150 g of d-α-tocopherol succinate, 354 g of crystalline cellulose (Theorus KG802), 36 g of calcium silicate (FLORITE RE) It sprayed with the fluid bed granulator (MP-10, Paulek), and granulated. The obtained granulated powder was sized with a sizing machine (Power Mill, Showa Mechanics) to obtain a sized powder. Mixer (Tumbler mixer (15L)) 2163.2g of sized powder, 624g of L-cysteine, 145.6g of crystalline cellulose (Theolas KG802), 156g of low-substituted hydroxypropylcellulose (L-HPC, LH31), 31.2g of magnesium stearate , Showa Chemical Machinery Co., Ltd.) to obtain a mixed powder. Use the rotary powder press (Collect 12HUK, Kikusui Seisakusho Co., Ltd.) to obtain an uncoated tablet with a weight of 300mg and a thickness of 5.29mm using a pestle with a diameter of 8.8mm and a radius of curvature of 7mm. It was.
アズレンスルホン酸ナトリウム含量安定性
実施例1〜4および比較例1、2の錠剤を60℃で2週間ガラス瓶密栓保存し、錠剤中のアズレンスルホン酸ナトリウム含量をHPLC法により測定し、その残存率で評価した。
Stability of sodium azulene sulfonate content The tablets of Examples 1 to 4 and Comparative Examples 1 and 2 were sealed in glass bottles at 60 ° C. for 2 weeks, and the content of sodium azulene sulfonate in the tablets was measured by the HPLC method. evaluated.
アズレンスルホン酸ナトリウム含量試験
錠剤20錠をとり、粉砕機で粉砕し、試料粉末とする。試料粉末(1錠分)に溶解液50mLを添加し、振とう抽出を30分間行い、その後、遠心分離(約9400×g、10分間)を行い、得られた上澄液5mLに内部標準液5mLを添加、混合し、試料溶液とした。試料溶液を下記HPLC条件下、測定した。なお、溶解液として、メタノール/水(6/4)を用いた。内部標準液として、フタル酸ビス(2―エチルヘキシル)メタノール溶液を用いた。
HPLC条件
検出器:紫外吸光光度計(測定波長285nm)
カラム:YMC-Pack AM-3E2(YMC社)
カラム温度:50℃
移動相:0.003mol/Lトリオクチルアミン含有メタノール/水(17/3)混液(pH6.0)
流量:0.35mL/min
HPLC condition detector: UV spectrophotometer (measurement wavelength 285 nm)
Column: YMC-Pack AM-3E2 (YMC)
Column temperature: 50 ° C
Mobile phase: 0.003mol / L trioctylamine-containing methanol / water (17/3) mixture (pH 6.0)
Flow rate: 0.35mL / min
外観安定性
実施例1,2および比較例1,2の錠剤を40℃75%RH開栓1カ月保存し、錠剤の外観変化をカラーコンピュター(S&Mカラーコンピュター、スガ試験機)により測定し、色差(ΔE)で評価した。また、実施例1、2に関しては40℃75%RH開栓1カ月保存後、コーティング層をカッターで削り取り、内部の錠剤の外観変化も同様に、色差(ΔE)で評価した。
実施例1,2は比較例1,2に比べ、薬物含量のみならず錠剤外部と錠剤内部の外観も安定化された。 In Examples 1 and 2, compared to Comparative Examples 1 and 2, not only the drug content, but also the appearance of the tablet exterior and tablet interior was stabilized.
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