JP5179142B2 - Target material conveyor system - Google Patents
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本発明は、ターゲット物質コンベヤシステムに関し、特に、安定的に液体同位元素を作製する時の圧力を制御し、液体同位元素を作製する時、より良い安全性が得られるものに関する。 The present invention relates to a target material conveyor system, and more particularly, to a system capable of controlling the pressure when stably producing a liquid isotope and obtaining better safety when producing a liquid isotope.
全世界の陽電子造影薬品の発展が速く、その中、液体ターゲット技術により発展されたフッ素−１８フッ素イオンを、陽電子造影の主要放射造影核種とするフッ素−１８フッ素イオンターゲットは、各加速器センターにおいて不可欠のターゲット技術になり、また、フッ素−１８をフッ素化マークして、各種類の化合物を形成し、陽電子核医学薬品を作製することに応用され、また、液体ターゲットのコンベヤシステムが直接にフッ素−１８フッ素イオンのコンベヤに影響するため、高安定度に、液体ターゲット物質の供給とターゲット体の照射が実現され、半減期が１１０分であるフッ素−１８放射活性同位元素にとって、安定的に製造できる重要な条件であり、各陽電子サイクロトロンセンターの不可欠なターゲット技術であり、市場潜在性が非常に膨大である。 The development of positron contrast agents around the world is fast. Among them, the fluorine-18 fluorine ion target, which uses fluorine-18 fluorine ions developed by liquid target technology as the main radionuclide nuclide for positron imaging, is indispensable in each accelerator center. Fluorine-18 is marked with fluorination to form each kind of compound, and positron nuclear medicine is made, and the liquid target conveyor system is directly applied to fluorine- Since it affects the conveyor of 18 fluorine ions, the liquid target material can be supplied and the target body can be irradiated with high stability, and the fluorine-18 radioactive isotope having a half-life of 110 minutes can be manufactured stably. It is an important condition and is an indispensable target technology for each positron cyclotron center. Sex is very large.
一般の従来の液体同位元素は、作製する時、操作員により保管瓶から所定の容量である液体を吸い上げ、その後、照射ターゲットチェンバに入り、ターゲットチェンバの液体注入弁と排気弁を開けて該液体をターゲットチェンバに注入し、その後、液体注入弁と排気弁を締めて加圧弁を開け、ターゲットチェンバを必要とする圧力に加圧し、そして、同時にターゲットチェンバに対して陽子線照射を行い、これにより液体をフッ素−１８水の液体同位元素に形成する。 When a general conventional liquid isotope is prepared, an operator draws up a predetermined volume of liquid from a storage bottle, and then enters an irradiation target chamber and opens the liquid injection valve and exhaust valve of the target chamber to open the liquid. Is then injected into the target chamber, then the liquid injection valve and the exhaust valve are tightened to open the pressurization valve, the target chamber is pressurized to the required pressure, and simultaneously the target chamber is irradiated with proton beam, A liquid is formed into a liquid isotope of fluorine-18 water.
しかし、上記の従来の方式によれば、液体が陽子線照射によりフッ素−１８水の液体同位元素に変換形成するが、毎度、陽子線照射を行う前、操作員により液体をターゲットチェンバに注入することが必要であるため、注入された液体の量が制御し難く、人的ミスで作製する時の過ちが発生し易く、また、チェンバの輻射値が非常に高いため、操作員が比較的に高い輻射投与量に晒され、安全の恐れがあり、また、高いエネルギーである陽子線を照射することにより、ターゲットチェンバの圧力が不安定になる恐れがあり、そのため、一般の従来の液体同位元素の作製方式は実用的とは言えない。 However, according to the above-described conventional method, the liquid is converted into a liquid isotope of fluorine-18 water by proton beam irradiation. However, before every proton beam irradiation, the operator injects the liquid into the target chamber. It is difficult to control the amount of injected liquid, it is easy to make mistakes when making it by human error, and because the radiation value of the chamber is very high, Exposure to high radiation doses may cause safety, and irradiation with high energy proton beams may cause the pressure in the target chamber to become unstable. Therefore, general conventional liquid isotopes This production method is not practical.
本発明の主な目的は、自動化で安定的に、液体同位元素を作製する時の圧力を制御でき、液体同位元素を作製する時、より良い安全性が得られるターゲット物質コンベヤシステムを提供する。 The main object of the present invention is to provide a target material conveyor system that can control the pressure at the time of producing liquid isotopes stably by automation, and can obtain better safety when producing liquid isotopes.
本発明は、上記の目的を達成するため、少なくとも、第１、２と３の調節弁を有する圧力制御機構と、第２の調節弁に連接される送りユニットと、第３の調節弁と送りユニットに連接されるターゲットチェンバと、ターゲットチェンバの一側に設置される陽子線照射ユニットと、ターゲットチェンバに連接される保管ユニットと、が備えられるターゲット物質コンベヤシステムである。 In order to achieve the above object, the present invention provides at least a pressure control mechanism having first, second and third control valves, a feed unit connected to the second control valve, a third control valve and a feed. A target material conveyor system comprising a target chamber connected to a unit, a proton beam irradiation unit installed on one side of the target chamber, and a storage unit connected to the target chamber.
図１と２は、それぞれ、本発明の基本構造ブロック概念図と、本発明の全体構造概念図である。図のように、本発明はターゲット物質コンベヤシステムであり、少なくとも、圧力制御機構１と送りユニット２、ターゲットチェンバ３、陽子線照射ユニット４及び保管ユニット５から構成され、自動化で安定的に液体同位元素を作製する時の圧力を制御でき、液体同位元素を作製する時、より良い安全性が得られる。 1 and 2 are a basic structural block conceptual diagram of the present invention and an overall structural conceptual diagram of the present invention, respectively. As shown in the figure, the present invention is a target material conveyor system, which comprises at least a pressure control mechanism 1, a feed unit 2, a target chamber 3, a proton beam irradiation unit 4 and a storage unit 5, and is stable and liquid isotope by automation. The pressure when producing the element can be controlled, and better safety is obtained when producing the liquid isotope.
上記の圧力制御機構１は、少なくとも、第１の調節弁１１と、それぞれ、第１の調節弁１１に連接される第２、３の調節弁１２、１３が備えられ、該第１の調節弁１１は高圧調節弁であり、該第２、３の調節弁１２、１３は低圧調節弁であり、該第１の調節弁１１に給気ボンベ１１１が連接され、また、該第１、２の調節弁１１、１２の間に第１のスイッチ部１１２が設けられ、また、該第２の調節弁１２に、更に洗浄ユニット６が連接され、該洗浄ユニット６は、第２のスイッチ部６１を介してターゲットチェンバ３に連接され、そして、該圧力制御機構１は、更に第３の調節弁１３に連接され、第６のスイッチ部１５３を有する圧力バッファ１５が備えられ、該圧力バッファ１５は、第７のスイッチ部１５１を介して給気ボンベ１４１を有する第４の調節弁１４が連接され、また、該圧力バッファ１５に、更に圧力転送器１５２が連接され、該圧力バッファ１５と第２のスイッチ部６１との間に、第１２のスイッチ部１５４が設置される。 The pressure control mechanism 1 includes at least a first control valve 11 and second and third control valves 12 and 13 connected to the first control valve 11, respectively. 11 is a high-pressure control valve, the second and third control valves 12 and 13 are low-pressure control valves, an air supply cylinder 111 is connected to the first control valve 11, and the first and second control valves A first switch unit 112 is provided between the control valves 11 and 12, and a cleaning unit 6 is further connected to the second control valve 12, and the cleaning unit 6 includes a second switch unit 61. The pressure control mechanism 1 is further connected to a third control valve 13 and is provided with a pressure buffer 15 having a sixth switch portion 153. The pressure buffer 15 is connected to the target chamber 3 via the target chamber 3. The supply cylinder 141 is connected via the seventh switch unit 151. The pressure regulator 152 is further connected to the pressure buffer 15, and the twelfth switch portion 154 is connected between the pressure buffer 15 and the second switch portion 61. Is installed.
該送りユニット２は上記の第２の調節弁１２に連接され、また、該第２の調節弁１２と送りユニット２との間に、第３のスイッチ部２１が設けられる。 The feed unit 2 is connected to the second control valve 12, and a third switch portion 21 is provided between the second control valve 12 and the feed unit 2.
該ターゲットチェンバ３は、上記第３の調節弁１３と送りユニット２に連接され、該第３の調節弁１３とターゲットチェンバ３との間に、第４と第５のスイッチ部１３１、３２が設けられ、また、該送りユニット２とターゲットチェンバ３との間に第８と第９のスイッチ部３３、３４が設けられ、更に、該ターゲットチェンバ３は、更に第１０のスイッチ部３５により回収ボンベ３６が連接される。 The target chamber 3 is connected to the third control valve 13 and the feed unit 2, and fourth and fifth switch portions 131 and 32 are provided between the third control valve 13 and the target chamber 3. In addition, eighth and ninth switch portions 33 and 34 are provided between the feed unit 2 and the target chamber 3, and the target chamber 3 is further moved to a recovery cylinder 36 by a tenth switch portion 35. Are connected.
該陽子線照射ユニット４は、上記のターゲットチェンバ３の一側に設置される。 The proton beam irradiation unit 4 is installed on one side of the target chamber 3.
該保管ユニット５は、上記のターゲットチェンバ３に連接され、該ターゲットチェンバ３と保管ユニット５との間に第１１のスイッチ部５１が設けられる。上記の構造により、新規のターゲット物質コンベヤシステムが構成される。 The storage unit 5 is connected to the target chamber 3, and an eleventh switch unit 51 is provided between the target chamber 3 and the storage unit 5. With the above structure, a new target material conveyor system is configured.
図３は本発明の第１の使用状態概念図である。図のように、本発明によれば、陽子線照射を行う時、該送りユニット２に酸素−１８水を注入してから、第１のスイッチ部１１２と第３のスイッチ部２１、第８及び第９のスイッチ部３３、３４を開き、また、第１と第２の調節弁１１、１２を駆動し、該給気ボンベ１１１により、第１の調節弁１１に対して気体圧力を供給し、その後、気体圧力を第２の調節弁１２を介して送りユニット２へ導入し、これにより、該送りユニット２の酸素−１８水がターゲットチェンバ３へ導引され、そして、第５と第１０のスイッチ部３２、３５を開き、オーバーフローした酸素−１８水を回収ボンベ３６で回收し、この時、陽子線照射ユニット４で高いエネルギーの陽子線照射を行い、ターゲットチェンバ３の酸素−１８水をフッ素−１８水に変換し、その後、第４と第１１のスイッチ部１３１、５１を開いて第３の調節弁１３を駆動し、第１の調節弁１１で、気体圧力を第３の調節弁１３を介して、ターゲットチェンバ３へ導引し、これにより、ターゲットチェンバ３のフッ素−１８水が保管ユニット５へ導入されて保管される。 FIG. 3 is a first usage state conceptual diagram of the present invention. As shown in the figure, according to the present invention, when proton beam irradiation is performed, oxygen-18 water is injected into the feed unit 2, and then the first switch unit 112, the third switch unit 21, the eighth switch, Open the ninth switch portion 33, 34, drive the first and second control valves 11, 12, supply the gas pressure to the first control valve 11 by the air supply cylinder 111, Thereafter, gas pressure is introduced into the feed unit 2 via the second control valve 12, whereby oxygen-18 water of the feed unit 2 is guided to the target chamber 3, and the fifth and tenth The switch units 32 and 35 are opened, and the overflowed oxygen-18 water is collected by the recovery cylinder 36. At this time, the proton beam irradiation unit 4 performs high energy proton beam irradiation, and the oxygen-18 water in the target chamber 3 is fluorinated. -18 converted to water, After, and open the fourth switch 131, 51 of the 11 drives the third control valve 13, the first control valve 11, the gas pressure through the third control valve 13, a target chamber In this way, fluorine-18 water in the target chamber 3 is introduced into the storage unit 5 and stored.
図４は、本発明の第２の使用状態概念図である。図のように、本発明によれば、第１と第２及び第３の調節弁１１、１２、１３を開いて陽子線照射を行う時、同時に第１２のスイッチ部１５４を開き、これにより、該圧力制御機構１の圧力バッファ１５が、圧力転送器１５２に合わせて、即時に、第１と第２及び第３の調節弁１１、１２、１３の圧力供給状況を持続的に検知し、圧力が過大になる時、第６のスイッチ部１５３を開いて減圧し、圧力が不足である時、第６のスイッチ部１５１を開いて、該第４の調節弁１４を介して給気ボンベ１４１から気体圧力を供給し、また、圧力バッファ１５を介して補助加圧を行い、これによりシステムが所定の圧力を維持できる。 FIG. 4 is a second usage state conceptual diagram of the present invention. As shown in the figure, according to the present invention, when the first, second and third control valves 11, 12, 13 are opened to perform proton beam irradiation, the twelfth switch unit 154 is opened at the same time. The pressure buffer 15 of the pressure control mechanism 1 continuously detects the pressure supply status of the first, second and third control valves 11, 12, 13 in accordance with the pressure transmitter 152, When the pressure becomes excessive, the sixth switch portion 153 is opened to reduce the pressure, and when the pressure is insufficient, the sixth switch portion 151 is opened to remove the air from the supply cylinder 141 via the fourth control valve 14. Gas pressure is supplied and auxiliary pressurization is performed via the pressure buffer 15 so that the system can maintain a predetermined pressure.
図５は本発明の第３の使用状態概念図である。図のように、陽子線照射を終了した後、第１のスイッチ部１１２と第３のスイッチ部２１、第２のスイッチ部６１、第９のスイッチ部３４及び第１１のスイッチ部５１を開いて、洗浄ユニット６に必要とする洗浄液や水を注入し、そして、第１と第２の調節弁１１、１２を駆動し、これにより、該給気ボンベ１１１により第１の調節弁１１に対して気体圧力を供給し、その後、気体圧力を、第２の調節弁１２を介して洗浄ユニット６へ導入し、これにより、該洗浄ユニット６の洗浄液や水がターゲットチェンバ３へ導引されて洗浄を行い、その後、保管ユニット５から廃水を排出し保管しない。
FIG. 5 is a third usage state conceptual diagram of the present invention. As shown in the figure, after the proton beam irradiation is finished, the first switch unit 112, the third switch unit 21, the second switch unit 61, the ninth switch unit 34, and the eleventh switch unit 51 are opened. Then, the cleaning liquid or water required for the cleaning unit 6 is injected, and the first and second control valves 11 and 12 are driven, whereby the air supply cylinder 111 causes the first control valve 11 to move. After supplying the gas pressure, the gas pressure is introduced into the cleaning unit 6 via the second control valve 12, whereby the cleaning liquid and water of the cleaning unit 6 are guided to the target chamber 3 for cleaning. After that, the waste water is discharged from the storage unit 5 and not stored.
以上のように、本発明に係わるターゲット物質コンベヤシステムは、有効に従来の諸欠点を改善でき、自動化で安定的に液体同位元素を作製する時の圧力を制御でき、液体同位元素を作製する時、より良い安全性が得られるため、本発明はより進歩的かつより実用的で、法に従って特許請求を出願する。 As described above, the target material conveyor system according to the present invention can effectively improve the conventional drawbacks, can control the pressure when producing liquid isotopes stably by automation, and can produce liquid isotopes. Because of the better security, the present invention is more progressive and more practical, and claims are filed according to law.
以上は、ただ、本発明のより良い実施例であり、本発明はそれによって制限されることが無く、本発明に係わる特許請求の範囲や明細書の内容に基づいて行った等価の変更や修正は、全てが本発明の特許請求の範囲内に含まれる。 The above are merely preferred embodiments of the present invention, and the present invention is not limited thereby, and equivalent changes and modifications made based on the scope of claims and the description of the present invention. Are all within the scope of the claims of the present invention.
１ 圧力制御機構
１１ 第１の調節弁
１１１ 給気ボンベ
１１２ 第１のスイッチ部
１２ 第２の調節弁
１３ 第３の調節弁
１４ 第４の調節弁
１４１ 給気ボンベ
１５ 圧力バッファ
１５１ 第７のスイッチ部
１５２ 圧力転送器
１５３ 第６のスイッチ部
１５４ 第１２のスイッチ部
２ 送りユニット
２１ 第３のスイッチ部
３ ターゲットチェンバ
３１ 第４のスイッチ部
３２ 第５のスイッチ部
３３ 第８のスイッチ部
３４ 第９のスイッチ部
３５ 第１０のスイッチ部
３６ 回収ボンベ
４ 陽子線照射ユニット
５ 保管ユニット
５１ 第１０のスイッチ部
６ 洗浄ユニット
６１ 第２のスイッチ部
DESCRIPTION OF SYMBOLS 1 Pressure control mechanism 11 1st control valve 111 Supply air cylinder 112 1st switch part 12 2nd control valve 13 3rd control valve 14 4th control valve 141 Supply air cylinder 15 Pressure buffer 151 7th switch Unit 152 pressure transfer unit 153 sixth switch unit 154 twelfth switch unit 2 feed unit 21 third switch unit 3 target chamber 31 fourth switch unit 32 fifth switch unit 33 eighth switch unit 34 ninth Switch unit 35 tenth switch unit 36 recovery cylinder 4 proton beam irradiation unit 5 storage unit 51 tenth switch unit 6 cleaning unit 61 second switch unit
Claims (2)
該第１の給気ボンベの気体の出力圧を該第１の圧力調節弁で調節した出力を分岐してそれぞれ該第２の圧力調節弁と該第３の圧力調節弁とで調節するように接続され、
該第２の圧力調節弁の出力は該ターゲット物質送りユニットに気体の圧力を掛け、ターゲット物質を該ターゲット物質送りユニットから該ターゲットチェンバに送り込むように、該ターゲット物質送りユニットの入力部に複数のスイッチ部を介して接続され該ターゲット物質送りユニットの出力部は複数のスイッチ部を介して該ターゲットチェンバの第１の側に接続され、
該回収ボンベは該ターゲットチェンバからオーバーフローしたターゲット物質を回収するように、複数のスイッチ部を介して該ターゲットチェンバの第２の側に接続され、
該ターゲットチェンバは、ターゲット物質に気体の圧力を掛けた状態で、該陽子線照射ユニットから放射される陽子線が照射されるように配置され、
該第３の圧力調節弁の出力は該ターゲットチェンバの第２の側に圧力を掛け、陽子線照射を受けたターゲット物質を、該ターゲットチェンバの第１の側から該保管ユニットに導くように、複数のスイッチ部を介して接続され、
該第４の圧力調整弁は該第２の給気ボンベに接続され、
該第４の圧力調整弁の出力側は、少なくとも１つのスイッチ部を介して該圧力バッファの一方の側と該圧力転送器とに接続され、
該圧力バッファの他方の側は、複数のスイッチ部を介して該ターゲットチェンバの第２の側に接続され、
該圧力転送器により該ターゲットチェンバの圧力を所定の値に維持するように制御する構成であることを特徴とするターゲット物質コンベヤシステム。 At least a first air supply cylinder, a first pressure regulating valve, a second pressure regulating valve, a third pressure regulating valve, a target material feed unit, a target chamber, and a proton beam irradiation unit; A target material comprising a storage unit, a recovery cylinder, a plurality of switch parts, a second air supply cylinder, a fourth pressure regulating valve, a pressure buffer, a pressure transfer device, and a plurality of switch parts A conveyor system,
An output obtained by adjusting the output pressure of the gas in the first supply cylinder by the first pressure control valve is branched and adjusted by the second pressure control valve and the third pressure control valve, respectively. Connected,
The output of the second pressure regulating valve is a pressure of the gas in the target material feed unit, the target material from the target material feed unit to feed to the target chamber, a plurality of the input portion of the target material feed unit The output unit of the target material feeding unit connected through a switch unit is connected to the first side of the target chamber through a plurality of switch units,
The recovery cylinder is connected to the second side of the target chamber via a plurality of switch parts so as to recover the target material overflowed from the target chamber,
The target chamber is arranged to be irradiated with a proton beam emitted from the proton beam irradiation unit in a state where a gas pressure is applied to a target material.
The output of the third pressure control valve applying pressure to the second side of the target chamber, the target material that have undergone proton beam irradiation, so as to guide the-holding tube units from a first side of the target chamber, Connected through multiple switches,
The fourth pressure regulating valve is connected to the second supply cylinder;
The output side of the fourth pressure regulating valve is connected to one side of the pressure buffer and the pressure transfer device via at least one switch part,
The other side of the pressure buffer is connected to the second side of the target chamber via a plurality of switch parts,
A target material conveyor system, wherein the pressure transfer device is controlled to maintain the pressure of the target chamber at a predetermined value .
該洗浄ユニットの入力部は少なくとも１つのスイッチ部を介して前記第２の圧力調節弁の出力側に接続され、
該洗浄ユニットの出力部は少なくとも１つのスイッチ部を介して前記ターゲットチェンバの第２の側に接続され、
該洗浄ユニットに気体の圧力を掛け、洗浄剤を、前記ターゲットチェンバを経由して前記保管ユニットに導くようにしたことを特徴とする請求項１に記載のターゲット物質コンベヤシステム。 In addition to the target material conveyor system according to claim 1, further comprising a cleaning unit,
An input part of the cleaning unit is connected to an output side of the second pressure regulating valve via at least one switch part,
An output of the cleaning unit is connected to the second side of the target chamber via at least one switch;
The target material conveyor system according to claim 1, wherein a gas pressure is applied to the cleaning unit to guide the cleaning agent to the storage unit via the target chamber.
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| JP2007276428A JP5179142B2 (en) | 2007-10-24 | 2007-10-24 | Target material conveyor system |
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| CN102933019B (en) * | 2011-08-10 | 2016-01-13 | 上海原子科兴药业有限公司 | Simulation target system in a kind of cyclotron target chamber |
| EP2581914B1 (en) | 2011-10-10 | 2014-12-31 | Ion Beam Applications S.A. | Method and facility for producing a radioisotope |
| KR101443513B1 (en) * | 2013-03-27 | 2014-09-19 | 조선대학교산학협력단 | Manufacturing method for F-18 radio-isotope using target device for manufacturing radio-isotope |
| KR101443512B1 (en) * | 2013-03-27 | 2014-09-22 | 조선대학교산학협력단 | Target device for manufacturing radio-isotope with automatic loading and withdraw function of O-18 water |
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| JPS603600A (en) * | 1983-06-21 | 1985-01-09 | 住友重機械工業株式会社 | Forced circulation type radioisotope continuous systhetic method and device used for said method |
| JPH07318694A (en) * | 1994-05-24 | 1995-12-08 | Seitai Kinou Kenkyusho:Kk | Method and apparatus for automatically synthesizing injection formulation of 11c labeled methyl compound |
| EP1429345A1 (en) * | 2002-12-10 | 2004-06-16 | Ion Beam Applications S.A. | Device and method of radioisotope production |
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