JP5175190B2 - シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤 - Google Patents

シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤 Download PDF

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JP5175190B2
JP5175190B2 JP2008526154A JP2008526154A JP5175190B2 JP 5175190 B2 JP5175190 B2 JP 5175190B2 JP 2008526154 A JP2008526154 A JP 2008526154A JP 2008526154 A JP2008526154 A JP 2008526154A JP 5175190 B2 JP5175190 B2 JP 5175190B2
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compound
pseudomonas
nhac
salt
composition
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JP2009504660A (ja
JP2009504660A5 (enExample
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ジョン エル． マニャーニ，
ジョン ティー． ジュニア パットン，
アルン ケー． サルカール，
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グリコミメティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/21—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2008526154A 2005-08-09 2006-08-08 シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤 Expired - Fee Related JP5175190B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US70654605P 2005-08-09 2005-08-09
US60/706,546 2005-08-09
US81019006P 2006-06-01 2006-06-01
US60/810,190 2006-06-01
PCT/US2006/030993 WO2007021721A2 (en) 2005-08-09 2006-08-08 Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas

Related Child Applications (1)

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JP2012267339A Division JP2013049718A (ja) 2005-08-09 2012-12-06 シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤

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JP2009504660A JP2009504660A (ja) 2009-02-05
JP2009504660A5 JP2009504660A5 (enExample) 2009-09-24
JP5175190B2 true JP5175190B2 (ja) 2013-04-03

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JP2008526154A Expired - Fee Related JP5175190B2 (ja) 2005-08-09 2006-08-08 シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤
JP2012267339A Withdrawn JP2013049718A (ja) 2005-08-09 2012-12-06 シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤

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US (3) US7517980B2 (enExample)
EP (1) EP1928892B1 (enExample)
JP (2) JP5175190B2 (enExample)
CN (1) CN101291946B (enExample)
AT (1) ATE528311T1 (enExample)
AU (1) AU2006280101B2 (enExample)
CA (1) CA2618638C (enExample)
DK (1) DK1928892T3 (enExample)
ES (1) ES2375979T3 (enExample)
WO (1) WO2007021721A2 (enExample)

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ES2524363T3 (es) 2010-12-10 2014-12-05 Centre National De La Recherche Scientifique (Cnrs) Compuestos glicomiméticos como agentes antiinfecciosos frente a lectinas patógenas
WO2013096926A1 (en) 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
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CN103342725B (zh) * 2013-07-26 2016-09-14 济南尚博生物科技有限公司 一种β端基硫代糖苷化合物的分离提纯方法
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WO2016089872A1 (en) 2014-12-03 2016-06-09 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
JP2019524791A (ja) 2016-08-08 2019-09-05 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ
US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
BR112020013198A2 (pt) 2017-12-29 2020-12-01 Glycomimetics, Inc. inibidores heterobifuncionais de e-selectina e galectina-3
KR20200128025A (ko) 2018-03-05 2020-11-11 글리코미메틱스, 인크. 급성 골수성 백혈병 및 관련 병태의 치료 방법
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
KR20210110645A (ko) 2018-12-27 2021-09-08 글리코미메틱스, 인크. 갈렉틴-3 억제 c-글리코사이드

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AU2006280101A1 (en) 2007-02-22
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US8258290B2 (en) 2012-09-04
WO2007021721A2 (en) 2007-02-22
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DK1928892T3 (da) 2012-01-30
CN101291946A (zh) 2008-10-22
US7517980B2 (en) 2009-04-14
CN101291946B (zh) 2011-06-29
US20070037775A1 (en) 2007-02-15
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