JP5153948B1 - Allergic rhinitis coating agent - Google Patents
Allergic rhinitis coating agent Download PDFInfo
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- JP5153948B1 JP5153948B1 JP2012053116A JP2012053116A JP5153948B1 JP 5153948 B1 JP5153948 B1 JP 5153948B1 JP 2012053116 A JP2012053116 A JP 2012053116A JP 2012053116 A JP2012053116 A JP 2012053116A JP 5153948 B1 JP5153948 B1 JP 5153948B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
【課題】簡単に塗付することが可能であって、しかも即効性のある対症療法剤として用いることが可能なアレルギー性鼻炎用塗付剤を提供する。
【解決手段】ワセリン等の基剤中に、とうがらし、ゆず、しょうが等の感温物質から成る有効成分を５〜３５重量％添加し、さらに必要に応じて乳化剤、防腐剤、保湿剤等を添加した軟膏あるいはクリーム状の薬剤であって、チューブあるいはプラスチック容器に充填して提供されるアレルギー性鼻炎用塗付剤である。
【選択図】なし
The present invention provides a coating agent for allergic rhinitis that can be easily applied and can be used as an immediate symptomatic therapeutic agent.
[MEANS FOR SOLVING PROBLEMS] 5 to 35% by weight of an active ingredient composed of a temperature-sensitive substance such as pepper, citron, ginger, etc. is added to a base such as petrolatum, and further an emulsifier, preservative, moisturizer, etc. are added as necessary. An ointment or cream-like drug, which is a coating agent for allergic rhinitis provided by filling a tube or a plastic container.
[Selection figure] None
Description
本発明はアレルギー性鼻炎用塗付剤に係り、とくに鼻孔の内腔表面の粘膜の部分が炎症を起している鼻の外表面に塗付して有効成分を皮膚に浸透させることにより鼻孔内の炎症を抑えるアレルギー性鼻炎用塗付剤に関する。 The present invention relates to a coating agent for allergic rhinitis, and in particular, by applying the active ingredient to the skin by applying the mucosal portion of the luminal surface of the nostril to the outer surface of the inflamed nose, and passing the active ingredient into the skin. It is related with the coating agent for allergic rhinitis which suppresses inflammation of the skin.
アレルギー性鼻炎は、鼻孔内腔の内表面の粘膜が炎症を起し、これによって鼻づまりや鼻水、あるいはまた呼吸困難等の各種の症状を発症する疾病である。このような疾病に対する薬剤としては、例えば特開平９−２９６９号公報や特開２００４−７５５７１号公報に開示されているように、グアバの葉の乾燥粉末またはその乾燥粉末から溶媒抽出させたエキスを含むアレルギー疾患治療剤が提案されている。このような治療剤は、液剤、ローション、懸濁剤、クリーム、軟膏、噴霧液、入浴剤などの剤形とされており、アトピー性皮膚炎を始め、ヒスタミンの関与する、気管支喘息、アレルギー性鼻炎、花粉症等のアレルギー疾患にも適用できるものである。 Allergic rhinitis is a disease in which the mucous membrane of the inner surface of the nasal cavity is inflamed, thereby causing various symptoms such as nasal congestion, runny nose, and dyspnea. As a drug for such diseases, for example, as disclosed in JP-A-9-2969 and JP-A-2004-75571, a dried powder of guava leaves or an extract obtained by solvent extraction from the dried powder is used. Including allergic disease therapeutic agents. Such therapeutic agents are in the form of liquids, lotions, suspensions, creams, ointments, sprays, baths, etc., including atopic dermatitis, histamine-related bronchial asthma, allergic It can also be applied to allergic diseases such as rhinitis and hay fever.
このような薬剤は、石榴の一種であるグアバの葉を有効成分の原料とするものであって、熱帯地方で栽培されている植物を利用している。従ってグアバは比較的入手が困難で、高価である。これに対して本願発明は、極めて簡単に入手することができる各種の感温物質、例えばとうがらし、ゆず、しょうが等の身近な天然成分を用いるようにしている。 Such a drug uses guava leaf, which is a kind of sarcophagus, as a raw material for active ingredients, and uses plants cultivated in the tropics. Therefore, guava is relatively difficult to obtain and expensive. On the other hand, the present invention uses various temperature sensitive substances that can be obtained very easily, for example, familiar natural ingredients such as pepper, yuzu, ginger and the like.
本願発明の課題は、身近に存在する感温物質を有効成分として利用し、アレルギー性鼻炎を抑えるようにしたアレルギー性鼻炎用塗付剤を提供することである。 The subject of this invention is providing the coating agent for allergic rhinitis which utilized the temperature sensitive substance which exists near as an active ingredient, and suppressed allergic rhinitis.
本願発明の別の課題は、アレルギー性鼻炎を対症療法的に抑制するようにしたアレルギー性鼻炎用塗付剤を提供することである。 Another object of the present invention is to provide a coating agent for allergic rhinitis that suppresses allergic rhinitis in a symptomatic manner.
本願発明のさらに別の課題は、鼻孔の内腔表面の粘膜の部分が炎症を起している鼻の外表面あるいは頬骨の外表面に単に塗付するだけでアレルギー性鼻炎を抑えることができるようにしたアレルギー性鼻炎用塗付剤を提供することである。 Yet another object of the present invention is to suppress allergic rhinitis by simply applying the mucosal portion of the luminal surface of the nostril to the outer surface of the inflamed nose or the outer surface of the cheekbone. An allergic rhinitis coating agent is provided.
本願発明の上記の課題および別の課題は、以下に述べる本願発明の技術的思想、およびその実施の形態によって明らかにされる。 The above-described problems and other problems of the present invention will be made clear by the technical idea of the present invention described below and the embodiments thereof.
本願の主要な発明は、天然の感温物質であるとうがらし、ゆず、しょうがの内の１種または２種以上から成る有効成分を基剤中に５〜３５重量％含有し、鼻孔の粘膜の部分が炎症を起している鼻の外表面あるいは頬骨の外側に塗付して皮膚に浸透させて炎症を抑えるアレルギー性鼻炎用塗付剤に関するものである。 The main invention of the present application contains 5 to 35% by weight of an active ingredient consisting of one or more of pepper, citron and ginger, which is a natural temperature-sensitive substance , in the base of the mucous membrane of the nostril There relates allergic rhinitis coating with agents given coating and to penetrate the skin REDUCE inflammation on the outside of the outer surface or cheekbone nose are inflamed.
ここで、前記感温物質から成る有効成分を分散させる乳化剤を含有してよい。また微生物による腐敗、発酵を防止する防腐剤を含有してよい。また保湿剤を含有してよい。また香料を含有してよい。また有効成分を構成する感温物質が香料を兼用してよい。 Here, you may contain the emulsifier which disperse | distributes the active ingredient which consists of the said thermosensitive substance. Moreover, you may contain antiseptic | preservative which prevents the decay and fermentation by microorganisms. Moreover, you may contain a humectant. Moreover, you may contain a fragrance | flavor. Moreover, the temperature sensitive substance which comprises an active ingredient may serve as a fragrance | flavor.
本願の主要な発明は、天然の感温物質から成る有効成分を基剤中に５〜３５重量％含有するアレルギー性鼻炎用塗付剤に関するものである。 The main invention of the present application relates to a coating agent for allergic rhinitis containing an active ingredient comprising a natural temperature-sensitive substance in an amount of 5 to 35% by weight.
従ってこのようなアレルギー性鼻炎用塗付剤によると、鼻孔の粘膜の部分が炎症を起している鼻の外表面や頬骨の外表面に単に塗付するだけで、このアレルギー性鼻炎用塗付剤の有効成分が皮膚に浸透して粘膜に作用し、これによって鼻孔の粘膜の炎症を抑えることが可能になる。そしてここで、有効成分が天然の感温物質、例えばとうがらし、ゆず、しょうが等から構成されるために、人体に対して悪影響を及ぼすことがない。またその療法も、単に鼻の外表面あるいは頬の部位に塗付するだけでよいために、使用が極めて容易になる。 Therefore, according to such an allergic rhinitis coating agent, the mucous membrane portion of the nostril is simply applied to the outer surface of the inflamed nose or the outer surface of the cheekbone, and this allergic rhinitis coating is applied. The active ingredient of the agent penetrates the skin and acts on the mucous membrane, thereby suppressing inflammation of the mucous membrane of the nostril. Here, the active ingredient is composed of natural temperature-sensitive substances such as pepper, citron, ginger, etc., so that it does not adversely affect the human body. The therapy is also very easy to use because it only needs to be applied to the outer surface of the nose or the cheek area.
以下本願発明を実施の形態によって説明する。本実施の形態に係るアレルギー性鼻炎用塗付剤は、基剤、感温物質（有効成分）、乳化剤、防腐剤、保湿剤、さらに必要であれば香料等を添加して調製される。 The present invention will be described below with reference to embodiments. The allergic rhinitis coating agent according to the present embodiment is prepared by adding a base, a temperature-sensitive substance (active ingredient), an emulsifier, an antiseptic, a moisturizing agent, and if necessary a fragrance.
ここで基剤とは、主として有効成分である感温物質を担持するマトリックス剤であって、一般にはワセリンが好適に用いられる。なおワセリンの他に、鉱物油、オリーブ油等の他の基剤を用いることもできる。基剤の含有量は、重量比で５０％以上であって、通常は６０〜８０重量％の範囲内である。 Here, the base is a matrix agent mainly supporting a temperature-sensitive substance as an active ingredient, and generally petrolatum is preferably used. In addition to petrolatum, other bases such as mineral oil and olive oil can be used. The content of the base is 50% or more by weight, and is usually in the range of 60 to 80% by weight.
次に有効成分を成す感温物質については、とうがらし、ゆず、しょうが等の天然物質が用いられる。とくにこの中で、とうがらしが有用である。とうがらしは、カプサイシンを含有している。カプサイシンは人体に対して発汗作用を生じさせるとともに、感温物質として知られている。この他に、ゆずやしょうがも感温物質である。これらの天然の感温物質が効果的な有効成分として利用される。 Next, natural substances such as red pepper, yuzu, ginger, etc. are used for the temperature-sensitive substance that constitutes the active ingredient. Of these, red pepper is particularly useful. Red pepper contains capsaicin. Capsaicin causes sweating action on the human body and is known as a temperature sensitive substance. In addition, yuzu and ginger are temperature sensitive substances. These natural temperature sensitive substances are used as effective active ingredients.
次に乳化剤は、有効成分の感温物質をマトリックス剤である基剤中に分散させるために用いられる。このような乳化剤の例としては、グリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ショ糖脂肪酸エステル等が知られており、これらの乳化剤が好んで用いられる。またそれ以外の乳化剤としては、大豆や卵黄から採られるレシチン、キラヤから採られるサポニン、牛乳を原料とするカゼインナトリウム等が利用される。なお乳化剤の量は、少量であってよく、通常は５％以下であってよい。 Next, the emulsifier is used to disperse the thermosensitive substance as an active ingredient in a base material which is a matrix agent. Examples of such emulsifiers are glycerin fatty acid esters, sorbitan fatty acid esters, propylene glycol fatty acid esters, sucrose fatty acid esters and the like, and these emulsifiers are preferably used. As other emulsifiers, lecithin taken from soybeans and egg yolk, saponin taken from Kiraya, sodium caseinate made from milk and the like are used. The amount of the emulsifier may be a small amount, and usually 5% or less.
次に防腐剤について説明する。防腐剤は、この薬剤中に微生物が侵入し、発育し、増殖をするのを抑制するためのものであって、腐敗や発酵を阻止する。このような防腐剤としては、パラヒドロキシ安息香酸エステルが好適に用いられる。なお防腐剤の量は、少量であってよく、通常３重量％以下の含有量である。 Next, the preservative will be described. The preservative is for suppressing the invasion, growth, and proliferation of microorganisms into the drug, and prevents rot and fermentation. As such a preservative, a parahydroxybenzoic acid ester is preferably used. The amount of the preservative may be a small amount, and is usually 3% by weight or less.
次に必要であれば、保湿剤が添加される。保湿剤としては、ヒアルロン酸等が用いられる。なおヒアルロン酸から成る保湿剤は、２重量％以下の含有量である。また必要に応じて、香料が添加される。香料としては、天然香料、合成香料、調合香料等が用いられる。とくに感温物質が発する臭気を抑制するために、香料を調合することができる。なおゆずを有効成分とする場合には、ゆずそれ自体が香料と兼用される。なお香料の使用量は、３重量％以下であって、通常１．５重量％以下に抑えられる。 Next, if necessary, a humectant is added. As the humectant, hyaluronic acid or the like is used. The humectant composed of hyaluronic acid has a content of 2% by weight or less. Moreover, a fragrance | flavor is added as needed. As the fragrance, a natural fragrance, a synthetic fragrance, a blended fragrance or the like is used. In particular, in order to suppress the odor emitted by the temperature sensitive substance, a fragrance can be prepared. When citron is used as an active ingredient, citron itself is also used as a fragrance. In addition, the usage-amount of a fragrance | flavor is 3 weight% or less, Comprising: Usually, 1.5 weight% or less is suppressed.
上記のような各種の薬剤あるいは添加剤が混合攪拌される。なお混合攪拌時に、必要に応じて加熱することも可能である。そして基剤中に感温物質から成る有効成分や、他の添加剤が均一に混合されたならば、チューブやプラスチック製の容器に充填し、これによって流通に供する。 Various chemicals or additives as described above are mixed and stirred. In addition, it is also possible to heat as needed at the time of mixing and stirring. When an active ingredient composed of a temperature-sensitive substance and other additives are uniformly mixed in the base, it is filled into a tube or a plastic container and is then distributed.
このようなアレルギー性鼻炎用塗付剤は、患者の鼻の外側あるいは頬骨の外側の皮膚に直接塗付される。すなわち、入浴あるいは洗顔を行なった後に、このアレルギー性鼻炎用塗付剤を炎症が内部の粘膜に発生していると思われる鼻孔の外側の鼻あるいは頬骨の表面に塗付する。するとこの塗付剤中に含まれるとくに有効成分が、鼻や頬の皮膚から内部に浸透し、これによって鼻孔の粘膜の部分に上記感温物質によって温度を局部的に高めるようにし、鼻孔の粘膜の部分の炎症を抑制する。この抑制の効果は、かなり即効性があり、塗付した直後から極めて短時間で粘膜の炎症を抑制する効果を発生する。従って、とくにアレルギー性鼻炎の対症療法剤として有効である。また本発明の塗付剤は、冷気アレルギー（冷感アレルギー）にも効果がある。さらに本発明の塗付剤は、睡眠中の鼻づまりに対しても効果がある。 Such an allergic rhinitis coating is applied directly to the skin outside the patient's nose or cheekbone. That is, after bathing or washing the face, this allergic rhinitis coating agent is applied to the surface of the nose or cheekbone outside the nostrils where inflammation is thought to have occurred in the internal mucosa. Then, the particularly active ingredient contained in this coating penetrates into the inside of the skin of the nose and cheeks, thereby increasing the temperature locally in the mucosa of the nostril by the above-mentioned temperature-sensitive substance, and the mucous membrane of the nostril Inhibits inflammation of the part. This inhibitory effect is quite immediate and produces an effect of suppressing mucosal inflammation in a very short time immediately after application. Therefore, it is particularly effective as a symptomatic treatment for allergic rhinitis. The coating agent of the present invention is also effective for cold air allergy (cool feeling allergy). Furthermore, the coating agent of the present invention is also effective for nasal congestion during sleep.
実施例１
ワセリン６５重量％中に、とうがらし２０重量％、乳化剤（ソルビタン脂肪酸エステル）１０％を添加した。さらにパラオキシ安息香酸エステルから成る防腐剤３重量％と、ヒアルロン酸から成る保湿剤１重量％と、合成香料１重量％とを加え、５０℃の温度で混合攪拌することによって、軟膏剤を得た。
Example 1
In 65% by weight of petroleum jelly, 20% by weight of pepper and 10% of an emulsifier (sorbitan fatty acid ester) were added. Further, 3% by weight of a preservative composed of paraoxybenzoic acid ester, 1% by weight of a moisturizing agent composed of hyaluronic acid, and 1% by weight of a synthetic fragrance were added and mixed and stirred at a temperature of 50 ° C. to obtain an ointment. .
実施例２
ワセリン６０重量％、ゆず２５重量％、プロピレングリコール脂肪酸エステルから成る乳化剤１０％に、さらにパラヒドロキシ安息香酸エステルから成る防腐剤２重量％と、ヒアルロン酸から成る保湿剤３重量％とを添加し、常温で攪拌混合してクリーム状の薬剤を得た。
Example 2
To an emulsifier consisting of 60% by weight of petroleum jelly, 25% by weight of yuzu, 10% of propylene glycol fatty acid ester, 2% by weight of a preservative made of parahydroxybenzoic acid ester and 3% by weight of a moisturizing agent made of hyaluronic acid, A creamy drug was obtained by stirring and mixing at room temperature.
実施例３
ワセリン６０重量％、しょうが２５重量％、グリセリン脂肪酸エステル１０重量％に、さらにパラオキシ安息香酸エステル２重量％、ヒアルロン酸から成る保湿剤２重量％および調合香料１重量％を併せて添加し、６５℃の温度で加熱混合してほぼ均一な軟膏剤を得た。
Example 3
60% by weight petrolatum, 25% by weight ginger, 10% by weight glycerin fatty acid ester, 2% by weight of paraoxybenzoic acid ester, 2% by weight of a moisturizer composed of hyaluronic acid and 1% by weight of a blended fragrance were added at 65 ° C. A substantially uniform ointment was obtained by heating and mixing.
上記の３つの実施例で得たアレルギー性鼻炎用塗付剤について、２６人の試験者に対して実際にアレルギー性鼻炎の対症療法の効果を確認した。用法は、原則として１日２回鼻の外表面に直接塗布し、これを毎日続ける方法により実施した。その結果を表１に示す。 With regard to the allergic rhinitis coating agent obtained in the above three examples, the effect of symptomatic treatment of allergic rhinitis was actually confirmed for 26 testers. In principle, the method was applied by applying directly to the outer surface of the nose twice a day and continuing this daily. The results are shown in Table 1.
これらの結果において、「良く効く」とは、鼻づまりや鼻の粘膜内の炎症が軽減したと自覚される状態を言う。また「少し効く」とは、アレルギー性鼻炎に伴う症状の内の一部の症状、例えば鼻水、くしゃみ、涙、発声等において何らかの症状の改善が見られた状態を言う。「分からない」とは、このアレルギー性鼻炎用塗付剤を塗付したことによって何らかの症状が自覚できたかどうか分からないことを言う。また「不明」とは、使用した結果についての回答が無かったものを言う。 In these results, “effectively” means a state in which it is perceived that nasal congestion and inflammation in the mucous membrane of the nose are reduced. “Slightly effective” refers to a state in which some symptoms are improved in some of the symptoms associated with allergic rhinitis, such as runny nose, sneezing, tears, and vocalization. “I do not know” means that it is not known whether or not any symptoms can be realized by applying the allergic rhinitis coating agent. “Unknown” means that there was no answer about the result of use.
表１の結果から明らかなように、感温物質としては、とうがらしが最も効果的であることが判明している。なおその他に、ゆずおよびしょうがにおいても、かなりの症状の改善が見られることが確認された。 As is apparent from the results in Table 1, pepper has been found to be the most effective temperature sensitive substance. In addition to this, it was confirmed that there was a considerable improvement in symptoms in citron and ginger.
以上本願発明を図示の実施の形態によって説明したが、本願発明は上記実施の形態によって限定されることなく、本願発明の技術的思想の範囲内において各種の変更が可能である。例えば上記実施の形態における基剤、感温物質（有効成分）、乳化剤、防腐剤、保湿剤等の成分の割合や、その種類、また各薬剤の組合わせについては、各種の選択が可能であって、上記実施の形態あるいは実施例によって限定されるものではない。 Although the present invention has been described above with reference to the illustrated embodiments, the present invention is not limited to the above-described embodiments, and various modifications can be made within the scope of the technical idea of the present invention. For example, various ratios can be selected for the ratio of the components such as the base, temperature-sensitive substance (active ingredient), emulsifier, preservative, moisturizer and the like, and the combination of each agent in the above embodiment. The present invention is not limited to the above embodiment or examples.
本願発明は、アレルギー性鼻炎用塗付剤として利用することが可能である。 The present invention can be used as a coating agent for allergic rhinitis.
Claims (6)
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| JP2012053116A JP5153948B1 (en) | 2012-03-09 | 2012-03-09 | Allergic rhinitis coating agent |
| PCT/JP2013/054689 WO2013133062A1 (en) | 2012-03-09 | 2013-02-25 | Coating agent for allergic rhinitis |
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| WO2013133062A1 (en) * | 2012-03-09 | 2013-09-12 | 株式会社オーエーハウジング設計 | Coating agent for allergic rhinitis |
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| CN104645135A (en) * | 2015-01-19 | 2015-05-27 | 杜强 | Traditional Chinese medicine composition for treating allergic rhinitis and preparation method thereof |
| CN104547597A (en) * | 2015-02-05 | 2015-04-29 | 刘洪军 | Traditional Chinese medicine for treating lung meridian accumulated heat type allergic rhinitis |
| JP6608620B2 (en) * | 2015-05-26 | 2019-11-20 | ロート製薬株式会社 | Topical skin preparation |
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| JP2003169631A (en) * | 2001-12-07 | 2003-06-17 | Snow Brand Milk Prod Co Ltd | Anti-allergic drink or food |
| JP2010106001A (en) * | 2008-10-31 | 2010-05-13 | Theravalues Corp | Ppar activator |
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| JP5153948B1 (en) * | 2012-03-09 | 2013-02-27 | 株式会社オーエーハウジング設計 | Allergic rhinitis coating agent |
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| JP2003169631A (en) * | 2001-12-07 | 2003-06-17 | Snow Brand Milk Prod Co Ltd | Anti-allergic drink or food |
| JP2010106001A (en) * | 2008-10-31 | 2010-05-13 | Theravalues Corp | Ppar activator |
Non-Patent Citations (3)
| Title |
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| JPN6012049905; 久保伸夫: 'アレルギ-性鼻炎：現状の治療と問題点 ５）アレルギ-性鼻炎の手術治療' アレルギーの臨床 Ｎｏ．３８２, 2008, Ｐａｇｅ．１２２４-１２３０ * |
| JPN6012049906; 久保伸夫: '鼻過敏症に対する化学的神経変性療法' 日本鼻科学会会誌 Ｖｏｌ．３４，Ｎｏ．２, 1996, Ｐａｇｅ．３８５-３８８ * |
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|---|---|---|---|---|
| WO2013133062A1 (en) * | 2012-03-09 | 2013-09-12 | 株式会社オーエーハウジング設計 | Coating agent for allergic rhinitis |
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