JP5152600B2 - 高い有機物含有量および向上性細孔形状を有するクロマトグラフィー分離用の多孔質無機/有機ハイブリッド粒子 - Google Patents

高い有機物含有量および向上性細孔形状を有するクロマトグラフィー分離用の多孔質無機/有機ハイブリッド粒子 Download PDF

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JP5152600B2
JP5152600B2 JP2009550915A JP2009550915A JP5152600B2 JP 5152600 B2 JP5152600 B2 JP 5152600B2 JP 2009550915 A JP2009550915 A JP 2009550915A JP 2009550915 A JP2009550915 A JP 2009550915A JP 5152600 B2 JP5152600 B2 JP 5152600B2
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particles
organic
porous inorganic
organic hybrid
inorganic
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JP2010519542A (ja
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ウインダム,ケビン・デイー
オガラ,ジヨン・イー
ローレンス,ニコル・エル
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ウオーターズ・テクノロジーズ・コーポレイシヨン
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    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282Porous sorbents
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    • B01J20/32Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
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    • B01J20/3246Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3257Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
    • B01J20/3259Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical Kinetics & Catalysis (AREA)
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  • Inorganic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Silicon Polymers (AREA)
JP2009550915A 2007-02-21 2008-02-21 高い有機物含有量および向上性細孔形状を有するクロマトグラフィー分離用の多孔質無機/有機ハイブリッド粒子 Expired - Fee Related JP5152600B2 (ja)

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US90265507P 2007-02-21 2007-02-21
US60/902,655 2007-02-21
PCT/US2008/002312 WO2008103423A1 (en) 2007-02-21 2008-02-21 Porous inorganic/organic hybrid particles having high organic content and enhanced pore geometry for chromatographic separations

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JP2010519542A JP2010519542A (ja) 2010-06-03
JP2010519542A5 JP2010519542A5 (https=) 2011-01-13
JP5152600B2 true JP5152600B2 (ja) 2013-02-27

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US (1) US9120083B2 (https=)
EP (1) EP2150402A4 (https=)
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CN (2) CN101657325B (https=)
WO (1) WO2008103423A1 (https=)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6686035B2 (en) 1999-02-05 2004-02-03 Waters Investments Limited Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation
US7250214B2 (en) 2001-08-09 2007-07-31 Waters Investments Limited Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation
WO2004041398A2 (en) 2002-10-30 2004-05-21 Waters Investments Limited Porous inorganic/organic hybrid materials and preparation thereof
US10773186B2 (en) 2004-07-30 2020-09-15 Waters Technologies Corporation Porous inorganic/organic hybrid materials with ordered domains for chromatographic separations and processes for their preparation
DE112005001838B4 (de) 2004-07-30 2018-11-29 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Poröse anorganische/organische Hybridmaterialien mit geordneten Domänen für chromatographische Auftrennungen, Verfahren für deren Herstellung sowie Auftrennvorrichtung und chromatographische Säule
US9440869B2 (en) 2005-09-30 2016-09-13 Abs Materials, Inc. Sol-gel derived compositions
JP2010515804A (ja) 2007-01-12 2010-05-13 ウオーターズ・テクノロジーズ・コーポレイシヨン クロマトグラフ分離用多孔質炭素−ヘテロ原子−ケイ素ハイブリッド無機/有機材料およびその調製のための方法
US20090208542A1 (en) * 2008-02-18 2009-08-20 Conopco, Inc., D/B/A Unilever Product and method for transferring heated flowable cosmetic onto skin
US11439977B2 (en) 2009-06-01 2022-09-13 Waters Technologies Corporation Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material
WO2010141426A1 (en) 2009-06-01 2010-12-09 Waters Technologies Corporation Hybrid material for chromatographic separations
JP6125230B2 (ja) 2009-08-04 2017-05-10 ウオーターズ・テクノロジーズ・コーポレイシヨン イオン性修飾剤を含有する高純度クロマトグラフィー材料
US10159911B2 (en) 2009-08-04 2018-12-25 Waters Technologies Corporation High purity chromatographic materials comprising an ionizable modifier
WO2012012311A2 (en) * 2010-07-23 2012-01-26 The Regents Of The University Of California Compositions and methods for synthesis of organic-silica hybrid materials
US20130112605A1 (en) 2010-07-26 2013-05-09 Waters Technologies Corporation Superficially porous materials comprising a substantially nonporous core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
AU2012290005A1 (en) * 2011-08-02 2014-02-20 Abs Materials, Inc. Sol-gel derived compositions
CN102503518B (zh) * 2011-11-16 2013-02-13 黑龙江大学 一种多孔晶态TiO2泡沫陶瓷的制备方法
CN111644164B (zh) * 2012-05-15 2024-03-08 沃特世科技公司 用于分离不饱和分子的色谱材料
WO2013173501A2 (en) 2012-05-15 2013-11-21 Waters Technologies Corporation Chromatographic materials
WO2014201033A1 (en) 2013-06-11 2014-12-18 Waters Technologies Corporation Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography
JP6393964B2 (ja) * 2013-07-22 2018-09-26 東ソー株式会社 時間制御による試料注入装置及びそれを備えた液体クロマトグラフィ
JP6800875B2 (ja) 2015-03-06 2020-12-16 マイクロマス ユーケー リミテッド 急速蒸発イオン化質量分析(「reims」)装置に連結されたイオンアナライザのための流入器具
US11139156B2 (en) 2015-03-06 2021-10-05 Micromass Uk Limited In vivo endoscopic tissue identification tool
CN107533032A (zh) 2015-03-06 2018-01-02 英国质谱公司 用于从块状组织直接映射的原位电离质谱测定成像平台
US11031222B2 (en) 2015-03-06 2021-06-08 Micromass Uk Limited Chemically guided ambient ionisation mass spectrometry
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
EP3265822B1 (en) 2015-03-06 2021-04-28 Micromass UK Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
US11037774B2 (en) 2015-03-06 2021-06-15 Micromass Uk Limited Physically guided rapid evaporative ionisation mass spectrometry (“REIMS”)
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
EP3264989B1 (en) 2015-03-06 2023-12-20 Micromass UK Limited Spectrometric analysis
GB2551294B (en) 2015-03-06 2021-03-17 Micromass Ltd Liquid trap or separator for electrosurgical applications
US10978284B2 (en) 2015-03-06 2021-04-13 Micromass Uk Limited Imaging guided ambient ionisation mass spectrometry
WO2016142691A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of swabs and biopsy samples
CA2978165A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Improved ionisation of gaseous samples
CA2977900A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Collision surface for improved ionisation
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
CN106892937A (zh) * 2015-12-18 2017-06-27 长春工业大学 一种基于苄基的有机钛杂化材料及其制备方法
US20190015815A1 (en) 2016-03-06 2019-01-17 Waters Technologies Corporation Superficially porous materials comprising a coated core having narrow particle size distribution; process for the preparation thereof; and use thereof for chromatographic separations
WO2017178833A1 (en) 2016-04-14 2017-10-19 Micromass Uk Limited Spectrometric analysis of plants
US10618920B2 (en) * 2016-06-03 2020-04-14 Agilent Technologies, Inc. Functionalized particles having modified phases
US11280766B2 (en) 2016-07-28 2022-03-22 Waters Technologies Corporation Encapsulated pre-analytic workflows for flow-through devices, liquid chromatography and mass spectrometric analysis
CN107163170A (zh) * 2017-05-31 2017-09-15 宁夏大学 单分散表面多孔的核壳型聚合物色谱介质及其制备方法
WO2019183334A1 (en) 2018-03-21 2019-09-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
US11376561B2 (en) 2018-10-02 2022-07-05 Waters Technologies Corporation Sorbent particles for sample treatment
CN111426762B (zh) * 2020-03-31 2022-04-12 湖北航天化学技术研究所 一氨基胍硝酸盐和二氨基胍硝酸盐含量的测定方法
US11964874B2 (en) 2020-06-09 2024-04-23 Agilent Technologies, Inc. Etched non-porous particles and method of producing thereof
CN112240917B (zh) * 2020-09-03 2024-09-17 四川科正检测技术有限公司 一种离子色谱仪
WO2022061035A1 (en) 2020-09-16 2022-03-24 Waters Technologies Corporation Improved size exclusion chromatography utilizing low concentration amino acids in size exclusion chromatography mobile phase
CN116209517A (zh) 2020-09-16 2023-06-02 沃特世科技公司 具有羟基封端的peg键合和甲氧基封端的peg表面改性的基于二氧化硅的颗粒
JP7666599B2 (ja) * 2021-06-29 2025-04-22 株式会社レゾナック 充填剤およびその製造方法、並びにサイズ排除クロマトグラフィー用カラム
US12551864B2 (en) 2021-11-19 2026-02-17 Waters Technologies Corporation Double surface modified porous material with minimized nonspecific interaction
CN121127312A (zh) 2023-05-05 2025-12-12 沃特世科技公司 用于亲和色谱的蛋白a/g颗粒及其使用方法
EP4613371A1 (en) 2024-03-04 2025-09-10 Dionex Softron GmbH Mixed mode chromatographic packing material
EP4613370A1 (en) 2024-03-04 2025-09-10 Dionex Softron GmbH Mixed mode chromatographic packing material

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403908A (en) * 1989-10-06 1995-04-04 Idemitsu Kosan Company, Limited Aryl styrene-based copolymer
DE19751857A1 (de) * 1997-11-22 1999-05-27 Kronos Titan Gmbh Phosphonatosiloxanbehandelte anorganische Partikel
US6686035B2 (en) * 1999-02-05 2004-02-03 Waters Investments Limited Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation
EP1733786B1 (en) * 1999-02-05 2010-04-14 Waters Technologies Corporation Porous hybrid particles for chromatographic separations
US20060194919A1 (en) 1999-08-04 2006-08-31 Lichtenhan Joseph D Porosity control with polyhedral oligomeric silsesquioxanes
US6528167B2 (en) * 2001-01-31 2003-03-04 Waters Investments Limited Porous hybrid particles with organic groups removed from the surface
US7250214B2 (en) * 2001-08-09 2007-07-31 Waters Investments Limited Porous inorganic/organic hybrid monolith materials for chromatographic separations and process for their preparation
WO2004041398A2 (en) * 2002-10-30 2004-05-21 Waters Investments Limited Porous inorganic/organic hybrid materials and preparation thereof
DE112005000269T5 (de) * 2004-02-17 2007-01-25 Waters Investments Ltd., New Castle Poröse Hybridmonolithmaterialien mit von der Oberfläche entfernten organischen Gruppen

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