JP5142621B2 - Topical skin preparation - Google Patents
Topical skin preparation Download PDFInfo
- Publication number
- JP5142621B2 JP5142621B2 JP2007206026A JP2007206026A JP5142621B2 JP 5142621 B2 JP5142621 B2 JP 5142621B2 JP 2007206026 A JP2007206026 A JP 2007206026A JP 2007206026 A JP2007206026 A JP 2007206026A JP 5142621 B2 JP5142621 B2 JP 5142621B2
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- Prior art keywords
- mass
- skin
- external preparation
- components
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、潤いを与え、のびの良さやべたつきのなさといった使用性、使用感を持ちながら、高い保湿効果を付与することができる皮膚外用剤に関するものである。 The present invention relates to an external preparation for skin that can be moisturized and can provide a high moisturizing effect while having a usability and a feeling of use such as good spread and non-stickiness.
皮膚に潤いを付与し、のびをよくする等の保湿効果を持つ皮膚外用剤として、一般に乳液、美容液、クリーム等が挙げられる。これらの皮膚外用剤には、主に多価アルコールが配合されており、さらに保湿効果を高めるため高級アルコール、流動パラフィン、エステル油等が配合されている。これらの成分が、皮膚に付着することにより、前記記載の保湿効果が得られることが知られている。 Examples of external skin preparations that have a moisturizing effect such as moisturizing the skin and improving spreading generally include emulsions, cosmetics, creams and the like. These external preparations for skin mainly contain polyhydric alcohols, and further contain higher alcohols, liquid paraffins, ester oils and the like to enhance the moisturizing effect. It is known that the moisturizing effect described above can be obtained when these components adhere to the skin.
例えば、多価アルコール，高級アルコール等を含有した皮膚外用剤（特許文献１参照）が開示されており、それらは保湿成分の効果を与えることが示されている。
また、固形油分及び半固形油分を特定の質量比にて含む皮膚外用剤（特許文献２参照）が開示されており、それらが使用性、保湿効果を付与することが示されている。
また、半固形油脂分と、低分子環状シリコーンとゲル化剤とを特定の質量比にて含有してなるゲル状組成物（特許文献３参照）が開示されており、なめらかでのびがよくサラッとしたさわやかな使用感を付与することが提示されている。
Moreover, the skin external preparation (refer patent document 2) which contains solid oil and a semi-solid oil by specific mass ratio is indicated, and it is shown that they provide usability and a moisturizing effect.
Also disclosed is a gel-like composition (see Patent Document 3) comprising a semi-solid oil and fat, a low molecular weight cyclic silicone and a gelling agent at a specific mass ratio, which is smooth and smooth and has a smooth and smooth surface. It is proposed to give a refreshing feeling of use.
上記従来技術は、いずれも皮膚外用剤として一定の改善がなされているが、のびの良さやべとつき、保湿の効果において、満足できる特性を十分に得られない。
そこで、本発明の目的は、従来の組成物が有する利点を低下させることなく、潤いを与え、のびの良さ、高い保湿効果を与え、使用性、使用感に優れた皮膚外用剤を提供することにある。
Although all of the above conventional techniques have been improved as a skin external preparation, satisfactory properties cannot be sufficiently obtained in terms of good spreading, stickiness, and moisturizing effect.
Accordingly, an object of the present invention is to provide an external preparation for skin that is moisturized, has good spreading properties, has a high moisturizing effect, and has excellent usability and usability without reducing the advantages of conventional compositions. It is in.
上記目的を達成するため鋭意研究を行った結果、多価アルコール、半固形油、固形油だけでは成しえなかった上記課題に対して、水溶性高分子、液状油、室温でペースト状の油剤、さらにトリポリヒドロキシ脂肪酸ジペンタエリスリチルを含有することで、のびの良さやべたつきのなさといった使用性、使用感を持ちながら、高い保湿効果を付与することができることを見出した。 As a result of diligent research to achieve the above object, water-soluble polymers, liquid oils, and oils in paste form at room temperature were not able to be achieved with only polyhydric alcohols, semi-solid oils and solid oils. Furthermore, it has been found that by containing the tripolyhydroxy fatty acid dipentaerythrityl, a high moisturizing effect can be imparted while having usability and usability such as good spread and non-stickiness.
即ち、本発明の請求項１は、（Ａ）水溶性高分子、（Ｂ）液状油、（Ｃ）室温でペースト状の油剤、及び（Ｄ）トリポリヒドロキシ脂肪酸ジペンタエリスリチルを含有することを特徴とする皮膚外用剤である。 That is, claim 1 of the present invention is characterized by containing (A) a water-soluble polymer, (B) a liquid oil, (C) a paste-like oil agent at room temperature, and (D) a tripolyhydroxy fatty acid dipentaerythrityl. It is a skin external preparation.
また、本発明の請求項２は、さらに（Ｅ）多価アルコールを含有することを特徴とする請求項１記載の皮膚外用剤、本発明の請求項３は、（Ｂ）液状油と（Ｃ）室温でペースト状の油剤と（Ｄ）トリポリヒドロキシ脂肪酸ジペンタエリスリチルとの総含有量が、皮膚外用剤の総量を基準として５〜３０質量％である請求項１又は２に記載の皮膚外用剤、本発明の請求項４は、成分（Ｂ）と（Ｄ）の質量比が１０：１〜５：５で、さらに成分（Ｃ）と（Ｄ）の質量比が（Ｃ）：（Ｄ）＝６：１〜１：９である請求項１〜３のいずれか１
項に記載の皮膚外用剤、並びに本発明の請求項５は、加温溶解させた（Ｃ）及び（Ｄ）が予め（Ｂ）に分散して配合されることを特徴とする請求項１〜４のいずれか１項に記載の皮膚外用剤である。
Further, claim 2 of the present invention further comprises (E) a polyhydric alcohol, and claim 3 of the present invention is characterized in that (B) liquid oil and (C The skin external preparation according to claim 1 or 2, wherein the total content of the oily agent in the form of paste at room temperature and (D) tripolyhydroxy fatty acid dipentaerythrityl is 5 to 30% by mass based on the total amount of the external preparation for skin. According to a fourth aspect of the present invention, the mass ratio of the components (B) and (D) is 10: 1 to 5: 5, and the mass ratio of the components (C) and (D) is (C) :( D) = 6. The ratio is from 1: 1 to 1: 9.
The external preparation for skin according to claim 5 and claim 5 of the present invention are characterized in that (C) and (D) dissolved by heating are previously dispersed and blended in (B). 5. The external preparation for skin according to any one of 4 above.
本発明の皮膚外用剤は、潤いを与え、のびの良さ、高い保湿効果を与え、使用性、使用感に優れたものである。 The external preparation for skin according to the present invention provides moisture, good spreading, high moisturizing effect, and excellent usability and usability.
以下、本発明の構成について詳述する。
本発明で使用する成分（Ａ）水溶性高分子は、アラビヤガム、トラガカントガム、カラヤガム、キサンタンガム、タマリンドガム、グアーガム、ヒドロキシプロピルグアーガム、ローカストビーンガム、クインスシード、ジェランガム、ネイティブジェランガム、ポリアクリル酸、ポリメタアクリル酸、ポリビニルアルコール、ポリエチレングリコール、ポリビニルピロリドン、ポリアクリルアミド、ポリメタアクリルアミドや、メタクリロイルオキシエチルトリメチルアンモニウムクロライド、メタクリルアミドプロピルトリメチルアンモニウムクロライド、Ｎ−ｎ−ブトキシメチルアクリルアミド、Ｎ−ｉｓｏ−ブトキシアクリルアミド、ｔｅｒｔ−ブチルアクリルアミドスルホン酸、ジメチルアミノプロピルメタアクリルアミド、またはこれら重合性モノマー原料と他の重合性モノマーとの共重合体、あるいは、メチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロース、アルギン酸、カラギーナン、ヒアルロン酸、コンドロイチン硫酸、デルマタン硫酸、コラーゲン、キチン誘導体、ペクチン、ゼラチン、カルボキシビニルポリマー、アクリル酸・メタクリル酸アルキル共重合体およびこれらの塩等が挙げられる。これらは１種又は２種以上を組み合わせて使用される。
中でも特に好ましいものは、キサンタンガム、カルボキシビニルポリマー、アクリル酸・メタクリル酸アルキル共重合体、ポリアクリルアミドである。
Hereinafter, the configuration of the present invention will be described in detail.
Component (A) water-soluble polymer used in the present invention is arabic gum, tragacanth gum, karaya gum, xanthan gum, tamarind gum, guar gum, hydroxypropyl guar gum, locust bean gum, quince seed, gellan gum, native gellan gum, polyacrylic acid, polymeta Acrylic acid, polyvinyl alcohol, polyethylene glycol, polyvinyl pyrrolidone, polyacrylamide, polymethacrylamide, methacryloyloxyethyltrimethylammonium chloride, methacrylamidepropyltrimethylammonium chloride, Nn-butoxymethylacrylamide, N-iso-butoxyacrylamide, tert -Butylacrylamide sulfonic acid, dimethylaminopropyl methacrylamide, or Copolymers of these polymerizable monomer raw materials with other polymerizable monomers, or methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, alginic acid, carrageenan, hyaluronic acid, chondroitin sulfate, dermatan sulfate, collagen, chitin derivatives, pectin , Gelatin, carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, and salts thereof. These are used alone or in combination of two or more.
Of these, xanthan gum, carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, and polyacrylamide are particularly preferable.
成分（Ａ）の含有量は、全組成中０．００１〜１０質量％であり、適度な粘性を付与するには、０．０１〜５質量％が好ましい。
０．００１質量％未満では、十分な粘性付与効果が得られない場合があり、１０質量％を超えると、粘性が高くなりすぎて使用性を損ない、べたつきを感じて使用感を損なう場合がある。
Content of a component (A) is 0.001-10 mass% in the whole composition, and 0.01-5 mass% is preferable in order to provide moderate viscosity.
If it is less than 0.001% by mass, a sufficient viscosity-imparting effect may not be obtained. If it exceeds 10% by mass, the viscosity becomes too high and the usability may be impaired, and stickiness may be felt and the feeling of use may be impaired. .
本発明で使用する成分（Ｂ）液状油は、流動パラフィン、スクワランなどの炭化水素油、２−エチルヘキサン酸セチル、トリ（２−エチルヘキサン酸）グリセリル、ジネオペンタン酸トリプロピレンポリグリコールなどの合成エステル油、イソノナン酸イソノニル、ジメチルポリシロキサン、ジヒドロキシジメチルポリシロキサン、メチルフェニルポリシロキサン、デカメチルシクロペンタシロキサン、ポリエーテル変性シリコーン、アミノ変性シリコーンなどの２５℃における動粘度が１０００ｍｍ２／ｓ以下のシロキサン化合物、ホホバ油、マカデミアナッツ油、サフラワー油などの植物油などが挙げられる。これらは１種又は２種以上を組み合わせて使用される。
上記液状油の中でも特に好ましいものは、流動パラフィン、スクワラン、２５℃における動粘度が１０００ｍｍ２／ｓ以下のジメチルポリシロキサン、メチルフェニルポリシロキサン、デカメチルシクロペンタシロキサンであり、ジメチルポリシロキサンにおいてはさらに２５℃における動粘度が１００ｍｍ２／ｓ以下が好ましい。
Component (B) liquid oil used in the present invention is a hydrocarbon oil such as liquid paraffin or squalane, a synthetic ester such as cetyl 2-ethylhexanoate, glyceryl tri (2-ethylhexanoate), or tripropylene polypropylene glycoline Siloxane compounds having a kinematic viscosity at 25 ° C. of 1000 mm 2 / s or less, such as oil, isononyl isononanoate, dimethylpolysiloxane, dihydroxydimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, polyether-modified silicone, amino-modified silicone , Vegetable oils such as jojoba oil, macadamia nut oil, safflower oil and the like. These are used alone or in combination of two or more.
Particularly preferred among the liquid oils are liquid paraffin, squalane, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane having a kinematic viscosity at 25 ° C. of 1000 mm 2 / s or less. The kinematic viscosity at 25 ° C. is preferably 100 mm 2 / s or less.
成分（Ｂ）の含有量は、全組成中１〜３０質量％、好ましくは５〜２０質量％である。３０質量％を超える場合は、肌に塗布した場合の感触が重くなるなどオイル独特の使用感になるため好ましくなく、１質量％未満の場合は、効果が十分に発揮されない場合があり好ましくない。 Content of a component (B) is 1-30 mass% in the whole composition, Preferably it is 5-20 mass%. When it exceeds 30% by mass, it is not preferable because it gives a unique feeling of use such as a heavy feel when applied to the skin, and when it is less than 1% by mass, the effect may not be sufficiently exhibited, which is not preferable.
本発明で使用する成分（Ｃ）室温でペースト状の油剤は、例えば、ラノリン、トリラノリン脂肪酸グリセリル、軟質ラノリン脂肪酸、ワセリン、シア脂、分岐脂肪酸（Ｃ１２−３１）コレステリル、ジペンタエリトリット脂肪酸エステル（ヘキサオキシステアリン酸ジペンタエリトリット等）、イソステアリン酸硬化ヒマシ油、モノヒドロキシステアリン酸硬化ヒマシ油、マカデミアナッツ油脂肪酸フィトステリル、トリ（カプリル・カプリン・ミリスチン・ステアリン酸）グリセリド、乳酸ミリスチルなどが挙げられる。これらは１種又は２種以上を組み合わせて使用される。
これらは、室温でペースト状（半固体）の油剤であり、室温（１５〜２５℃）の範囲を超える温度に融点を持ち、かつこの範囲で完全に固化しない点で液体油、固体油脂と区別される油剤である。
上記ペースト状の油剤の中でも、ワセリン、シア脂、分岐またはヒドロキシル化した脂肪酸コレステリル、マカデミアナッツ脂肪酸フィトステリル、トリ（カプリル・カプリン・ミリスチン・ステアリン酸）グリセリドが好ましい。
Component (C) used in the present invention is a paste-form oil agent at room temperature, for example, lanolin, trilanoline fatty acid glyceryl, soft lanolin fatty acid, petrolatum, shea fat, branched fatty acid (C12-31) cholesteryl, dipentaerythritol fatty acid ester ( Hexahydroxystearic acid dipentaerythritol, etc.), isostearic acid hydrogenated castor oil, monohydroxystearic acid hydrogenated castor oil, macadamia nut oil fatty acid phytosteryl, tri (capryl / caprin / myristin / stearic acid) glyceride, myristyl lactate and the like. These are used alone or in combination of two or more.
These are oils that are pasty (semi-solid) at room temperature, have a melting point at a temperature exceeding the range of room temperature (15 to 25 ° C.), and do not solidify completely within this range, and are distinguished from liquid oils and solid fats and oils. Is an oil.
Among the oils in the form of paste, petrolatum, shea fat, branched or hydroxylated fatty acid cholesteryl, macadamia nut fatty acid phytosteryl, and tri (capryl / caprin / myristin / stearic acid) glyceride are preferable.
成分（Ｃ）の含有量は、全組成中１〜３０質量％、好ましくは１〜２０質量％である。３０質量％を超える場合は、肌に塗布した場合の感触がべたつくなど使用感が悪くなるため好ましくなく、１質量％未満の場合は、効果が十分に発揮されない場合があり好ましくない。 Content of a component (C) is 1-30 mass% in the whole composition, Preferably it is 1-20 mass%. When it exceeds 30% by mass, it is not preferable because the feeling of use when it is applied to the skin is deteriorated. For example, the effect is not sufficiently exhibited when it is less than 1% by mass.
本発明で使用する成分（Ｄ）トリポリヒドロキシ脂肪酸ジペンタエリスリチルは、トリポリヒドロキシラウリン酸ジペンタエリスリチル、トリポリヒドロキシミリスチン酸ジペンタエリスリチル、トリポリヒドロキシパルミチン酸ジペンタエリスリチル、トリポリヒドロキシステアリン酸ジペンタエリスリチル、トリヒドロキシべへニン酸ジペンタエリスリチルなどが挙げられる。これらは１種又は２種以上を組み合わせて使用される。
上記トリポリヒドロキシ脂肪酸ジペンタエリスリチルの中でも、トリポリヒドロキシステアリン酸ジペンタエリスリチルが好ましく、市販品としては日清オイリオ社製の「サラコスＷＯ−６」が挙げられる。
Examples of the component (D) tripolyhydroxy fatty acid dipentaerythrityl used in the present invention include dipentaerythrityl tripolyhydroxylaurate, dipentaerythritol tripolyhydroxymyristate, dipentaerythrity tripolyhydroxypalmitate, dipentaerythritol tripolyhydroxystearate, dipentaerythrity trihydroxybehenate, and the like. . These are used alone or in combination of two or more.
Among the above-mentioned tripolyhydroxy fatty acid dipentaerythrityls, tripentahydroxystearic acid dipentaerythrityl is preferable, and “Saracos WO-6” manufactured by Nisshin Oillio Co., Ltd. is mentioned as a commercial product.
成分（Ｄ）の含有量は、全組成中１〜３０質量％、好ましくは１〜２０質量％である。３０質量％を超える場合は、肌に塗布した場合の感触がべたつくなど使用感が悪くなるため好ましくなく、１質量％未満の場合は、保湿効果が十分に発揮されない場合があり好ましくない。 Content of a component (D) is 1-30 mass% in the whole composition, Preferably it is 1-20 mass%. When it exceeds 30% by mass, the feeling of use when applied to the skin is deteriorated because the feeling of use is deteriorated. For example, when it is less than 1% by mass, the moisturizing effect may not be sufficiently exhibited.
本発明で使用する成分（Ｅ）として多価アルコールを配合すると、保湿の面でより効果が向上することができる。成分（Ｅ）は、グリセリン、エチレングリコール、ポリエチレングリコール（平均分子量が１０００以下）、プロピレングリコール、１，３−ブチレングリコール、ジプレピレングリコール、ソルビトール、マルチトール等が挙げられる。これらは１種又は２種以上を組み合わせて使用される。 When a polyhydric alcohol is blended as the component (E) used in the present invention, the effect can be further improved in terms of moisture retention. Examples of the component (E) include glycerin, ethylene glycol, polyethylene glycol (average molecular weight is 1000 or less), propylene glycol, 1,3-butylene glycol, diprepylene glycol, sorbitol, maltitol and the like. These are used alone or in combination of two or more.
成分（Ｅ）の含有量は、０．１〜２０．０質量％、特に１〜２０．０質量％が好ましい。０．１質量％未満では、保湿の向上が十分に発揮されず、２０．０質量％を超える場合は、べたつき感が生じ好ましくない。 The content of the component (E) is preferably 0.1 to 20.0% by mass, particularly preferably 1 to 20.0% by mass. If it is less than 0.1% by mass, the improvement of moisture retention is not sufficiently exhibited, and if it exceeds 20.0% by mass, a sticky feeling is generated, which is not preferable.
本発明の皮膚外用剤は（Ｂ）液状油と（Ｃ）室温でペースト状の油剤と（Ｄ）トリポリヒドロキシ脂肪酸ジペンタエリスリチルの総含有量は、全組成中５〜３０質量％、好ましくは５〜２５質量％、さらに好ましくは１０〜２５％である。総含有量が５質量％未満では、保湿効果が十分に発揮されず、３０％超える場合は、油性感が強く、べたつきが生じ好ましくない。 The skin external preparation of the present invention has a total content of (B) liquid oil, (C) oil agent in paste form at room temperature, and (D) tripolyhydroxy fatty acid dipentaerythrityl in the total composition of 5 to 30% by mass, preferably 5 to 25%. % By mass, more preferably 10 to 25%. When the total content is less than 5% by mass, the moisturizing effect is not sufficiently exhibited. When the total content exceeds 30%, the oily feeling is strong and stickiness is not preferable.
本発明の皮膚外用剤は、成分（Ｂ）と（Ｄ）の質量比が１０：１〜５：５で、さらに成分（Ｃ）と（Ｄ）の質量比が（Ｃ）：（Ｄ）＝６：１〜１：９であり、好ましくは、成分（Ｂ）と（Ｄ）の質量比が１０：１〜３：１で、さらに成分（Ｃ）と（Ｄ）の質量比が（Ｃ）：（Ｄ）＝２：１〜１：３である。
成分（Ｂ）が、（Ｂ）：（Ｄ）＝１０：１の比率を超えて多く配合されると、本発明の高い保湿効果を付与することができず、また、成分（Ｄ）が、（Ｂ）：（Ｄ）＝５：５の比率を超えて多く配合されると、べとつきが生じ好ましくない。成分（Ｃ）が、（Ｃ）：（Ｄ）＝６：１の比率を超えて配合されると、（Ｄ）のエモリエント性の効果が発揮されず、また成分（Ｄ）が、（Ｃ）：（Ｄ）＝１：９の比率を超えて配合されると、べたつきやきしみが生じ好ましくない。
In the external preparation for skin of the present invention, the mass ratio of the components (B) and (D) is 10: 1 to 5: 5, and the mass ratio of the components (C) and (D) is (C) :( D) = 6: 1 to 1: 9, preferably the mass ratio of components (B) and (D) is 10: 1 to 3: 1, and the mass ratio of components (C) and (D) is (C) : (D) = 2: 1 to 1: 3.
When the component (B) is blended more than the ratio of (B) :( D) = 10: 1, the high moisturizing effect of the present invention cannot be imparted, and the component (D) (B): When it exceeds (D) = 5: 5 and mix | blends many, stickiness will arise and it is unpreferable. When component (C) is blended in a ratio exceeding (C) :( D) = 6: 1, the emollient effect of (D) is not exhibited, and component (D) is : (D) = 1: 9 If it is blended in excess of the ratio, stickiness and squeak are generated, which is not preferable.
本発明の皮膚外用剤は加温溶解させた（Ｃ）及び（Ｄ）が予め２０℃〜３５℃の（Ｂ）に分散して配合することができ、また、逆に加温溶解させた（Ｃ）及び（Ｄ）に２０℃〜３５℃の（Ｂ）を分散して配合することができる。この方法は通常の乳化工程にある高温での乳化を要せず、常温付近（２０℃〜４５℃）にて製造することができる。また、固形の活性剤・活性助剤等（高級アルコール、高級脂肪酸は含まない）を配合する場合は、予め（Ｂ）に加温溶解させた固形の活性剤・活性助剤等を分散し、さらに加温溶解させた（Ｃ）及び（Ｄ）を分散することで、常温付近にて製造することができる。この場合は上記手順が好ましいが、特に分散する順番は問わない。
また、予め（Ｅ）に加温溶解させた固形の活性剤・活性助剤等を分散（ゲル化）し、さらに上記手順にて作製した（Ｃ）及び（Ｄ）を含有した（Ｂ）を分散することで、常温付近にて製造することができる。
The external preparation for skin of the present invention can be formulated by dispersing (C) and (D) dissolved in warm in (B) of 20 ° C. to 35 ° C. in advance, and conversely dissolved in warm ( (B) at 20 ° C. to 35 ° C. can be dispersed and blended in C) and (D). This method does not require emulsification at a high temperature in a normal emulsification process, and can be produced at around room temperature (20 ° C. to 45 ° C.). In addition, when blending solid activators / activities (not including higher alcohols or higher fatty acids), disperse the solid activators / activities previously dissolved in (B) by heating, Furthermore, it can manufacture in normal temperature vicinity by disperse | distributing (C) and (D) dissolved by heating. In this case, the above procedure is preferable, but the order of dispersion is not particularly limited.
Also, (B) containing (C) and (D) prepared by the above procedure by dispersing (gelling) a solid activator / activity assistant previously dissolved in (E) by heating. By dispersing, it can be produced near room temperature.
本発明の皮膚外用剤は、特に限定されるものではないが、クリーム、乳液、美容液、サンスクリーン、などが挙げられる。 Although the skin external preparation of this invention is not specifically limited, A cream, milky lotion, a cosmetic liquid, a sunscreen, etc. are mentioned.
本発明の皮膚外用剤は、前記の必須成分に加えて必要に応じて本発明の効果を損なわない範囲で通常使用されている任意の成分を使用することが出来る。これらの成分としては、アニオン性界面活性剤、カチオン性界面活性剤、非イオン性界面活性剤、油分、紫外線吸収剤、防腐剤、保湿剤、ポリマー類、アミノ酸誘導体、糖誘導体、香料、水、アルコール、増粘剤、色剤、金属イオン封鎖剤、酸化防止剤、薬剤等が挙げられる。 The external preparation for skin of the present invention can use any components that are usually used within the range not impairing the effects of the present invention, if necessary, in addition to the above essential components. These components include anionic surfactants, cationic surfactants, nonionic surfactants, oils, UV absorbers, preservatives, moisturizers, polymers, amino acid derivatives, sugar derivatives, perfumes, water, Examples include alcohol, thickener, colorant, sequestering agent, antioxidant, and drug.
次に本発明を実施例に基づいて詳細に説明するが、これに限定されるものではない。実施例に先立ち、各実施例で採用した試験法、評価法を説明する。 EXAMPLES Next, although this invention is demonstrated in detail based on an Example, it is not limited to this. Prior to the examples, test methods and evaluation methods employed in each example will be described.
（評価方法）保湿感、のび、つき、べたつきのなさ及びきしみ： 専門パネラー１０名により、各化粧料を使用したときの保湿感、のび、つき（均一に伸びてむらにならない）、べたつきのなさ及びきしみについて、１点から５点の５段階の官能評価を行い、その平均点を求め、以下の基準で判定した。
◎ ：平均点が４．５以上
〇 ：平均点が３．５以上、４．５未満
△ ：平均点が２．５以上、３．５未満
× ：平均点が１．５以上、２．５未満
××：平均点が１．５未満
(Evaluation method) Moisturizing feeling, spread, stickiness, non-stickiness and squeakiness: 10 panelists, moisturizing feeling, spread, stickiness (evenly uneven) and no stickiness For squeak and creaking, sensory evaluation was performed in 5 stages from 1 point to 5 points, the average score was obtained, and judged according to the following criteria.
◎: Average score is 4.5 or more 〇: Average score is 3.5 or more and less than 4.5 △: Average score is 2.5 or more and less than 3.5 ×: Average score is 1.5 or more, 2.5 Less than xx: Average score is less than 1.5
実施例１〜８、比較例１〜３
表１に示した処方の皮膚外用剤を常法により作製し、前記各試験を実施した。その結果を表１に併せて示す。
Examples 1-8, Comparative Examples 1-3
A skin external preparation having the formulation shown in Table 1 was prepared by a conventional method, and the above tests were performed. The results are also shown in Table 1.
（製造方法）
常温の成分Ｅに加温溶解したポリオキシエチレン硬化ヒマシ油（６０Ｅ．Ｏ．)を分散、ゲル化したもの（ベース２）に、常温の成分Ｂに加温溶解した成分Ｃ及び成分Ｄを分散させたもの（ベース１）を投入し、ベース３を調製した。次いで、精製水に成分Ａを投入、分散させた後、ベース３及び水酸化カリウムを順次投入、分散させ、目的とする皮膚化粧料を得た。尚、すべての工程は常温（２５℃）で行うことが可能であった。
(Production method)
Disperse and gel components (base 2) of polyoxyethylene hydrogenated castor oil (60E.O.) dissolved by heating in component E at room temperature, and component C and component D dissolved by heating in component B at room temperature. A base 3 was prepared by charging the mixture (base 1). Next, after component A was charged and dispersed in purified water, base 3 and potassium hydroxide were sequentially charged and dispersed to obtain the intended skin cosmetic. All the steps could be performed at room temperature (25 ° C.).
表１より明らかなように本発明の成分を用いた実施例の皮膚外用剤はいずれも優れた性能を有していた。
一方、必須成分のいずれかを欠いた比較例では、保湿感、のび、つき、べたつきのなさ及びきしみのいずれかの面で劣っており、本発明の目的を達成できなかった。
As is clear from Table 1, all of the external preparations for skin of the examples using the components of the present invention had excellent performance.
On the other hand, the comparative example lacking any of the essential components was inferior in any aspect of moisturizing feeling, spread, stickiness, non-stickiness, and squeaking, and the object of the present invention could not be achieved.
実施例９（乳液）
・カルボキシビニルポリマー ０．２％
・水酸化ナトリウム ０．１％
・グリセリン １０．０％
・スクワラン ９．０％
・デカメチルシクロペンタシロキサン ２．０％
・トリ（カプリル・カプリン・ミリスチン・ステアリン酸） ２．０％
（商品名：サラコス３３４ 日清オイリオ社製）
・トリポリヒドロキシステアリン酸ジペンタエリスリチル ３．０％
（商品名：サラコスＷＯ−６ 日清オイリオ社製）
・ポリオキシエチレン硬化ヒマシ油（６０Ｅ．Ｏ．） １．５％
・火棘抽出物（商品名：火棘 サントリー社製） ０．１％
・アンズ果汁（商品名：アプリコットエキスＫ エスペリス社製） ０．１％
・キョウニンエキス（商品名：キョウニン抽出液ＬＡ 丸善製薬社製） ０．１％
・加水分解コンキオリン液 ０．１％
（商品名：真珠タンパク抽出液 丸善製薬社製）
・加水分解シルク液 ０．１％
（商品名：シルクプロテインエキスＫ 一丸ファルコス社製）
・紫蘭根エキス（商品名：ランヴェール−ＥＸ テクノーブル社製） ０．１％
・オウバクエキス（商品名：オウバク抽出液Ｊ 丸善製薬社製） ０．１％
・グリチルリチン酸ジカリウム ０．１％
・エデト酸二ナトリウム ０．０５％ ・エタノール １．０％
・フェノキシエタノール ０．４％
・キサンタンガム ０．１％
・香料 ０．１％
・精製水 残 部
Example 9 (milky lotion)
・ Carboxyvinyl polymer 0.2%
・ Sodium hydroxide 0.1%
・ Glycerin 10.0%
・ Squalane 9.0%
・ Decamethylcyclopentasiloxane 2.0%
・ Tori (Capryl / Caprin / Myristine / Stearic acid) 2.0%
(Product name: Saracos 334, manufactured by Nisshin Oilio Inc.)
・ Dipentaerythrityl tripolyhydroxystearate 3.0%
(Product name: Saracos WO-6 manufactured by Nissin Oilio Co., Ltd.)
・ Polyoxyethylene hydrogenated castor oil (60EO) 1.5%
・ Fire Thorn Extract (Brand name: Fire Thorn Suntory) 0.1%
・ Apricot juice (Brand name: Apricot Extract K, Esperis) 0.1%
・ Kyonin extract (trade name: Kyonin extract LA Maruzen Pharmaceutical Co., Ltd.) 0.1%
・ Hydrolyzed conchiolin solution 0.1%
(Product name: Pearl Protein Extract Maruzen Pharmaceutical Co., Ltd.)
・ Hydrolysis silk solution 0.1%
(Product name: Silk Protein Extract K Ichimaru Falcos)
・ Purple orchid root extract (trade name: Lambert-EX Technoble) 0.1%
・ Owaku extract (trade name: Awaku extract J Maruzen Pharmaceutical Co., Ltd.) 0.1%
・ Dipotassium glycyrrhizinate 0.1%
・ Edetate disodium 0.05% ・ Ethanol 1.0%
・ Phenoxyethanol 0.4%
・ Xanthan gum 0.1%
・ Perfume 0.1%
・ Purified water balance
上記組成の皮膚外用剤（乳液）を常法により調製し、保湿感、のび、つき、べたつきのなさ及びきしみのいずれの面においても優れていた。 An external preparation for skin (milky lotion) having the above composition was prepared by a conventional method, and was excellent in all aspects of moisturizing feeling, spread, stickiness, non-stickiness and squeaking.
実施例１０（クリーム）
・カルボキシビニルポリマー ０．２％
・アクリル酸・メタクリル酸アルキル共重合体 ０．２％
・水酸化ナトリウム ０．２％
・ジプロピレングリコール １２．０％
・流動パラフィン ８．０％
・メチルフェニルポリシロキサン ２．０％
・ジメチルポリシロキサン（１０００００ｍｍ２／ｓ；２５℃） １．０％
・トリ（カプリル・カプリン・ミリスチン・ステアリン酸） ３．０％
（商品名：サラコス３３４日清オイリオ社製）
・トリポリヒドロキシステアリン酸ジペンタエリスリチル ３．０％
（商品名：サラコスＷＯ−６ 日清オイリオ社製）
・ポリオキシエチレン硬化ヒマシ油（６０Ｅ．Ｏ．） １．５％
・ポリオキシエチレンオレイルエーテル（２Ｅ．Ｏ．） ０．５％
・オレンジ果汁（商品名：ホモフルーツ（オレンジ）Ｎ 香栄興業社製） ０．１％
・オウバクエキス（商品名：オウバク抽出液Ｊ 丸善製薬社製） ０．１％
・酵母エキス（商品名：ディスムチンＢＴＪ ペンタファーム社製） ０．１％
・チョウジエキス（商品名：チョウジ抽出液 丸善製薬社製） ０．１％
・海草エキス（商品名：マリンパージ 一丸ファルコス社製） ０．１％
・キイチゴエキス ０．１％
（商品名：ファルコレックスキイチゴＢ 一丸ファルコス社製）
・ディオスコレアコンポジタエキス ０．１％
（商品名：ディオスコレアコンポジタ根エキス 三井化学社製）
・豆乳発酵液（商品名：豆乳発酵液 三省製薬社製） ０．１％
・ユズエキス（商品名：ユズ抽出液 丸善製薬社製） ０．１％
・グリチルリチン酸ジカリウム ０．１％
・エデト酸二ナトリウム ０．０５％
・エタノール １．０％
・フェノキシエタノール ０．４％
・クロロフェネシン ０．１％
・キサンタンガム ０．１５％
・香料 ０．１％
・精製水 残 部
Example 10 (cream)
・ Carboxyvinyl polymer 0.2%
・ Acrylic acid / alkyl methacrylate copolymer 0.2%
・ Sodium hydroxide 0.2%
・ Dipropylene glycol 12.0%
-Liquid paraffin 8.0%
・ Methylphenylpolysiloxane 2.0%
・ Dimethylpolysiloxane (100,000 mm 2 / s; 25 ° C.) 1.0%
・ Tori (Capryl / Caprin / Myristine / Stearic acid) 3.0%
(Product name: Saracos 334 Nissin Oillio)
・ Dipentaerythrityl tripolyhydroxystearate 3.0%
(Product name: Saracos WO-6 manufactured by Nissin Oilio Co., Ltd.)
・ Polyoxyethylene hydrogenated castor oil (60EO) 1.5%
・ Polyoxyethylene oleyl ether (2E.O.) 0.5%
・ Orange fruit juice (Brand name: Homofruit (Orange) N Koei Kogyo Co., Ltd.) 0.1%
・ Owaku extract (trade name: Awaku extract J Maruzen Pharmaceutical Co., Ltd.) 0.1%
・ Yeast extract (trade name: Dismutin BTJ, manufactured by Pentafarm) 0.1%
-Clove extract (trade name: Clove extract Maruzen Pharmaceutical Co., Ltd.) 0.1%
・ Seaweed extract (trade name: Marine Purge Ichimaru Falcos) 0.1%
・ Raspberry extract 0.1%
(Product name: Falco Rex Kistrawberry B Ichimaru Falcos)
・ Dioscorea compositor extract 0.1%
(Product name: Dioscorea Compositor Root Extract, Mitsui Chemicals)
・ Soymilk fermentation broth (trade name: Soymilk fermentation broth, manufactured by Sansho Pharmaceutical Co., Ltd.) 0.1%
・ Yuzu Extract (trade name: Yuzu Extract Maruzen Pharmaceutical Co., Ltd.) 0.1%
・ Dipotassium glycyrrhizinate 0.1%
・ Edetate disodium 0.05%
・ Ethanol 1.0%
・ Phenoxyethanol 0.4%
・ Chlorophenesin 0.1%
・ Xanthan gum 0.15%
・ Perfume 0.1%
・ Purified water balance
上記組成の皮膚外用剤（クリーム）を常法により調製し、保湿感、のび、つき、べたつきのなさ及びきしみのいずれの面においても優れていた。 A skin external preparation (cream) having the above composition was prepared by a conventional method, and was excellent in all aspects of moisturizing feeling, stretch, stickiness, non-stickiness and squeak.
尚、上記処方中での香料は、表２記載の香料処方のものを用いた。
Claims (5)
（Ａ）水溶性高分子 ０．０１〜５質量％
（Ｂ）液状油 １〜２０質量％
（Ｃ）室温でペースト状の油剤 ０．５〜２０質量％
（Ｄ）トリポリヒドロキシ脂肪酸ジペンタエリスリチル １〜２０質量％ The following components (A) to (D) are contained, and the total content of the components (B), (C) and (D) is 10 to 25% by mass based on the total amount of the external preparation for skin. An emulsified skin external preparation.
(A) Water-soluble polymer 0.01-5 mass%
(B) 1-20% by mass of liquid oil
(C) 0.5-20% by mass of a paste-like oil agent at room temperature
(D) Tripolyhydroxy fatty acid dipentaerythrityl 1 to 20% by mass
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| JP6762553B2 (en) * | 2016-07-06 | 2020-09-30 | 日本メナード化粧品株式会社 | Emulsified cosmetics |
| CN112933027B (en) * | 2021-02-24 | 2023-04-28 | 江西建昌帮食疗科技有限公司 | Deoiling and moisturizing facial foam and preparation method thereof |
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