JP5135439B2 - 生物活性コーティングを形成する方法 - Google Patents
生物活性コーティングを形成する方法 Download PDFInfo
- Publication number
- JP5135439B2 JP5135439B2 JP2010530535A JP2010530535A JP5135439B2 JP 5135439 B2 JP5135439 B2 JP 5135439B2 JP 2010530535 A JP2010530535 A JP 2010530535A JP 2010530535 A JP2010530535 A JP 2010530535A JP 5135439 B2 JP5135439 B2 JP 5135439B2
- Authority
- JP
- Japan
- Prior art keywords
- implant
- coating
- electrolyte solution
- series
- voltage pulses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/26—Anodisation of refractory metals or alloys based thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/024—Anodisation under pulsed or modulated current or potential
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Description
−多様な微細孔性を備える、硬質の適切な接着性及び一様な構造、
−複雑な3D形状の成分上でさえ、10〜30μの厚さ、
−高生物活性を提供するために十分な高濃度のCa及びP、及び
−結晶性生物活性相の直接合成及び表面構造内への組み込み。
CaTiO3<HA<TCP<非晶性Ca、P化合物<CaCO3
この組成は、インプラント表面での骨芽細胞の増殖に寄与するためにCa及びPイオンの(多孔性チャネルを通しての)段階的遊離を保証する。したがって表面では長期間生物活性作用が達成される。さらに、一様な骨誘導は、コーティングされた表面全体でのCa及びPの一様な分布によって保証される。
Claims (12)
- インプラント上に生物活性コーティングをプラズマ電解酸化させるための方法であって、
電解質溶液内にコーティングすべきインプラントを提供する工程であって、前記電解質溶液はCa及びPイオンを提供するためである工程と;
前記インプラントを電源へ接続する工程と;
前記電解質溶液内へ対向電極を提供する工程と;
前記インプラント及び対向電極を横断するように一連の電圧パルスを適用する工程であって、前記一連の電圧パルスは交互極性を有する工程と;を含み、
前記一連の電圧パルス間に、10μs未満の休止が存在する、ことを特徴とするインプラント上に生物活性コーティングをプラズマ電解酸化させるための方法。 - 各電圧パルスは、0.5〜20msの持続時間を有する、請求項1記載の方法。
- パルス間の休止は、5μsである、請求項1記載の方法。
- 前記電圧パルスの振幅は、前記一連の電圧パルスを適用する前記工程の初期5〜300秒間中に前記ピーク振幅まで、徐々に増加する、請求項1乃至3のいずれか一項に記載の方法。
- 一連の電圧パルスを適用する前記工程は、0.5〜30分間持続する、請求項1乃至4のいずれか一項に記載の方法。
- 前記電解質溶液は、一連の電圧パルスを適用する前記工程の間は20℃〜50℃の範囲内で維持される、請求項1乃至5のいずれか一項に記載の方法。
- 前記インプラント及び前記対向電極の間隔は、20mm〜100mmの範囲内で、設定される、請求項1乃至6のいずれか一項に記載の方法。
- 前記正電圧パルスのピーク振幅は、550Vを超えない、請求項1乃至7のいずれか一項に記載の方法。
- 前記負電圧パルスのピーク振幅は、−100Vを超えない、請求項1乃至8のいずれか一項に記載の方法。
- 前記電解質溶液は、含水酢酸カルシウム及びオルトリン酸三ナトリウムを含む、請求項1乃至9のいずれか一項に記載の方法。
- 前記電解質溶液は、水1L当たり0.05〜0.2Mの酢酸カルシウム及び0.025〜0.1Mのオルトリン酸三ナトリウムを含む、請求項10記載の方法。
- 前記インプラントは、チタン又はチタン合金を含む、請求項1乃至11のいずれか一項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0720982.8A GB0720982D0 (en) | 2007-10-25 | 2007-10-25 | Method of forming a bioactive coating |
GB0720982.8 | 2007-10-25 | ||
PCT/GB2008/003432 WO2009053670A2 (en) | 2007-10-25 | 2008-10-10 | Method of forming a bioactive coating |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011500970A JP2011500970A (ja) | 2011-01-06 |
JP5135439B2 true JP5135439B2 (ja) | 2013-02-06 |
Family
ID=38829956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010530535A Expired - Fee Related JP5135439B2 (ja) | 2007-10-25 | 2008-10-10 | 生物活性コーティングを形成する方法 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8852418B2 (ja) |
EP (1) | EP2212453B1 (ja) |
JP (1) | JP5135439B2 (ja) |
CN (1) | CN102216500B (ja) |
AU (1) | AU2008315782B2 (ja) |
DK (1) | DK2212453T3 (ja) |
ES (1) | ES2385770T3 (ja) |
GB (1) | GB0720982D0 (ja) |
HK (1) | HK1141842A1 (ja) |
PL (1) | PL2212453T3 (ja) |
PT (1) | PT2212453E (ja) |
WO (1) | WO2009053670A2 (ja) |
Families Citing this family (23)
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US10004604B2 (en) * | 2006-09-08 | 2018-06-26 | Kyocera Corporation | Bioimplant for artifical joint with evanescent coating film |
US10610614B2 (en) | 2006-09-08 | 2020-04-07 | Kyocera Corporation | Bioimplant with evanescent coating film |
US11278642B2 (en) | 2006-09-08 | 2022-03-22 | Takao Hotokebuchi | Bioimplant with evanescent coating film |
EP2179752B1 (de) * | 2008-10-06 | 2014-08-13 | Biotronik VI Patent AG | Implantat sowie Verfahren zur Herstellung desselben |
AU2010231092B2 (en) * | 2009-03-30 | 2016-06-30 | Accentus Medical Limited | Metal treatment |
DE102009023459B4 (de) * | 2009-06-02 | 2017-08-31 | Aap Implantate Ag | Osteosynthese mit Nanosilber |
US20120093909A1 (en) * | 2009-06-17 | 2012-04-19 | Ahmed El-Ghannam | Ceramic Coatings and Applications Thereof |
NL2003250C2 (en) * | 2009-07-20 | 2011-01-24 | Metal Membranes Com B V | Method for producing a membrane and such membrane. |
GB0918484D0 (en) * | 2009-10-22 | 2009-12-09 | Depuy Int Ltd | A medical implant device |
DE102010027532B8 (de) * | 2010-07-16 | 2014-09-18 | Aap Biomaterials Gmbh | Verfahren zur PEO-Beschichtung |
US9297090B2 (en) | 2010-07-16 | 2016-03-29 | Aap Implantate Ag | PEO coating on Mg screws |
JP5785705B2 (ja) * | 2010-11-19 | 2015-09-30 | 学校法人 関西大学 | 人工骨材の製造方法 |
DE102011007424B8 (de) * | 2011-04-14 | 2014-04-10 | Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH | Verfahren zur Herstellung einer Beschichtung auf der Oberfläche eines Substrats auf Basis von Leichtmetallen durch plasmaelektrolytische Oxidation und beschichtetes Substrat |
KR20130022252A (ko) * | 2011-08-25 | 2013-03-06 | 오스템임플란트 주식회사 | 친수성 표면을 갖는 임플란트 |
US20130233717A1 (en) * | 2012-03-02 | 2013-09-12 | John Disegi | Anodized Titanium Devices and Related Methods |
WO2014088944A1 (en) * | 2012-12-03 | 2014-06-12 | The Regents Of The University Of California | Devices, systems and methods for coating surfaces |
KR101311990B1 (ko) * | 2013-07-18 | 2013-09-27 | 오스템임플란트 주식회사 | 임플란트 표면의 생체활성과 골결합력 및 골융합을 증진시키는 물질이 코팅된 임플란트와 그 제조방법 및 임플란트의 보관 방법 |
CN103898591B (zh) * | 2014-03-27 | 2016-05-25 | 昆明冶金研究院 | 一种直接制备含有羟基磷灰石的微弧氧化陶瓷膜的方法 |
CN104611759B (zh) * | 2015-02-12 | 2017-03-08 | 广州市精源电子设备有限公司 | 变极性脉冲酸洗控制方法 |
RU2598626C1 (ru) * | 2015-06-11 | 2016-09-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ формирования биоактивного покрытия на поверхности эндопротезов крупных суставов |
RU2694963C1 (ru) * | 2016-12-27 | 2019-07-18 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет" (СПбГУ) | Способ получения композиционного нанопокрытия на наноструктурированном титане |
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-
2007
- 2007-10-25 GB GBGB0720982.8A patent/GB0720982D0/en not_active Ceased
-
2008
- 2008-10-10 WO PCT/GB2008/003432 patent/WO2009053670A2/en active Application Filing
- 2008-10-10 EP EP08806569A patent/EP2212453B1/en not_active Not-in-force
- 2008-10-10 JP JP2010530535A patent/JP5135439B2/ja not_active Expired - Fee Related
- 2008-10-10 PT PT08806569T patent/PT2212453E/pt unknown
- 2008-10-10 AU AU2008315782A patent/AU2008315782B2/en not_active Ceased
- 2008-10-10 PL PL08806569T patent/PL2212453T3/pl unknown
- 2008-10-10 ES ES08806569T patent/ES2385770T3/es active Active
- 2008-10-10 US US12/739,487 patent/US8852418B2/en not_active Expired - Fee Related
- 2008-10-10 CN CN200880122630.9A patent/CN102216500B/zh not_active Expired - Fee Related
- 2008-10-10 DK DK08806569.3T patent/DK2212453T3/da active
-
2010
- 2010-08-26 HK HK10108158.9A patent/HK1141842A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2009053670A3 (en) | 2010-02-25 |
CN102216500A (zh) | 2011-10-12 |
PL2212453T3 (pl) | 2013-01-31 |
ES2385770T3 (es) | 2012-07-31 |
CN102216500B (zh) | 2014-09-17 |
HK1141842A1 (en) | 2010-11-19 |
WO2009053670A2 (en) | 2009-04-30 |
US8852418B2 (en) | 2014-10-07 |
GB0720982D0 (en) | 2007-12-05 |
JP2011500970A (ja) | 2011-01-06 |
AU2008315782B2 (en) | 2013-02-07 |
AU2008315782A1 (en) | 2009-04-30 |
EP2212453B1 (en) | 2012-07-04 |
DK2212453T3 (da) | 2012-07-23 |
US20110218643A1 (en) | 2011-09-08 |
PT2212453E (pt) | 2012-10-24 |
EP2212453A2 (en) | 2010-08-04 |
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