JP5133987B2 - クロマトグラフィーカラム、システム及び方法 - Google Patents
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Description
「被分析物」とは、天然若しくは合成起源の物質、化合物若しくは化学物質、又はこれらの反応生成物若しくは誘導体若しくは代謝物と定義される。疑念を避けるために、この用語には、タンパク質、ペプチド、アミノ酸及び核酸のような生物学的分子、並びに薬剤及び/又はプロドラッグのような合成分子が含まれるものとする。
側壁を含むハウジング、
前記側壁で隔てられ、軸方向に間隔をおいて対向する第1及び第2のエンドユニットと、
第1のエンドユニットに隣接する第1のフィルター及び第2のエンドユニットに隣接する第2のフィルターとを含んでなり、これらのフィルターは前記側壁と共に、粒状媒体のベッドを収容するための囲繞ベッドスペースを画成しており、
第1のエンドユニットは、前記囲繞ベッドスペースに液体を添加し、又はそこから液体を除去するための、前記ベッドスペースと流体連通した第1のポートを含んでおり、
第2のエンドユニットは、前記囲繞ベッドスペースに液体を添加し、又はそこから液体を除去するための、前記ベッドスペースと流体連通した第2のポートを含んでおり、
第1のポートと第2のポートが、クロマトグラフィーカラムにおいて前記ベッドスペースのレベルの上方で本質的に同じレベル又は高さにある
ことを特徴とする軸流クロマトグラフィーカラムが提供される。
前記液体と流体連通した入口又は入口マニフォルドと、
ポンプと、
上記クロマトグラフィーカラムと、
出口又は出口マニフォルドと
を含んでなる。
Af 非対称係数
dp 粒径
h 低減したプレート高さ
HETP 理論的プレートと等価な高さ
L ベッド高さ、充填ベッド
us 充填ベッドにおける表面速度
VR 保持体積
wh 最大ピーク高さの50%におけるピーク幅
204 第1のフィルター
206 第2のフィルター
209 ベッドスペース
211 ハウジング、側壁
212 第1のエンドユニット
213 第2のエンドユニット
220 バルブ手段
224 ノズル
233 第1のポート
240 第2のポート
242 通路
260 中空部材
401 カラム
405 バルブ
407 カラムバルブ
408 入口マニフォルド
409 出口マニフォルド
420 第1のポート
440 第2のポート
470 ポンプ
Claims (13)
- 側壁を含むハウジングと、
上記側壁で隔てられ、軸方向に間隔をおいて対向する第1及び第2のエンドユニット、
第1のエンドユニットに隣接する第1のフィルター及び第2のエンドユニットに隣接する第2のフィルターであって、上記側壁と共に粒状媒体のベッドを収容するための囲繞ベッドスペースを画成する第1及び第2のフィルターと
を備える軸流クロマトグラフィーカラムであって、
第1のエンドユニットが、上記ベッドスペースへの液体の添加又は上記ベッドスペースからの液体の除去のため、上記囲繞ベッドスペースと流体連通した第1のポートを含んでおり、
上記クロマトグラフィーカラムが、上記ベッドスペースへの液体の添加又は上記ベッドスペースからの液体の除去のため、上記囲繞ベッドスペースと流体連通した第2のポートを更に備え、
第2のポートが、第2のエンドユニット内の通路に接続した中空部材によってベッドスペースと流体連通し、
第1のポートと第2のポートとが、当該クロマトグラフィーカラムにおいて上記ベッドスペースのレベルの上方で本質的に同じレベル又は高さにあることを特徴とするクロマトグラフィーカラム。 - 第1及び第2のエンドユニットを固定するテンションロッドを備える、請求項1記載のクロマトグラフィーカラム。
- 前記中空部材がカラムの一体部分である、請求項2記載のクロマトグラフィーカラム。
- 前記通路が、ベッドスペースから第2のエンドユニットの側方壁を通して延在している、請求項2又は請求項3に記載のクロマトグラフィーカラム。
- 第1のエンドユニットがさらに、囲繞ベッドスペースと流体連通したバルブ手段を含んでおり、該バルブ手段が、第1のフィルターを通して延在していてその内部に通路を有する長手方向部材を含んでおり、該バルブが作動可能に開閉可能であって、上記通路を介して粒状媒体を前記ベッドスペースに充填することができる、請求項1乃至請求項4のいずれか1項記載のクロマトグラフィーカラム。
- 前記バルブ手段の前記長手方向部材がノズルを含んでいる、請求項5記載のクロマトグラフィーカラム。
- 前記ノズルがベッドスペース内に固定されているか又はベッドスペース内の所定の位置に収納できる、請求項6記載のクロマトグラフィーカラム。
- 前記バルブ手段がベッドスペースから粒状媒体を除いて空にすることができない、請求項1乃至請求項7のいずれか1項記載のクロマトグラフィーカラム。
- 前記カラムが粒状媒体で予め充填されている、請求項1乃至請求項8のいずれか1項記載のクロマトグラフィーカラム。
- 前記カラムが使い捨て式カラムである、請求項8又は請求項9記載のクロマトグラフィーカラム。
- 液体中の1種以上の被分析物を互いに分離する方法であって、上記1種以上の被分析物を含有する液体を、粒状媒体のベッドを収容した請求項1乃至請求項10のいずれか1項記載の軸流クロマトグラフィーカラムに流し、1種以上の被分析物を移動相で溶出し、カラムから溶出する移動相の画分を回収することを含んでなる、方法。
- 液体中の1種以上の被分析物を互いに分離するためのシステムであって、
上記液体と流体連通した入口又は入口マニフォルド、
ポンプ、
請求項1乃至請求項9のいずれか1項記載のクロマトグラフィーカラム、及び
出口又は出口マニフォルド
を備えるシステム。 - さらに、カラムベッドスペースへの液体の添加又はカラムベッドスペースからの液体の除去ができるように作動可能に開閉可能なバルブを備える、請求項12記載のシステム。
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US (7) | US20080017580A1 (ja) |
EP (1) | EP2081660B1 (ja) |
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GB0614315D0 (en) | 2006-07-19 | 2006-08-30 | Ge Healthcare Bio Sciences Ab | Chromatography columns, systems and methods |
US8621737B2 (en) * | 2008-06-25 | 2014-01-07 | Ge Healthcare Bio-Sciences Corp. | Automated installation procedure for a disposable flow path |
CN102656452B (zh) * | 2009-12-22 | 2015-07-22 | 通用电气健康护理生物科学股份公司 | 用于干填充色谱柱的方法 |
JP6111330B2 (ja) * | 2012-06-21 | 2017-04-05 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | クロマトグラフィーカラムノズル |
US20150298025A1 (en) * | 2014-04-17 | 2015-10-22 | Munson Technology LLC | Focused sample delivery and eluent selection for chromatography |
KR101736250B1 (ko) * | 2014-07-30 | 2017-05-16 | 인하대학교 산학협력단 | 판형 크로마토그래피 칼럼 |
US9950278B1 (en) * | 2015-04-03 | 2018-04-24 | Yury Zelechonok | Chromatography column with inlet and outlet at one end |
JP6650756B2 (ja) * | 2015-06-10 | 2020-02-19 | アルプスアルパイン株式会社 | 流路ユニット |
CN105136915B (zh) * | 2015-07-08 | 2017-05-10 | 浙江省海洋水产研究所 | 一种免疫亲和方法 |
KR101717271B1 (ko) | 2016-08-30 | 2017-03-17 | 한국지질자원연구원 | 크로마토그래피 거치장치 |
CN107008033B (zh) * | 2017-06-06 | 2022-04-22 | 利穗科技(苏州)有限公司 | 一种层析柱排气装置 |
GB201711249D0 (en) * | 2017-07-13 | 2017-08-30 | Ge Healthcare Bioprocess R&D Ab | Chromatography column |
KR102677029B1 (ko) * | 2017-09-21 | 2024-06-24 | 리플리겐 코포레이션 | 크로마토그래피 컬럼으로부터 압력 및 공기를 제거하기 위한 방법 및 시스템 |
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2006
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US20080017580A1 (en) | 2008-01-24 |
US11927573B2 (en) | 2024-03-12 |
GB2440243B (en) | 2009-10-07 |
EP2081660B1 (en) | 2015-07-08 |
US20180356375A1 (en) | 2018-12-13 |
US20190324001A1 (en) | 2019-10-24 |
US20170097327A1 (en) | 2017-04-06 |
CA2657066A1 (en) | 2008-01-24 |
KR20090038430A (ko) | 2009-04-20 |
GB2440243A (en) | 2008-01-23 |
US20210148870A1 (en) | 2021-05-20 |
US10928365B2 (en) | 2021-02-23 |
AU2007276411A1 (en) | 2008-01-24 |
GB0713570D0 (en) | 2007-08-22 |
US20140224739A1 (en) | 2014-08-14 |
US20120241379A1 (en) | 2012-09-27 |
DE202007019578U1 (de) | 2014-02-20 |
US9527009B2 (en) | 2016-12-27 |
GB2440243C (en) | 2017-03-22 |
US10048235B2 (en) | 2018-08-14 |
CN101489636B (zh) | 2011-09-28 |
US8702983B2 (en) | 2014-04-22 |
CN101489636A (zh) | 2009-07-22 |
GB0614315D0 (en) | 2006-08-30 |
WO2008009413A1 (en) | 2008-01-24 |
EP2081660A1 (en) | 2009-07-29 |
JP2010513848A (ja) | 2010-04-30 |
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