JP4993834B2 - 細胞増殖および血管形成の調節物質、その使用方法および特定方法 - Google Patents
細胞増殖および血管形成の調節物質、その使用方法および特定方法 Download PDFInfo
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- JP4993834B2 JP4993834B2 JP2002507845A JP2002507845A JP4993834B2 JP 4993834 B2 JP4993834 B2 JP 4993834B2 JP 2002507845 A JP2002507845 A JP 2002507845A JP 2002507845 A JP2002507845 A JP 2002507845A JP 4993834 B2 JP4993834 B2 JP 4993834B2
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- pyrazol
- hgf
- chlorophenyl
- thienyl
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- C—CHEMISTRY; METALLURGY
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- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
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- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pathology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60662800A | 2000-06-29 | 2000-06-29 | |
| US09/606,628 | 2000-06-29 | ||
| US27617001P | 2001-03-15 | 2001-03-15 | |
| US60/276170 | 2001-03-15 | ||
| PCT/US2001/020849 WO2002002593A2 (en) | 2000-06-29 | 2001-06-29 | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005520480A JP2005520480A (ja) | 2005-07-14 |
| JP2005520480A5 JP2005520480A5 (enExample) | 2008-08-14 |
| JP4993834B2 true JP4993834B2 (ja) | 2012-08-08 |
Family
ID=28794211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002507845A Expired - Fee Related JP4993834B2 (ja) | 2000-06-29 | 2001-06-29 | 細胞増殖および血管形成の調節物質、その使用方法および特定方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1355921A2 (enExample) |
| JP (1) | JP4993834B2 (enExample) |
| AU (2) | AU2001277854B2 (enExample) |
| CA (1) | CA2452445C (enExample) |
| WO (1) | WO2002002593A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192976B2 (en) * | 2002-12-21 | 2007-03-20 | Angion Biomedica Corporation | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| EP2341067A1 (en) | 2003-07-18 | 2011-07-06 | Amgen, Inc | Specific binding agents to hepatocyte growth factor |
| CN100363383C (zh) * | 2003-07-21 | 2008-01-23 | 中国人民解放军军事医学科学院基础医学研究所 | 能够与金葡菌毒力因子调控蛋白结合的小分子多肽及其医药用途 |
| DE602004028266D1 (de) * | 2003-10-29 | 2010-09-02 | Univ Ramot | Angiogene peptide und ihre verwendungen |
| US20060008844A1 (en) * | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| EP1816913A4 (en) * | 2004-11-01 | 2010-02-24 | Univ Southern California | NEW COMPOUNDS FOR THE TREATMENT OF CANCER AND ILLNESS IN CONNECTION WITH THE ANGIOGENIC FUNCTION |
| US7947682B2 (en) * | 2004-12-29 | 2011-05-24 | University Of Southern California | Substituted N′-pyrrolo[1,2-a]quinoxalin-4-yl-hydrazides as anti-cancer agents |
| WO2006052840A2 (en) * | 2004-11-04 | 2006-05-18 | University Of Virginia Patent Foundation | Bone tropic peptides |
| SI1846406T1 (sl) | 2005-02-09 | 2011-02-28 | Arqule Inc | Maleimidni derivati, farmacevtski sestavki in postopki za zdravljenje raka |
| US7879898B1 (en) | 2006-02-14 | 2011-02-01 | Angion Biomedica Corp. | Hepatocyte growth factor pathway activators in chronic obstructive pulmonary disease |
| US8236761B2 (en) | 2006-07-07 | 2012-08-07 | Washington State University Research Foundation | C-Met receptor regulation by angiotensin IV (AT4) receptor ligands |
| WO2008005531A2 (en) * | 2006-07-07 | 2008-01-10 | Washington State University Research Foundation | C-met receptor regulation by angiotensin iv (at4) receptor ligands |
| JP5186632B2 (ja) | 2006-10-19 | 2013-04-17 | ブリッタ ハーディ, | 血管形成を誘導するための組成物および方法 |
| US8232285B2 (en) | 2007-06-22 | 2012-07-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| US8513292B2 (en) | 2007-06-22 | 2013-08-20 | Arqule, Inc. | Compositions and methods for the treatment of cancer |
| CA2690799C (en) | 2007-06-22 | 2015-06-16 | Arqule, Inc. | Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer |
| WO2009062143A2 (en) * | 2007-11-09 | 2009-05-14 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium using cytokines and variants thereof |
| CA2767331A1 (en) | 2008-07-10 | 2010-01-14 | Angion Biomedica Corp. | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| JP6055312B2 (ja) | 2010-03-10 | 2017-01-11 | ゲンマブ エー/エス | C−metに対するモノクローナル抗体 |
| WO2012047826A2 (en) * | 2010-10-05 | 2012-04-12 | Angion Biomedica Corp. | Methods of use of small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| JP2012193155A (ja) * | 2011-03-18 | 2012-10-11 | Tohoku Univ | 金属酸化物ナノ粒子の結晶面を認識することが出来るペプチド |
| EP2810198B1 (en) | 2012-01-30 | 2023-07-12 | Universiteit Gent | Anti-invasive compounds |
| US11143659B2 (en) | 2015-01-27 | 2021-10-12 | Arterez, Inc. | Biomarkers of vascular disease |
| JP2022520139A (ja) | 2018-10-12 | 2022-03-29 | セラダプティブ インク | β-リン酸三カルシウム結合配列を含むポリペプチドとその使用 |
| KR20220004083A (ko) | 2019-04-11 | 2022-01-11 | 앤지온 바이오메디카 코포레이션 | (e)-3-[2-(2-티에닐)비닐]-1h-피라졸의 고체 형태 |
| BR112022020809A2 (pt) | 2020-04-15 | 2023-02-23 | Theradaptive Inc | Composições e métodos para entrega terapêutica direcionada ao osso |
| CN115317469A (zh) * | 2021-05-11 | 2022-11-11 | 四川大学 | 白及联菲c在制备预防和/或治疗乳腺癌或乳腺癌转移的药物中的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2144856A1 (en) * | 1992-09-18 | 1994-03-31 | Donna L. Faletto | A method of preventing tumor metastasis |
| US5646036A (en) * | 1995-06-02 | 1997-07-08 | Genentech, Inc. | Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies |
| IL127558A0 (en) * | 1996-07-03 | 1999-10-28 | Genentech Inc | Hepatocyte growth factor receptor agonists and uses thereof |
| WO1999046237A1 (en) * | 1998-03-12 | 1999-09-16 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases |
| AU5382200A (en) * | 1999-06-15 | 2001-01-02 | University Health Network | Muc1 ligands |
-
2001
- 2001-06-29 WO PCT/US2001/020849 patent/WO2002002593A2/en not_active Ceased
- 2001-06-29 AU AU2001277854A patent/AU2001277854B2/en not_active Ceased
- 2001-06-29 EP EP01955795A patent/EP1355921A2/en not_active Withdrawn
- 2001-06-29 CA CA2452445A patent/CA2452445C/en not_active Expired - Fee Related
- 2001-06-29 AU AU7785401A patent/AU7785401A/xx active Pending
- 2001-06-29 JP JP2002507845A patent/JP4993834B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2452445A1 (en) | 2002-01-10 |
| CA2452445C (en) | 2011-02-15 |
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| EP1355921A2 (en) | 2003-10-29 |
| AU2001277854B2 (en) | 2007-03-01 |
| WO2002002593A2 (en) | 2002-01-10 |
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