JP4977350B2 - 微粒子の分析および操作のためのナノ構造表面 - Google Patents
微粒子の分析および操作のためのナノ構造表面 Download PDFInfo
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- JP4977350B2 JP4977350B2 JP2005281351A JP2005281351A JP4977350B2 JP 4977350 B2 JP4977350 B2 JP 4977350B2 JP 2005281351 A JP2005281351 A JP 2005281351A JP 2005281351 A JP2005281351 A JP 2005281351A JP 4977350 B2 JP4977350 B2 JP 4977350B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Description
TC ChangとAH Huang、Journal of Clinical Microbiology、2000年10月、3589〜3594頁、第38巻10号 The Seventh Foresight Conference on Molecular Nanotechnology、1995年10月15〜17日、カリフォルニア州サンタクララ、M.P.Hughes、AC Electrokinetics:Applications for Nanotechnology
ここで図7を参照すると、第1の剛性面710を有する第1の機械的構造体705を形成した後に部分的に構成した装置700を示している。ある場合には、第1の機械的構造体705はシリコン・ウェハなどの半導体基板を含み、またある場合には、機械的剛性を増大させる表面材料、例えば、SiO2層、窒化シリコン、または電気めっきした金属層を含む。
Claims (10)
- 第1の剛性面を有し、前記第1の剛性面のある領域がナノ構造表面を有する第1の機械的構造体と、
第2の剛性面を有し、かつ微細粒子が前記ナノ構造表面と前記第2の剛性面との間に位置決め可能になるように前記第1の機械的構造体と対向し前記ナノ構造表面と協働可能な第2の機械的構造体とからなり、
前記剛性面の一方が、もう一方の剛性面に対して可動で、前記ナノ構造表面を通して微細粒子に接触力を加えるように協働可能であり、
前記ナノ構造表面が、導電性コアを有するピンを備え、前記導電性コア及び前記第2の剛性面は電圧源に電気的に結合され、
前記第1の剛性面の前記領域が、前記ピン間に、透過膜を形成する開口部を含むことを特徴とする装置。
- 前記ナノ構造表面は、前記微粒子の平均径の約1/2よりも小さいものに等しいピッチを有するように構成されたピンを含む請求項1に記載の装置。
- 前記第2の剛性面は、第2の透過膜を形成する開口部をさらに含む請求項1に記載の装置。
- 前記ナノ構造表面は絶縁された導電性コアを有するピンを含み、前記導電性コアおよび前記第2の剛性面は電圧源に電気的に結合されている請求項1に記載の装置。
- 前記微細粒子は、前記ナノ構造表面と前記第2の剛性面との間に位置付けられることを特徴とする請求項1に記載の装置。
- 前記ピンの各々の前記導電性コアが絶縁層で覆われていることを特徴とする請求項1に記載の装置。
- 前記第1の剛性面または前記第2の剛性面のうちの少なくとも一方まで加えられる音波を生成するように構成されたデバイスをさらに含む請求項1に記載の装置。
- 破壊された前記微粒子から放出される物質を分析するように構成されたシステムと、
前記物質を前記システムに導く微小流体チャネルと、
前記物質を前記第2又は第1の剛性面の一方または両方における開口部を介して前記システムに通すように構成されたデバイス
をさらに含む請求項1に記載の装置。
- 前記接触力を加えることに応答して前記微細粒子の物理的性質を分析するように構成されたシステムをさらに含む請求項1に記載の装置。
- 前記物理的性質は、前記微細粒子の弾性特性又は圧縮率であり、前記微細粒子と前記ナノ構造表面のピンとの間に前記接触力を適用することにより評価されることを特徴とする請求項9に記載の装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/954552 | 2004-09-30 | ||
US10/954,552 US7608446B2 (en) | 2004-09-30 | 2004-09-30 | Nanostructured surface for microparticle analysis and manipulation |
Publications (3)
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JP2006105980A JP2006105980A (ja) | 2006-04-20 |
JP2006105980A5 JP2006105980A5 (ja) | 2008-11-13 |
JP4977350B2 true JP4977350B2 (ja) | 2012-07-18 |
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JP2005281351A Active JP4977350B2 (ja) | 2004-09-30 | 2005-09-28 | 微粒子の分析および操作のためのナノ構造表面 |
Country Status (4)
Country | Link |
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US (2) | US7608446B2 (ja) |
EP (1) | EP1642962B1 (ja) |
JP (1) | JP4977350B2 (ja) |
DE (1) | DE602005003086T2 (ja) |
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US20080138581A1 (en) * | 2006-07-17 | 2008-06-12 | Rajmohan Bhandari | Masking high-aspect aspect ratio structures |
DE102007019842A1 (de) * | 2007-04-25 | 2008-10-30 | Forschungsinstitut Für Die Biologie Landwirtschaftlicher Nutztiere | Verfahren und Anordnung zum elektrischen Kontaktieren eines membranumhüllten Objekts mit einer Elektrode |
US7898096B1 (en) * | 2007-08-22 | 2011-03-01 | Thomas Nikita Krupenkin | Method and apparatus for energy harvesting using microfluidics |
FR2921185B1 (fr) * | 2007-09-17 | 2009-10-30 | Univ D Auvergne Clermont 1 Eta | Appareil de simulation de la mastication chez un mammifere |
KR101155085B1 (ko) * | 2009-12-18 | 2012-06-11 | 광주과학기술원 | 세포 용해 장치 및 그 제조 방법 |
US8785177B2 (en) | 2011-11-04 | 2014-07-22 | The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois | Methods for nano-mechanoporation |
US10468124B2 (en) | 2012-01-23 | 2019-11-05 | Toyota Motor Engineering & Manufacturing North America, Inc. | Process for designing and producing cooling fluids |
US20230407235A1 (en) * | 2020-11-12 | 2023-12-21 | The University Of Chicago | Microfluidic and mems cell lysis system and method |
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- 2005-09-22 DE DE602005003086T patent/DE602005003086T2/de active Active
- 2005-09-22 EP EP05255909A patent/EP1642962B1/en not_active Expired - Fee Related
- 2005-09-28 JP JP2005281351A patent/JP4977350B2/ja active Active
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Also Published As
Publication number | Publication date |
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US20060068487A1 (en) | 2006-03-30 |
DE602005003086D1 (de) | 2007-12-13 |
US7608446B2 (en) | 2009-10-27 |
US7960167B2 (en) | 2011-06-14 |
DE602005003086T2 (de) | 2008-10-02 |
US20090295408A1 (en) | 2009-12-03 |
JP2006105980A (ja) | 2006-04-20 |
EP1642962B1 (en) | 2007-10-31 |
EP1642962A1 (en) | 2006-04-05 |
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