JP4974222B2 - 造影剤 - Google Patents

造影剤 Download PDF

Info

Publication number
JP4974222B2
JP4974222B2 JP2006541067A JP2006541067A JP4974222B2 JP 4974222 B2 JP4974222 B2 JP 4974222B2 JP 2006541067 A JP2006541067 A JP 2006541067A JP 2006541067 A JP2006541067 A JP 2006541067A JP 4974222 B2 JP4974222 B2 JP 4974222B2
Authority
JP
Japan
Prior art keywords
tungsten
particles
groups
core
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006541067A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007512322A5 (https=
JP2007512322A (ja
Inventor
アクセルソン,オスカー
ルウンバッハ,アイビー
カールソン,マグナス
Original Assignee
ジーイー・ヘルスケア・アクスイェ・セルスカプ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO20035294A external-priority patent/NO20035294D0/no
Application filed by ジーイー・ヘルスケア・アクスイェ・セルスカプ filed Critical ジーイー・ヘルスケア・アクスイェ・セルスカプ
Publication of JP2007512322A publication Critical patent/JP2007512322A/ja
Publication of JP2007512322A5 publication Critical patent/JP2007512322A5/ja
Application granted granted Critical
Publication of JP4974222B2 publication Critical patent/JP4974222B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0423Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/0428Surface-modified nanoparticles, e.g. immuno-nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0419Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B22CASTING; POWDER METALLURGY
    • B22FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05Metallic powder characterised by the size or surface area of the particles
    • B22F1/054Nanosized particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B22CASTING; POWDER METALLURGY
    • B22FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/10Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B22CASTING; POWDER METALLURGY
    • B22FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F9/00Making metallic powder or suspensions thereof
    • B22F9/16Making metallic powder or suspensions thereof using chemical processes
    • B22F9/18Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
    • B22F9/24Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP2006541067A 2003-11-28 2004-11-26 造影剤 Expired - Fee Related JP4974222B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NO20035294A NO20035294D0 (no) 2003-11-28 2003-11-28 Forbindelser
NO20035294 2003-11-28
NO20044622 2004-10-26
NO20044622 2004-10-26
PCT/NO2004/000364 WO2005051435A2 (en) 2003-11-28 2004-11-26 Tungsten particles as x-ray contrast agents

Publications (3)

Publication Number Publication Date
JP2007512322A JP2007512322A (ja) 2007-05-17
JP2007512322A5 JP2007512322A5 (https=) 2008-01-17
JP4974222B2 true JP4974222B2 (ja) 2012-07-11

Family

ID=34635761

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006541067A Expired - Fee Related JP4974222B2 (ja) 2003-11-28 2004-11-26 造影剤

Country Status (10)

Country Link
US (1) US20070031339A1 (https=)
EP (1) EP1694366A2 (https=)
JP (1) JP4974222B2 (https=)
KR (1) KR101128577B1 (https=)
AU (1) AU2004292917A1 (https=)
BR (1) BRPI0416993A (https=)
CA (1) CA2547476A1 (https=)
MX (1) MXPA06006044A (https=)
RU (1) RU2361617C2 (https=)
WO (1) WO2005051435A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20052429D0 (no) * 2005-05-20 2005-05-20 Amersham Health As Konstrastmidler
NO20052428D0 (no) * 2005-05-20 2005-05-20 Amersham Health As Kontrastmidler
US8173166B2 (en) * 2005-09-09 2012-05-08 Honda Motor Co., Ltd. Methods of producing tungsten nanoparticles
US9149545B2 (en) 2005-11-02 2015-10-06 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography and methods for making same
US20070122620A1 (en) * 2005-11-02 2007-05-31 General Electric Company Nanoparticle-based imaging agents for x-ray / computed tomography and methods for making same
US8003883B2 (en) 2007-01-11 2011-08-23 General Electric Company Nanowall solar cells and optoelectronic devices
US7977568B2 (en) 2007-01-11 2011-07-12 General Electric Company Multilayered film-nanowire composite, bifacial, and tandem solar cells
CN100565156C (zh) * 2007-02-09 2009-12-02 中国钢铁股份有限公司 混凝土结构物的裂缝检测方法
RU2508053C2 (ru) 2008-07-07 2014-02-27 Конинклейке Филипс Электроникс Н.В. Визуализация к-края
EP2376137A2 (en) * 2008-11-23 2011-10-19 Medtronic, Inc. Medical devices with encapsulated visibility particles
WO2013022499A2 (en) * 2011-04-22 2013-02-14 Emory University Polymer coated metal particles and uses related thereto
WO2013034446A1 (en) * 2011-09-07 2013-03-14 Dahan Elodie An apparatus and method for generating useful energy
US9989482B2 (en) * 2016-02-16 2018-06-05 General Electric Company Methods for radiographic and CT inspection of additively manufactured workpieces
US20200179539A1 (en) * 2016-06-22 2020-06-11 Board Of Regents, The University Of Texas System Contrast Agents and Methods of Making the Same for Spectral CT That Exhibit Cloaking and Auto-Segmentation
JP2019128288A (ja) * 2018-01-25 2019-08-01 三井化学株式会社 きずの観察方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181626A (en) * 1977-12-27 1980-01-01 Ppg Industries, Inc. Method of preparing tungsten hexacarbonyl containing polymers and polymers prepared thereby
US5314679A (en) * 1986-07-03 1994-05-24 Advanced Magnetics Inc. Vascular magnetic resonance imaging agent comprising nanoparticles
DE69207589T2 (de) * 1992-06-01 1996-05-23 Basf Ag Anwendung von Dispersionen von magneto-ionischen Partikeln in MRI-Kontrast-Mitteln
US5728590A (en) * 1994-07-29 1998-03-17 Nanoprobes, Inc. Small organometallic probes
AU687093B2 (en) * 1994-09-27 1998-02-19 Nycomed Imaging As Contrast agent
US5759230A (en) * 1995-11-30 1998-06-02 The United States Of America As Represented By The Secretary Of The Navy Nanostructured metallic powders and films via an alcoholic solvent process
JP3411497B2 (ja) * 1998-03-25 2003-06-03 科学技術振興事業団 W超微粒子とその製造方法、およびwナノ結晶薄膜
FR2777016B1 (fr) * 1998-04-06 2002-06-14 Rhone Poulenc Agrochimie Silicone azotee utile pour compacter les sequences d'acides nucleiques et utilisation pour la transfection
WO2000028920A1 (en) * 1998-11-13 2000-05-25 Biocompatibles Limited Therapeutic use of polymers
US6203778B1 (en) * 1998-12-08 2001-03-20 The Regents Of The University Of California Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization
RU2173173C2 (ru) * 1999-05-12 2001-09-10 Институт химии твердого тела Уральского Отделения РАН Средство для контрастирования при рентгенодиагностике (варианты) и способ его получения
RU2172990C2 (ru) * 1999-06-01 2001-08-27 Валерий Иванович Печенкин Рентгенопоглощающий материал
CA2401270A1 (en) * 2000-03-10 2001-09-20 Jeff W. Lichtman Method for labeling individual cells
CA2309575A1 (en) * 2000-05-26 2001-11-26 James E. Guillet Internally cross-linked macromolecules
ITVI20010126A1 (it) * 2001-05-30 2002-11-30 Tecres Spa Cemento osseo radiopaco per uso ortopedico nonche' metodo di realizzazione
JP2004537551A (ja) 2001-07-20 2004-12-16 イオメド インコーポレイテッド メトトレキサートに基づく薬剤を投与することによって腫瘍性、血管原性、繊維芽細胞性及び/又は免疫抑制性眼球異常を治療する方法及びメトトレキサートに基づく薬剤を送達するための眼球イオン導入装置。
FR2830022B1 (fr) * 2001-09-26 2004-08-27 Cime Bocuze Alliage base tungstene fritte a haute puissance
US6686308B2 (en) * 2001-12-03 2004-02-03 3M Innovative Properties Company Supported nanoparticle catalyst
AU2002351240A1 (en) * 2002-03-08 2003-09-22 James Hainfeld Gold nanoparticles used for x-rays imaging
US7462366B2 (en) * 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US8012454B2 (en) * 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization

Also Published As

Publication number Publication date
MXPA06006044A (es) 2006-09-04
RU2006117818A (ru) 2008-01-10
KR101128577B1 (ko) 2012-03-28
RU2361617C2 (ru) 2009-07-20
EP1694366A2 (en) 2006-08-30
AU2004292917A1 (en) 2005-06-09
JP2007512322A (ja) 2007-05-17
WO2005051435A2 (en) 2005-06-09
BRPI0416993A (pt) 2007-02-06
WO2005051435A3 (en) 2006-07-13
CA2547476A1 (en) 2005-06-09
US20070031339A1 (en) 2007-02-08
KR20060118515A (ko) 2006-11-23

Similar Documents

Publication Publication Date Title
JP4974222B2 (ja) 造影剤
JP3337075B2 (ja) 小粒子径水溶性カルボキシ多糖−磁性酸化鉄複合体
JP5951769B2 (ja) 単糖類リン酸又はその誘導体で表面改質された親水性ナノ粒子、そのコロイド溶液及びその用途
KR101879572B1 (ko) 표면 개질된 산화탄탈륨 나노입자, 이의 제조 방법, 이를 이용한 x-선 컴퓨터 단층촬영용 조영제 및 고유전 박막
WO1999012577A1 (en) Polymer particles made of polyvinyl alcohol and comprising a contrast agent for chemoembolization
Sung et al. Multimetallic complexes and functionalized gold nanoparticles based on a combination of d-and f-elements
Wang et al. Controlled synthesis and assembly of ultra-small nanoclusters for biomedical applications
JP2011500652A (ja) 放射線増感剤としてのランタニド系ナノ粒子の使用
EP2604289B1 (en) Radial shape of polymer compound containing iodine, preparation method thereof, and ct contrast medium composition containing same
JP5651468B2 (ja) Mri造影能を有する重合体−金属錯体複合体、並びにそれを用いたmri造影用及び/又は抗腫瘍用組成物
CN1249070C (zh) 顺磁性金属-酞菁配位化合物和使用其的造影剂
Simao et al. Laser-synthesized ligand-free Au nanoparticles for contrast agent applications in computed tomography and magnetic resonance imaging
US20180236106A1 (en) Radiographic nanoparticle contrast agents for dual-energy x-ray imaging and computed tomography scanning and methods of using thereof
CN110862546B (zh) 一种甲氨蝶呤金属配位聚合物及其制备方法和应用
EP1883428B1 (en) Contrast agents
CN101193659A (zh) 作为x-射线造影剂的钨粒子
US20080233052A1 (en) Contrast Agents
CN119792583A (zh) 一种金属配位碘海醇纳米粒子及其制备方法与应用
KR100368840B1 (ko) 진단용조영제
WO2022158377A1 (ja) 複合体、脈管造影剤、x線造影剤、複合体の製造方法、および、脈管の構造変化をとらえる撮影方法
JP2010280594A (ja) 複合粒子を含む生体適合性製剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071121

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071121

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101026

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110125

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20110125

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110125

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110204

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110426

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20110726

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111125

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20120124

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120306

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120405

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150420

Year of fee payment: 3

LAPS Cancellation because of no payment of annual fees