JP4918476B2 - 増殖性疾患を治療するための置換フェノキシ−及びフェニルチオ−誘導体 - Google Patents

増殖性疾患を治療するための置換フェノキシ−及びフェニルチオ−誘導体 Download PDF

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JP4918476B2
JP4918476B2 JP2007503993A JP2007503993A JP4918476B2 JP 4918476 B2 JP4918476 B2 JP 4918476B2 JP 2007503993 A JP2007503993 A JP 2007503993A JP 2007503993 A JP2007503993 A JP 2007503993A JP 4918476 B2 JP4918476 B2 JP 4918476B2
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formula
compound
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alkyl
methoxyphenyl
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JP2007529530A5 (enExample
JP2007529530A (ja
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レディー イー．プレムクマル
レディー エム．ヴィ．ラマナ
シー．ベル スタンリー
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Temple Univ School of Medicine
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    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61P35/00—Antineoplastic agents
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    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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JP2007503993A 2004-03-16 2005-03-15 増殖性疾患を治療するための置換フェノキシ−及びフェニルチオ−誘導体 Expired - Fee Related JP4918476B2 (ja)

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US55400804P 2004-03-16 2004-03-16
US60/554,008 2004-03-16
PCT/US2005/008429 WO2005089269A2 (en) 2004-03-16 2005-03-15 Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders

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JP2007529530A JP2007529530A (ja) 2007-10-25
JP2007529530A5 JP2007529530A5 (enExample) 2008-05-08
JP4918476B2 true JP4918476B2 (ja) 2012-04-18

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US (1) US7932242B2 (enExample)
EP (2) EP3138832A1 (enExample)
JP (1) JP4918476B2 (enExample)
KR (1) KR101274524B1 (enExample)
AU (2) AU2005222947B2 (enExample)
CA (1) CA2559187C (enExample)
DK (1) DK1740530T3 (enExample)
EA (2) EA012980B1 (enExample)
ES (1) ES2609084T3 (enExample)
HU (1) HUE030786T2 (enExample)
IL (1) IL176836A (enExample)
NZ (1) NZ549962A (enExample)
WO (1) WO2005089269A2 (enExample)

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DK1689706T3 (da) 2003-11-14 2017-04-03 Temple Univ - Of The Commonwealth System Of Higher Education Alfa, beta-umættede sulfoxider til behandling af proliferative forstyrrelser
AU2006204103B2 (en) * 2005-01-05 2011-11-24 Temple University Of The Commonwealth System Of Higher Education Treatment of drug-resistant proliferative disorders
WO2006104668A2 (en) * 2005-03-11 2006-10-05 Temple University - Of The Commonwealth System Of Higher Education Composition and methods for the treatment of proliferative diseases
WO2008033475A2 (en) 2006-09-15 2008-03-20 Onconova Therapeutics, Inc. Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions
CN104689298A (zh) 2008-01-22 2015-06-10 阿拉伊姆药品公司 用于预防和治疗组织损伤相关疾病和病症的组织保护肽和肽类似物
WO2010075026A2 (en) * 2008-12-16 2010-07-01 Onconova Therapeutics Inc Methods for determining efficacy of a therapeutic regimen against deleterious effects of cytotoxic agents in human
US8735620B2 (en) 2008-12-17 2014-05-27 Epr Pharmaceuticals Pvt. Ltd Processes for preparing (E)-styrylbenzylsulfone compounds and uses thereof for treating proliferative disorders
US9730913B2 (en) 2011-10-13 2017-08-15 The Johns Hopkins University High affinity beta lactamase inhibitors
WO2014047110A2 (en) 2012-09-20 2014-03-27 Temple University - Of The Commonwealth System Of Higher Education Substituted alkyl diaryl derivatives, methods of preparation and uses
US10052339B2 (en) 2014-03-21 2018-08-21 Bodybio Inc. Methods and compositions for treating symptoms of diseases related to imbalance of essential fatty acids
WO2015142500A2 (en) 2014-03-21 2015-09-24 Bodybio Inc. Compositions and methods for treating addiction
WO2017023912A1 (en) 2015-08-03 2017-02-09 Temple University - Of The Commonwealth System Of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
CN110621655B (zh) * 2017-03-15 2023-03-10 卢内拉生物技术有限公司 Mitoriboscin：靶向癌细胞、细菌和致病性酵母的基于线粒体的治疗剂
CN112694499B (zh) * 2020-12-14 2023-09-19 上海科技大学 一种交联剂及其制备与在质谱交联技术中的应用

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