JP4913602B2 - 医用デバイスに生細胞を磁気的にコーティングするためのキット、装置、および方法 - Google Patents
医用デバイスに生細胞を磁気的にコーティングするためのキット、装置、および方法 Download PDFInfo
- Publication number
- JP4913602B2 JP4913602B2 JP2006542715A JP2006542715A JP4913602B2 JP 4913602 B2 JP4913602 B2 JP 4913602B2 JP 2006542715 A JP2006542715 A JP 2006542715A JP 2006542715 A JP2006542715 A JP 2006542715A JP 4913602 B2 JP4913602 B2 JP 4913602B2
- Authority
- JP
- Japan
- Prior art keywords
- magnetic
- medical device
- kit
- cells
- catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000576 coating method Methods 0.000 title claims abstract description 47
- 239000011248 coating agent Substances 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title abstract description 85
- 230000005291 magnetic effect Effects 0.000 claims abstract description 345
- 239000007788 liquid Substances 0.000 claims abstract description 87
- 238000001727 in vivo Methods 0.000 claims abstract description 67
- 239000012530 fluid Substances 0.000 claims description 21
- 230000002792 vascular Effects 0.000 claims description 14
- 210000003709 heart valve Anatomy 0.000 claims description 8
- 230000002861 ventricular Effects 0.000 claims description 7
- 238000011144 upstream manufacturing Methods 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 2
- 230000000717 retained effect Effects 0.000 abstract description 16
- 238000000338 in vitro Methods 0.000 abstract description 14
- 238000002513 implantation Methods 0.000 abstract description 12
- 230000005415 magnetization Effects 0.000 abstract description 9
- 210000004027 cell Anatomy 0.000 description 204
- 239000000696 magnetic material Substances 0.000 description 34
- 210000004204 blood vessel Anatomy 0.000 description 27
- 239000006249 magnetic particle Substances 0.000 description 21
- 239000000463 material Substances 0.000 description 20
- 239000002245 particle Substances 0.000 description 19
- 210000002889 endothelial cell Anatomy 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 230000008901 benefit Effects 0.000 description 10
- 239000003446 ligand Substances 0.000 description 10
- 229910052751 metal Inorganic materials 0.000 description 10
- 239000002184 metal Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 230000027455 binding Effects 0.000 description 9
- 230000005347 demagnetization Effects 0.000 description 9
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 150000002739 metals Chemical class 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 210000000170 cell membrane Anatomy 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 229910001092 metal group alloy Inorganic materials 0.000 description 6
- 230000014759 maintenance of location Effects 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 229910000859 α-Fe Inorganic materials 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000005684 electric field Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229910052759 nickel Inorganic materials 0.000 description 4
- 238000010899 nucleation Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 102000016359 Fibronectins Human genes 0.000 description 3
- 108010067306 Fibronectins Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 238000007385 chemical modification Methods 0.000 description 3
- 239000007943 implant Substances 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 238000002715 modification method Methods 0.000 description 3
- 229910001000 nickel titanium Inorganic materials 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 229910000938 samarium–cobalt magnet Inorganic materials 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 206010002329 Aneurysm Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 206010072810 Vascular wall hypertrophy Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 150000001412 amines Chemical group 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
- -1 antibodies Proteins 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000002473 artificial blood Substances 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 239000010941 cobalt Substances 0.000 description 2
- 229910017052 cobalt Inorganic materials 0.000 description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
- KPLQYGBQNPPQGA-UHFFFAOYSA-N cobalt samarium Chemical compound [Co].[Sm] KPLQYGBQNPPQGA-UHFFFAOYSA-N 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000004520 electroporation Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000005294 ferromagnetic effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000005298 paramagnetic effect Effects 0.000 description 2
- 238000009832 plasma treatment Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 210000000130 stem cell Anatomy 0.000 description 2
- 239000003104 tissue culture media Substances 0.000 description 2
- 210000000626 ureter Anatomy 0.000 description 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical group NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 1
- 206010003226 Arteriovenous fistula Diseases 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910052692 Dysprosium Inorganic materials 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- HHZHOPJRSHTPOP-UHFFFAOYSA-N [O--].[O--].[Fe++].[Sr++] Chemical compound [O--].[O--].[Fe++].[Sr++] HHZHOPJRSHTPOP-UHFFFAOYSA-N 0.000 description 1
- HZEWFHLRYVTOIW-UHFFFAOYSA-N [Ti].[Ni] Chemical compound [Ti].[Ni] HZEWFHLRYVTOIW-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000009830 antibody antigen interaction Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- UTKFUXQDBUMJSX-UHFFFAOYSA-N boron neodymium Chemical compound [B].[Nd] UTKFUXQDBUMJSX-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002121 endocytic effect Effects 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 210000001900 endoderm Anatomy 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 230000000799 fusogenic effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000009149 molecular binding Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229910001172 neodymium magnet Inorganic materials 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 238000005949 ozonolysis reaction Methods 0.000 description 1
- 210000000277 pancreatic duct Anatomy 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000006557 surface reaction Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003573 thiols Chemical group 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/009—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof magnetic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/64—Animal cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52652203P | 2003-12-03 | 2003-12-03 | |
| US60/526,522 | 2003-12-03 | ||
| PCT/US2004/040242 WO2005056073A2 (en) | 2003-12-03 | 2004-12-02 | Kits, apparatus and methods for magnetically coating medical devices with living cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007512910A JP2007512910A (ja) | 2007-05-24 |
| JP2007512910A5 JP2007512910A5 (enExample) | 2008-01-31 |
| JP4913602B2 true JP4913602B2 (ja) | 2012-04-11 |
Family
ID=34676624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006542715A Expired - Fee Related JP4913602B2 (ja) | 2003-12-03 | 2004-12-02 | 医用デバイスに生細胞を磁気的にコーティングするためのキット、装置、および方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1699501B1 (enExample) |
| JP (1) | JP4913602B2 (enExample) |
| CN (1) | CN100556469C (enExample) |
| AT (1) | ATE544477T1 (enExample) |
| WO (1) | WO2005056073A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090118817A1 (en) | 2005-06-16 | 2009-05-07 | Mayo Foundation For Medical Education And Research | Magnetic Medical Apparatus, Kits, and Methods |
| US8465453B2 (en) | 2003-12-03 | 2013-06-18 | Mayo Foundation For Medical Education And Research | Kits, apparatus and methods for magnetically coating medical devices with living cells |
| EP1734893A4 (en) * | 2004-03-19 | 2010-04-28 | Nicanor I Moldovan | SYSTEM FOR ENSURING THE COMPATIBLITY OF AN IMPLANT WITH A RECEIVER |
| WO2008057565A2 (en) * | 2006-11-06 | 2008-05-15 | Howmedica Osteonics Corp. | Artificial cushion joints and methods of making the same |
| CN101756754B (zh) * | 2009-11-05 | 2012-01-11 | 中国人民解放军第四军医大学第一附属医院 | 磁性封堵器的制备方法 |
| US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
| US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
| GB201116879D0 (en) * | 2011-09-30 | 2011-11-16 | Magnus Stent Ic | Endoprosthesis |
| US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
| CN103565564B (zh) * | 2012-08-02 | 2017-02-22 | 上海微创医疗器械(集团)有限公司 | 一种含磁性底层的双面涂层药物洗脱支架及其制作方法 |
| US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
| CN104174110B (zh) * | 2013-05-23 | 2017-06-27 | 微创心脉医疗科技(上海)有限公司 | 一种药物球囊及其制备方法 |
| US10631984B2 (en) | 2015-12-15 | 2020-04-28 | Neovasc Tiara Inc. | Transseptal delivery system |
| CA3007670C (en) | 2016-01-29 | 2024-09-17 | Neovasc Tiara Inc. | PROSTHETIC VALVE PREVENTING OBSTRUCTION THAT WOULD PREVENT FLOW |
| US10327667B2 (en) * | 2016-05-13 | 2019-06-25 | Becton, Dickinson And Company | Electro-magnetic needle catheter insertion system |
| AU2017361296B2 (en) | 2016-11-21 | 2022-09-29 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
| US10765835B2 (en) * | 2017-04-05 | 2020-09-08 | Becton, Dickinson And Company | Needle magnetizer |
| WO2019036810A1 (en) | 2017-08-25 | 2019-02-28 | Neovasc Tiara Inc. | TRANSCATHETER MITRAL VALVULE PROSTHESIS WITH SEQUENTIAL DEPLOYMENT |
| AU2019374743B2 (en) | 2018-11-08 | 2022-03-03 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
| EP3934591A4 (en) | 2019-03-08 | 2022-11-23 | Neovasc Tiara Inc. | RETRIEVABLE PROSTHETIC RELEASE SYSTEM |
| EP3946163B1 (en) | 2019-04-01 | 2025-08-20 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
| AU2020271896B2 (en) | 2019-04-10 | 2022-10-13 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
| CN114025813B (zh) | 2019-05-20 | 2024-05-14 | 内奥瓦斯克迪亚拉公司 | 具有止血机构的引入器 |
| AU2020295566B2 (en) | 2019-06-20 | 2023-07-20 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
| CN114762753B (zh) * | 2021-01-13 | 2025-04-01 | 江千里 | 磁导向装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0382465A (ja) * | 1989-08-25 | 1991-04-08 | Kanegafuchi Chem Ind Co Ltd | 磁性を有する人工血管 |
| CA2074304C (en) * | 1991-08-02 | 1996-11-26 | Cyril J. Schweich, Jr. | Drug delivery catheter |
| IL119189A0 (en) * | 1996-09-03 | 1996-12-05 | Lev Shlomo | Annulus catheter |
| US6129704A (en) * | 1997-06-12 | 2000-10-10 | Schneider (Usa) Inc. | Perfusion balloon catheter having a magnetically driven impeller |
| US6689119B1 (en) * | 2000-06-02 | 2004-02-10 | Scimed Life Systems, Inc. | Self-aligning medical device |
| EP1351624B1 (en) * | 2001-01-19 | 2008-02-27 | Boston Scientific Limited | Introducer for deployment of branched prosthesis |
| US6673104B2 (en) * | 2001-03-15 | 2004-01-06 | Scimed Life Systems, Inc. | Magnetic stent |
| US20030082148A1 (en) * | 2001-10-31 | 2003-05-01 | Florian Ludwig | Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo |
-
2004
- 2004-12-02 EP EP04812694A patent/EP1699501B1/en not_active Expired - Lifetime
- 2004-12-02 WO PCT/US2004/040242 patent/WO2005056073A2/en not_active Ceased
- 2004-12-02 AT AT04812694T patent/ATE544477T1/de active
- 2004-12-02 JP JP2006542715A patent/JP4913602B2/ja not_active Expired - Fee Related
- 2004-12-02 CN CNB2004800362295A patent/CN100556469C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005056073A2 (en) | 2005-06-23 |
| ATE544477T1 (de) | 2012-02-15 |
| WO2005056073A8 (en) | 2006-07-20 |
| EP1699501A2 (en) | 2006-09-13 |
| CN100556469C (zh) | 2009-11-04 |
| EP1699501B1 (en) | 2012-02-08 |
| CN1897991A (zh) | 2007-01-17 |
| WO2005056073A3 (en) | 2005-09-29 |
| JP2007512910A (ja) | 2007-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4913602B2 (ja) | 医用デバイスに生細胞を磁気的にコーティングするためのキット、装置、および方法 | |
| JP2007512910A5 (enExample) | ||
| US8465453B2 (en) | Kits, apparatus and methods for magnetically coating medical devices with living cells | |
| US9468516B2 (en) | Magnetic medical apparatus, kits, and methods | |
| US8900293B2 (en) | Magnetically-controllable delivery system for therapeutic agents | |
| US20020133225A1 (en) | Methods and apparatuses for delivering a medical agent to a medical implant | |
| US20030082148A1 (en) | Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo | |
| AU2007240758B2 (en) | Magnetic targeting and sequestering of therapeutic formulations | |
| EP2365007A2 (en) | Magnetically controllable drug and gene delivery stents | |
| JP5243552B2 (ja) | 磁気アシスト治療薬送達の方法とシステム | |
| JP2014503232A (ja) | 磁気標的装置、システム、及び方法 | |
| US20150313995A1 (en) | Magnetic Retention of Regenerative Cells for Wound Repair | |
| CN1950109A (zh) | 用于靶向输送的包含细胞和磁性材料的组合物 | |
| US8012200B2 (en) | Endovascular magnetic method for targeted drug delivery | |
| US20100047313A1 (en) | Medical devices having a coating for electromagnetically-controlled release of therapeutic agents | |
| WO2012104848A1 (en) | Controllable flow regulator system | |
| Forbes | Magnetizable implants for targeted drug delivery | |
| CA2821214A1 (en) | Magnetically controllable drug and gene delivery stents | |
| AU2011203100A1 (en) | Magnetically controllable drug and gene delivery stents | |
| NL2007134A (en) | Controllable flow regulator system. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071203 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071203 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100518 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100817 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100824 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20101118 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110208 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110506 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110513 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110808 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111220 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120119 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4913602 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150127 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |