JP4908434B2 - Granular granule and method for producing the same - Google Patents
Granular granule and method for producing the same Download PDFInfo
- Publication number
- JP4908434B2 JP4908434B2 JP2008015251A JP2008015251A JP4908434B2 JP 4908434 B2 JP4908434 B2 JP 4908434B2 JP 2008015251 A JP2008015251 A JP 2008015251A JP 2008015251 A JP2008015251 A JP 2008015251A JP 4908434 B2 JP4908434 B2 JP 4908434B2
- Authority
- JP
- Japan
- Prior art keywords
- collagen peptide
- peptide powder
- granular
- water
- granulated product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000008187 granular material Substances 0.000 title claims description 32
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 102000008186 Collagen Human genes 0.000 claims description 84
- 108010035532 Collagen Proteins 0.000 claims description 84
- 229920001436 collagen Polymers 0.000 claims description 84
- 239000000843 powder Substances 0.000 claims description 70
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 18
- 239000011230 binding agent Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 9
- 238000002036 drum drying Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 40
- 239000000047 product Substances 0.000 description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 239000000243 solution Substances 0.000 description 19
- 238000004062 sedimentation Methods 0.000 description 11
- 238000005469 granulation Methods 0.000 description 10
- 230000003179 granulation Effects 0.000 description 10
- 238000001694 spray drying Methods 0.000 description 7
- 108010010803 Gelatin Proteins 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 239000008273 gelatin Substances 0.000 description 6
- 229920000159 gelatin Polymers 0.000 description 6
- 235000019322 gelatine Nutrition 0.000 description 6
- 235000011852 gelatine desserts Nutrition 0.000 description 6
- 235000013361 beverage Nutrition 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 230000005484 gravity Effects 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 4
- 238000000635 electron micrograph Methods 0.000 description 4
- 230000003301 hydrolyzing effect Effects 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 229920002567 Chondroitin Polymers 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 229960002442 glucosamine Drugs 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- -1 iron and calcium Chemical compound 0.000 description 2
- 235000015110 jellies Nutrition 0.000 description 2
- 239000008274 jelly Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000001465 calcium Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 235000016213 coffee Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229940080237 sodium caseinate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000000515 tooth Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Description
本発明は、速やかに水に浸透溶解することができるコラーゲンを含む顆粒状造粒物とその製造方法に関する。 The present invention relates to a granular granulated product containing collagen that can rapidly permeate and dissolve in water and a method for producing the same.
コラーゲンは、皮膚、血管、腱、歯などの組織に存在する繊維状の蛋白質で、体を構成する全蛋白質の約３０％を占めるものである。コラーゲンは、「美容によい」「骨・関節疾患に伴う症状の緩和によい」等といわれており、飲料、サプリメントなどの健康食品に幅広く用いられている。コラーゲン又はゼラチンを酵素や酸で加水分解処理して溶解性等を改善したコラーゲンペプチドもこれらに用いられている。
特許文献１には、コラーゲンパウダー及びショ糖を流動層造粒装置に仕込み、攪拌混合して、結着剤となるグアーガム水溶液とメチルセルロース水溶液を噴霧して造粒した顆粒形態のコラーゲン含有食品組成物が記載されている（段落番号００１６）。この組成物は水無で食するのに好適なものである（段落番号０００１）。
特許文献１には、コラーゲンパウダーとして「コラーゲンパウダーＦＧＨ」（ユニッテクフーズ株式会社製）を好適に用いることが記載されている（段落番号０００８、００１６）。非特許文献１によれば、「コラーゲンパウダーＦＧＨ」は、コラーゲンの液体を微細な霧状にし、これを熱風中に噴出させて粉状の乾燥物を得るスプレー乾燥法によって得られたコラーゲンペプチドであることが記載されている。
Patent Document 1 discloses a collagen-containing food composition in the form of granules in which collagen powder and sucrose are charged into a fluidized bed granulator, stirred and mixed, and sprayed with a guar gum aqueous solution and a methylcellulose aqueous solution as a binder. (Paragraph number 0016). This composition is suitable for eating without water (paragraph 0001).
Patent Document 1 describes that “collagen powder FGH” (manufactured by Unitech Foods Co., Ltd.) is preferably used as the collagen powder (paragraph numbers 0008 and 0016). According to Non-Patent Document 1, “collagen powder FGH” is a collagen peptide obtained by a spray-drying method in which a collagen liquid is made into a fine mist and ejected into hot air to obtain a powdery dried product. It is described that there is.
また、特許文献１記載の水無で食する形態の他に、コラーゲンペプチド粉末と結着剤を造粒した、水に溶解して飲料等にする顆粒形態のコラーゲン含有食品も市販されている。 In addition to the form of eating without water described in Patent Document 1, a collagen-containing food in the form of granules in which collagen peptide powder and a binder are granulated and dissolved in water to form a beverage or the like is also commercially available.
本発明者らは、前記の水に溶解して飲料等にする顆粒形態のコラーゲンを含む食品の開発を試みる過程で、市販されている顆粒食品を水に加えると、水中への沈降性及び溶解性がわるく、速やかに沈降溶解せず、同時に、微小気泡の発生により水が著しく白濁化して透明性が失われる問題に遭遇した。
したがって、本発明は、コラーゲンペプチド粉末を含む顆粒形態のコラーゲンを含む造粒物であって、水に加えた際に、沈降溶解性がよく、速やかに沈降溶解する前記造粒物を提供することを目的とする。また、このような顆粒状造粒物の製造方法を提供することを目的とする。
In the process of trying to develop a food containing granular form of collagen that is dissolved in water to make a beverage or the like, the present inventors added a commercially available granular food to water, and settled and dissolved in water. However, the problem was that the solution was not settled and dissolved quickly, and at the same time, water was remarkably clouded due to the generation of microbubbles and the transparency was lost.
Therefore, the present invention provides a granulated product comprising collagen in the form of granules containing collagen peptide powder, which has good sedimentation solubility when added to water and rapidly settles and dissolves. With the goal. Moreover, it aims at providing the manufacturing method of such a granular granule.
本発明者らは、前記の水に溶解して用いる顆粒食品について研究し、特に原料であるコラーゲンペプチド粉末の形態に着目したところ、市販されているコラーゲンペプチド粉末は、スプレー乾燥法によって得られたものが殆どであった。また、市販されている含有食品は全て、スプレー乾燥法によって得られたコラーゲンペプチド粉末が使用されていると推察された。
そして、スプレー乾燥法によって得られたコラーゲンペプチド粉末は、水に加えた場合に、沈降溶解性がわるく、微小の気泡が発生して溶液が白濁することが判明した。また、スプレー乾燥法によって得られたコラーゲンペプチド粉末とバインダー液との造粒物も沈降溶解性がわるく、同様に溶液が白濁することが判明した。
The inventors of the present invention have studied the granular food used by dissolving in water, and particularly focused on the form of the collagen peptide powder as a raw material. The commercially available collagen peptide powder was obtained by a spray drying method. Most of them were. Moreover, it was guessed that the collagen peptide powder obtained by the spray-drying method was used for all the containing foodstuffs marketed.
And when the collagen peptide powder obtained by the spray drying method was added to water, it became clear that sedimentation solubility was poor, and microbubbles were generated and the solution became cloudy. Further, it was found that the granulated product of the collagen peptide powder obtained by the spray drying method and the binder liquid has poor precipitation solubility, and the solution becomes cloudy in the same manner.
他方、加熱された回転ドラムの表面に材料をフィルム状に付着させ、ドラムが回転する間に乾燥し、これを掻き取って乾燥品を得るドラム乾燥法によって得られたコラーゲンペプチド粉末も知られている。しかし、上記のドラム乾燥法によって得られたコラーゲンペプチド粉末（原末）では、前記のスプレー乾燥品に比べて溶液の透明性は保持されるが、水に対する沈降溶解性がわるいことを確認した。
そして、ドラム乾燥法によって得られたコラーゲンペプチド粉末とバインダー液との造粒物だけが、水に対する沈降溶解性に優れ、溶液の透明性を保持することができることを見出した。
On the other hand, a collagen peptide powder obtained by a drum drying method in which a material is attached to the surface of a heated rotating drum in a film form, dried while the drum rotates, and scraped off to obtain a dried product is also known. Yes. However, it was confirmed that the collagen peptide powder (raw powder) obtained by the above-described drum drying method retains the transparency of the solution as compared with the above-mentioned spray-dried product, but has poor sedimentation solubility in water.
And it discovered that only the granulated product of the collagen peptide powder obtained by the drum drying method and the binder liquid was excellent in sedimentation solubility in water and could maintain the transparency of the solution.
本発明は、非多孔質で薄片状のコラーゲンペプチド粉末と結着剤とを造粒したことを特徴とする顆粒状造粒物を特徴とする。
また、本発明は、非多孔質で薄片状のコラーゲンペプチド粉末を流動層造粒機に投入し、結着剤の溶液を噴霧して該コラーゲンペプチド粉末を造粒することを特徴とする顆粒状造粒物の製造方法を別の特徴とする。
The present invention is characterized by a granular granulated product obtained by granulating non-porous and flaky collagen peptide powder and a binder.
The present invention also provides a granulated product characterized in that non-porous, flaky collagen peptide powder is put into a fluidized bed granulator, and the collagen peptide powder is granulated by spraying a binder solution. Another feature is a method for producing a granulated product.
本発明のコラーゲンペプチド粉末を含む顆粒状造粒物は、水に溶解して飲料等にする場合に、沈降溶解性がよく、速やかに沈降溶解するという利点がある。 The granulated granule containing the collagen peptide powder of the present invention has the advantage of good sedimentation solubility and rapid sedimentation when dissolved in water to make a beverage or the like.
本発明で用いるコラーゲンペプチド粉末は、コラーゲン又はゼラチンを酵素や酸で加水分解処理したものを乾燥処理して粉末としたものである。粉末とする際には、精製された動物の皮等の動物組織を水中で分散または溶解、なめし（安定化）、脱水、造粒、乾燥、粉砕の各処理を順次なすことができる。
コラーゲンペプチド粉末は、分子量が数百〜１万程度のものが望ましく、これにより水に対する沈降溶解性と、溶解時にゾル化・ゲル化しない性能が得られ、顆粒状造粒物の沈降溶解性が好適に達成される。コラーゲンペプチド粉末は、生理機能性を得るものとして用いることができる。
The collagen peptide powder used in the present invention is a powder obtained by drying collagen or gelatin hydrolyzed with an enzyme or acid. When powdered, animal tissues such as purified animal skin can be dispersed or dissolved in water, tanned (stabilized), dehydrated, granulated, dried, and pulverized sequentially.
The collagen peptide powder preferably has a molecular weight of about several hundred to 10,000, which provides the sediment solubility in water and the ability not to form a sol or gel when dissolved, and the granule granules have a sediment solubility. Preferably achieved. Collagen peptide powder can be used to obtain physiological functionality.
本発明で用いるコラーゲンペプチド粉末は、非多孔質であり、顕微鏡で観察した場合に、コラーゲンペプチド粉末の表面あるいは断面の組織に、多数の略円形の穴がみられない。尚、一般に市販されているスプレー乾燥品のコラーゲンペプチド粉末は、コラーゲンペプチド粉末の表面あるいは断面の組織に、多数の略円形の穴が認められる。 The collagen peptide powder used in the present invention is non-porous, and when observed with a microscope, many substantially circular holes are not observed on the surface or cross-sectional tissue of the collagen peptide powder. In general, commercially available spray-dried collagen peptide powders have a number of substantially circular holes on the surface or cross-sectional tissue of the collagen peptide powder.
更に、本発明で用いるコラーゲンペプチド粉末は、薄片状のものである。ここで、薄片状とは、顕微鏡で観察した場合に、球形乃至それが壊れた形状ではない、角のある破片状の薄片として認められるものをいう。一般に市販されているスプレー乾燥品のコラーゲンペプチド粉末では、上記の球形乃至それが壊れた形状が認められる。前記の非多孔質の構造及び薄片形状は、顕微鏡により通常１００〜１０００倍程度の倍率で観察することができる。
前記の非多孔質の構造及び薄片形状によって、顆粒状造粒物の水に対する沈降溶解性が向上する。また、溶液中に微小の気泡が発生せず、溶液が透明な場合等はその透明性を保持することができる。前記の非多孔質の構造及び薄片状でない場合には、顆粒状造粒物の沈降溶解性がわるく、溶液中に微小の気泡が発生して溶液が白濁する。
Furthermore, the collagen peptide powder used in the present invention is in the form of flakes. Here, the term “flaky shape” refers to a piece that is recognized as a flaky piece having a corner or not a broken shape when observed with a microscope. In the collagen peptide powder of the spray-dried product generally marketed, the above-mentioned spherical shape or a broken shape is recognized. The non-porous structure and flake shape can be observed with a microscope, usually at a magnification of about 100 to 1000 times.
Due to the non-porous structure and the flake shape, the sedimentary solubility of the granular granule in water is improved. In addition, when the bubbles are not generated in the solution and the solution is transparent, the transparency can be maintained. In the case of the non-porous structure and not in the form of flakes, the granular granulated product has poor sedimentation solubility, and fine bubbles are generated in the solution, causing the solution to become cloudy.
コラーゲンペプチド粉末は、４２メッシュ（目開き３５５μm）を通過するものが８０％以上のものがよく、８３メッシュ（目開き１８０μm）を通過するものが６０％以上のものがさらによい。顆粒状造粒物の水に対する沈降溶解性が向上するためである。尚、本発明でメッシュの目開きの値はＪＩＳ規格に準じたものである。 As for the collagen peptide powder, those passing through 42 mesh (aperture 355 μm) are preferably 80% or more, and those passing through 83 mesh (aperture 180 μm) are more preferably 60% or more. This is because the sedimentation solubility of granular granules in water is improved. In the present invention, the mesh opening value conforms to the JIS standard.
コラーゲンペプチド粉末を調製する場合は、コラーゲン又はゼラチンを酵素や酸で加水分解処理したコラーゲンペプチド溶液を乾燥処理して前記構成の粉末とすればよい。非多孔質で薄片状のコラーゲンペプチド粉末は、ドラム乾燥法によって得ることができる。より具体的には、コラーゲンペプチドを加熱されたドラムの表面に押し当てて乾燥し、これを掻き取ることによって得ることができる。 When preparing a collagen peptide powder, a collagen peptide solution obtained by hydrolyzing collagen or gelatin with an enzyme or an acid may be dried to obtain a powder having the above-described configuration. Non-porous and flaky collagen peptide powder can be obtained by a drum drying method. More specifically, the collagen peptide can be obtained by pressing it against the surface of a heated drum, drying it, and scraping it off.
結着剤は、コラーゲンペプチド粉末を造粒により結合するため、通常溶液として用いる。物質としては、グアガム、アラビアガム、ローカストビーンガムなどのガム類、トレハロース、ゼラチン、デキストリン、アルギン酸ソーダ、各種澱粉、糖類、糖蜜、グリセリン、カゼインナトリウム、ポリリン酸ナトリウム、ポリアクリル酸ナトリウム、各種結晶セルロース、メチルセルロース、ポリエチレングリコール、樹脂、ヒアルロン酸、コンドロイチン、グルコサミンが挙げられ、求める造粒物などに応じ適宜選択すればよい。ヒアルロン酸、コンドロイチン、グルコサミン等の生理機能性の水溶性物質を用いる場合には、前述の生理機能性の水溶性物質のコラーゲンペプチド粉末と組合せて、生理機能性の高い顆粒状造粒物を調製することが可能となる。 The binder is usually used as a solution in order to bind the collagen peptide powder by granulation. Substances include gums such as guar gum, gum arabic, locust bean gum, trehalose, gelatin, dextrin, sodium alginate, various starches, sugars, molasses, glycerin, sodium caseinate, sodium polyphosphate, sodium polyacrylate, various crystalline cellulose , Methyl cellulose, polyethylene glycol, resin, hyaluronic acid, chondroitin, and glucosamine, and may be appropriately selected according to the desired granulated product. When using physiologically functional water-soluble substances such as hyaluronic acid, chondroitin, glucosamine, etc., prepare granular granules with high physiological function by combining with the above-mentioned collagen peptide powder of physiologically functional water-soluble substances It becomes possible to do.
結着剤溶液には、必要により、甘味料、調味料、ビタミンＣなどの各種ビタミン、鉄分、カルシウムなどのミネラル、食物繊維、乳酸菌などの栄養素、リンゴ酸、クエン酸、酒石酸、フマール酸などの有機酸を含むことができる。 In the binder solution, sweeteners, seasonings, vitamins such as vitamin C, minerals such as iron and calcium, dietary fiber, nutrients such as lactic acid bacteria, malic acid, citric acid, tartaric acid, fumaric acid, etc. Organic acids can be included.
本発明の顆粒状造粒物は、造粒によりコラーゲンペプチド粉末と結着剤を結着させ、粉末状に形成したものである。
造粒手段としては、流動層造粒、転動造粒、押出し造粒、撹拌造粒、スプレー乾燥造粒法が挙げられ、特に流動層造粒が好適である。顆粒状造粒物の水に対する沈降溶解性が向上することができる。流動層造粒は粉体（本発明ではコラーゲンペプチド粉末となる）を空気で流動化させ、結着剤溶液をスプレーして凝集造粒する方式である。尚、造粒後には更に粉砕処理や整粒処理等を施してもよい。
The granular granulated product of the present invention is formed by binding a collagen peptide powder and a binder by granulation.
Examples of the granulating means include fluidized bed granulation, rolling granulation, extrusion granulation, stirring granulation, and spray drying granulation methods, and fluidized bed granulation is particularly preferable. The sedimentation solubility of the granular granule in water can be improved. Fluidized bed granulation is a system in which a powder (which is a collagen peptide powder in the present invention) is fluidized with air and sprayed with a binder solution to agglomerate and granulate. In addition, you may perform a grinding | pulverization process, a sizing process, etc. after granulation.
本発明の顆粒状造粒物は、非多孔質であり、コラーゲンペプチド粉末の場合と同様に、顕微鏡で観察した場合に、造粒物の表面あるいは断面の組織に、多数の略円形の穴がみられない。これに対し、一般に市販されているスプレー乾燥品のコラーゲンペプチド粉末の造粒物では、上記の多数の略円形の穴が認められる。 The granular granulated product of the present invention is non-porous, and when observed with a microscope, as in the case of collagen peptide powder, a number of substantially circular holes are formed on the surface of the granulated product or the tissue of the cross section. I can't see it. On the other hand, in the granulated product of collagen peptide powder as a spray-dried product that is generally commercially available, the above-described many substantially circular holes are recognized.
本発明の顆粒状造粒物は、顕微鏡で観察した場合に、薄片状のコラーゲンペプチド粉末が集合した形状として認められるものをいう。 The granular granulated product of the present invention refers to what is recognized as a shape in which flaky collagen peptide powders are aggregated when observed with a microscope.
顆粒状造粒物の粒径は、１４０メッシュ（目開き１０６μm）にオンするものが５０％以上のものがよい。１４０メッシュにオンし、かつ１６メッシュ（目開き１０００μm）を通過するものが６０％以上のものが更によい。顆粒状造粒物の水に対する沈降溶解性が向上するためである。 The particle size of the granular granule is preferably 50% or more when turned on to 140 mesh (aperture 106 μm). More preferably 60% or more of those that turn on to 140 mesh and pass 16 mesh (aperture 1000 μm). This is because the sedimentation solubility of granular granules in water is improved.
本発明の顆粒状造粒物を利用した製品形態としては、水、牛乳、ジュース、コーヒー等の液体に溶解して飲料等にする形態、ヨーグルト、ゼリー等に溶解して喫食する形態、ゼリー等のように液体に溶解にしてゲル化させる形態が挙げられる。透明な液体に溶解して、透明なコラーゲンペプチドの溶解した食品形態が併せて挙げられる。 Product forms using the granulated granules of the present invention include forms that dissolve in liquids such as water, milk, juice, coffee, etc., forms that dissolve in yogurt, jelly, etc. The form which makes it melt | dissolve in a liquid and gelatinize like this. A food form in which a transparent collagen peptide is dissolved in a transparent liquid is also mentioned.
以下実施例に基づいて本発明について説明するが、これに限らず種々応用変形をなし得ることはいうまでもない。 The present invention will be described below based on examples, but it is needless to say that the present invention is not limited to this and can be modified in various ways.
（実施例１）
（コラーゲンペプチド粉末）
ゼラチン溶液を加水分解処理したコラーゲンペプチド溶液をドラム乾燥法により乾燥処理して得たコラーゲンペプチド粉末（（株）ニッピ社製、ニッピペプタイドＦＥＰ）を使用した。このコラーゲンペプチド粉末は、次の性能を有していた。
１．電子顕微鏡により１００〜３００倍の倍率で観察すると、表面あるいは断面の組織に、多数の略円形の穴がみられない非多孔質の構造で、球形乃至それが壊れた形状ではない、角のある破片状の薄片状のものであった。上記の電子顕微鏡で観察されたコラーゲンペプチド粉末の撮影写真を図１に示す。
Example 1
(Collagen peptide powder)
Collagen peptide powder (Nippi Peptide FEP, manufactured by Nippi Co., Ltd.) obtained by drying a collagen peptide solution obtained by hydrolyzing a gelatin solution by a drum drying method was used. This collagen peptide powder had the following performance.
1. When observed at a magnification of 100 to 300 times with an electron microscope, the surface or cross-sectional structure has a non-porous structure in which a large number of substantially circular holes are not seen, and is spherical or not broken, with a corner It was a flaky piece. A photograph of the collagen peptide powder observed with the electron microscope is shown in FIG.
２．粒径は、８３メッシュ（目開き１８０μm）を通過し、２３５メッシュ（目開き６３μm）にオンするものが全体の約５０％存在するものであった。 2. About 50% of the total particle size passed through 83 mesh (aperture 180 μm) and turned on to 235 mesh (aperture 63 μm).
３．エタノール中に沈めた場合に、全く気泡を抱かないものであった。実体顕微鏡により１００倍の倍率で観察されたコラーゲンペプチド粉末の撮影写真を図２に示す。
４．コラーゲンペプチド粉末５ｇを、口径６３ｍｍの２００ｍｌビーカーに入れた２２℃の水１００ｍｌに加えると、約５分間で全てが水中に沈んだ。尚、本明細書で、粉末又造粒物を上記のようにして測定した値を「基準沈降時間」という。
3. When submerged in ethanol, it had no bubbles. FIG. 2 shows a photograph of collagen peptide powder observed with a stereomicroscope at a magnification of 100 times.
4). When 5 g of collagen peptide powder was added to 100 ml of water at 22 ° C. placed in a 200 ml beaker having a diameter of 63 mm, everything was submerged in water in about 5 minutes. In the present specification, a value obtained by measuring the powder or granulated product as described above is referred to as “reference settling time”.
（結着剤水溶液）
水３００ｇに、各々粉末状のトレハロース２００ｇ、ヒアルロン酸３．０ｇ及び甘味料３０ｇを混合し、溶解して調製した。
(Binder aqueous solution)
It was prepared by mixing 200 g of water, 200 g of powdered trehalose, 3.0 g of hyaluronic acid, and 30 g of sweetener, and dissolving them.
前記のコラーゲンペプチド粉末２．５ｋｇを流動層造粒装置に仕込み、攪拌混合し昇温させた後、前記の結着剤水溶液を噴霧して造粒し、７０℃で３０分乾燥して顆粒を得た。
このものを篩過して、１２メッシュ（目開き１４００μｍ）を通過するものを集め、本発明の顆粒状造粒物を得た。
Charge 2.5 kg of the above collagen peptide powder into a fluidized bed granulator, stir and mix, heat up, spray and granulate the aqueous binder solution, and dry at 70 ° C. for 30 minutes to form granules. Obtained.
This was passed through a sieve, and those passing through 12 mesh (aperture 1400 μm) were collected to obtain a granular granulated product of the present invention.
上記の顆粒状造粒物は、次の性能のものであった。
１．電子顕微鏡により１５０倍の倍率で観察すると、表面あるいは断面の組織に、多数の略円形の穴がみられない非多孔質の構造で、球形乃至それが壊れた形状ではない、角のある破片状の薄片状のものであった。上記の電子顕微鏡で観察したコラーゲンペプチド粉末の写真を図３に示す。
２．粒径は、１６メッシュ（目開き１０００μm）を通過し、１４０メッシュ（目開き１０６μｍ）にオンするものが全体の約８０％存在するものであった。
３．エタノール中に沈めた場合に、５μｍ以上の泡を抱かないものであった。実体顕微鏡により１００倍の倍率で観察した顆粒状造粒物の写真を図４に示す。
４．基準沈降時間が約３秒であった。
５．水分約６質量％で、かさ比重約３．０ｇ／ｃｍ３のものであった。
The above granular granule had the following performance.
1. When observed with an electron microscope at a magnification of 150 times, the structure of the surface or cross section is a non-porous structure in which a large number of substantially circular holes are not seen, and it is not a spherical shape or a broken shape. It was a flaky shape. A photograph of the collagen peptide powder observed with the electron microscope is shown in FIG.
2. About 80% of the total particle size passed through 16 mesh (aperture 1000 μm) and turned on to 140 mesh (aperture 106 μm).
3. When submerged in ethanol, it did not hold bubbles of 5 μm or more. FIG. 4 shows a photograph of the granular granule observed with a stereomicroscope at a magnification of 100 times.
4). The standard settling time was about 3 seconds.
5. The water content was about 6% by mass and the bulk specific gravity was about 3.0 g / cm 3 .
なお、本発明で顆粒状造粒物の水分及びかさ比重は次のように計測した値を指す。
顆粒状造粒物の水分：常圧３ｇ１０５℃４時間乾燥法
顆粒状造粒物のかさ比重：かさ比重測定装置（JIS K 6721）
In addition, the water | moisture content and bulk specific gravity of a granular granule in this invention point out the value measured as follows.
Moisture content of granular granule: normal pressure 3g, 105 ° C, 4 hours drying method Bulk specific gravity of granulated granule: Bulk specific gravity measuring device (JIS K 6721)
６．得られた顆粒状造粒物５ｇを、コップに入れた水１００ｇに加えたところ、全ての造粒物が水中に沈むまでの時間（以下コップ中沈降時間という）が約３秒間で、全ての造粒物が水中に溶解して見えなくなるまでの時間（以下溶解時間という）が約３０秒間であった。尚、溶解は造粒物が水中に沈んでからスプーンを約１０回転/５秒のスピードで攪拌した。上記の造粒物は、速やかに水に沈降溶解し、水は造粒物を加える前と同様に透明であった。 6). When 5 g of the obtained granular granulated product was added to 100 g of water in a glass, the time until all the granulated product was submerged in water (hereinafter referred to as settling time in the cup) was about 3 seconds. The time until the granulated product was dissolved in water and disappeared (hereinafter referred to as dissolution time) was about 30 seconds. The dissolution was performed by stirring the spoon at a speed of about 10 rotations / 5 seconds after the granulated product was submerged in water. The above granulated product quickly settled and dissolved in water, and the water was transparent as before the granulated product was added.
（比較例１）
（コラーゲンペプチド粉末）
コラーゲンペプチド粉末としてコラーゲンパウダー（（株）ニッピ社製、ニッピペプタイドＰＳ−１）を使用した。このコラーゲンペプチド粉末は、ゼラチン溶液を加水分解処理したコラーゲンペプチド溶液をスプレー乾燥法により乾燥処理して得た、次の性能のものであった。
１．顕微鏡により２００倍の倍率で観察すると、表面あるいは断面の組織に、多数の略円形の穴がみられる多孔質の構造で、球形乃至それが壊れた形状のものであった。上記の電子顕微鏡で観察したコラーゲンペプチド粉末の写真を図５に示す。
２．粒径は、８３メッシュ（目開き１８０μm）を通過し、２３５メッシュ（目開き６３μm）にオンするものが全体の約６０％存在するものであった。
３．エタノール中に沈めた場合に、泡を抱いたものであった。実体顕微鏡により６００倍の倍率で観察したコラーゲンペプチド粉末の写真を図６に示す。
４．基準沈降時間が５分以上であった。
(Comparative Example 1)
(Collagen peptide powder)
Collagen powder (Nippi Corporation, Nippi Peptide PS-1) was used as the collagen peptide powder. This collagen peptide powder had the following performance obtained by drying a collagen peptide solution obtained by hydrolyzing a gelatin solution by a spray drying method.
1. When observed at a magnification of 200 times with a microscope, it was a porous structure in which a large number of substantially circular holes were seen on the surface or cross-sectional structure, and was spherical or a broken shape. A photograph of the collagen peptide powder observed with the electron microscope is shown in FIG.
2. About 60% of the total particle size passed through 83 mesh (aperture 180 μm) and turned on to 235 mesh (aperture 63 μm).
3. When submerged in ethanol, it had foam. A photograph of the collagen peptide powder observed at a magnification of 600 times with a stereomicroscope is shown in FIG.
4). The standard settling time was 5 minutes or more.
前記のコラーゲンペプチド粉末を使用する以外は、実施例１と同様にして顆粒状造粒物を得た。
上記の顆粒状造粒物は、次の性能のものであった。
１．電子顕微鏡により２００倍の倍率で観察すると、表面あるいは断面の組織に、多数の略円形の穴がみられる多孔質の構造で、球形乃至それが壊れた形状のものであった。上記の電子顕微鏡で観察したコラーゲンペプチド粉末の写真を図７に示す。
２．粒径は、１６メッシュ（目開き１０００μm）を通過し、１４０メッシュ（目開き１０６μm）にオンするものが全体の約８５％存在するものであった。
３．エタノール中に沈めた場合に、泡を抱いたものであった。実体顕微鏡により２００倍の倍率で観察した顆粒状造粒物の写真を図８に示す。
４．基準沈降時間が約５分であった。
５．水分約５質量％で、かさ比重約３．２ｇ／ｃｍ３のものであった。
A granular granulated product was obtained in the same manner as in Example 1 except that the collagen peptide powder was used.
The above granular granule had the following performance.
1. When observed with an electron microscope at a magnification of 200 times, it was a porous structure in which a large number of substantially circular holes were seen in the surface or cross-sectional structure, and it had a spherical shape or a broken shape. A photograph of the collagen peptide powder observed with the electron microscope is shown in FIG.
2. About 85% of the particle diameter passed through 16 mesh (aperture 1000 μm) and turned on to 140 mesh (aperture 106 μm).
3. When submerged in ethanol, it had foam. A photograph of the granular granule observed with a stereomicroscope at a magnification of 200 times is shown in FIG.
4). The standard settling time was about 5 minutes.
5. The water content was about 5% by mass and the bulk specific gravity was about 3.2 g / cm 3 .
６．得られた顆粒状造粒物５ｇを、コップに入れた水１００ｇに加えたところ、コップ中沈降時間が約５分間で、溶解時間が約２分であった（上記と同じ攪拌条件）。上記の造粒物は、実施例１のものに比べて明らかに水に対する沈降性及び溶解性がわるいものであった。また、造粒物を溶解後の水は白濁し、白濁は造粒物を加えてから２分程度経過しても完全に消えなかった。 6). When 5 g of the obtained granular granulated product was added to 100 g of water in a cup, the settling time in the cup was about 5 minutes and the dissolution time was about 2 minutes (the same stirring conditions as above). The above granulated product was clearly poor in sedimentation and solubility in water as compared with Example 1. Moreover, the water after dissolving the granulated product became cloudy, and the cloudiness did not completely disappear even after about 2 minutes had passed since the granulated product was added.
（参考例１）
実施例１で使用したコラーゲンペプチド粉末（原末）を、コップに入れた水１００ｇに加えたところ、コップ中沈降時間が約５分で、溶解時間が約1分４０秒であった（上記と同じ攪拌条件）。コラーゲンペプチド粉末は、水の透明性は保持されるものであったが、実施例１の顆粒状造粒物に比べて明らかに水に対する溶解性がわるいものであった。
(Reference Example 1)
When the collagen peptide powder (raw powder) used in Example 1 was added to 100 g of water in a cup, the settling time in the cup was about 5 minutes and the dissolution time was about 1 minute and 40 seconds (above and above). Same stirring conditions). Although the collagen peptide powder maintained water transparency, it was clearly poor in solubility in water as compared with the granular granulated product of Example 1.
本発明は、水や牛乳などの液体に溶解して飲料等にする形態、ゼリー等のように液体に溶解にしてゲル化させる形態のコラーゲンペプチドの顆粒状造粒物の製造技術として有用である。 INDUSTRIAL APPLICABILITY The present invention is useful as a technique for producing a granular granulated product of collagen peptide in a form in which it is dissolved in a liquid such as water or milk to form a beverage, or in a form in which it is dissolved in a liquid such as jelly and gelled. .
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008015251A JP4908434B2 (en) | 2008-01-25 | 2008-01-25 | Granular granule and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008015251A JP4908434B2 (en) | 2008-01-25 | 2008-01-25 | Granular granule and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009171903A JP2009171903A (en) | 2009-08-06 |
| JP4908434B2 true JP4908434B2 (en) | 2012-04-04 |
Family
ID=41027755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008015251A Active JP4908434B2 (en) | 2008-01-25 | 2008-01-25 | Granular granule and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4908434B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102014108502A1 (en) * | 2014-06-17 | 2015-12-17 | Gelita Ag | Composition in the form of compacted particles and their use |
| JP6688024B2 (en) * | 2015-08-26 | 2020-04-28 | 株式会社明治 | Composition containing collagen peptide and ceramide and method for producing the same |
| JP7376009B2 (en) * | 2017-09-26 | 2023-11-08 | キリンホールディングス株式会社 | Collagen-containing beverage and its manufacturing method |
| JPWO2021054454A1 (en) * | 2019-09-20 | 2021-03-25 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02289663A (en) * | 1990-04-27 | 1990-11-29 | Koei Kasei Kk | Gelatin powder having excellent water soluble property and production thereof |
| DE19632455C1 (en) * | 1996-08-12 | 1997-08-21 | Cpc Maizena Gmbh | Production of liquid protein hydrolysate |
| JP3881453B2 (en) * | 1998-05-14 | 2007-02-14 | 新田ゼラチン株式会社 | Calcium absorption promoter and method for producing the same |
| JP3958909B2 (en) * | 1999-12-28 | 2007-08-15 | 株式会社ニッピ | Cold water soluble granular gelatin |
| JP2005287506A (en) * | 2004-03-08 | 2005-10-20 | Fuji Oil Co Ltd | Powdery composition for protein-containing acid food and drink |
| JP4360986B2 (en) * | 2004-07-28 | 2009-11-11 | ポーラ化成工業株式会社 | Food composition |
| JP2007055919A (en) * | 2005-08-23 | 2007-03-08 | Suzuhiro Kamaboko Honten:Kk | Peptide derived from fish meat, method for producing the same, and food containing the peptide |
| JP4536665B2 (en) * | 2006-02-08 | 2010-09-01 | 森永乳業株式会社 | Method for producing casein hydrolyzate-containing granulated product |
-
2008
- 2008-01-25 JP JP2008015251A patent/JP4908434B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009171903A (en) | 2009-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4472699B2 (en) | Thickening composition with improved viscosity development | |
| CN103917092A (en) | Method for producing hydrogels | |
| JP3188657B2 (en) | Tablet or granular product | |
| KR101491393B1 (en) | Collagen powder and/or collagen-derived powder, and production method for same | |
| BR112014023611B1 (en) | BIOCOMPOSITE POWDER, METHOD OF PREPARATION OF A BIOCOMPOSITE POWDER AND USE OF SUCH BIOCOMPOSITE POWDER | |
| JP2007082415A (en) | Gelling agent | |
| JP4908434B2 (en) | Granular granule and method for producing the same | |
| EP1906764A1 (en) | Process and composition of preparing granular sucralose for emulating table sugar | |
| US20150004286A1 (en) | Method of instantizing amino acids | |
| JP2008104398A (en) | Low-temperature gelling gelatin | |
| JPWO2018174207A1 (en) | Method for producing thickening polysaccharide-containing preparation | |
| JP4568636B2 (en) | Chitosan-containing green leaf composition and beverage with improved floating and coagulation sedimentation | |
| TW201021715A (en) | A composition for beverage use containing acidic soluble protein and process for producing the same | |
| CN101775162B (en) | Chitosan inwrapped konjak composition, preparation process and application thereof | |
| WO2018070382A1 (en) | Konjac powder and production method therefor | |
| JP4494000B2 (en) | Medicinal capsule | |
| JP3737881B2 (en) | Chitosan composition and method for producing the same | |
| CN111511216A (en) | Protein hydrolysate and method of preparation | |
| JP6938238B2 (en) | Konjac powder and its manufacturing method | |
| JP3231276B2 (en) | Chitosan composition and method for producing the same | |
| JP4143312B2 (en) | Food composition and method for producing the same | |
| WO2009090950A1 (en) | Chitosan-containing compositions and process for production thereof | |
| JP7011300B2 (en) | HMBCa-containing granule manufacturing method and supplements | |
| KR100741531B1 (en) | The preparation method of carrier comprising polymer electrolyte complex | |
| JP5888845B2 (en) | Easy dispersible granular food |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20091221 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20110322 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110329 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120110 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120112 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150120 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4908434 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |