JP4864158B2 - Method for producing functional gel - Google Patents

Description

  The present invention relates to a method for producing a functional gel (jelly) containing fine bubbles inside.

  Patent Document 1 describes a method for producing an oily gel (W / O type emulsion) and a method for producing an aqueous gel (O / W type emulsion). As a method for producing an aqueous gel, hydrogenated water in which hydrogen gas is dissolved is prepared. And a step of dissolving a water-soluble polymer (gelator) in the hydrogenated water in the next step.

Patent Documents 2 to 4 propose gels in which bubbles of hydrogen gas are kneaded into a highly viscous solution.

Patent Document 5 describes a method of producing tofu for freeze-dried tofu by injecting air into soy milk in a high temperature state to contain bubbles, adding a gelling agent, and solidifying the mixture.

In Patent Document 6, hydrogen gas and oxygen gas are generated by electrolysis, and the generated hydrogen gas and oxygen gas are sent to a pressurized dissolution tank and pressurized in the pressurized dissolution tank to increase the solubility in water. After that, it is disclosed that fine bubbles in which hydrogen gas and oxygen gas are mixed are generated by supplying the pressure water to a low-pressure receiving tank and releasing the pressure.

JP 2007-314496 A Utility Model Registration No. 3139460 JP 2008-279424 A Utility Model Registration No. 3106002 JP 2001-000126 A JP 2010-115594 A

It is very difficult to control and use the gas in a liquid state (use it in a high-pressure state sealed in a tank).
Patent Document 1 does not positively leave uniform fine bubbles in the gel, as it is described that the gas mixed during the manufacturing process is finally removed from the gel. Moreover, the content disclosed by patent documents 2-4 kneads gas in the highly viscous solution, and a bubble becomes large and will be biased. In other words, it is difficult to control the bubbles.

  In Patent Document 5, bubbles are too large to form a large number of bubbles in a minute gel. In Patent Document 6, if water containing fine bubbles is made into small particles in order to use as a supplement, for example, the generated fine bubbles escape from the water (aqueous solution) in a short time.

  In order to solve the above-mentioned problem, the method for producing a functional gel according to the first aspect of the present invention is to provide hydrogen gas, oxygen gas, ozone, nitrogen gas, carbon dioxide gas, helium gas in a sealed container containing water or a low-viscosity solution. Then, a high-pressure gas consisting of chlorine gas or bromine gas is fed to make the gas phase region in the upper part of the sealed container a high-pressure atmosphere, and the concentration of the gas dissolved in water or a low-viscosity solution in the sealed container is increased, and then the dissolution Water or low-viscosity solution with increased gas concentration is sent to water or low-viscosity solution under normal pressure using the pressure in the gas phase region, and dissolved in water or low-viscosity solution under normal pressure. Fine gas is generated by the gas, and a gelling agent is added to the water or low-viscosity solution in which the fine bubbles are generated, thereby obtaining a gel holding the fine bubbles inside.

  The functional gel production method according to the second aspect of the present invention includes hydrogen gas, oxygen gas, ozone, nitrogen gas, carbon dioxide gas, helium gas, chlorine gas or the like in a sealed container containing water or a low-viscosity solution. Bring in bromine gas to make the gas phase region in the upper part of the sealed container a high-pressure atmosphere, and generate fine bubbles in the water or low-viscosity solution at the same time as or before or after the step of making this high-pressure atmosphere. The water or low-viscosity solution in which is generated is sent to the adjacent container with the pressure in the closed container, and the gelling agent previously charged in the adjacent container or the gelling agent to be charged later is used. The water or aqueous solution is gelled to keep fine bubbles inside.

In the first invention, by increasing the pressure, the solubility of the gas in water (aqueous solution) is increased. In the second invention, in addition to the pressure, ultrasonic waves and microtubes are used as means for generating fine bubbles in the sealed container. Etc.
In either case, by supplying gas from the bottom of the sealed container, the contact area between the gas and water (aqueous solution) increases and the dissolution rate increases.

  Gelation adjustment is performed by adding an amount of gelation modifier, heating, cooling, irradiation with electromagnetic waves including light, radiation or radio waves, irradiation with sound waves or ultrasonic waves, application of physical vibration or pressure, exposure to an electric field or magnetic field, It is possible to adjust the pH by applying a voltage.

The gas supplied to increase the pressure in the sealed container is preferably the same gas as the fine bubbles generated in the water or low-viscosity solution.

In the present invention, the low-viscosity solution is a solution containing an organic solvent (alcohol, ether, benzene, acetone, toluene, hexane, etc.) or a low-viscosity oil (saturated fatty acid, unsaturated fatty acid) in addition to an aqueous solution. Including.

The gel containing air bubbles has the following functions.
(1) Unless the gel melts, the gas separates from the solvent and is not easily released into the atmosphere. Moreover, when this foamed gel state is used, the gas can be transported and used in the same manner as a solid even at a room temperature where the gel does not melt.
(2) In order to keep the gas in a liquid state, it is necessary to maintain a cryogenic state. However, if the gas is gelled, it is easy to keep the gas at room temperature unless the gelled state melts.
(3) Sturdy and heavy tanks and equipment necessary for storing gas should be prepared in case the gas contained in the bubbles in the gel is toxic or ignitable. However, the maintenance of the present application is much easier than in the liquid or gaseous state.
(4) If the gas is toxic, if it is liquid or gaseous, it will be dispersed in the atmosphere at once if leaked, and it will be very dangerous for transportation, management, and working environment, but it is held in gel form In some cases, rapid dispersion into the atmosphere is unlikely to occur.
(5) As symbolized by the difficulty in controlling the engine of a space rocket that mixes and burns liquid oxygen and liquid hydrogen, when using gas at room temperature, it is vaporized from liquid or directly from the tank. It is very difficult to control the timing of release, and it is difficult to control a single liquid gas directly in a liquid state. However, if it is in the state of a bubble gel, it can be held at room temperature in the gel while adjusting the gas concentration and mixing ratio from the beginning, so that handling becomes much easier.
(6) The control when using the gas after directly mixing the gases becomes more difficult as the number of types increases. In particular, it is almost impossible to use a mixture of gases in the living body of animals and plants in a liquid or gaseous form. Trying to use a small amount of gas in a living body for a long time is difficult due to problems with the tank and the device. Furthermore, it is extremely difficult to use a plurality of gases in a small amount for a long time. However, if a bubble gel is used, a gel containing a single gas can be combined and temperature, moisture, and chemical changes can be used to supply a small amount in a living body for a long time. Alternatively, the type of gas generated can be changed in accordance with the elapsed time by forming a cylindrical layer like Baumkuchen.
(7) By placing the foam gel in the capsule (for example, enteric capsule), the foam gel can be delivered to a specific place. It is also possible to insert or apply the gel directly to the target site, melt the gel there, and supply gas.

According to the present invention, the following effects are exhibited in producing a gel that exhibits the functions (1) to (7) described above.
First, since bubbles are generated in water (aqueous solution) before gelation, it is possible to obtain a small and uniformly dispersed bubble, and the bubble content per unit volume of the gel can be adjusted.
In addition, since the container to be gelled is separated from the hermetically sealed container, for example, a large number of gelling containers are set on a turntable or a conveyor, and water (aqueous solution) containing bubbles is filled in one gelling container. A functional gel can be continuously produced by switching the piping for feeding water (aqueous solution) containing bubbles or high-pressure water to the next gelling vessel.
Furthermore, water (aqueous solution) is not exposed to air, and oxidation, alteration, or contamination can be reliably prevented, which is optimal when applied as a supplement manufacturing method.

The figure explaining the state which is supplying the high pressure gas to the airtight container among the manufacturing methods of the functional gel which concerns on 1st invention. The figure explaining the state melt | dissolved in the saturated state of the high pressure gas with the airtight container among the manufacturing methods of the functional gel which concerns on 1st invention. The figure explaining the state in which the fine bubble has generate | occur | produced within the container adjacent to a sealed container among the manufacturing methods of the functional gel which concerns on 1st invention. The figure explaining the state which has added the gelatinizer among the manufacturing methods of the functional gel which concerns on 1st invention. The figure explaining the manufacturing method of the functional gel which concerns on 2nd invention The figure explaining the manufacturing method of the functional gel which concerns on another Example

  An apparatus for carrying out the method for producing a functional gel according to the first invention includes a sealed container 1 for generating fine bubbles, and a high-pressure gas (hydrogen gas, oxygen gas, ozone, nitrogen gas, carbon dioxide gas, helium in the sealed container 1. Gas, chlorine gas or bromine gas), a pressure source 2 such as a cylinder, a pipe 3 with a valve for connecting the pressure source 2 and the sealed container 1, a container 4 for gelling, and a valve for connecting the sealed container 1 and the container 4 for gelling. An attached pipe 5 and an exhaust pipe 6 with a valve provided on the ceiling of the sealed container 1 are provided.

  In the first invention, first, the valve of the pipe 3 is opened, the valve of the pipe 5 is closed, and the valve of the exhaust pipe 6 is opened as shown in FIG. A predetermined high-pressure gas is fed into the bottom. Then, the predetermined high-pressure gas rises in the water (low viscosity solution) stored in the sealed container 1 in advance, expelling the gas in the gas phase region above the sealed container 1, It is filled with a predetermined gas.

  Next, the valve of the exhaust pipe 6 is closed as shown in FIG. Then, the gas phase region becomes high pressure. For example, if the inside of the cylinder is 50 MPa, the inside of the gas phase region is also 50 MPa. When the pressure in the gas phase region becomes high, the solubility of the gas also increases and a large amount of gas dissolves in water (low viscosity solution). Incidentally, since the gas goes up in the water (low viscosity solution), the contact area with water becomes larger than when the predetermined high pressure gas is fed from the ceiling of the sealed container 1 until the saturated concentration is reached. Is shortened.

Thereafter, as shown in FIG. 3, the valve of the pipe 5 is opened. Then, high-pressure water in which the predetermined gas is dissolved to a saturated concentration at high pressure in water (low-viscosity solution) filled in the container 4 in advance is supplied. The supplied high-pressure water is released in water in the container 4 and the dissolved gas is generated as fine bubbles.
When the pressure of the predetermined gas was 50 MPa, the number of fine bubbles generated in the container 4 was about 15 million / cc.

  Thereafter, as shown in FIG. 4, a gelling agent is added into the container 4 to gel water (low viscosity solution) containing fine bubbles.

As shown in FIG. 5, the apparatus for carrying out the method for producing a functional gel according to the second invention is similar to the first invention, in a sealed container 1 for generating fine bubbles, a container 4 for gelling, and these containers. 1 and 4, a valve-equipped pipe 5 for connecting the pipes 1 and 4 and a gas supply pipe 11 for pressurization connected to the upper plate of the sealed container 1 are provided.

An ultrasonic vibration plate 8 for generating fine bubbles connected to a high-frequency power source 7 is provided at the bottom of the sealed container 1, and a gas supply pipe that penetrates the ultrasonic vibration plate 8 and opens into the sealed container 1 from below. 9 is provided. In the case of the second aspect of the invention, the gas pressure supplied into the sealed container 1 is lower than that of the first aspect since the first purpose is not to increase the solubility.

The means for generating the fine bubbles is not limited to the ultrasonic vibration plate 8 but may be a perforated plate, a stirrer, a jet injection nozzle, an aspirator, or the like.

In order to produce a functional gel, first, water (aqueous solution) is filled in the sealed container 1. Then, gas is supplied from the gas supply pipe 9. At this time, only the gas is supplied without driving the ultrasonic vibration plate 8, and the ultrasonic vibration plate 8 is driven when the inside of the sealed container 1 reaches a predetermined pressure. Then, gas fine bubbles are generated. For example, since the diameter of these fine bubbles is nano-sized, the speed of rising in water is slow, and even if the ultrasonic vibration plate 6 is stopped, it remains in water for about 10 minutes.

After the fine bubbles are generated in the water (aqueous solution), the valve of the pipe 5 is opened, and the water (aqueous solution) containing the fine bubbles is sent to the gelling container 4 through the pipe 5 by the pressure in the sealed container 1. A gelling agent is added to water (aqueous solution) in the container 4.
Through the above steps, a functional gel in which fine bubbles are uniformly dispersed in the gel as a continuous phase is obtained.

As a gelling agent, almond gum, Elemi resin, danmar resin, gum arabic, karaya gum, tragacanth gum, arabinigalactan, gati gum, peach resin, amase gum, guar gum enzymatic degradation product, tamarind seed gum, cassia gum, silium seed gum, tara gum, Carob bean gum (locust bean gum), mackerel mugwort seed gum, triacan sos gum, guar gum, sesbania gum, alginic acid, fukuronori extract, fur celeran, carrageenan, aloe vera extract, yellow aloe extract, pectin, okra extract, troro aoi, aeromonas gum , Enterobacter gum, Natto fungus gum, Aureobasidium broth, Curdlan, Pullulan, Azotobacter vinelanzie gum, Xanthan gum, Macrohomopsis gum Welan gum, gellan gum, ramzan gum, erwinia mitsuen cis gum, sclero gum, levan, enterobacter shimanas gum, textlan, yeast cell membrane, chitin, oligoglucosamine, microfibrous cellulose, chitosan, microcrystalline cellulose, glucosamine, agar, soybean polysaccharide , Nata de coco, starch, konjac potato extract, gelatin, lectin and the like are used. Further, vitamins and minerals may be added in addition to the gelling agent in order to enhance functionality.

Moreover, the following are mentioned as gelling agents other than the above.
(1) Oil gelling agent for low molecular weight compounds
1,3: 2,4-Dibenzylidene-D-sorbitol, 12-hydroxystearic acid, N-lauroyl-L-glutamic acid-α, γ-bis-n-butyramide, spin-labeled steroid, cholesterol derivative, dialkylphosphoric acid Aluminum, phenolic cyclic oligomer, 2,3-bis-n-hexadecyloxyanthracene, cyclic depsipeptide, partially fluorinated alkane, cystine derivative, bis (2-ethylhexyl) sulfosuccinate sodium, triphenylamine derivative, butyrolactone derivative, 4 Quaternary ammonium salts, fluorinated alkylated oligomers, urea derivatives, vitamin H derivatives, gluconamides derivatives, cholic acid derivatives,
(2) Amino acid oil gelling agent
L-isoleucine derivative, L-valine derivative
(3) Cyclic dipeptide type oil gelling agent
Consists of 2,5-diketopiperazine derivatives, neutral amino acids (L-valine, L-leucine, L-phenylalanine) and acidic amino acids (L-glutamic acid-γ-ester, L-aspartic acid-β-ester) Cyclic dipeptide, cyclo (L-asp (OR) L-phe
(4) Oil gelator diamide of cyclohexanediamine derivative derivative (synthesized from trans 1,2-cyclohexanediamine)
Urea derivatives (synthesized from trans 1,2-cyclohexanediamine)
(5) Oil-gelling agent of double-headed amino acid derivative Double-headed L-isoleucine derivative, Double-headed L-valine derivative,
(6) Other oil gelling agents
1,3; 2,4-Dibenzylidene-D-sorbitol, N-lauroyl-L-glutamic acid-α, γ-bis-n-butyramide, benzoylgluconamide derivative, L-isoleucine derivative, L-valyl-L-valine Derivatives, diamide (synthesized from trans 1,2-cyclohexanediamine), diurea derivatives (synthesized from trans 1,2-cyclohexanediamine), double-headed amino acid derivatives, L-lysine derivatives, O- Methyl-4,6-benzylidene-D-galactose, 2,3-O-isopropylideneglyceraldehyde derivative.
(7) Hydrogelators of amino acid derivatives dibenzoyl-L-cystine, L-cystine derivatives, compounds obtained by crosslinking glutamic acid monoesters with diisothionate (dissolved only in phosphate buffer), L-leucine, L-valine, L -Double-headed amino acid derivatives cross-linked with phenyl glycine with oxalic acid, L-lysine-based organic gelling agent (positive or negative charge), ethanol compound with pyridine group, L-serine-based hydrogel Agent,
(8) Hydrogelator containing sugar
D-lactose derivatives, D-maltose derivatives, D-glucose derivatives, D-mannose derivatives, D-galactose derivatives, azobenzene compounds.
(9) Other hydrogelling agents, arpolol-type dendrimers, nucleotide-containing double-headed hydrogelators, bile acid derivatives, vancomycin, dendrimers with phosphorus in the center, lixarenne derivatives, double-headed surfactant hydrogels, naphthalenesulfonic acid Cationic glutamic acid compound having a deoxyuridine compound.
(10) Temperature-responsive high molecular weight polyethylene glycol / polypropylene glycol copolymer,
Polyethers (polyethylene oxide = PEO, poly (EO / PO) copolymer, PEO-PPO-PEO triblock surfactant, alkiel PEO surfactant, poly (vinyl methyl ether) = PVME, poly (oxyethylene vinyl ether) = POE VE), hydroxypropyl acrylate, cellulose derivatives (hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose), polyvinyl alcohol derivatives, poly (N-substituted acrylamide) derivatives (poly (N-substituted acrylamide), poly (N-vinylpyrrolidone) ), Poly (ethyl oxazoline), poly (N-vinylisobutyramide) = PNVIBA, poly (2-carboxyisopropylacrylamide) = PCIPAAm, poly (N-isopropylamide).

Hydrogen gel is considered to have a function of neutralizing active oxygen in the body as described above, but specific usage of oxygen gel, ozone gel, nitrogen gel, carbon dioxide gel, helium gel, chlorine gel, bromine gel State.

[Oxygen gel]
The amount of gas dissolved in water is extremely small, and in a normal usage method, a large amount of gas cannot be used except for gas stored in a tank under high pressure. Liquefied gas can be used for storage in a special environment, but it is rare in a normal environment.
Therefore, the gas is made into nano- or micro-bubbles in water, and a large amount of gas is fixed in the gel by introducing a gelling agent while slowly rising in water over about 10 minutes. can do.
Further, the oxygen concentration in the bubbles can be freely adjusted. Furthermore, it may be used as a mixed gas by adding another gas to oxygen.
When the gas is changed to oxygen, a large amount of oxygen in the form of nano or micro bubbles is present in the gel. If the gel material is water-soluble, oxygen can be generated by adding water. Further, by adding a hardly soluble or insoluble material, the gel can be gradually dissolved in water and oxygen can be gradually supplied.
This is referred to as “oxygen sustained release gel” (OTRG = Oxygen Time Releasing Gel).

OTRG practical example 1
In water tanks that carry fish, etc., it is necessary to use a motor pump or the like to constantly supply oxygen and continue to supply oxygen to the fish in the container. However, when the oxygen supply is stopped due to electrical or mechanical troubles, the business in containers such as water tanks is killed and difficult to save.
However, by supplying this OTRG into the container, it becomes possible to continue supplying oxygen for a certain period of time. In the unlikely event that an excessive amount of OTRG is added, under a pressure of 1 atmosphere, a certain amount of oxygen abnormality will not be dissolved, and it will escape to the outside of the container, so it will not be in an overoxygen state.

OTRG practical example 2
In general, for people whose blood oxygen saturation level has fallen due to illness, etc., use an oxygen mask or oxygen supply device to make the concentration higher than that of oxygen present in normal gas (20 → 30%). ) To supply oxygen into the body to increase saturation (saturation).
However, there is a drawback that the apparatus for supplying oxygen is bulky, from the apparatus that requires an oxygen cylinder to the apparatus that uses a permeable membrane.
Therefore, as an example, a mask-type small and simple oxygen supply device using OTRG can be created. If this mask is used, it will be a perfect oxygen supply method for those who go to high altitudes for emergency oxygen masks, mountain climbing, traveling, etc. installed in the aircraft.

OTRG practical example 3
This OTRG can be used as a supplement. Currently, "oxygen water", which is said to contain more dissolved oxygen than normal water, is manufactured and sold all over the world.
Ordinary water has dissolved oxygen of about 3 to 5 mg / liter depending on the temperature, but according to the manufacturer, “oxygen water” is said to have a dissolved oxygen amount of about 10 to 40 times.
By ingesting a large amount of oxygen-containing water, oxygen is supplied to the body, and the following effects are expected.
(1) It can activate brain cells, improve learning ability, and get sleepy.
(2) Immunostimulation (3) Decompose fatigue substance "lactic acid" generated by exercise and promote fatigue recovery (4) Promote lipolysis and expect a diet effect (5) As seen in oxygen therapy It stimulates skin cells and activates skin metabolism.
However, after drinking, the amount of dissolved oxygen decreases as the temperature rises in the body after drinking, so most oxygen is vaporized in the stomach, so the oxygen amount reaches the intestines or blood. Is extremely small.
Therefore, it is difficult to measure the efficacy of “oxygen water”, and there are an overwhelming number of medical professionals who question the effectiveness.
On the other hand, OTRG dissolves in the stomach and generates oxygen when ingested as it is, but if you add an enteric substance to make a gel or drink it in an enteric capsule, OTRG is oxygen in the stomach. The oxygen supply to the body is overwhelmingly increased compared to “oxygen water” because oxygen can be easily supplied only by the intestine without generating any oxygen.
In addition, OTRG containing nano- or micro-bubble oxygen makes it very easy to set the oxygen content per unit volume to several times that of “oxygen water”.
OTRG can continue to generate oxygen in the intestine for a long time. It has been found that inhaling 500 ml of air in a single breath takes about 100 ml of oxygen into the body.
Therefore, there are many papers that generally reject the supply of oxygen water to improve athletic performance.
However, it can be expected to play a role in supplementing body oxygen in sports such as athletics and swimming, especially in short-distance sports performed with apnea.
Although it is impossible to drink a large amount of oxygen-containing water immediately before the start, it is extremely easy to replenish oxygen in the body with a combination of an oxygen gel and an enteric capsule.

OTRG practical example 4
This gel can be applied to the surface of animals and plants and internal tissues or inserted.
For example, wounds (including wounds, stab wounds, wounds, split wounds, bruises, tears, gun wounds, explosion wounds, bite wounds, bruises, bruises) or surfaces such as palate, vagina, etc. Anaerobic bacteria, molds, and fungi grow in areas not exposed to oxygen, causing disease.
Therefore, by applying and attaching this OTRG to a part not exposed to the atmosphere, or inserting it in the form of a capsule, a tablet, etc., it will continue to supply oxygen for a long time and kill anaerobic microorganisms. Or weaken it.
In addition, pharmaceutical ingredients such as antibiotics, medicinal ingredients such as quasi-drugs, cosmetics, and animal and plant extract substances may be mixed with the gel.
According to medical data, it is known that wounds are healed faster when exposed to atmospheric oxygen than by suturing and blocking oxygen.
This is thought to be due to the rapid regeneration of capillaries due to the presence of oxygen. Therefore, hyperbaric oxygen therapy is utilized.
However, hyperbaric oxygen therapy is effective for the treatment of wounds, etc., but it is difficult to reduce the size due to the large equipment such as the tank, and it is difficult to manage because it uses high-pressure oxygen. On the other hand, carrying is almost impossible and the convenience is greatly inferior. Thus, it is expected that capillary regeneration can be promoted by applying or injecting OTRG to wounds, particularly those that do not come into contact with the atmosphere.
At this time, the oxygen concentration in the bubbles contained in the gel can be adjusted, or a mixed gas in which oxygen and other gases are combined can also be used.
Furthermore, a gel for connective tissue regeneration such as hyaluronic acid, collagen, elastin, and placenta extract can be used in combination as a gel component.

OTRG practical example 5
Combining oxygen gel with combustibles can be used as a combustion accelerator.
It can also be used as an “oxidation promoting material” that uses the action of “oxidizing” the target.

OTRG practical example 6
When scuba diving, humans cannot stay in the water for a long time without using oxygen cylinders.
However, normally, an atmosphere of up to about 200 atm is compressed and packed in the cylinder, but the oxygen is generally consumed in 1 to 1.5 hours depending on the depth of the dive. You have to get out of the water.
However, in the cylinder or in an adjacent place, the oxygen gel is melted by temperature, water-solubilized, or chemically changed and melted to take out oxygen in the form of bubbles and replenish the oxygen by adding it to the air in the tank. It is possible to dramatically extend the staying time in the water.

OTRG practical example 7
Combined with hydrogen gel, it plays the role of fuel cell as “hydrogen fuel”.
For example, when gelled with extremely high viscosity in a state filled with hydrogen or oxygen micro or nano bubbles in an environment of several atmospheres or tens of atmospheres instead of 1 atm, the amount of hydrogen or oxygen contained is reduced. Can be increased.

[Ozone gel]
Gels containing fine ozone bubbles are considered effective for inactivating norovirus and the like. That is, the bactericidal action works by free radicals generated when the ozone gel melts and ozone is released and decomposed into oxygen. In this case, even if the ozone concentration is low, ozone bubbles are negatively charged. On the other hand, since many viruses are positively charged, they are attracted to the ozone bubbles and sterilized.

[Nitrogen gel]
Recently, nitric oxide (NO) has attracted attention. From vasodilatory action to drugs for circulatory diseases, ED therapy Body builders are also using this NO to build muscle.
(1) Drinking a sustained-release gel or capsule containing a large amount of nitric oxide nano and micro bubbles helps to strengthen muscles and eliminate ED.
(2) Macrophages around cancer cells produce NO, paralyze the mitochondrial function of cancer cells, and interfere with DNA synthesis to drive death.
(3) When insulin is administered for the treatment of diabetes, there is a drawback of reducing NO.
(4) NO has the role of signal transmission in the brain.
(5) By using nitrogen gel for containers, building materials, etc., the gel dissolves when the temperature rises, and it can have fire resistance.
(6) Nitrogen gel can be used as an antioxidant.
Therefore, combination of nitrogen gel or enteric capsules to achieve sustained release is useful in the fields of sports and medicine as described in (1) to (4) above. In some cases, the nitrogen gel is directly injected or applied to a necessary site in animals or plants (for example, around a cancer tissue or an organ), so that the medical (1) to (4) and (6) Expected utility.

[CO2 gel]
(1) Used as cosmetics to promote blood circulation and skin activation.
(2) If you put it in drinking water as it is, you can easily make carbonated drinks. In addition, the carbonic acid once lost can be replenished to restore the flavor of carbonated beverages and sparkling wine.
(3) A large amount of carbon dioxide gel functions as a fire prevention when high heat is generated and as a fire extinguishing agent when a fire occurs. For example, a sheet coated with carbon dioxide gel is covered with a large amount in the event of a fire in a home kitchen, so that not only oxygen is blocked, but carbon dioxide is also generated, so that it can be extinguished efficiently.
(4) Carbon dioxide is known as a “respiratory stimulant” and is also used to treat hyperventilation syndrome. Therefore, the carbon dioxide gel can be effectively used not only for hyperventilation syndrome but also for people who need respiratory stimulants.
(5) It is known that when oxygen is sucked by an oxygen cylinder used for scuba diving and medical use, it is more effective to mix 5 to 10% of carbon dioxide than oxygen alone. Therefore, a mixed gas can be easily produced by putting carbon dioxide gel in an oxygen cylinder.
(6) “Dry ice” made of carbon dioxide is used as a preservative for the remains of humans and animals. However, since it is close to minus 80 ° C, there is a risk of frostbite when touched directly, making it difficult to handle. Furthermore, when dry ice sublimates and directly becomes a gas, it swells 750 times, so there is a risk that containers such as plastic bottles may burst.
In addition, since the amount of carbon dioxide generated during sublimation is large, the concentration in the atmosphere may reach 10 to 50%, which may cause carbon dioxide poisoning.
It can be used as a preservative easily and safely anytime and anywhere by applying carbon dioxide gel directly to the body or enclosing and sealing it.
(7) When storing industrial products and parts in a sealed container or room, using a sufficient amount of carbon dioxide gel immediately before sealing, sealing and rust prevention effects can be obtained safely at low cost.
(8) The phenomenon of “carbon dioxide starvation”, which causes the growth of plants to stop due to the lack of carbon dioxide, which is essential for photosynthesis in plants, during the cultivation of large quantities of plants in greenhouses and in greenhouses in winter.
As a countermeasure, in order to replenish carbon dioxide, it is necessary to apply carbon dioxide, but there is a method to generate carbon dioxide by burning propane gas, but it is very difficult considering the cost, danger, and replenishment amount It was a problem.
Therefore, carbon dioxide gel can be gradually generated and replenished by installing, applying, or spraying the carbon dioxide gel in a greenhouse or directly on a plant, so that “carbon dioxide starvation” can be avoided. Furthermore, when carbon dioxide gel is used, it is a great advantage that it is inexpensive and safe.
(9) Carbon dioxide is essential for “photosynthesis” of plants. Therefore, while the plant is performing “photosynthesis”, carbon dioxide gel is applied or sprayed onto the branches and leaves of the plant to create an environment in which carbon dioxide is continuously generated around the plant, thereby promoting photosynthesis. Forcing cultivation. For carbon dioxide fertilization, an aqueous solution or solid of an alkali metal or alkaline earth metal that absorbs carbon dioxide is often used. However, after releasing carbon dioxide, a compound of an alkali metal or alkaline earth metal remains. is there. However, when carbon dioxide gel is used, no harmful components remain after the gel melt carbon dioxide release.

[Helium gel]
(1) Helium also enters micropores. Therefore, it is also used for nondestructive inspection methods.
Helium gas is injected into the pipe and detected with a helium detector, but when helium gas is used, only a part of the site can be detected in an extremely short time. However, if helium gel is used, helium can be generated over a wider range, which greatly improves the detection efficiency.
(2) As one of the party goods, helium gas is used to modify the voice (Donald Duck effect).
This occurs because the speed of sound is approximately tripled in helium. Normally, a gas mixture of 80% helium + 20% oxygen is used in a cylinder, but when helium gel is used, it is possible to easily modify the voice by simply applying or spraying the gel to the nostrils. .

[Chlorine gel, bromine gel]
Although it can be used as a strong oxidizing agent, it can be generated for a long time by making it into a gel.

  FIG. 6 is a diagram for explaining a method for producing a functional gel according to another embodiment. In this embodiment, a gelling agent is put in the container 4 in advance, and the container 4 in this state is placed in this state. Water (aqueous solution) in which fine bubbles are generated is supplied through the pipe 5.

The functional gel according to the present invention can be used in various fields such as antioxidant foods, cosmetics, pharmaceuticals.
For example, combustible gas and explosive gas use a combustion promoting action.
In addition to inducing repellent behavior of animals and plants, toxic gases are used to control animals and plants such as insecticide, sterilization, and hay.
Non-flammable or inert gas is used for fire fighting, fire prevention, and non-flammable action.
The water-soluble gas and the water-insoluble gas can be selected from gel materials, coating agents, and excipient materials in order to stably maintain the state of being taken into the gel in the form of bubbles.
In the case of containing heat-absorbing gas bubbles, as a heat-absorbing gel, and in the case of non-endothermic gas, as a gel for heat insulation, heat insulation, and cold insulation, "clothing""shoes""bedding""sportsequipment""architecture" It can be used for materials, daily necessities, and machinery.
Nitrogen and carbon dioxide gas can also be used for plant growth.
For the promotion, suppression and control of chemical reactions including combustion, explosion, heat absorption, heat dissipation, etc., foam gel is added.
All the foam gels can be used in various fields such as pharmaceuticals, cosmetics, building materials, chemical reaction promotion, catalysis and control agents, depending on the type of gas contained.

DESCRIPTION OF SYMBOLS 1 ... Sealed container, 2 ... Pressure air source, 3 ... Piping, 4 ... Container to gelatinize, 5 ... Piping, 6 ... Exhaust pipe, 7 ... High frequency power supply 8 ... Ultrasonic vibration Plate, 9 ... Piping, 11 ... Gas supply piping for pressurization.

Claims (3)

A high-pressure gas composed of hydrogen gas, oxygen gas, ozone, nitrogen gas, carbon dioxide gas, helium gas, chlorine gas or bromine gas is fed into a sealed container containing water or a low-viscosity solution to The gas phase region is set to a high-pressure atmosphere, the concentration of the gas dissolved in water or a low-viscosity solution in a sealed container is increased, and then the water or low-viscosity solution in which the concentration of the dissolved gas is increased is changed to the pressure in the gas phase region. Is used to feed water under normal pressure or a low-viscosity solution, and fine bubbles are generated by the gas dissolved in water or low-viscosity solution under normal pressure. Alternatively, a method for producing a functional gel, characterized in that a gelling agent is added to a low-viscosity solution to form a gel that retains fine bubbles therein. Hydrogen gas, oxygen gas, ozone, nitrogen gas, carbon dioxide gas, helium gas, chlorine gas or bromine gas is fed into a sealed container containing water or a low-viscosity solution, and the gas phase region in the upper part of the sealed container is A fine bubble is generated in the water or the low-viscosity solution at the same time or before and after the step of setting the high-pressure atmosphere, and the water or the low-viscosity solution in which the fine bubbles are generated is added to the sealed container. The water or aqueous solution is gelled by the gelling agent that is fed into the adjacent container with the internal pressure and gelled in the adjacent container in advance or the gelling agent that is charged later to keep the fine bubbles inside. A method for producing a functional gel, comprising: 3. The method for producing a functional gel according to claim 1, wherein the gas is supplied from a bottom portion of the sealed container.

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