JP2012050898A - Method for producing functional gel - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a functional gel which contains a large quantity of gas inside of the gel.SOLUTION: Water or a solution of low viscosity is poured into a container 1, and a gas is poured into the water or the solution of low viscosity to produce bubbles 5. After some microbubbles 5a in the produced bubbles 5 are broken by a liquid pressure to disappear without reaching the water surface, a gelling agent is added to the water or the solution of low viscosity to generate gelled water or solution of low viscosity.

Description

  The present invention relates to a method for producing a functional gel (jelly) from water or a low viscosity solution.

Patent Document 1 describes a method for producing an oily gel (W / O emulsion) and a method for producing an aqueous gel (O / W emulsion). As a method for producing an aqueous gel, hydrogenated water in which hydrogen gas is dissolved is prepared. And a step of dissolving a water-soluble polymer (gelator) in the hydrogenated water in the next step.

Patent Document 2 describes a method for producing freeze-dried tofu for tofu by injecting air into soymilk 7 in a high temperature state to contain bubbles, adding a gelling agent, and solidifying the mixture.

In Patent Document 3, fine bubbles of hydrogen gas are generated in water contained in a container, and water in this state is fed into another adjacent container via a tubular pump, while the fine bubbles remain in the water. It is described that a gelling agent is added to gel the water to keep the fine bubbles of hydrogen gas inside.

Patent Document 4 describes that bubbles generated in water exhibit completely different behavior depending on the particle size.
That is, as shown in FIG. 3, fine bubbles having a particle size of about 50 μm gradually become smaller in water and eventually disappear. The mechanism of this disappearance is that the surface tension at the interface (gas-liquid interface) between the surface of the fine bubble and the liquid surrounding the bubble becomes larger as the particle size becomes smaller, so the bubble becomes smaller. When the bubbles become smaller, the pressure inside the bubbles becomes high, the solubility of the gas increases, and the gas in the bubbles dissolves in the surrounding water (solvent). Due to this dissolution, the bubbles become smaller and the pressure inside the bubbles becomes higher. It is said that by repeating this, the bubbles will eventually be crushed. It is said that the pressure when crushing is over 1000 atmospheres

JP 2007-314496 A JP 2001-000126 A Japanese Patent No. 4450863 Japanese Patent No. 4378543 Japanese Patent No. 4144669 Japanese Patent No. 4080440 Japanese Patent No. 4059506 JP 2009-039600 A JP 2009-084258 A JP 2009-131769 A JP 2009-131770 A

  As disclosed in Patent Documents 1 to 3, it is conceivable that there is an unprecedented method of use as a supplement or as a means for transporting (carrying) a gas by holding the gas in the gel.

  However, even if the gas is held in the gel, the amount of gas that can be held is the sum of the gas dissolved in the water (aqueous solution) before the gel and the gas dispersed in the gel as bubbles. . The maximum amount of gas dissolved in water (aqueous solution) is defined by the saturation concentration, and no more gas can be retained.

On the other hand, Patent Documents 4 to 11 describe a mechanism for crushing fine bubbles, and there is a description that gas temporarily stays in the solution after crushing, but there is no suggestion about means for holding them. .

  In order to solve the above-mentioned problems, the present invention puts water or a low-viscosity solution in a container, sends gas into the water or low-viscosity solution to generate bubbles, and one of the fine bubbles among the generated bubbles. Waiting for the part to reach the water surface and crushing and disappearing due to hydraulic pressure, a gelling agent was added to the water or low viscosity solution to gel the water or low viscosity solution .

  Here, the low-viscosity solution in the present invention refers to a viscosity that allows bubbles to rise in the solution by buoyancy without stopping inside. Viscosity that does not raise the generated bubbles does not make a gel and is not included in the low-viscosity solution of the present invention. Specifically, the low-viscosity solution is a solution that uses an organic solvent (alcohol, ether, benzene, acetone, toluene, hexane, etc.) or low-viscosity oils (saturated fatty acids, unsaturated fatty acids) in addition to aqueous solutions. including. The water in the present invention includes ionized water.

  In addition, the particle size of the first generated bubbles is larger than the particle size that disappears by crushing (about 50 μm). Originally, the diameter of bubbles formed by a high-frequency diaphragm or the like is larger than 50 μm, and it is difficult to directly create bubbles having a smaller particle diameter, and the bubble crushing mechanism is small from bubbles having a larger particle diameter. Bubbles break up, and the bubbles with this small particle size become smaller and crush and disappear. That is, the crushing of the bubbles does not occur from the time when the bubbles are generated, but is a phenomenon that occurs after a certain amount of time has passed. Further, as disclosed in Patent Documents 4 to 11, it is also known that more gas is crushed and included by repeatedly bubbling the same solution without using physical force such as electricity or ultrasonic waves. .

  Therefore, the timing for adding the gelling agent is not possible from the beginning of the generation of bubbles, but after at least some of the fine bubbles are crushed. For example, if a particle counter in liquid is used, it is possible to easily know the change in the diameter of fine bubbles in the solution, the content thereof, and the like, and the gelling agent can be added at the targeted timing.

  In addition, the container for generating bubbles and the container for gelling may be the same or separated. In the case of separation, water or a low-viscosity solution in which bubbles are generated is sent to a container to be gelled using a pressure or pump such as a tubular pump.

  In the present invention, if the microscopic view of the bubbles in the solution before adding the gelling agent and the vicinity of the gas-liquid interface of the liquid surrounding it, the pressure in the bubbles and the gas in the liquid near the gas-liquid interface Dissolved amount is in equilibrium and not supersaturated, but when viewed macroscopically, that is, when compared to a saturated liquid of the same volume with no microbubbles generated, the amount of dissolved gas is clearly Since it is increasing, it can be regarded as supersaturated.

In general, the gel has a function as described below by containing gas, and according to the present invention, the gas content per unit volume can be increased, so that the following effects can be further enhanced.
(1) Unless the gel melts, the gas separates from the solvent and is not released into the atmosphere. Moreover, when it is in the state of the gel of the present application, the gas can be transported and used in the same manner as a solid even at a room temperature where the gel does not melt.
(2) In order to keep the gas in a liquid state, it is necessary to maintain a cryogenic state. However, if the gel is formed, the gas can be held at room temperature as long as the gelled state does not melt.
(3) Sturdy and heavy tanks and equipment necessary for storing gas should be prepared in case the gas contained in the gel is toxic or ignitable. The maintenance of the present application is much easier than in the liquid or gaseous state.
(4) If the gas is toxic, if it is liquid or gaseous, it will be dispersed in the atmosphere at once if leaked, and it will be very dangerous for transportation, management and working environment, but it is kept in a gel form In some cases, rapid dispersion into the atmosphere is unlikely to occur.
(5) As symbolized by the difficulty in controlling the engine of a space rocket that mixes and burns liquid oxygen and liquid hydrogen, when using gas at room temperature, it is vaporized from liquid or directly from the tank. It is very difficult to control the timing of release, and it is difficult to control a single liquid gas directly in a liquid state. However, if it is in the state of the gel of the present application, it can be kept in the gel at room temperature while adjusting the gas concentration and the mixing ratio from the beginning, so that it is much easier to use and handle.
(6) The control when using the gas after directly mixing the gases becomes more difficult as the number of types increases. In particular, it is almost impossible to use a mixture of gases in the living body of animals and plants in a liquid or gaseous form. Trying to use a small amount of gas in a living body for a long time is difficult due to problems with the tank and the device. Furthermore, it is extremely difficult to use a plurality of gases in a small amount for a long time. However, if the gel of the present application is used, a gel containing a single gas is combined and temperature, moisture, and chemical changes can be used to supply a small amount in a living body for a long time. Alternatively, the type of gas generated can be changed in accordance with the elapsed time by forming a cylindrical layer like Baumkuchen.
(7) By placing the gel of the present application in a capsule (for example, a microcapsule or an enteric capsule), it becomes possible to deliver the bubble gel to a specific place. It is also possible to insert or apply the gel directly to the target site or place, melt the gel there, and supply the gas.
(8) As described in all of Patent Documents 4 to 11, gas exists in the solution for a certain period of time, but conversely, it exists for a long period of time so that it can be used in general. It is said that it is very difficult to keep doing it. Even if it is stored in the capsule, if it remains in a liquid state, it is easily affected by the material of the capsule, and it is difficult to keep the gas in the solution. In this case, due to the change in the pH of the body fluid and the presence of minerals and organic substances, the gas present in the solution is quickly washed away from the target site, so that it is difficult to bring out the purpose of anticancer action. However, if a gas is held in the gel, it can be released depending on the material and the melting method, and can be supplied to the target location for a long time.

(A)-(c) is the figure explaining the manufacturing method of the functional gel which concerns on this invention to process order The figure explaining the manufacturing method of the functional gel which concerns on another Example Diagram explaining the process of crushing microbubbles

As shown in FIG. 1 (a), the functional gel manufacturing apparatus is provided with an ultrasonic diaphragm 3 connected to a high frequency power source 2 at the bottom of a container 1 for generating bubbles. A gas supply pipe 4 that penetrates and opens into the container 1 from below is provided. The means for generating bubbles is not limited to the ultrasonic vibration plate 3, and may be a perforated plate, a stirrer, a jet injection nozzle, an aspirator, or the like.

In order to produce a functional gel, first, the container 1 is filled with water (aqueous solution). Then, the ultrasonic vibration plate 3 is driven while supplying gas from the gas supply pipe 4 to generate bubbles 5.

The generated bubbles 5 rise as they are, and further, fine bubbles 5a having a particle size of about 50 μm are separated from the bubbles 5. The fine bubbles 5a have a very slow rising speed. Therefore, as shown in FIG.1 (b), after stopping supply of gas, even if the big bubble 5 scatters from the water surface, it remains in water.

Further, the fine bubbles 5a are gradually reduced by the surface tension and dissolution in water, and finally collapse and disappear as shown in FIG. 1 (c). In the present invention, the gelling agent is added when all or part of the fine bubbles 5a disappear.
The gel which hold | maintains gas in a substantially supersaturated state by the above process is obtained.

In addition, before and after bubbling, after the gelation process or after gelation, only to keep fine bubbles or crushed gas in the solution (1) Addition of gelling modifier (2) Heating,
(3) Cooling (4) Irradiation of electromagnetic waves including light, radiation and radio waves (5) Sound wave, ultrasonic wave irradiation (6) Physical vibration, applying pressure (7) Exposure to electric and magnetic fields (8) Applying voltage (9) Adjust pH (including organic and mineral additions)
The amount of retained gas in the gas and the gelation state can be adjusted by the above.
By the way, if it becomes a fine bubble, buoyancy will become small even if it does not crush. In addition, the surface of the bubble is often charged or has chemical characteristics. Therefore, utilizing the chemical, electrical, magnetic, or electromagnetic force for the crushed gas or the fine bubbles with reduced buoyancy by using the above methods (1) to (9) or a combination thereof. As a result, more gas can be stably retained in the water or the solution. (Includes adjustment of solution pH, reduction potential, etc.)
Furthermore, the supersaturated state can be maintained more stably over a long period of time by adjusting the pH with a gelling agent to be added. That is, it becomes possible to gel and store for a long time while keeping more gas in the solution.

Here, the gas supplied from the gas supply pipe 4 is not particularly limited, and the following (A) to (E), or a mixture of these may be considered.
(B) Combustible gas, toxic gas, (b) Explosive gas, (c) Non-combustible gas, (d) Water-soluble gas, (e) Water-insoluble gas

Gases classified as (a) include methane, propane, n-butane, i-butane, n-pentane, ethylene, propylene, butylene, acetylene, toluene, Oxylene, methanol, ethanol, acetone, methyl ethyl ketone, ethyl acetate, butyl acetate. , City gas (methane standard), LPG (isobutane standard), gasoline, kerosene, n-hexane, butadiene, acetaldehyde, vinyl chloride, carbon monoxide, ammonia, hydrogen sulfide, chlorine, sulfur dioxide, benzene, acrylonitrile, methyl bromide , Ethylene oxide, hydrogen cyanide, phosgene, hydrogen chloride, arsine, phosphine, silane, diborane, germane, dichlorocyanide, hydrogen selenide, fluorine, nitrogen dioxide, chlorine trifluoride, hydrogen fluoride, hydrogen bromide, ozone, etc. It is done.

Gases classified as (b) include ignition grades G1 to G5, explosion grades 1 to 3, acetone, ammonia, carbon monoxide, ethane, acetic acid, ethyl acetate, toluene, propane, benzene, methanol, methane, coal Gas, water gas, hydrogen, ethanol, isopentyl acetate, 1 butanol, butane, acetic anhydride, ethylene, ethylene oxide, acetylene, gasoline, hexane, acetaldehyde, ethyl ether, carbon disulfide, etc. ) According to international regulations, temperature grades are T1-T5, group IIA-IIC, acetone, ammonia, carbon monoxide, ethyl acetate, toluene, propane, benzene, methanol, methane, LP gas, ethane, acetic acid, City gas, hydrogen, ethanol, i-butane, 1-butanol, iso-acetate Examples include ventil, acetic anhydride, ethylene, ethylene oxide, acetylene, gasoline, n-hexane, acetaldehyde, ethyl ether, carbon disulfide, and the like.

In the PF, the gases classified as (c) are collectively referred to as “special gas” in addition to “special material gas” stipulated by laws and regulations, as well as “toxic gas” and “combustible gas”.
The special material gas is a gas which is used for semiconductor manufacturing and is considered to be a highly reactive and dangerous gas, and refers to the following 39 types.
Silane system: Monosilane (SiH4), Disilane (Si2H6), Dichlorosilane (SiH2Cl2), Trichlorosilane (SiHCl3), Silicon Tetrachloride (SiCl4), Silicon Tetrafluoride (SiF4),
Arsenic: Arsine (AsH3), Arsenic trifluoride (AsF3), Arsenic pentafluoride (AsF5), Arsenic trichloride (AsCl3), Arsenic pentachloride (AsCl5),
Phosphorus: Phosphine (PH3), Phosphorus trifluoride (PF3), Phosphorus pentafluoride (PF5), Phosphorus trichloride (PCl3), Phosphorus pentachloride (PCl5), Phosphorus oxychloride (POCl3),
Boron-based: diborane (B2H6), boron trifluoride (BF3), boron trichloride (BCl3), boron tribromide (BBr3),
Metal hydride; hydrogen selenide (H2Se), monogermane (GeH4), hydrogen telluride (H2Te), stibine (SbH3), tin hydride (SnH4),
Halides: nitrogen trifluoride (NF3), sulfur tetrafluoride (SF4), tungsten hexafluoride (WF6), molybdenum hexafluoride (MoF6), germanium tetrachloride (GeCl4), tin tetrachloride (SnCl4), five Antimony chloride (SbCl5), tungsten hexachloride (WCl6), molybdenum pentachloride (MoCl5),
Metal alkylates: trialkylgallium (Ga (CH3) 3, Ga (C2H5) 3, etc.), trialkylindium (In (CH3) 3, In (C2H5) 3, etc.)
Seven types of monosilane (SiH4), disilane (Si2H6), arsine (AsH3), phosphine (PH3), diborane (B2H6), hydrogen selenide (H2Se), and monogermane (GeH4) are in a high pressure state (1 MPa [~ [10 atmospheres] or more) is prohibited (referred to as “special high pressure gas”). Arsenic, Phosphine (PH3), Phosphorus trifluoride (PF3), Phosphorus trichloride (PCl3), Phosphorus pentachloride (PCl5), Phosphorus oxychloride (POCl3), Diborane (B2H6), Boron trifluoride (BF3), Some are designated as poisonous or deleterious substances such as boron trichloride (BCl3), hydrogen selenide (H2Se), sulfur tetrafluoride (SF4), and so on.
Toxic gases are harmful gases that have an allowable concentration of 200 ppm or less, including those in the table below. Acrylonitrile (C2H3CN), sulfurous acid gas (SO2), ammonia (NH3), carbon monoxide (CO), hydrogen chloride (HCl), chlorine (Cl2), chloromethyl (CH3Cl), hydrogen cyanide (HCN), carbon disulfide (CS2) , Fluorine (F2), bromomethyl (CH3Br), benzene (C6H6), phosgene (COCl2), hydrogen sulfide (H2S)
These represent only a few substances. In addition, hydrogen cyanide (HCN) is designated as a poisonous substance, acrylonitrile (C2H3CN), ammonia (NH3), hydrogen chloride (HCl), chlorine (Cl2), carbon disulfide (CS2), bromomethyl (CH3Br), etc. .
The combustible gas means that the lower limit of the explosion limit when mixed with air is 10% or less and the difference between the upper limit and the lower limit of the explosion limit is 20% or more, and includes the following.
Acrylonitrile (C2H3CN), acetylene (C2H2), ammonia (NH3), carbon monoxide (CO), ethylene (C2H4), chloromethyl (CH3Cl), hydrogen cyanide (HCN), cyclopropane (C3H6), hydrogen (H2), disulfide Carbon (CS2), butadiene (C4H6), butane (C4H10), propane (C3H8), propylene (C3H6), bromomethyl (CH3Br), benzene (C6H6), methane (CH4), methyl ether ((CH3) 2O), sulfide Hydrogen (H2S).
Ammonia (NH3), carbon disulfide (CS2), bromomethyl (CH3Br), etc. are designated as deleterious substances.

Gases classified as (d) include oxygen, nitrogen, argon, methane, hydrogen, acetylene, hydrogen chloride, carbon dioxide, nitrogen monoxide (NO), nitrous oxide (NO) as commonly used gases. Dinitrogen = N2O) and various high-pressure gases (hydrogen sulfide, LP gas, propane, ammonia, chlorine, sulfurous acid gas, butane, hydrogen cyanide, ethylene oxide).

Examples of the gas classified as (e) include those (bromine) displayed in the periodic table in addition to the above gas group.

As a gelling agent, almond gum, Elemi resin, danmar resin, gum arabic, karaya gum, tragacanth gum, arabinigalactan, gati gum, peach resin, amase gum, guar gum enzymatic degradation product, tamarind seed gum, cassia gum, silium seed gum, tara gum, Carob bean gum (locust bean gum), mackerel mugwort seed gum, triacan sos gum, guar gum, sesbania gum, alginic acid, fukuronori extract, fur celeran, carrageenan, aloe vera extract, yellow aloe extract, pectin, okra extract, troro aoi, aeromonas gum , Enterobacter gum, Natto fungus gum, Aureobasidium broth, Curdlan, Pullulan, Azotobacter vinelanzie gum, Xanthan gum, Macrohomopsis gum Welan gum, gellan gum, ramzan gum, erwinia mitsuen cis gum, sclero gum, levan, enterobacter shimanas gum, textlan, yeast cell membrane, chitin, oligoglucosamine, microfibrous cellulose, chitosan, microcrystalline cellulose, glucosamine, agar, soybean polysaccharide , Nata de coco, starch, konjac potato extract, gelatin, lectin and the like are used. Further, vitamins and minerals may be added in addition to the gelling agent in order to enhance functionality.

Moreover, the following are mentioned as gelling agents other than the above.
(1) Oil gelling agent for low molecular weight compounds
1,3: 2,4-Dibenzylidene-D-sorbitol, 12-hydroxystearic acid, N-lauroyl-L-glutamic acid-α, γ-bis-n-butyramide, spin-labeled steroid, cholesterol derivative, dialkylphosphoric acid Aluminum, phenolic cyclic oligomer, 2,3-bis-n-hexadecyloxyanthracene, cyclic depsipeptide, partially fluorinated alkane, cystine derivative, bis (2-ethylhexyl) sulfosuccinate sodium, triphenylamine derivative, butyrolactone derivative, 4 Quaternary ammonium salts, fluorinated alkylated oligomers, urea derivatives, vitamin H derivatives, gluconamides derivatives, cholic acid derivatives,
(2) Amino acid oil gelling agent
L-isoleucine derivative, L-valine derivative
(3) Cyclic dipeptide type oil gelling agent
Consists of 2,5-diketopiperazine derivatives, neutral amino acids (L-valine, L-leucine, L-phenylalanine) and acidic amino acids (L-glutamic acid-γ-ester, L-aspartic acid-β-ester) Cyclic dipeptide, cyclo (L-asp (OR) L-phe
(4) Oil gelator diamide of cyclohexanediamine derivative derivative (synthesized from trans 1,2-cyclohexanediamine)
Urea derivatives (synthesized from trans 1,2-cyclohexanediamine)
(5) Oil-gelling agent of double-headed amino acid derivative Double-headed L-isoleucine derivative, Double-headed L-valine derivative,
(6) Other oil gelling agents
1,3; 2,4-Dibenzylidene-D-sorbitol, N-lauroyl-L-glutamic acid-α, γ-bis-n-butyramide, benzoylgluconamide derivative, L-isoleucine derivative, L-valyl-L-valine Derivatives, diamide (synthesized from trans 1,2-cyclohexanediamine), diurea derivatives (synthesized from trans 1,2-cyclohexanediamine), double-headed amino acid derivatives, L-lysine derivatives, O- Methyl-4,6-benzylidene-D-galactose, 2,3-O-isopropylideneglyceraldehyde derivative.
(7) Hydrogelators of amino acid derivatives dibenzoyl-L-cystine, L-cystine derivatives, compounds obtained by crosslinking glutamic acid monoesters with diisothionate (dissolved only in phosphate buffer), L-leucine, L-valine, L -Double-headed amino acid derivatives cross-linked with phenyl glycine with oxalic acid, L-lysine-based organic gelling agent (positive or negative charge), ethanol compound with pyridine group, L-serine-based hydrogel Agent,
(8) Hydrogelator containing sugar
D-lactose derivatives, D-maltose derivatives, D-glucose derivatives, D-mannose derivatives, D-galactose derivatives, azobenzene compounds.
(9) Other hydrogelling agents, arpolol-type dendrimers, nucleotide-containing double-headed hydrogelators, bile acid derivatives, vancomycin, dendrimers with phosphorus in the center, lixarenne derivatives, double-headed surfactant hydrogels, naphthalenesulfonic acid Cationic glutamic acid compound having a deoxyuridine compound.
(10) Temperature-responsive high molecular weight polyethylene glycol / polypropylene glycol copolymer,
Polyethers (polyethylene oxide = PEO, poly (EO / PO) copolymer, PEO-PPO-PEO triblock surfactant, alkiel PEO surfactant, poly (vinyl methyl ether) = PVME, poly (oxyethylene vinyl ether) = POE VE), hydroxypropyl acrylate, cellulose derivatives (hydroxypropylmethylcellulose, hydroxypropylcellulose, methylcellulose), polyvinyl alcohol derivatives, poly (N-substituted acrylamide) derivatives (poly (N-substituted acrylamide), poly (N-vinylpyrrolidone) ), Poly (ethyl oxazoline), poly (N-vinylisobutyramide) = PNVIBA, poly (2-carboxyisopropylacrylamide) = PCIPAAm, poly (N-isopropylamide).

Next, specific methods for using hydrogen gel, oxygen gel, ozone gel, nitric oxide gel, nitrous oxide gel, and carbon dioxide gel will be described.

[Hydrogen gel]
Hydrogen is considered to have a function of neutralizing active oxygen that causes aging and the like. On the other hand, even if hydrogen is ingested orally, it will disperse outside the body within 10 minutes, so that conventional methods cannot deliver hydrogen to the small intestine.
According to the present invention, it is possible to easily carry hydrogen to the small intestine by making the gel enteric.

[Oxygen gel]
The amount of gas dissolved in water is extremely small, and in a normal usage method, a large amount of gas cannot be used except for gas stored in a tank under high pressure. Liquefied gas can be used for storage in a special environment, but it is rare in a normal environment.
According to the method of the present invention, a large amount of gas can be fixed in the gel.
Further, the oxygen concentration in the bubbles can be freely adjusted. Furthermore, it may be used as a mixed gas by adding another gas to oxygen. As the mixed gas, a brown gas in which hydrogen and oxygen are mixed at a ratio of 2: 1 can be considered.
When the gas is changed to oxygen, there is a large amount of oxygen in the gel. If the gel material is water-soluble, oxygen can be generated by adding water. Further, by adding a hardly soluble or insoluble material, this gel can be gradually dissolved in water and oxygen can be gradually supplied.
This is called “oxygen sustained release gel” (OTRG = Oxygen Time Releasing Gel).

OTRG practical example 1
In water tanks that carry fish, etc., it is necessary to use a motor pump or the like to constantly supply oxygen and continue to supply oxygen to the fish in the container. However, when the oxygen supply is stopped due to electrical or mechanical troubles, the business in containers such as water tanks is killed and difficult to save.
However, by supplying this OTRG into the container, it becomes possible to continue supplying oxygen for a certain period of time. In the unlikely event that an excessive amount of OTRG is added, under one atmospheric pressure, a certain amount of oxygen and a certain amount or more of oxygen will not be dissolved and will escape to the outside of the container, so an overoxygen state will not occur.

OTRG practical example 2
In general, for people whose blood oxygen saturation level has fallen due to illness, etc., use an oxygen mask or oxygen supply device to make the concentration higher than that of oxygen present in normal gas (20 → 30%). ) To supply oxygen into the body to increase saturation (saturation).
However, there is a drawback that the apparatus for supplying oxygen is bulky, from the apparatus that requires an oxygen cylinder to the apparatus that uses a permeable membrane.
Therefore, as an example, a mask-type small and simple oxygen supply device using OTRG can be created. If this mask is used, it will be a perfect oxygen supply method for those who go to high altitudes for emergency oxygen masks, mountain climbing, traveling, etc. installed in the aircraft. In addition, recent research has clarified the relationship between depressive symptoms and decreased oxygen saturation in the brain, but OTRG is also useful in the treatment of such cases.

OTRG practical example 3
This OTRG can be used as a supplement. Currently, "oxygen water", which is said to contain more dissolved oxygen than normal water, is manufactured and sold all over the world.
Ordinary water has dissolved oxygen at a concentration of about 8 ppm, depending on the temperature, but according to the manufacturer, “oxygen water” is said to have a dissolved oxygen amount of about 10 to 40 times.
By ingesting a large amount of oxygen-containing water, oxygen is supplied to the body, and the following effects are expected.
(1) It can activate brain cells, improve learning ability, and get sleepy.
(2) Immunostimulation (3) Decompose fatigue substance "lactic acid" generated by exercise and promote fatigue recovery (4) Promote lipolysis and expect a diet effect (5) As seen in oxygen therapy It stimulates skin cells and activates skin metabolism.
However, after drinking, the amount of dissolved oxygen decreases as the temperature rises in the body after drinking, so most oxygen is vaporized in the stomach, so the oxygen amount reaches the intestines or blood. Is extremely small.
Therefore, it is difficult to measure the efficacy of “oxygen water”, and there are an overwhelming number of medical professionals who question the effectiveness.
On the other hand, OTRG, when ingested as it is, dissolves in the stomach and generates oxygen, but if you add an enteric substance to make a gel or drink it in an enteric capsule, OTRG is oxygenated in the stomach The oxygen supply to the body is overwhelmingly increased compared to “oxygen water” because oxygen can be easily supplied only by the intestine without generating any oxygen.
In addition, OTRG containing oxygen is extremely easy to set the oxygen content per unit volume to several times that of “oxygen water”.
OTRG can continue to generate oxygen in the intestine for a long time. It has been found that inhaling 500 ml of air in a single breath takes about 100 ml of oxygen into the body. Therefore, there are many papers that generally reject the supply of oxygen water to improve athletic performance.
However, it can be expected to play a role in supplementing body oxygen in sports such as athletics and swimming, especially in short-distance sports performed with apnea. Although it is impossible to drink a large amount of oxygen-containing water immediately before the start, it is extremely easy to replenish oxygen in the body with a combination of an oxygen gel and an enteric capsule.

OTRG practical example 4
This gel can be applied to the surface of animals and plants and internal tissues or inserted.
For example, wounds (including wounds, stab wounds, wounds, split wounds, bruises, tears, gun wounds, explosion wounds, bite wounds, bruises, bruises) or surfaces such as palate, vagina, etc. Anaerobic bacteria, molds, and fungi grow in areas not exposed to oxygen, causing disease.
Therefore, by applying and attaching this OTRG to a part not exposed to the atmosphere, or inserting it in the form of a capsule, a tablet, etc., it will continue to supply oxygen for a long time and kill anaerobic microorganisms. Or weaken it.
Moreover, medicinal components such as antibiotics, quasi-drugs, cosmetics, and animal and plant extract substances may be mixed with the gel.
According to medical data, it is known that wounds are healed faster when exposed to atmospheric oxygen than by suturing and blocking oxygen. This is thought to be due to the rapid regeneration of capillaries due to the presence of oxygen. Therefore, hyperbaric oxygen therapy is utilized.
However, hyperbaric oxygen therapy is effective for the treatment of wounds, etc., but it is difficult to reduce the size due to the large equipment such as the tank, and it is difficult to manage because it uses high-pressure oxygen. On the other hand, carrying is almost impossible and the convenience is greatly inferior. Thus, it is expected that capillary regeneration can be promoted by applying or injecting OTRG to wounds, particularly those that do not come into contact with the atmosphere.
At this time, the oxygen concentration in the bubbles contained in the gel can be adjusted, or a mixed gas in which oxygen and another gas are combined can also be used.
Further, gels for regeneration of connective tissue such as hyaluronic acid, collagen, elastin, and placenta extract can be used in combination as gel components.

OTRG practical example 5
Combining oxygen gel with combustibles can be used as a combustion accelerator.
It can also be used as an “oxidation promoting material” that uses the action of “oxidizing” the target.

OTRG practical example 6
When scuba diving, humans cannot stay in the water for a long time without using oxygen cylinders.
However, normally, an atmosphere of up to about 200 atm is compressed and packed in the cylinder, but the oxygen is generally consumed in 1 to 1.5 hours depending on the depth of the dive. You have to get out of the water.
However, in the cylinder or in an adjacent location, the oxygen gel is melted at a temperature, water-solubilized, or chemically changed and melted to take out bubbled oxygen and add it to the air in the tank to supply oxygen. It is possible to dramatically extend the staying time in the water.

OTRG practical example 7
Combined with hydrogen gel, it plays the role of fuel cell as “hydrogen fuel”.
For example, when the gel is filled with hydrogen or oxygen under an environment of several atmospheric pressures or several tens of atmospheric pressures instead of 1 atm, the amount of hydrogen or oxygen contained can be increased.

[Ozone gel]
Gels containing fine ozone bubbles are considered effective for inactivating noroviruses and the like. That is, the bactericidal action is caused by free radicals generated when the ozone gel melts and ozone is released and decomposed into oxygen. In this case, even if the ozone concentration is low, ozone bubbles are negatively charged. On the other hand, since many viruses are positively charged, they are attracted to the ozone bubbles and sterilized. However, in the conventional method of containing ozone bubbles in water as in the prior art (Patent Document 4), since the medium is water, it is not possible to accurately provide ozone to the inside of a living body or a target place. It was not easy. In addition, water-like substances are fatally unsuitable in environments where moisture is strictly prohibited. However, if the gel holds ozone inside, there are options such as water solubility, fat solubility, volatility, etc., and it delivers ozone accurately to the inside of the living body and the target place, melts it at the target timing, and ozone is Can be provided.

[Nitrogen gel]
(A) Nitric oxide (NO) has recently attracted attention. From vasodilatory action to drugs for circulatory diseases, ED therapy Body builders are also using this NO to build muscle.
(1) Drinking sustained release gels or capsules containing a large amount of nitric oxide nano and micro bubbles will help strengthen muscles and eliminate ED.
(2) Macrophages around cancer cells produce NO, paralyze the mitochondrial function of cancer cells, and interfere with DNA synthesis to drive death.
(3) When insulin is administered for the treatment of diabetes, there is a drawback of reducing NO.
(4) NO has the role of signal transmission in the brain.
Therefore, combining nitric oxide gel or enteric capsules to achieve sustained release is useful in the fields of sports and medicine described in (1) to (4) above. In some cases, the nitric oxide gel is directly injected or applied to a necessary site in animals or plants (for example, around a cancer tissue or an organ), so that the medicines (1) to (4) and (6) Can be expected. In addition to nitric oxide alone, a therapeutic effect can be expected by using it in combination with other drugs (for example, anticancer drugs, vitamin C preparations, free radicals by radiotherapy, etc.).
(B) Nitrous oxide gel (nitrous oxide gel)
Dinitrogen monoxide is useful as an anesthetic. It is also called laughing gas, but at present it can only be used in the form of gas filled in a cylinder. However, if dinitrogen monoxide gel is used, it can be used as a finer part of the human body or as an anesthetic with excellent portability. In addition, it can be easily used for small animals.

[CO2 gel]
(1) Used as cosmetics to promote blood circulation and skin activation.
(2) If you put the gel in the drinking water, you can easily make a carbonated drink. In addition, the carbonic acid once lost can be replenished to restore the flavor of carbonated beverages and sparkling wine.
(3) Carbon dioxide is known as a “respiratory stimulant” and is also used to treat hyperventilation syndrome. Therefore, carbon dioxide gel can be effectively used for people who need respiratory stimulants in addition to hyperventilation syndrome.
(4) It is known that when oxygen is sucked by an oxygen cylinder used for scuba diving and medical use, it is more effective to mix 5 to 10% of carbon dioxide than oxygen alone. Therefore, a mixed gas can be easily produced by putting carbon dioxide gel in an oxygen cylinder.
(5) “Dry ice” made of carbon dioxide is used as a preservative for the remains of humans and animals. However, since it is close to minus 80 ° C, there is a risk of frostbite when touched directly, making it difficult to handle. Furthermore, when dry ice sublimates and directly becomes a gas, it swells 750 times, so there is a risk that containers such as plastic bottles may burst.
In addition, since the amount of carbon dioxide generated during sublimation is large, the concentration in the atmosphere may reach 10 to 50%, which may cause carbon dioxide poisoning.
It can be used as a preservative easily and safely anytime and anywhere by applying carbon dioxide gel directly to the body or sealing it in a package.
(6) When storing industrial products and parts in a sealed container or room, using a sufficient amount of carbon dioxide gel immediately before sealing, sealing and anti-corrosion effects can be obtained safely at low cost.
(7) The phenomenon of “carbon dioxide starvation”, which causes plant growth to stop due to the lack of carbon dioxide, which is indispensable for plant photosynthesis, is a serious problem when cultivating a large amount of plants in a greenhouse or in a winter greenhouse.
As a countermeasure, in order to replenish carbon dioxide, it is necessary to apply carbon dioxide, but there is a method to generate carbon dioxide by burning propane gas, but it is very difficult considering the cost, danger, and replenishment amount It was a problem.
Therefore, by installing, applying, or spraying carbon dioxide gel in a greenhouse or directly on a plant, carbon dioxide can be gradually generated and replenished, so that “carbon dioxide starvation” can be avoided. In addition, when carbon dioxide gel is used, it is a great advantage that it is inexpensive and safe.
(8) Carbon dioxide is essential for “photosynthesis” of plants. Therefore, while the plant is performing "photosynthesis", carbon dioxide gel is applied or sprayed on the branches and leaves of the plant to create an environment in which carbon dioxide is continuously generated around the plant, and promotes photosynthesis. Forcing cultivation. For carbon dioxide fertilization, an aqueous solution or solid of an alkali metal or alkaline earth metal that absorbs carbon dioxide is often used. However, after releasing carbon dioxide, a compound of an alkali metal or alkaline earth metal remains. is there. However, when carbon dioxide gel is used, no harmful components remain after the gel melt carbon dioxide release.

[Helium gel]
(1) Helium also enters micropores. Therefore, it is also used for nondestructive inspection methods.
Helium gas is injected into the pipe and detected with a helium detector, but when helium gas is used, only a part of the site can be detected in an extremely short time. However, when helium gel is used, helium can be generated over a wider range, which greatly improves the detection efficiency.
(2) As one of the party goods, helium gas is used to modify the voice (Donald Duck effect).
This occurs because the speed of sound is approximately tripled in helium. Normally, a gas mixture of 80% helium + 20% oxygen is used in a cylinder, but when helium gel is used, it is possible to easily modify the voice by simply applying or spraying the gel to the nostrils. .

[Chlorine gel, bromine gel, fluorine gel]
Although it can be used as a strong oxidizing agent, it can be generated over a long period of time by making it into a gel.

  FIG. 2 is a diagram for explaining a method for producing a functional gel according to another embodiment. In this embodiment, the container 1 for generating bubbles is a hermetically sealed container and is gelled separately from the container 1. A container 11 is provided, the container 1 and the container 11 are connected by a pipe 12 having a valve, and water or a low-viscosity solution in which bubbles are generated by the pressure in the container 1 is fed into the container 11. The fine bubbles 5a are crushed and a gelling agent is added.

  In FIG. 2, water or a low-viscosity solution in which bubbles are generated by pressure is sent into the container 11, but it may be sent using a pump such as a tubular pump. Further, a gelling agent may be set in the container 11 in advance.

The functional gel according to the present invention can be used in various fields such as antioxidant foods, cosmetics, pharmaceuticals.
For example, combustible gas and explosive gas use a combustion promoting action.
In addition to inducing repellent behavior of animals and plants, toxic gases are used to control animals and plants such as insecticide, sterilization, and hay.
For the water-soluble gas and the water-insoluble gas, the gel material, the coating agent, and the excipient material can be selected in order to stably maintain the state taken into the gel.
In the case of containing an endothermic gas, as a heat-absorbing gel, and in the case of a non-endothermic gas, as a gel for heat insulation, heat insulation, and cold insulation, “clothing” “shoes” “bedding” “sporting goods” “building materials” It can be used for "daily necessities" and "machinery".
Nitrogen and carbon dioxide gas can also be used for plant growth.
The gel of the present application is added for the promotion, suppression and control of the above-described chemical reactions including combustion, explosion, heat absorption, and heat dissipation.
All gels can be used in various fields, such as pharmaceuticals, cosmetics, building materials, chemical reaction promotion, catalysis and control agents, depending on the type of gas contained.

DESCRIPTION OF SYMBOLS 1 ... Container which generate | occur | produces a bubble, 2 ... High frequency power supply, 3 ... Ultrasonic diaphragm piping, 4 ... Gas supply pipe, 5 ... Bubble, 5a ... Fine bubble, 11. ..Vessel that gels, 12 ... pipe.

Claims (3)

Put water or a low-viscosity solution in the container, send gas into this water or low-viscosity solution to generate bubbles, and some of the generated bubbles do not reach the water surface, and the liquid pressure is reduced. A method for producing a functional gel, comprising waiting for crushing and disappearing by adding a gelling agent to the water or low-viscosity solution to cause the water or low-viscosity solution to gel. The method for producing a functional gel according to claim 1, wherein the container for generating bubbles is separated from the container for gelation, and water or a low-viscosity solution in which bubbles are generated is applied using pressure or a pump. A method for producing a functional gel, which is fed into a container that is gelled. 2. The method of producing a functional gel according to claim 1, wherein a gas of fine bubbles having a small buoyancy, including a crushed one in water or a solution having a low viscosity, is electrically or magnetically retained only in the solution. A function that can keep more gas in the solution by using electromagnetic or chemical force, and can keep the gas inside more stably and stably by adjusting the pH of the gelling agent. Method for producing sex gel.

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